Motif ID: TP53.p2

Z-value: 1.116


Transcription factors associated with TP53.p2:

Gene SymbolEntrez IDGene Name
TP53 7157 tumor protein p53

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TP53chr17_-_75314560.136.4e-01Click!


Activity profile for motif TP53.p2.

activity profile for motif TP53.p2


Sorted Z-values histogram for motif TP53.p2

Sorted Z-values for motif TP53.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TP53.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_36752244 3.569 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr1_+_3597092 1.655 NM_001126240
NM_001126241
NM_001126242
TP73


tumor protein p73


chr6_-_138470160 1.356 NM_022121
PERP
PERP, TP53 apoptosis effector
chr16_-_66558197 1.266 NM_001145964
SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr6_+_24511123 1.089 NM_020662
MRS2
MRS2 magnesium homeostasis factor homolog (S. cerevisiae)
chr15_-_50608296 1.050 NM_000259
NM_001142495
MYO5A

myosin VA (heavy chain 12, myoxin)

chr1_-_2447848 0.968 NM_018216
PANK4
pantothenate kinase 4
chr6_+_116798791 0.961 NM_013352
DSE
dermatan sulfate epimerase
chr22_-_18687511 0.948 NM_033257
DGCR6L
DiGeorge syndrome critical region gene 6-like
chr11_-_72986738 0.890 NM_015159
FAM168A
family with sequence similarity 168, member A
chr10_-_30388439 0.890 NM_020848
KIAA1462
KIAA1462
chr7_-_74705276 0.885 NM_001145064
GATSL2
GATS protein-like 2
chr6_-_167491305 0.787 NM_005299
GPR31
G protein-coupled receptor 31
chr1_+_153799637 0.763 LOC645676
hypothetical LOC645676
chr1_+_32443822 0.753 NM_001160042
NM_018134
IQCC

IQ motif containing C

chr20_-_32354736 0.746 NM_000687
AHCY
adenosylhomocysteinase
chr14_-_30959487 0.717 HEATR5A
HEAT repeat containing 5A
chr2_-_26058941 0.707 NM_002254
KIF3C
kinesin family member 3C
chr16_-_14695930 0.637 NM_003561
PLA2G10
phospholipase A2, group X
chr4_+_148872902 0.636 NM_024605
ARHGAP10
Rho GTPase activating protein 10
chr22_+_35777561 0.617 NM_024681
KCTD17
potassium channel tetramerisation domain containing 17
chr5_+_52320660 0.617 NM_002203
ITGA2
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
chr7_+_116099648 0.605 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr9_+_129962292 0.593 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr7_+_65307816 0.589 TPST1
tyrosylprotein sulfotransferase 1
chr19_+_5855842 0.584 NM_001017921
VMAC
vimentin-type intermediate filament associated coiled-coil protein
chr19_+_2736464 0.568 NM_003249
THOP1
thimet oligopeptidase 1
chr2_+_169021001 0.548 LASS6
LAG1 homolog, ceramide synthase 6
chr12_+_122652572 0.548 NM_020936
DDX55
DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
chr6_+_117910472 0.544 NM_173674
DCBLD1
discoidin, CUB and LCCL domain containing 1
chr8_+_23016271 0.542 NM_003841
TNFRSF10C
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
chr2_+_47021866 0.540 TTC7A
tetratricopeptide repeat domain 7A
chr2_-_26058831 0.534 KIF3C
kinesin family member 3C
chr2_+_169021039 0.513 NM_203463
LASS6
LAG1 homolog, ceramide synthase 6
chr3_+_184898234 0.510 NM_018023
YEATS2
YEATS domain containing 2
chr21_+_42807052 0.490 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr2_+_47021816 0.474 NM_020458
TTC7A
tetratricopeptide repeat domain 7A
chr15_+_86965526 0.473 NM_022767
AEN
apoptosis enhancing nuclease
chr9_-_94936319 0.465 NM_004148
NINJ1
ninjurin 1
chr19_-_47438583 0.465 GSK3A
glycogen synthase kinase 3 alpha
chr2_-_201536425 0.463 NM_006190
ORC2
origin recognition complex, subunit 2
chr19_+_61344501 0.444 ZNF444
zinc finger protein 444
chr7_+_72206961 0.440 GTF2IP1
general transcription factor IIi, pseudogene 1
chr1_+_15957832 0.432 NM_017556
FBLIM1
filamin binding LIM protein 1
chr8_+_98950453 0.432 NM_002380
NM_030583
MATN2

