Motif ID: IRF1,2,7.p3

Z-value: 2.439


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IRF7chr11_-_605649-0.582.0e-02Click!
IRF2chr4_-_1856326100.253.5e-01Click!
IRF1chr5_-_1318543250.126.5e-01Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_34521945 4.391 SRP54
signal recognition particle 54kDa
chr12_+_111900650 3.766 NM_001032731
NM_002535
NM_016817
 OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr9_-_32516164 3.542 NM_014314
 DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr6_-_46997579 3.366 NM_001098518
 GPR116
G protein-coupled receptor 116
chr14_+_34521854 3.130 NM_001146282
NM_003136
 SRP54

signal recognition particle 54kDa

chr6_+_26473376 3.073 NM_001197247
NM_001197249
NM_007047
NM_001197248
 BTN3A2



butyrophilin, subfamily 3, member A2



chr20_+_1194959 2.993 NM_014723
 SNPH
syntaphilin
chr14_+_31100330 2.985 NM_025152
 NUBPL
nucleotide binding protein-like
chr13_-_42464301 2.959 NM_001002264
NM_033255
 EPSTI1

epithelial stromal interaction 1 (breast)

chr6_+_26510443 2.858 NM_001145008
NM_001145009
NM_007048
NM_194441
 BTN3A1



butyrophilin, subfamily 3, member A1



chr6_+_26548678 2.789 NM_006994
NM_197974
 BTN3A3

butyrophilin, subfamily 3, member A3

chr20_-_55628852 2.661 NM_001160417
NM_001160418
NM_001160419
NM_030776
 ZBP1



Z-DNA binding protein 1



chr2_-_70329067 2.627 NM_022037
NM_022173
 TIA1

TIA1 cytotoxic granule-associated RNA binding protein

chr2_-_1905508 2.500 MYT1L
myelin transcription factor 1-like
chr12_+_27568311 2.458 NM_001198915
NM_001198916
NM_003622
NM_177444
 PPFIBP1



PTPRF interacting protein, binding protein 1 (liprin beta 1)



chr2_+_122229590 2.444 NM_004622
 TSN
translin
chr20_-_5048443 2.436 NM_182649
 PCNA
proliferating cell nuclear antigen
chr16_+_55580910 2.429 NM_032206
 NLRC5
NLR family, CARD domain containing 5
chr2_-_142605739 2.407 NM_018557
 LRP1B
low density lipoprotein receptor-related protein 1B
chr7_+_154351087 2.393 LOC100132707
hypothetical LOC100132707

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 72 entries
enrichment   p-value GO term description
13.79 8.92e-04 GO:0019883 antigen processing and presentation of endogenous antigen
9.90 4.99e-04 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
8.05 2.03e-04 GO:0048002 antigen processing and presentation of peptide antigen
5.88 2.86e-09 GO:0034340 response to type I interferon
5.77 3.78e-07 GO:0006521 regulation of cellular amino acid metabolic process
5.71 1.72e-08 GO:0060337 type I interferon-mediated signaling pathway
5.71 1.72e-08 GO:0071357 cellular response to type I interferon
5.01 5.86e-06 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
5.01 5.86e-06 GO:0072395 signal transduction involved in cell cycle checkpoint
5.01 5.86e-06 GO:0072401 signal transduction involved in DNA integrity checkpoint
5.01 5.86e-06 GO:0072404 signal transduction involved in G1/S transition checkpoint
5.01 5.86e-06 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
5.01 5.86e-06 GO:0072422 signal transduction involved in DNA damage checkpoint
5.01 5.86e-06 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
5.01 5.86e-06 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
4.80 5.16e-06 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
4.78 1.44e-05 GO:0033238 regulation of cellular amine metabolic process
4.78 1.44e-05 GO:0071158 positive regulation of cell cycle arrest
4.73 6.89e-06 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
4.60 1.21e-05 GO:0051352 negative regulation of ligase activity

Gene overrepresentation in compartment category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
8.05 2.90e-05 GO:0005839 proteasome core complex
4.85 1.53e-06 GO:0000502 proteasome complex
1.13 1.47e-02 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
7.66 8.24e-05 GO:0004298 threonine-type endopeptidase activity
7.66 8.24e-05 GO:0070003 threonine-type peptidase activity