Motif ID: IRF1,2,7.p3

Z-value: 2.439


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IRF7chr11_-_605649-0.582.0e-02Click!
IRF2chr4_-_1856326100.253.5e-01Click!
IRF1chr5_-_1318543250.126.5e-01Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_34521945 4.391 SRP54
signal recognition particle 54kDa
chr12_+_111900650 3.766 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr9_-_32516164 3.542 NM_014314
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr6_-_46997579 3.366 NM_001098518
GPR116
G protein-coupled receptor 116
chr14_+_34521854 3.130 NM_001146282
NM_003136
SRP54

signal recognition particle 54kDa

chr6_+_26473376 3.073 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr20_+_1194959 2.993 NM_014723
SNPH
syntaphilin
chr14_+_31100330 2.985 NM_025152
NUBPL
nucleotide binding protein-like
chr13_-_42464301 2.959 NM_001002264
NM_033255
EPSTI1

epithelial stromal interaction 1 (breast)

chr6_+_26510443 2.858 NM_001145008
NM_001145009
NM_007048
NM_194441
BTN3A1



butyrophilin, subfamily 3, member A1



chr6_+_26548678 2.789 NM_006994
NM_197974
BTN3A3

butyrophilin, subfamily 3, member A3

chr20_-_55628852 2.661 NM_001160417
NM_001160418
NM_001160419
NM_030776
ZBP1



Z-DNA binding protein 1



chr2_-_70329067 2.627 NM_022037
NM_022173
TIA1

TIA1 cytotoxic granule-associated RNA binding protein

chr2_-_1905508 2.500 MYT1L
myelin transcription factor 1-like
chr12_+_27568311 2.458 NM_001198915
NM_001198916
NM_003622
NM_177444
PPFIBP1



PTPRF interacting protein, binding protein 1 (liprin beta 1)



chr2_+_122229590 2.444 NM_004622
TSN
translin
chr20_-_5048443 2.436 NM_182649
PCNA
proliferating cell nuclear antigen
chr16_+_55580910 2.429 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr2_-_142605739 2.407 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr7_+_154351087 2.393 LOC100132707
hypothetical LOC100132707
chr10_+_101532544 2.313 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr7_-_92615593 2.306 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr16_+_10878539 2.297 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr17_+_38719371 2.245 NM_145041
TMEM106A
FLJ77644
transmembrane protein 106A
hypothetical LOC728772
chr17_+_44263370 2.195 NM_005831
CALCOCO2
calcium binding and coiled-coil domain 2
chr10_+_101532450 2.195 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr6_+_37081387 2.155 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr1_+_234624266 2.149 NM_145861
EDARADD
EDAR-associated death domain
chr2_-_230792844 2.141 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr4_-_169476391 2.092 NM_017631
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr6_-_30289092 1.981 NM_003449
TRIM26
tripartite motif containing 26
chr12_+_4628521 1.927 NM_005002
NDUFA9
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
chr2_-_68143618 1.921 C1D
C1D nuclear receptor corepressor
chr10_+_63478974 1.900 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr17_-_41018291 1.799


chr4_+_187227302 1.787 NM_003265
TLR3
toll-like receptor 3
chr12_+_25096472 1.767 NM_006152
LRMP
lymphoid-restricted membrane protein
chr14_-_34252695 1.746 NM_021914
CFL2
cofilin 2 (muscle)
chr2_-_112358204 1.704 NM_022662
ANAPC1
anaphase promoting complex subunit 1
chr8_+_101232014 1.700 NM_005034
POLR2K
polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
chr2_+_6935246 1.699 NM_080657
RSAD2
radical S-adenosyl methionine domain containing 2
chr14_-_34253473 1.677 NM_138638
CFL2
cofilin 2 (muscle)
chr4_+_88147107 1.654 NM_005935
AFF1
AF4/FMR2 family, member 1
chr4_+_144654526 1.640


chr12_+_25096755 1.621 LRMP
lymphoid-restricted membrane protein
chr10_+_92970487 1.618 PCGF5
polycomb group ring finger 5
chr2_+_178986617 1.605


chr13_-_33148899 1.602 STARD13
StAR-related lipid transfer (START) domain containing 13
chr9_-_122852356 1.561 NM_001735
C5
complement component 5
chr7_-_134845363 1.558 NM_001008225
NM_001190847
NM_001190848
NM_001190849
NM_001190850
NM_013316
CNOT4





