Motif ID: NR3C1.p2

Z-value: 1.507


Transcription factors associated with NR3C1.p2:

Gene SymbolEntrez IDGene Name
NR3C1 2908 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR3C1chr5_-_142764295-0.495.3e-02Click!


Activity profile for motif NR3C1.p2.

activity profile for motif NR3C1.p2


Sorted Z-values histogram for motif NR3C1.p2

Sorted Z-values for motif NR3C1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR3C1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_202726068 2.875 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr22_+_21042091 2.157 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr7_+_105390892 2.133 NM_152750
CDHR3
cadherin-related family member 3
chr1_-_144426918 2.073 NM_007053
CD160
CD160 molecule
chr7_-_16811131 1.893 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr22_+_21053972 1.831


chr10_+_77212524 1.772 NM_032024
C10orf11
chromosome 10 open reading frame 11
chr6_+_36752244 1.734 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr15_-_68781662 1.660 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr7_+_116182676 1.651


chr10_+_114033403 1.465 NM_058222
TECTB
tectorin beta
chr16_+_8722068 1.376 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr1_-_181889070 1.331 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr1_-_156800017 1.300 NM_001160325
OR6P1
olfactory receptor, family 6, subfamily P, member 1
chr6_-_89984214 1.278 NM_002042
GABRR1
gamma-aminobutyric acid (GABA) receptor, rho 1
chr11_-_123414917 1.276 NM_001004463
OR10G7
olfactory receptor, family 10, subfamily G, member 7
chr11_+_124294355 1.230 NM_001037558
HEPN1
hepatocellular carcinoma, down-regulated 1
chr7_+_117651947 1.183 NM_019644
ANKRD7
ankyrin repeat domain 7
chr7_-_143587653 1.162 NM_001005328
OR2A7
OR2A4
olfactory receptor, family 2, subfamily A, member 7
olfactory receptor, family 2, subfamily A, member 4
chr1_-_94359266 1.143 NM_000350
ABCA4
ATP-binding cassette, sub-family A (ABC1), member 4
chr11_+_4799126 1.119 NM_001004753
OR51F2
olfactory receptor, family 51, subfamily F, member 2
chr1_-_177106702 1.111 NM_004673
ANGPTL1
angiopoietin-like 1
chr21_+_43024936 1.097 PDE9A
phosphodiesterase 9A
chr10_+_685887 1.078 C10orf108
chromosome 10 open reading frame 108
chr7_-_99312591 1.075 NM_001005276
OR2AE1
olfactory receptor, family 2, subfamily AE, member 1
chr6_+_150731720 1.027 NM_001164694
NM_001164695
NM_203395
IYD


iodotyrosine deiodinase


chr11_-_8695974 0.992 ST5
suppression of tumorigenicity 5
chr11_+_73036241 0.991 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr3_+_125586241 0.986 KALRN
kalirin, RhoGEF kinase
chr19_+_14913298 0.959 NM_012377
OR7C2
olfactory receptor, family 7, subfamily C, member 2
chr1_-_6468108 0.928 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr1_+_20837001 0.921


chr11_+_59804634 0.866 NM_148975
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4
chr15_-_31999815 0.849


chr10_-_7699192 0.838 ITIH5
inter-alpha (globulin) inhibitor H5
chr16_-_70591377 0.827 NM_181536
PKD1L3
polycystic kidney disease 1-like 3
chr5_+_169749068 0.821


chr11_-_4924905 0.820 NM_001005329
OR51A4
olfactory receptor, family 51, subfamily A, member 4
chr16_+_4485859 0.809 NM_001127205
HMOX2
heme oxygenase (decycling) 2
chr7_-_124192265 0.808 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr1_+_84646621 0.808 NM_058248
DNASE2B
deoxyribonuclease II beta
chr7_-_98643024 0.803 NM_001145715
KPNA7
karyopherin alpha 7 (importin alpha 8)
chr22_-_15453440 0.803 NM_014406
CCT8L2
chaperonin containing TCP1, subunit 8 (theta)-like 2
chr16_+_70654625 0.792 NM_020995
HPR
haptoglobin-related protein
chr11_+_44742551 0.769 NM_130783
TSPAN18
tetraspanin 18
chr21_+_29322100 0.744 USP16
ubiquitin specific peptidase 16
chr12_+_91654395 0.739 NM_001004330
PLEKHG7
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr1_+_246468853 0.723 NM_017504
OR2M4
olfactory receptor, family 2, subfamily M, member 4
chr19_-_56841819 0.720 NM_001098612
SIGLEC14
sialic acid binding Ig-like lectin 14
chr7_-_7541974 0.718 NM_001037763
COL28A1
collagen, type XXVIII, alpha 1
chr5_+_149867866 0.711 NM_001543
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr6_-_152681171 0.710 NM_015293
SYNE1
spectrin repeat containing, nuclear envelope 1
chrX_-_100434700 0.707 NM_024885
TAF7L
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
chr19_+_62844143 0.673 ZNF211
zinc finger protein 211
chr16_-_20610078 0.673 NM_052956
ACSM1
acyl-CoA synthetase medium-chain family member 1
chr6_-_76027286 0.659 TMEM30A
transmembrane protein 30A
chr1_+_111571803 0.656 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr7_-_132131742 0.653 CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3
chr11_-_33678861 0.652 NM_001166692
C11orf91
chromosome 11 open reading frame 91
chr1_-_157950898 0.650 NM_000567
CRP
C-reactive protein, pentraxin-related
chr6_-_132064233 0.648 NM_030908
OR2A4
olfactory receptor, family 2, subfamily A, member 4
chr1_-_10779291 0.645 NM_001079843
NM_017766
CASZ1

