Motif ID: TFEB.p2

Z-value: 0.748


Transcription factors associated with TFEB.p2:

Gene SymbolEntrez IDGene Name
TFEB 7942 transcription factor EB

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFEBchr6_-_41781655-0.332.1e-01Click!


Activity profile for motif TFEB.p2.

activity profile for motif TFEB.p2


Sorted Z-values histogram for motif TFEB.p2

Sorted Z-values for motif TFEB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFEB.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_27162688 1.296 NM_006896
HOXA7
homeobox A7
chr10_-_14090459 0.971 FRMD4A
FERM domain containing 4A
chr17_-_44022595 0.852 HOXB3
homeobox B3
chr5_-_159730196 0.791 NM_031908
C1QTNF2
C1q and tumor necrosis factor related protein 2
chr11_-_8849485 0.776 ST5
suppression of tumorigenicity 5
chr16_-_66072477 0.766 NM_004691
ATP6V0D1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr17_-_33043514 0.747 NM_001163544
NM_001163545
NM_001163546
NM_001163547
NM_007247
NM_080550
NM_198882
SYNRG






synergin, gamma






chrX_-_114703273 0.743


chrX_+_10084984 0.739 NM_001830
CLCN4
chloride channel 4
chr13_-_95094920 0.719 NM_014934
NM_198968
DZIP1

DAZ interacting protein 1

chr10_-_45410197 0.704 NM_001002265
NM_145021
MARCH8

membrane-associated ring finger (C3HC4) 8

chr7_-_47588652 0.683 TNS3
tensin 3
chr1_-_26105477 0.669 NM_001145454
NM_005563
STMN1

stathmin 1

chr20_+_43953372 0.622 CTSA
cathepsin A
chr3_-_188945921 0.614 BCL6
B-cell CLL/lymphoma 6
chr19_+_7493436 0.611 NM_020533
MCOLN1
mucolipin 1
chr11_-_36267550 0.604 NM_001101653
NM_014186
COMMD9

COMM domain containing 9

chr1_-_239587090 0.600 NM_002924
RGS7
regulator of G-protein signaling 7
chr11_-_36267510 0.600 COMMD9
COMM domain containing 9
chr11_+_101485946 0.599 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr8_+_98857190 0.595 LAPTM4B
lysosomal protein transmembrane 4 beta
chr11_+_32993973 0.584 NM_001077242
DEPDC7
DEP domain containing 7
chr8_-_68103339 0.584 NM_001013626
LRRC67
leucine rich repeat containing 67
chr1_-_239587007 0.584 RGS7
regulator of G-protein signaling 7
chr3_+_160002605 0.575 MFSD1
major facilitator superfamily domain containing 1
chr20_+_43953428 0.574 CTSA
cathepsin A
chr6_-_26767892 0.561 NM_024639
ZNF322A
zinc finger protein 322A
chr3_+_160002582 0.550 MFSD1
major facilitator superfamily domain containing 1
chr3_-_172109119 0.537 NM_020390
EIF5A2
eukaryotic translation initiation factor 5A2
chr2_+_238060602 0.533 NM_001042467
NM_024101
MLPH

melanophilin

chr20_-_43953036 0.532 NM_080749
NEURL2
neuralized homolog 2 (Drosophila)
chr6_+_151602787 0.522 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr5_+_52812236 0.522 NM_006350
NM_013409
FST

follistatin

chr5_-_72780107 0.521 NM_004472
FOXD1
forkhead box D1
chr19_+_54149843 0.521 NM_004324
NM_138761
NM_138763
NM_138764
BAX



BCL2-associated X protein



chr19_+_54149941 0.518 BAX
BCL2-associated X protein
chr2_+_85834111 0.518 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr20_+_43953331 0.515 CTSA
cathepsin A
chr3_+_160002571 0.511 MFSD1
major facilitator superfamily domain containing 1
chr19_+_54149963 0.507 BAX
BCL2-associated X protein
chr13_-_49057629 0.506 RCBTB1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr5_+_34692352 0.492 NM_001145520
RAI14
retinoic acid induced 14
chr5_+_72957736 0.490 NM_001080479
NM_001177693
RGNEF