matrilin 2

chr1_-_52936573 0.431 C1orf163
chromosome 1 open reading frame 163
chr20_+_47862782 0.428 SLC9A8
solute carrier family 9 (sodium/hydrogen exchanger), member 8
chr14_+_99273751 0.426 EML1
echinoderm microtubule associated protein like 1
chr19_-_47438384 0.424 GSK3A
glycogen synthase kinase 3 alpha
chr10_-_105202139 0.423 NM_015916
CALHM2
calcium homeostasis modulator 2
chr14_+_35365266 0.422 NM_032352
BRMS1L
breast cancer metastasis-suppressor 1-like
chr12_+_54832470 0.421 NM_002475
MYL6B
myosin, light chain 6B, alkali, smooth muscle and non-muscle
chr1_+_13782838 0.417 NM_006474
NM_198389
PDPN

podoplanin

chr19_-_47438563 0.415 NM_019884
GSK3A
glycogen synthase kinase 3 alpha
chr20_+_47862656 0.414 NM_015266
SLC9A8
solute carrier family 9 (sodium/hydrogen exchanger), member 8
chr16_-_4243762 0.414 LOC100507501
hypothetical LOC100507501
chr1_-_153799186 0.414 ASH1L
ash1 (absent, small, or homeotic)-like (Drosophila)
chr1_-_23376860 0.414 LUZP1
leucine zipper protein 1
chr14_-_35859545 0.409 NM_001144891
NM_016586
MBIP

MAP3K12 binding inhibitory protein 1

chr10_+_124124196 0.408 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr11_-_1026654 0.397 NM_005961
MUC6
mucin 6, oligomeric mucus/gel-forming
chr19_-_47438518 0.393 GSK3A
glycogen synthase kinase 3 alpha
chr2_-_151826504 0.392 NM_198557
RBM43
RNA binding motif protein 43
chr3_-_46012303 0.391 NM_024513
FYCO1
FYVE and coiled-coil domain containing 1
chr6_-_48186868 0.389 C6orf138
chromosome 6 open reading frame 138
chr16_+_2593351 0.386 LOC652276
hypothetical LOC652276
chr1_+_117711575 0.382 NM_006699
MAN1A2
mannosidase, alpha, class 1A, member 2
chr10_+_11824361 0.377 NM_024693
ECHDC3
enoyl CoA hydratase domain containing 3
chr4_+_153676857 0.376 DKFZP434I0714
hypothetical protein DKFZP434I0714
chr20_-_47238082 0.371 STAU1
staufen, RNA binding protein, homolog 1 (Drosophila)
chr19_-_47438548 0.368 GSK3A
glycogen synthase kinase 3 alpha
chr1_-_52936602 0.367 C1orf163
chromosome 1 open reading frame 163
chr5_-_167938875 0.362 PANK3
pantothenate kinase 3
chr21_+_43186428 0.359 NM_001001503
NM_021075
NDUFV3

NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa

chr1_-_10455190 0.358 NM_004401
NM_213566
DFFA

DNA fragmentation factor, 45kDa, alpha polypeptide

chr8_-_22982435 0.357 NM_003842
NM_147187
TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

chr6_+_76515608 0.357 NM_004999
MYO6
myosin VI
chr11_+_1897374 0.353 NM_001042780
NM_001042781
NM_001042782
NM_006757
TNNT3



troponin T type 3 (skeletal, fast)



chr17_-_975809 0.348 ABR
active BCR-related gene
chr18_+_19523526 0.340 NM_001127717
NM_198129
LAMA3

laminin, alpha 3

chr11_-_66993211 0.340 NM_001078650
NM_001078651
NM_025124
TMEM134


transmembrane protein 134


chr6_-_30818198 0.336 NM_005803
FLOT1
flotillin 1
chr16_-_74024750 0.334 NM_006324
CFDP1
craniofacial development protein 1
chr13_-_100866706 0.333 NM_052867
NALCN
sodium leak channel, non-selective
chr6_+_33486750 0.333 NM_002636
NM_024165
PHF1