CCR4-NOT transcription complex, subunit 4





chr17_+_18320822 1.552 NM_001040078
LGALS9B
LGALS9C
lectin, galactoside-binding, soluble, 9B
lectin, galactoside-binding, soluble, 9C
chr2_+_169637255 1.548 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chrX_+_77041612 1.532 NM_001866
COX7B
cytochrome c oxidase subunit VIIb
chr12_+_38905053 1.522 NM_198578
LRRK2
leucine-rich repeat kinase 2
chr6_+_29902734 1.515 NM_002127
HLA-G
major histocompatibility complex, class I, G
chr22_+_34374358 1.505 NM_030641
APOL6
apolipoprotein L, 6
chr16_+_22011362 1.502 NM_173615
VWA3A
von Willebrand factor A domain containing 3A
chr2_-_68143662 1.465 NM_001190263
NM_001190265
NM_006333
NM_173177
C1D



C1D nuclear receptor corepressor



chr2_+_33555182 1.440 RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr21_+_42807052 1.438 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr8_+_79740813 1.437 NM_016010
FAM164A
family with sequence similarity 164, member A
chr17_+_70092651 1.437 NM_152460
C17orf77
chromosome 17 open reading frame 77
chr12_-_9913199 1.436 CLEC2B
C-type lectin domain family 2, member B
chr19_+_35555158 1.429 NM_014717
ZNF536
zinc finger protein 536
chr14_-_69953433 1.422 NM_018373
SYNJ2BP
synaptojanin 2 binding protein
chr4_-_100359353 1.419 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr17_-_44022595 1.414 HOXB3
homeobox B3
chr5_+_36642424 1.410 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr10_+_92970302 1.391 NM_032373
PCGF5
polycomb group ring finger 5
chr2_-_101134146 1.381 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr2_+_190014432 1.381 WDR75
WD repeat domain 75
chr6_-_138231006 1.378


chr6_-_133161318 1.371 NM_052831
C6orf192
chromosome 6 open reading frame 192
chr8_-_17797127 1.356 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr2_-_112358013 1.350 ANAPC1
anaphase promoting complex subunit 1
chr17_-_30783631 1.350 NM_018042
SLFN12
schlafen family member 12
chr4_+_89597257 1.348 NM_016323
HERC5
hect domain and RLD 5
chr11_+_18244383 1.334 NM_000331
NM_001178006
NM_199161
SAA1


serum amyloid A1


chr11_-_18226743 1.301 NM_001127380
NM_030754
SAA2

serum amyloid A2

chr2_-_55774451 1.295 NM_033109
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr1_+_110254755 1.292 NM_000757
NM_172210
NM_172211
NM_172212
CSF1



colony stimulating factor 1 (macrophage)



chr5_-_95184121 1.291 GLRX
glutaredoxin (thioltransferase)
chr1_+_149165438 1.289 NM_001145415
NM_012432
SETDB1

SET domain, bifurcated 1

chr16_-_18845223 1.288 NM_015092
SMG1
SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
chr1_-_180824967 1.269 RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr2_-_151826504 1.267 NM_198557
RBM43
RNA binding motif protein 43
chr1_+_87368044 1.267 LOC339524
hypothetical LOC339524
chr6_-_133126278 1.266 NM_078488
VNN2
vanin 2
chr3_+_114733907 1.266 NM_017699
SIDT1
SID1 transmembrane family, member 1
chr3_-_102888090 1.266 NM_000986
RPL24
ribosomal protein L24
chr6_-_31432543 1.250 HLA-B
major histocompatibility complex, class I, B
chr22_+_34374421 1.248 APOL6
apolipoprotein L, 6
chr17_-_57295451 1.246 NM_032043
BRIP1
BRCA1 interacting protein C-terminal helicase 1
chr6_-_24827265 1.236 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr3_-_69381995 1.231 FRMD4B
FERM domain containing 4B
chr22_+_25155220 1.225 NM_020437
ASPHD2
aspartate beta-hydroxylase domain containing 2
chr22_-_21204597 1.225 NM_080740
ZNF280A
zinc finger protein 280A
chr19_+_49361054 1.219 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
ZNF226