190 kDa guanine nucleotide exchange factor

chr17_-_43977273 0.486 NM_002145
HOXB2
homeobox B2
chr2_-_49235059 0.481 NM_000145
NM_181446
FSHR

follicle stimulating hormone receptor

chr16_+_31132842 0.480 NM_001008274
TRIM72
tripartite motif containing 72
chrX_-_13866451 0.469 GPM6B
glycoprotein M6B
chr5_+_52812165 0.467 FST
follistatin
chr11_+_32994303 0.467 NM_139160
DEPDC7
DEP domain containing 7
chrX_-_101284026 0.462 NM_001006938
TCEAL6
transcription elongation factor A (SII)-like 6
chr17_-_44026042 0.457 NM_002147
HOXB5
homeobox B5
chr2_-_238164042 0.454 RAB17
RAB17, member RAS oncogene family
chrX_+_101267315 0.454 NM_080390
TCEAL2
transcription elongation factor A (SII)-like 2
chr3_-_172109075 0.452 EIF5A2
eukaryotic translation initiation factor 5A2
chr4_+_128773529 0.451 NM_015693
INTU
inturned planar cell polarity effector homolog (Drosophila)
chr12_-_121316907 0.448 VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr13_-_49057707 0.444 NM_018191
RCBTB1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr7_-_44496703 0.441 NM_015332
NUDCD3
NudC domain containing 3
chr1_+_68070573 0.435


chr1_-_68470585 0.433 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr19_+_37528340 0.421 NM_001136156
NM_014910
ZNF507

zinc finger protein 507

chr12_-_9913199 0.420 CLEC2B
C-type lectin domain family 2, member B
chrX_+_102471769 0.418 NM_152278
TCEAL7
transcription elongation factor A (SII)-like 7
chr5_+_34692124 0.417 NM_001145522
NM_015577
RAI14

retinoic acid induced 14

chr1_+_11788889 0.416 CLCN6
chloride channel 6
chr2_-_183611470 0.415 NM_013436
NM_205842
NCKAP1

NCK-associated protein 1

chr3_-_188946168 0.413 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr3_+_160002619 0.407 MFSD1
major facilitator superfamily domain containing 1
chr14_-_64638974 0.407 NM_002382
NM_145112
NM_145113
NM_145114
NM_145116
NM_197957
MAX





MYC associated factor X





chr2_+_241174803 0.405 NM_023083
NM_023085
CAPN10

calpain 10

chr12_+_52806103 0.403 LOC400043
hypothetical LOC400043
chr17_-_44043361 0.402 NM_004502
HOXB7
homeobox B7
chr1_-_26105230 0.397 NM_203401
STMN1
stathmin 1
chr2_+_227898163 0.397 MFF
mitochondrial fission factor
chr7_-_47588160 0.394 TNS3
tensin 3
chrX_+_16714452 0.392 NM_001168683
NM_018360
TXLNG

taxilin gamma

chr7_+_101861007 0.391 ORAI2
ORAI calcium release-activated calcium modulator 2
chr16_-_28410580 0.388 NM_000086
CLN3
ceroid-lipofuscinosis, neuronal 3
chr13_-_49597776 0.387 DLEU2
deleted in lymphocytic leukemia 2 (non-protein coding)
chr3_-_127558747 0.381 NM_014079
KLF15
Kruppel-like factor 15
chr20_+_43953606 0.374 CTSA
cathepsin A
chr17_-_44010543 0.370 NM_024015
HOXB4
homeobox B4
chr19_-_52710129 0.370 NM_003827
NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr7_-_47588266 0.370 TNS3
tensin 3
chr2_+_46779553 0.368 NM_014011
SOCS5
suppressor of cytokine signaling 5
chr6_-_163754903 0.366 LOC100526820
hypothetical LOC100526820
chr14_-_19999475 0.365 NM_001100814
NM_144568
TMEM55B