PHD finger protein 1

chr9_+_103200939 0.331 NM_003452
NM_197977
ZNF189

zinc finger protein 189

chr20_-_5048443 0.331 NM_182649
PCNA
proliferating cell nuclear antigen
chr20_-_47238310 0.331 NM_001037328
NM_004602
NM_017452
NM_017453
NM_017454
STAU1




staufen, RNA binding protein, homolog 1 (Drosophila)




chr10_+_47216925 0.323 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr14_-_22693333 0.321 NM_182728
SLC7A8
solute carrier family 7 (amino acid transporter, L-type), member 8
chr3_+_16901455 0.319 NM_001144382
PLCL2
phospholipase C-like 2
chr19_+_61344341 0.310 NM_018337
ZNF444
zinc finger protein 444
chr1_-_52936611 0.309 NM_023077
C1orf163
chromosome 1 open reading frame 163
chr11_+_118544625 0.306 NM_024618
NM_170722
NLRX1

NLR family member X1

chr3_+_32123004 0.304 NM_015141
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr10_+_88404285 0.302 NM_001030015
NM_033282
OPN4

opsin 4

chr7_+_115953582 0.297 NM_001172896
NM_001172897
CAV1

caveolin 1, caveolae protein, 22kDa

chr2_-_175741096 0.296 NM_001880
ATF2
activating transcription factor 2
chr21_-_42172476 0.291 NM_001040424
NM_022115
PRDM15

PR domain containing 15

chr1_+_42920946 0.289 YBX1
Y box binding protein 1
chr12_+_47498778 0.288 NM_000725
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr16_-_87244896 0.287 NM_000101
CYBA
cytochrome b-245, alpha polypeptide
chr1_-_6375949 0.283 ACOT7
acyl-CoA thioesterase 7
chr17_+_20423628 0.281 NM_001190790
CDRT15L2
CMT1A duplicated region transcript 15-like 2
chr12_+_27377034 0.280 NM_020183
ARNTL2
aryl hydrocarbon receptor nuclear translocator-like 2
chr16_-_30841938 0.277 NCRNA00095
non-protein coding RNA 95
chr20_+_4077409 0.277 NM_175839
NM_175840
NM_175841
NM_175842
SMOX



spermine oxidase



chr3_-_184363126 0.276 LAMP3
lysosomal-associated membrane protein 3
chr19_+_1358664 0.269 DAZAP1
DAZ associated protein 1
chr8_-_57286412 0.268 NM_001114634
NM_001114635
NM_002655
PLAG1


pleiomorphic adenoma gene 1


chr11_+_3833495 0.266 NM_003156
STIM1
stromal interaction molecule 1
chr3_-_44494108 0.262 ZNF445
zinc finger protein 445
chr19_-_43406621 0.262 NM_001135155
NM_004647
DPF1

D4, zinc and double PHD fingers family 1

chr19_+_40183169 0.262 GRAMD1A
GRAM domain containing 1A
chr22_+_21852551 0.261 NM_004327
NM_021574
BCR

breakpoint cluster region

chr1_+_11718798 0.261 AGTRAP
angiotensin II receptor-associated protein
chr19_+_13090101 0.260 NM_052876
NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr1_-_201202956 0.260 NM_016243
CYB5R1
cytochrome b5 reductase 1
chr2_+_197212522 0.257 NM_001080539
CCDC150
coiled-coil domain containing 150
chr17_-_40122542 0.255 NM_001099225
NM_144609
CCDC43