zinc finger protein 226




chr8_-_143864933 1.215 NM_003695
LY6D
lymphocyte antigen 6 complex, locus D
chr12_+_111860384 1.201 OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr11_-_62363551 1.197 WDR74
WD repeat domain 74
chr19_-_51909416 1.197 NM_001079882
PRKD2
protein kinase D2
chr16_-_11257539 1.191 NM_003745
SOCS1
suppressor of cytokine signaling 1
chr2_+_190014403 1.191 NM_032168
WDR75
WD repeat domain 75
chr1_-_247086686 1.166 NM_030645
SH3BP5L
SH3-binding domain protein 5-like
chr6_+_20642665 1.161 NM_017774
CDKAL1
CDK5 regulatory subunit associated protein 1-like 1
chr11_-_104344473 1.157 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr2_+_201806410 1.149 NM_001080124
NM_001228
NM_033355
NM_033358
CASP8



caspase 8, apoptosis-related cysteine peptidase



chr11_+_28088406 1.147 METTL15
methyltransferase like 15
chr6_+_20510019 1.144 NM_001949
E2F3
E2F transcription factor 3
chr5_+_36642213 1.140 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr3_-_150993299 1.138 NM_001144960
C3orf16
chromosome 3 open reading frame 16
chr6_+_26195426 1.136 NM_000410
NM_139003
NM_139004
NM_139006
NM_139007
NM_139008
NM_139009
NM_139010
NM_139011
HFE








hemochromatosis








chr6_+_17501589 1.134 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr4_-_40212670 1.132 NM_019027
RBM47
RNA binding motif protein 47
chr6_-_121697305 1.129 NM_152730
C6orf170
chromosome 6 open reading frame 170
chr17_+_76988134 1.126 NM_001080519
BAHCC1
BAH domain and coiled-coil containing 1
chr8_+_22075112 1.116 NM_001172357
NM_001172410
NM_003018
SFTPC


surfactant protein C


chr5_+_56507029 1.104 NM_001127235
GPBP1
GC-rich promoter binding protein 1
chr19_+_17377502 1.101 LOC100507535
hypothetical LOC100507535
chr11_+_7463175 1.098 NM_198474
OLFML1
olfactomedin-like 1
chr14_+_93646831 1.096 NM_001130080
NM_005532
IFI27

interferon, alpha-inducible protein 27

chr12_-_4628436 1.096 AKAP3
A kinase (PRKA) anchor protein 3
chr6_-_48186868 1.086 C6orf138
chromosome 6 open reading frame 138
chr5_-_159730196 1.079 NM_031908
C1QTNF2
C1q and tumor necrosis factor related protein 2
chr5_-_95184221 1.073 NM_001118890
NM_002064
GLRX

glutaredoxin (thioltransferase)

chr22_+_38903825 1.073 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr20_+_13924263 1.072 MACROD2
MACRO domain containing 2
chr2_+_85665041 1.053 NM_006634
VAMP5
vesicle-associated membrane protein 5 (myobrevin)
chr16_+_48616593 1.052 NM_153261
TMEM188
transmembrane protein 188
chr8_-_95343696 1.047 GEM
GTP binding protein overexpressed in skeletal muscle
chr6_+_37509028 1.038 FTSJD2
FtsJ methyltransferase domain containing 2
chr14_-_34169047 1.035 NM_021249
NM_152233
SNX6