transmembrane protein 55B

chr6_+_123152044 0.363 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr2_+_37425240 0.362 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr8_+_85258257 0.360 RALYL
RALY RNA binding protein-like
chr12_-_61614930 0.357 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr2_-_25328452 0.357 NM_153759
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr12_+_52713098 0.353 NM_018953
HOXC5
homeobox C5
chr1_+_66772393 0.353 NM_032291
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr11_+_118443683 0.349 NM_021729
VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)
chr11_-_61441536 0.349 NM_013401
RAB3IL1
RAB3A interacting protein (rabin3)-like 1
chr9_+_114953087 0.346 SLC31A2
solute carrier family 31 (copper transporters), member 2
chr11_+_118443725 0.339 VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)
chr10_+_5478521 0.338 NM_005863
NET1
neuroepithelial cell transforming 1
chr3_+_150330060 0.337 NM_032383
HPS3
Hermansky-Pudlak syndrome 3
chr5_+_150807331 0.337 NM_078483
SLC36A1
solute carrier family 36 (proton/amino acid symporter), member 1
chr7_+_28415495 0.335 LOC401317
hypothetical LOC401317
chr16_-_57276108 0.332 NM_018231
SLC38A7
solute carrier family 38, member 7
chr7_-_27108826 0.331 NM_006735
HOXA2
homeobox A2
chr1_+_148521852 0.330 NM_144697
C1orf51
chromosome 1 open reading frame 51
chr2_-_39859912 0.329 NM_025264
THUMPD2
THUMP domain containing 2
chr17_-_21097170 0.324 NM_152914
C17orf103
chromosome 17 open reading frame 103
chr7_-_130443379 0.322 FLJ43663
hypothetical LOC378805
chr2_-_39859689 0.320 THUMPD2
THUMP domain containing 2
chr1_+_150937463 0.320 NM_178428
LCE2A
late cornified envelope 2A
chr2_+_223625105 0.319 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr11_-_85457469 0.317 PICALM
phosphatidylinositol binding clathrin assembly protein
chr14_-_64638809 0.314 MAX
MYC associated factor X
chr13_+_48582389 0.314 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr5_+_150807380 0.313 SLC36A1
solute carrier family 36 (proton/amino acid symporter), member 1
chr1_-_199635057 0.313 LAD1
ladinin 1
chr1_+_234372454 0.311 NM_003272
GPR137B
G protein-coupled receptor 137B
chr12_+_102883687 0.308 NM_003211
TDG
thymine-DNA glycosylase
chr15_-_38000379 0.308 NM_007223
GPR176
G protein-coupled receptor 176
chr17_-_44042924 0.305 HOXB7
homeobox B7
chr2_-_172675480 0.305 NM_004405
DLX2
distal-less homeobox 2
chr11_+_67532592 0.303 NM_001161473
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr17_-_44043278 0.302 HOXB7
homeobox B7
chr4_-_101034525 0.302 LAMTOR3
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
chr11_+_118443738 0.301 VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)
chr5_+_34692239 0.299 RAI14
retinoic acid induced 14
chr1_+_109810743 0.297 SYPL2
synaptophysin-like 2
chr11_-_9243408 0.293 NM_015213
DENND5A
DENN/MADD domain containing 5A
chrX_+_102356659 0.293 NM_001080425
NM_001127688
BEX4

brain expressed, X-linked 4

chr4_+_128870968 0.292 NM_031291
SLC25A31
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31
chrX_-_100434700 0.291 NM_024885
TAF7L
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
chr19_+_12709281 0.289 NM_004317
ASNA1
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
chr11_+_118443740 0.287 VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)
chr18_+_54682261 0.285 ZNF532
zinc finger protein 532
chr1_-_33669190 0.283 PHC2
polyhomeotic homolog 2 (Drosophila)
chr19_-_38704467 0.283 NM_000285
NM_001166056
NM_001166057
PEPD


peptidase D


chr12_+_52665196 0.283 NM_017409
HOXC10
homeobox C10
chrX_+_55760774 0.281 NM_006064
NM_016656
RRAGB