castor zinc finger 1

chr1_-_117554999 0.644 NM_024626
VTCN1
V-set domain containing T cell activation inhibitor 1
chr1_-_54256390 0.633 NM_001010978
LDLRAD1
low density lipoprotein receptor class A domain containing 1
chr7_+_128795280 0.626 AHCYL2
adenosylhomocysteinase-like 2
chr1_+_43539239 0.625 NM_005424
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr10_+_24795446 0.623 KIAA1217
KIAA1217
chr18_+_30652223 0.622 NM_001198942
NM_001198944
NM_032980
NM_032981
DTNA



dystrobrevin, alpha



chr1_-_11111387 0.614


chrX_+_46825179 0.604 RGN
regucalcin (senescence marker protein-30)
chr8_-_110724594 0.590 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr15_+_40481879 0.588 NM_173088
CAPN3
calpain 3, (p94)
chr1_+_190394214 0.581 NM_130782
RGS18
regulator of G-protein signaling 18
chrX_+_49223101 0.573 NM_001098405
GAGE12F
GAGE3
GAGE4
GAGE5
GAGE7
G antigen 12F
G antigen 3
G antigen 4
G antigen 5
G antigen 7
chr10_+_24795465 0.572 KIAA1217
KIAA1217
chr7_+_94377145 0.568 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr2_+_231569082 0.567 NM_139073
SPATA3
spermatogenesis associated 3
chr21_+_37713076 0.565 NM_130436
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr3_-_188935363 0.564 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr2_-_74460933 0.536 NM_001135040
NM_001190837
NM_004082
DCTN1


dynactin 1


chr6_+_31746706 0.536 NM_021221
LY6G5B
lymphocyte antigen 6 complex, locus G5B
chr8_-_62764839 0.535 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr2_-_121964373 0.533 CLASP1
cytoplasmic linker associated protein 1
chr2_-_85749374 0.525 NM_000542
NM_198843
SFTPB

surfactant protein B

chr4_+_35962038 0.522 NM_001170700
DTHD1
death domain containing 1
chr1_-_35692668 0.518 KIAA0319L
KIAA0319-like
chr7_-_107558021 0.513 NM_007356
LAMB4
laminin, beta 4
chr7_-_11643113 0.512 THSD7A
thrombospondin, type I, domain containing 7A
chr7_+_143263191 0.510 NM_001004685
OR2F2
olfactory receptor, family 2, subfamily F, member 2
chr11_-_123918759 0.508 NM_001005195
OR8B12
olfactory receptor, family 8, subfamily B, member 12
chr1_+_22852268 0.506 NM_000491
C1QB
complement component 1, q subcomponent, B chain
chr7_+_20008870 0.506 RPL21
ribosomal protein L21
chr2_+_64540843 0.505 HSPC159
galectin-related protein
chr5_-_156705250 0.501 NM_001001343
FNDC9
fibronectin type III domain containing 9
chr10_-_123343320 0.495 NM_001144913
NM_001144914
FGFR2

fibroblast growth factor receptor 2

chr6_-_47117951 0.495 NM_025048
NM_153840
GPR110

G protein-coupled receptor 110

chr1_-_60164912 0.485 NM_000775
CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr5_-_169749215 0.484 NM_004137
KCNMB1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr22_-_35835548 0.481 TMPRSS6
transmembrane protease, serine 6
chr19_-_59568222 0.479 LAIR1
leukocyte-associated immunoglobulin-like receptor 1
chr1_-_240228987 0.478 NM_001004343
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma
chr11_+_123398929 0.476 NM_001001953
OR10G9
olfactory receptor, family 10, subfamily G, member 9
chr3_-_152659186 0.475 NM_178822
IGSF10
immunoglobulin superfamily, member 10
chr10_-_123343761 0.474 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr11_+_19328846 0.473 NM_001111018
NAV2
neuron navigator 2
chr1_-_7998265 0.470 ERRFI1
ERBB receptor feedback inhibitor 1
chr10_+_170423 0.470 NM_001161482
NM_006624
NM_212479
ZMYND11