sorting nexin 6

chr3_+_139388770 1.028 NM_014154
NM_015396
NM_213654
ARMC8


armadillo repeat containing 8


chr14_-_22549168 1.014 NM_001130706
NM_001130708
NM_021944
C14orf93


chromosome 14 open reading frame 93


chr10_+_82290554 1.007 NM_001145719
SH2D4B
SH2 domain containing 4B
chr2_-_162883062 0.996 NM_022168
IFIH1
interferon induced with helicase C domain 1
chr1_-_13546097 0.990 NM_001024661
NM_001099854
PRAMEF13
PRAMEF14
PRAME family member 13
PRAME family member 14
chr15_+_67094087 0.985 NM_001184779
NM_024505
NOX5

NADPH oxidase, EF-hand calcium binding domain 5

chr13_-_40533072 0.980 ELF1
E74-like factor 1 (ets domain transcription factor)
chr6_+_6533932 0.978 NM_004271
LY86
lymphocyte antigen 86
chr17_-_51155073 0.977 NM_018286
TMEM100
transmembrane protein 100
chr6_-_170704251 0.975 PSMB1
proteasome (prosome, macropain) subunit, beta type, 1
chr15_+_82945223 0.973 NM_001007072
NM_017894
NM_181877
ZSCAN2


zinc finger and SCAN domain containing 2


chr6_+_32929902 0.972 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr14_+_72595055 0.972 RBM25
RNA binding motif protein 25
chr2_+_69822609 0.969 NM_001153
ANXA4
annexin A4
chr14_-_34168911 0.965 SNX6
sorting nexin 6
chr6_+_37508830 0.957 NM_015050
FTSJD2
FtsJ methyltransferase domain containing 2
chr9_+_5440455 0.942 NM_014143
CD274
CD274 molecule
chr2_+_230900121 0.940 NM_138402
SP140L
SP140 nuclear body protein-like
chr10_+_91082218 0.936 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr2_-_151854379 0.931 NMI
N-myc (and STAT) interactor
chr6_-_150253729 0.920 NM_139165
RAET1E
retinoic acid early transcript 1E
chr10_+_115429622 0.916 CASP7
caspase 7, apoptosis-related cysteine peptidase
chr12_-_8584658 0.915 NM_014358
CLEC4E
C-type lectin domain family 4, member E
chr1_+_234625338 0.913 NM_080738
EDARADD
EDAR-associated death domain
chr11_-_64520964 0.912 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr6_-_170704304 0.901 NM_002793
PSMB1
proteasome (prosome, macropain) subunit, beta type, 1
chr22_+_34979118 0.900 APOL1
apolipoprotein L, 1
chr20_+_226200 0.898 NM_033089
ZCCHC3
zinc finger, CCHC domain containing 3
chr11_+_63060848 0.895 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr1_-_27871245 0.894 IFI6
interferon, alpha-inducible protein 6
chr6_-_110843432 0.893 NM_003649
NM_004032
DDO

D-aspartate oxidase

chr1_-_27871287 0.892 IFI6
interferon, alpha-inducible protein 6
chr22_+_17012704 0.889 NM_017414
USP18
ubiquitin specific peptidase 18
chr16_-_73292188 0.888 NM_001142497
NM_152649
MLKL

mixed lineage kinase domain-like

chr12_+_106236281 0.883 NM_001018072
BTBD11
BTB (POZ) domain containing 11
chr5_-_147191428 0.879 NM_003122
SPINK1
serine peptidase inhibitor, Kazal type 1
chr14_+_72595020 0.878 RBM25
RNA binding motif protein 25
chr4_+_89519134 0.876 HERC6
hect domain and RLD 6
chr2_-_151854619 0.874 NM_004688
NMI
N-myc (and STAT) interactor
chr6_-_32929721 0.873 NM_000593
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr15_-_97607108 0.871 NM_001040655
NM_001040656
NM_001040657
NM_001040658
NM_001040659
NM_001040660
NM_022905
TTC23






tetratricopeptide repeat domain 23






chr6_-_32929570 0.871 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr16_-_74239030 0.857 NM_001130089
NM_005548
KARS

lysyl-tRNA synthetase

chr11_-_62364203 0.854 NM_018093
WDR74
WD repeat domain 74
chr2_-_242449662 0.851 NM_005018
PDCD1
programmed cell death 1
chr6_+_112481970 0.839 NM_003880
NM_198239
WISP3