Ras-related GTP binding B

chr11_+_62295412 0.281 NM_006473
TAF6L
TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
chr10_-_93382837 0.276 NM_005398
PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr5_-_141372721 0.274 NM_005471
GNPDA1
glucosamine-6-phosphate deaminase 1
chr12_-_61615124 0.271 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr12_-_102883602 0.270 C12orf73
chromosome 12 open reading frame 73
chr1_-_32054164 0.269 NM_144569
SPOCD1
SPOC domain containing 1
chr9_+_114953048 0.268 NM_001860
SLC31A2
solute carrier family 31 (copper transporters), member 2
chr11_+_119701047 0.268 NM_001198670
NM_001198671
NM_001198672
NM_001198673
NM_001198674
NM_001198675
NM_174926
TMEM136






transmembrane protein 136






chr6_+_151688327 0.266 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr6_-_99904251 0.266 NM_032511
C6orf168
chromosome 6 open reading frame 168
chr8_-_95343716 0.264 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr19_-_10287673 0.262 NM_001031734
FDX1L
ferredoxin 1-like
chr3_+_33293915 0.262 NM_012157
NM_001171713
FBXL2

F-box and leucine-rich repeat protein 2

chr2_-_40510923 0.261 NM_001112800
NM_001112801
NM_021097
SLC8A1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr20_+_56861430 0.257 NM_001077490
NM_080425
GNAS

GNAS complex locus

chr5_+_150807397 0.256 SLC36A1
solute carrier family 36 (proton/amino acid symporter), member 1
chr12_-_121316997 0.256 NM_022916
VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr2_-_227372574 0.254 IRS1
insulin receptor substrate 1
chr1_-_94475840 0.254 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr8_-_95343696 0.252 GEM
GTP binding protein overexpressed in skeletal muscle
chr16_+_5061862 0.252 ALG1
asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae)
chr10_+_121642204 0.251 NM_007190
SEC23IP
SEC23 interacting protein
chr9_-_16860664 0.250 BNC2
basonuclin 2
chr19_+_14405216 0.248 PKN1
protein kinase N1
chr14_-_80757327 0.247 NM_201595
GTF2A1
general transcription factor IIA, 1, 19/37kDa
chr16_+_5061810 0.246 NM_019109
ALG1
asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae)
chrX_-_100490329 0.246 NM_001145951
TIMM8A
translocase of inner mitochondrial membrane 8 homolog A (yeast)
chr22_-_49042065 0.245 NM_002969
MAPK12
mitogen-activated protein kinase 12
chr20_+_43028590 0.245 STK4
serine/threonine kinase 4
chr3_+_114948550 0.244 NM_001690
ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr11_-_85457736 0.243 PICALM
phosphatidylinositol binding clathrin assembly protein
chr1_-_203557379 0.242 NM_030952
NUAK2
NUAK family, SNF1-like kinase, 2
chr18_-_41801237 0.242 NM_020964
EPG5
ectopic P-granules autophagy protein 5 homolog (C. elegans)
chr10_-_93382779 0.242 PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr6_-_134538762 0.242 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr6_+_151603201 0.241 AKAP12
A kinase (PRKA) anchor protein 12
chr1_-_178113517 0.240 NM_022347
NM_145034
TOR1AIP2

torsin A interacting protein 2

chr18_+_12397894 0.239 NM_001142405
NM_006553
SLMO1

slowmo homolog 1 (Drosophila)

chr17_-_35510431 0.238 NM_021724
NR1D1
nuclear receptor subfamily 1, group D, member 1
chrX_-_100759562 0.238 NM_001009584
NM_001184768
NM_019007
ARMCX6


armadillo repeat containing, X-linked 6


chr3_-_31998241 0.238 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr11_-_85457753 0.237 NM_001008660
NM_007166
PICALM

phosphatidylinositol binding clathrin assembly protein

chr11_-_106394039 0.236 NM_000855
GUCY1A2
guanylate cyclase 1, soluble, alpha 2
chr9_+_102275310 0.236 NM_003692
TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr14_+_76634323 0.236 NM_033426
KIAA1737
KIAA1737
chr5_-_107034484 0.235 NM_001962
EFNA5
ephrin-A5
chr6_+_151603346 0.235 AKAP12
A kinase (PRKA) anchor protein 12
chr7_+_101860958 0.235 NM_001126340
NM_032831
ORAI2