zinc finger, MYND-type containing 11


chr1_-_23393808 0.469 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr20_-_54534387 0.465 NM_080615
GCNT7
glucosaminyl (N-acetyl) transferase family member 7
chr7_+_120752656 0.460 NM_016087
WNT16
wingless-type MMTV integration site family, member 16
chr1_+_32777556 0.459 ZBTB8A
zinc finger and BTB domain containing 8A
chr8_-_7297296 0.459 NM_058206
NM_058207
SPAG11B

sperm associated antigen 11B

chr20_+_30831298 0.454 NM_175850
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta
chr21_+_45396903 0.451 ADARB1
adenosine deaminase, RNA-specific, B1
chr7_+_127020924 0.447 NM_020369
FSCN3
fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)
chr1_-_54861656 0.445 NM_176782
FAM151A
family with sequence similarity 151, member A
chrX_+_49104714 0.443 NM_001098405
GAGE12F
GAGE1
GAGE4
GAGE5
GAGE7
G antigen 12F
G antigen 1
G antigen 4
G antigen 5
G antigen 7
chr11_-_36576352 0.440 NM_000536
RAG2
recombination activating gene 2
chr8_-_53484753 0.439 NM_014682
ST18
suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)
chr12_+_52126131 0.437 PRR13
proline rich 13
chr11_-_121492010 0.434 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr17_+_11726943 0.418 NM_004662
DNAH9
dynein, axonemal, heavy chain 9
chr19_-_59568483 0.415 NM_002287
NM_021706
LAIR1

leukocyte-associated immunoglobulin-like receptor 1

chr3_+_16949585 0.412 NM_015184
PLCL2
phospholipase C-like 2
chr20_-_44612619 0.408 NM_080721
C20orf123
chromosome 20 open reading frame 123
chr18_+_18989786 0.406 NM_138375
CABLES1
Cdk5 and Abl enzyme substrate 1
chr1_-_109957195 0.406 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr10_+_114144512 0.406 ACSL5
acyl-CoA synthetase long-chain family member 5
chr2_-_26717713 0.404 NM_001029881
CIB4
calcium and integrin binding family member 4
chr8_+_128497038 0.398 NM_001159542
POU5F1B
POU class 5 homeobox 1B
chr6_-_31756119 0.393 NM_025262
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr16_-_66075216 0.392 NM_001138
AGRP
agouti related protein homolog (mouse)
chr17_-_24491521 0.391 MYO18A
myosin XVIIIA
chr11_-_47467094 0.390 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr9_-_103237851 0.387 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr14_+_19365447 0.384 NM_001004723
OR4N2
olfactory receptor, family 4, subfamily N, member 2
chr14_+_62740878 0.383 NM_020663
RHOJ
ras homolog gene family, member J
chr16_-_67039874 0.381 NM_018667
SMPD3
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
chr8_-_13018123 0.381 NM_001164271
DLC1
deleted in liver cancer 1
chr6_+_37511383 0.379


chr15_+_64787983 0.376 NM_001142861
SMAD6
SMAD family member 6
chr19_+_59705824 0.375 NM_002288
NM_021270
LAIR2

leukocyte-associated immunoglobulin-like receptor 2

chr5_+_147628567 0.375 NM_001040129
SPINK13
serine peptidase inhibitor, Kazal type 13 (putative)
chr19_-_59568340 0.373 LAIR1
leukocyte-associated immunoglobulin-like receptor 1
chr7_+_128142661 0.368 NM_032599
FAM71F1
family with sequence similarity 71, member F1
chr17_-_36418869 0.368 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr1_-_158190585 0.368 NM_001146172
NM_001146173
NM_033438
SLAMF9


SLAM family member 9


chr1_+_89602023 0.366 NM_198460
GBP6
guanylate binding protein family, member 6
chr11_-_114593838 0.363 CADM1
cell adhesion molecule 1
chr5_-_176876224 0.360 DDX41
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
chr1_+_13588674 0.354 NM_001099851
PRAMEF17
PRAME family member 17
chr2_-_113310796 0.354 NM_000576
IL1B
interleukin 1, beta
chr9_+_130427988 0.353 SPTAN1
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
chrX_+_65300803 0.353 NM_001130860
NM_014799
HEPH

hephaestin

chr12_-_69838045 0.352 NM_004616
TSPAN8
tetraspanin 8
chr11_+_57123927 0.346 SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr3_-_11585264 0.345 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr1_+_181380837 0.342 LAMC1
laminin, gamma 1 (formerly LAMB2)
chr14_-_76612286 0.341