coiled-coil domain containing 43

chr17_-_14080874 0.254 NM_001007530
CDRT15
CMT1A duplicated region transcript 15
chr2_+_11213053 0.252 PQLC3
PQ loop repeat containing 3
chr6_+_146177723 0.249 LOC100507557
hypothetical LOC100507557
chr17_-_9870292 0.249 NM_001130831
GAS7
growth arrest-specific 7
chr8_+_95801375 0.249 DPY19L4
dpy-19-like 4 (C. elegans)
chr8_-_23077392 0.247 NM_003840
TNFRSF10D
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
chr2_+_176761552 0.247 NM_024501
HOXD1
homeobox D1
chr7_+_43589163 0.246 NM_004760
STK17A
serine/threonine kinase 17a
chr19_-_52426055 0.246 NM_014417
BBC3
BCL2 binding component 3
chr3_-_44494160 0.245 NM_181489
ZNF445
zinc finger protein 445
chr5_-_137099361 0.243 KLHL3
kelch-like 3 (Drosophila)
chr1_+_232107170 0.243 NM_173508
SLC35F3
solute carrier family 35, member F3
chr8_+_95801277 0.240 NM_181787
DPY19L4
dpy-19-like 4 (C. elegans)
chr3_+_9919511 0.239 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chrX_+_153767803 0.239 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr22_-_22422951 0.238 NM_021916
ZNF70
zinc finger protein 70
chr9_+_88953378 0.237 NM_001001709
C9orf170
chromosome 9 open reading frame 170
chr5_-_167938991 0.237 NM_024594
PANK3
pantothenate kinase 3
chr11_+_85017269 0.234 NM_001193537
NM_001193538
NM_018480
TMEM126B


transmembrane protein 126B


chr20_+_56900116 0.231 NM_001077488
GNAS
GNAS complex locus
chr2_+_97717300 0.231 NM_207519
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr6_+_37895570 0.231 ZFAND3
zinc finger, AN1-type domain 3
chr20_+_4077466 0.230 SMOX
spermine oxidase
chr2_+_113546365 0.230 NM_032556
IL1F10
interleukin 1 family, member 10 (theta)
chr12_-_74710741 0.230 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr15_-_40173949 0.224 NM_178034
PLA2G4D
phospholipase A2, group IVD (cytosolic)
chr6_+_76515690 0.221 MYO6
myosin VI
chrX_+_129133234 0.221 NM_004794
RAB33A
RAB33A, member RAS oncogene family
chr1_+_36169260 0.220 NM_024852
NM_177422
EIF2C3

eukaryotic translation initiation factor 2C, 3

chr2_+_171998988 0.220 NM_001164821
NM_025000
DCAF17

DDB1 and CUL4 associated factor 17

chr16_-_1410710 0.219 C16orf91
chromosome 16 open reading frame 91
chr6_-_30820264 0.219 NM_003897
IER3
immediate early response 3
chr7_+_65307691 0.218 NM_003596
TPST1
tyrosylprotein sulfotransferase 1
chr11_+_63758550 0.217 NM_003377
VEGFB
vascular endothelial growth factor B
chr16_-_29781842 0.216 NM_006319
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr21_+_45649429 0.215 NM_130445
COL18A1
collagen, type XVIII, alpha 1
chr13_-_100866839 0.215 NALCN
sodium leak channel, non-selective
chr3_+_32123140 0.214 GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr22_-_21231421 0.213 NM_206955
NM_206956
NM_006115
NM_206953
NM_206954
PRAME




preferentially expressed antigen in melanoma




chr4_-_108860740 0.212 NM_005443
PAPSS1
3'-phosphoadenosine 5'-phosphosulfate synthase 1
chr2_-_24161033 0.211 NM_147184
NM_004881
TP53I3

tumor protein p53 inducible protein 3

chr16_-_56789142 0.211 NM_001896
CSNK2A2
casein kinase 2, alpha prime polypeptide
chr7_+_100557098 0.209 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chrX_+_38548316 0.208 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr20_+_61760084 0.208 NM_016434
NM_032957
RTEL1