WNT1 inducible signaling pathway protein 3

chr7_-_76883642 0.838 NM_017439
PION
pigeon homolog (Drosophila)
chr11_-_4585947 0.838 NM_018073
TRIM68
tripartite motif containing 68
chr1_+_159462456 0.837 NM_032174
TOMM40L
translocase of outer mitochondrial membrane 40 homolog (yeast)-like
chr1_+_161558346 0.830 NM_031423
NM_145697
NUF2

NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)

chr10_+_91051685 0.827 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr2_+_33554824 0.824 NM_001139488
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr11_-_82289006 0.821 NM_005040
NM_199418
PRCP

prolylcarboxypeptidase (angiotensinase C)

chr19_-_17377383 0.815 NM_004335
BST2
bone marrow stromal cell antigen 2
chr17_+_53602013 0.813 NM_001004707
OR4D2
olfactory receptor, family 4, subfamily D, member 2
chr1_+_24518501 0.806 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr10_+_22765996 0.804 LOC100289455
hypothetical LOC100289455
chr9_-_134271985 0.803 NM_007344
TTF1
transcription termination factor, RNA polymerase I
chr10_-_45410197 0.803 NM_001002265
NM_145021
MARCH8

membrane-associated ring finger (C3HC4) 8

chr14_-_22358752 0.799 NM_001126106
SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr18_-_13905534 0.799 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr7_+_138469029 0.797 NM_001144920
NM_001144923
NM_024926
TTC26


tetratricopeptide repeat domain 26


chr15_-_72775378 0.797 EDC3
enhancer of mRNA decapping 3 homolog (S. cerevisiae)
chr14_+_72594985 0.797 RBM25
RNA binding motif protein 25
chr7_+_100515439 0.796 NM_030961
TRIM56
tripartite motif containing 56
chr17_-_44037332 0.793 NM_018952
HOXB6
homeobox B6
chr2_+_68855436 0.792 NM_001166276
NM_014882
ARHGAP25