ORAI calcium release-activated calcium modulator 2

chr9_-_135379888 0.234 NM_001080483
TMEM8C
transmembrane protein 8C
chr7_+_106472243 0.234 NM_002736
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr9_-_16860719 0.233 NM_017637
BNC2
basonuclin 2
chr16_+_30952350 0.233 STX4
syntaxin 4
chr8_+_126173264 0.232 NM_173685
NSMCE2
non-SMC element 2, MMS21 homolog (S. cerevisiae)
chr15_+_47249700 0.231 NM_002044
GALK2
galactokinase 2
chr14_+_44622916 0.230 NM_017922
PRPF39
PRP39 pre-mRNA processing factor 39 homolog (S. cerevisiae)
chr13_+_112999462 0.228 NM_005561
LAMP1
lysosomal-associated membrane protein 1
chr1_-_169888373 0.226 NM_000261
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response
chr7_-_142434340 0.225 NM_001001658
OR9A2
olfactory receptor, family 9, subfamily A, member 2
chr17_-_7471832 0.225 NM_133491
SAT2
spermidine/spermine N1-acetyltransferase family member 2
chr2_-_192767844 0.223 NM_016192
TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chrX_+_102498035 0.222 NM_001006612
NM_001006613
NM_001006614
NM_016303
WBP5



WW domain binding protein 5



chr2_-_183610992 0.221 NCKAP1
NCK-associated protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.70 4.50e-04 GO:0033036 macromolecule localization
1.75 1.26e-03 GO:0008104 protein localization
1.37 3.78e-03 GO:0006807 nitrogen compound metabolic process
1.81 4.29e-03 GO:0015031 protein transport
1.37 5.14e-03 GO:0034641 cellular nitrogen compound metabolic process
1.40 6.22e-03 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.78 7.86e-03 GO:0045184 establishment of protein localization
2.58 1.23e-02 GO:0003002 regionalization
1.48 2.48e-02 GO:0010467 gene expression

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.50 1.26e-12 GO:0005773 vacuole
4.60 1.73e-11 GO:0044437 vacuolar part
4.67 2.53e-11 GO:0005774 vacuolar membrane
1.23 6.93e-09 GO:0043227 membrane-bounded organelle
1.23 9.22e-09 GO:0043231 intracellular membrane-bounded organelle
3.16 5.72e-08 GO:0000323 lytic vacuole
3.16 5.72e-08 GO:0005764 lysosome
1.19 2.64e-07 GO:0043226 organelle
1.19 2.99e-07 GO:0043229 intracellular organelle
1.15 5.63e-07 GO:0044424 intracellular part
4.25 1.10e-06 GO:0005765 lysosomal membrane
1.13 1.03e-05 GO:0005622 intracellular
1.29 1.64e-05 GO:0044422 organelle part
1.28 2.72e-05 GO:0044446 intracellular organelle part
1.25 1.09e-04 GO:0044444 cytoplasmic part
2.65 2.38e-04 GO:0010008 endosome membrane
2.63 2.84e-04 GO:0044440 endosomal part
2.17 3.87e-04 GO:0005768 endosome
3.27 2.95e-03 GO:0005770 late endosome
1.16 3.54e-03 GO:0005737 cytoplasm
1.43 3.78e-03 GO:0031090 organelle membrane
2.95 4.62e-03 GO:0005769 early endosome
7.43 7.44e-03 GO:0033176 proton-transporting V-type ATPase complex
1.53 1.13e-02 GO:0005654 nucleoplasm
1.21 1.54e-02 GO:0005634 nucleus
1.36 4.85e-02 GO:0044428 nuclear part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.09 3.00e-02 GO:0005488 binding