regulator of telomere elongation helicase 1

chrX_-_153767625 0.206 NM_019863
F8
coagulation factor VIII, procoagulant component
chr10_-_95231933 0.205 NM_013451
NM_133337
MYOF

myoferlin

chr22_-_17846621 0.205 UFD1L
ubiquitin fusion degradation 1 like (yeast)
chr6_+_21774624 0.204 FLJ22536
hypothetical locus LOC401237
chr4_-_159863889 0.202 NM_005038
PPID
peptidylprolyl isomerase D
chr15_+_83724743 0.201 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr12_+_30970882 0.200 TSPAN11
tetraspanin 11
chr20_-_33007242 0.199 GSS
glutathione synthetase
chr1_+_11718715 0.198 NM_001040194
NM_001040195
NM_001040196
NM_001040197
NM_020350
AGTRAP




angiotensin II receptor-associated protein




chr20_+_34667624 0.196 C20orf24
chromosome 20 open reading frame 24
chr9_-_5997891 0.196 NM_001017969
KIAA2026
KIAA2026
chr20_-_33007243 0.196 NM_000178
GSS
glutathione synthetase
chr20_+_56899904 0.193 GNAS
GNAS complex locus
chr22_+_39096509 0.193 NM_015705
SGSM3
small G protein signaling modulator 3
chr10_+_124124083 0.192 NM_001001974
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr20_-_60435983 0.191 NM_080833
C20orf151
chromosome 20 open reading frame 151
chr19_+_55985483 0.190 NM_033068
ACPT
acid phosphatase, testicular
chrX_+_151837064 0.190 NM_001178113
ZNF185
zinc finger protein 185 (LIM domain)
chr20_-_33007209 0.188 GSS
glutathione synthetase
chr19_+_32976717 0.187


chr7_-_44496703 0.187 NM_015332
NUDCD3
NudC domain containing 3
chr1_+_54954082 0.183 NM_004623
TTC4
tetratricopeptide repeat domain 4
chr4_-_184662604 0.181 LOC389247
hypothetical LOC389247
chrX_+_38548373 0.181 MID1IP1
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr17_-_58877276 0.179 NM_001017916
NM_001915
CYB561

cytochrome b-561

chr2_-_69724480 0.179 NM_014911
AAK1
AP2 associated kinase 1
chr3_+_161601040 0.178 NM_005496
SMC4
structural maintenance of chromosomes 4
chr17_-_39447817 0.178 NM_032376
TMEM101
transmembrane protein 101
chr2_+_187266899 0.177 NM_177454
FAM171B
family with sequence similarity 171, member B
chr19_-_14089362 0.176 NM_002730
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr19_+_47056162 0.176 RPS19
ribosomal protein S19
chr18_+_3584056 0.176 FLJ35776
hypothetical LOC649446
chr1_-_207892420 0.176 NM_000228
LAMB3
laminin, beta 3
chr14_+_101853466 0.175 ZNF839
zinc finger protein 839
chr2_-_105312536 0.175 NM_001142621
NM_004257
TGFBRAP1

transforming growth factor, beta receptor associated protein 1


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.95 9.33e-03 GO:0009116 nucleoside metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.35 1.82e-09 GO:0044444 cytoplasmic part
1.23 1.85e-07 GO:0005737 cytoplasm
1.12 1.76e-03 GO:0044424 intracellular part
1.11 3.82e-03 GO:0005622 intracellular
1.65 8.93e-03 GO:0005794 Golgi apparatus
1.14 1.36e-02 GO:0043227 membrane-bounded organelle
1.14 1.62e-02 GO:0043231 intracellular membrane-bounded organelle
1.40 1.81e-02 GO:0005829 cytosol
1.12 2.47e-02 GO:0043226 organelle
1.12 2.69e-02 GO:0043229 intracellular organelle
1.20 4.07e-02 GO:0044446 intracellular organelle part
1.37 4.91e-02 GO:0031090 organelle membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
21.83 2.07e-03 GO:0004594 pantothenate kinase activity