Rho GTPase activating protein 25


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.87 2.51e-09 GO:0002376 immune system process
5.88 2.86e-09 GO:0034340 response to type I interferon
2.13 1.16e-08 GO:0006955 immune response
5.71 1.72e-08 GO:0060337 type I interferon-mediated signaling pathway
5.71 1.72e-08 GO:0071357 cellular response to type I interferon
2.56 2.58e-07 GO:0045087 innate immune response
5.77 3.78e-07 GO:0006521 regulation of cellular amino acid metabolic process
4.51 1.29e-06 GO:2000045 regulation of G1/S transition of mitotic cell cycle
1.89 2.84e-06 GO:0051704 multi-organism process
4.80 5.16e-06 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
5.01 5.86e-06 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
5.01 5.86e-06 GO:0072395 signal transduction involved in cell cycle checkpoint
5.01 5.86e-06 GO:0072401 signal transduction involved in DNA integrity checkpoint
5.01 5.86e-06 GO:0072404 signal transduction involved in G1/S transition checkpoint
5.01 5.86e-06 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
5.01 5.86e-06 GO:0072422 signal transduction involved in DNA damage checkpoint
5.01 5.86e-06 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
5.01 5.86e-06 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
4.73 6.89e-06 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
4.60 1.21e-05 GO:0051352 negative regulation of ligase activity
4.60 1.21e-05 GO:0051444 negative regulation of ubiquitin-protein ligase activity
4.39 1.26e-05 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
4.78 1.44e-05 GO:0033238 regulation of cellular amine metabolic process
4.78 1.44e-05 GO:0071158 positive regulation of cell cycle arrest
4.53 1.58e-05 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
1.89 1.60e-05 GO:0006952 defense response
4.33 1.63e-05 GO:0031575 mitotic cell cycle G1/S transition checkpoint
4.33 1.63e-05 GO:0071779 G1/S transition checkpoint
4.12 4.30e-05 GO:0051351 positive regulation of ligase activity
3.12 5.25e-05 GO:0031400 negative regulation of protein modification process
3.61 7.02e-05 GO:0042770 signal transduction in response to DNA damage
4.13 9.16e-05 GO:0051443 positive regulation of ubiquitin-protein ligase activity
3.93 1.06e-04 GO:0030330 DNA damage response, signal transduction by p53 class mediator
3.77 1.17e-04 GO:0051340 regulation of ligase activity
2.31 1.20e-04 GO:0044419 interspecies interaction between organisms
3.89 1.32e-04 GO:0031397 negative regulation of protein ubiquitination
4.02 1.45e-04 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
3.03 1.68e-04 GO:0009615 response to virus
2.61 1.70e-04 GO:0032269 negative regulation of cellular protein metabolic process
8.05 2.03e-04 GO:0048002 antigen processing and presentation of peptide antigen
3.76 2.48e-04 GO:0051438 regulation of ubiquitin-protein ligase activity
3.25 3.38e-04 GO:0007093 mitotic cell cycle checkpoint
3.43 3.74e-04 GO:0031398 positive regulation of protein ubiquitination
1.42 4.54e-04 GO:0006950 response to stress
3.92 4.83e-04 GO:0000216 M/G1 transition of mitotic cell cycle
9.90 4.99e-04 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
2.50 5.23e-04 GO:0051248 negative regulation of protein metabolic process
3.37 5.32e-04 GO:0051320 S phase
1.98 7.30e-04 GO:0016071 mRNA metabolic process
1.90 7.85e-04 GO:0009057 macromolecule catabolic process
2.71 8.28e-04 GO:0019221 cytokine-mediated signaling pathway
13.79 8.92e-04 GO:0019883 antigen processing and presentation of endogenous antigen
1.97 9.93e-04 GO:0044265 cellular macromolecule catabolic process
3.28 1.56e-03 GO:0000084 S phase of mitotic cell cycle
2.21 1.91e-03 GO:0044257 cellular protein catabolic process
2.28 2.21e-03 GO:0034097 response to cytokine stimulus
2.53 2.78e-03 GO:0071345 cellular response to cytokine stimulus
2.90 3.23e-03 GO:0000082 G1/S transition of mitotic cell cycle
2.85 4.24e-03 GO:0031396 regulation of protein ubiquitination
3.19 4.48e-03 GO:0000077 DNA damage checkpoint
2.15 7.10e-03 GO:0051603 proteolysis involved in cellular protein catabolic process
2.20 7.40e-03 GO:0031401 positive regulation of protein modification process
2.07 1.16e-02 GO:0030163 protein catabolic process
1.99 1.18e-02 GO:0051707 response to other organism
2.99 1.30e-02 GO:0031570 DNA integrity checkpoint
2.14 1.33e-02 GO:0006511 ubiquitin-dependent protein catabolic process
2.78 1.68e-02 GO:0010565 regulation of cellular ketone metabolic process
1.54 1.99e-02 GO:0044248 cellular catabolic process
2.10 2.17e-02 GO:0019941 modification-dependent protein catabolic process
2.09 2.54e-02 GO:0043632 modification-dependent macromolecule catabolic process
1.84 3.10e-02 GO:0009607 response to biotic stimulus
1.46 4.53e-02 GO:0009056 catabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.85 1.53e-06 GO:0000502 proteasome complex
8.05 2.90e-05 GO:0005839 proteasome core complex
1.13 1.47e-02 GO:0005737 cytoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
7.66 8.24e-05 GO:0004298 threonine-type endopeptidase activity
7.66 8.24e-05 GO:0070003 threonine-type peptidase activity