chr1_+_34997928 0.335 NM_153212
GJB4
gap junction protein, beta 4, 30.3kDa
chr11_-_5835507 0.330 NM_001005168
OR52E8
olfactory receptor, family 52, subfamily E, member 8
chr1_-_151630168 0.329 NM_002964
S100A8
S100 calcium binding protein A8
chrX_+_118598325 0.329 NM_181777
UBE2A
ubiquitin-conjugating enzyme E2A (RAD6 homolog)
chr19_-_40317829 0.327 NM_139284
LGI4
leucine-rich repeat LGI family, member 4
chrX_-_44945025 0.324 NM_024689
NM_176819
CXorf36

chromosome X open reading frame 36

chr5_+_55098469 0.323 NM_001166534
DDX4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr7_-_96492064 0.322 NM_005221
DLX5
distal-less homeobox 5
chr4_-_146315341 0.322 NM_017493
OTUD4
OTU domain containing 4
chr15_+_72892205 0.321 NM_021819
LMAN1L
lectin, mannose-binding, 1 like
chr11_-_116692128 0.316 NM_012104
NM_138971
NM_138972
NM_138973
BACE1



beta-site APP-cleaving enzyme 1



chr12_-_94914133 0.316 NM_002108
HAL
histidine ammonia-lyase
chr10_-_92670764 0.313 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr3_+_45902999 0.312 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr3_-_147696411 0.309 NM_020359
PLSCR2
phospholipid scramblase 2
chr2_+_31310383 0.309 NM_014600
EHD3
EH-domain containing 3
chr2_-_56266408 0.302 LOC100129434
hypothetical LOC100129434
chr21_-_31049566 0.300 NM_181619
KRTAP21-1
keratin associated protein 21-1
chr6_+_29515694 0.299 NM_013941
OR10C1
olfactory receptor, family 10, subfamily C, member 1
chr6_-_41230003 0.299 NM_178174
TREML1
triggering receptor expressed on myeloid cells-like 1
chr19_-_5821546 0.299 NM_002034
FUT5
fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
chr1_-_171442937 0.299 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr1_-_166779825 0.295 NM_003175
XCL1
XCL2
chemokine (C motif) ligand 1
chemokine (C motif) ligand 2
chr1_+_32777358 0.295 NM_001040441
ZBTB8A
zinc finger and BTB domain containing 8A
chr11_-_102331643 0.294 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr1_-_150065176 0.293 NM_001001523
RORC
RAR-related orphan receptor C
chr12_-_69837831 0.292 TSPAN8
tetraspanin 8
chr10_-_101680645 0.292 DNMBP
dynamin binding protein
chr17_-_68100537 0.291 LOC100499467
hypothetical LOC100499467
chr11_-_117552355 0.287 SCN2B
sodium channel, voltage-gated, type II, beta
chr16_+_88616508 0.287 NM_001481
GAS8
growth arrest-specific 8
chr11_+_61794205 0.286 NM_002411
SCGB2A2
secretoglobin, family 2A, member 2
chrX_-_52752935 0.285 NM_003147
NM_175698
NM_001164417
SSX2

SSX2B
synovial sarcoma, X breakpoint 2

synovial sarcoma, X breakpoint 2B
chr21_+_42792810 0.283 NM_018964
SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr1_+_112811562 0.282 NM_004185
WNT2B
wingless-type MMTV integration site family, member 2B
chr1_-_232962369 0.282 PP2672
hypothetical LOC100130249
chr19_-_57924946 0.280 NM_030972
ZNF611
zinc finger protein 611
chr12_+_5023345 0.278 NM_002234
KCNA5
potassium voltage-gated channel, shaker-related subfamily, member 5
chr9_+_101628829 0.275 NM_173200
NR4A3
nuclear receptor subfamily 4, group A, member 3
chr17_-_36570508 0.275 NM_032524
KRTAP4-4
keratin associated protein 4-4
chr14_-_105804211 0.274 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.80 7.07e-07 GO:0007608 sensory perception of smell
2.62 2.74e-06 GO:0007606 sensory perception of chemical stimulus
1.92 1.45e-03 GO:0007600 sensory perception
1.56 8.83e-03 GO:0003008 system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.36 6.36e-05 GO:0071944 cell periphery
1.36 7.79e-05 GO:0005886 plasma membrane
1.68 4.74e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.81 3.75e-07 GO:0004984 olfactory receptor activity
2.01 2.25e-05 GO:0004930 G-protein coupled receptor activity
1.46 6.41e-03 GO:0004871 signal transducer activity
1.46 6.41e-03 GO:0060089 molecular transducer activity