Motif ID: TGIF1.p2

Z-value: 1.448


Transcription factors associated with TGIF1.p2:

Gene SymbolEntrez IDGene Name
TGIF1 7050 TGFB-induced factor homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TGIF1chr18_+_34437710.621.1e-02Click!


Activity profile for motif TGIF1.p2.

activity profile for motif TGIF1.p2


Sorted Z-values histogram for motif TGIF1.p2

Sorted Z-values for motif TGIF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TGIF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_27573206 2.040 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr1_-_206484258 1.553 NM_025179
PLXNA2
plexin A2
chr7_-_27158726 1.510


chr1_-_143750988 1.343 NM_001198832
PDE4DIP
phosphodiesterase 4D interacting protein
chr1_+_243384868 1.304 NM_018012
KIF26B
kinesin family member 26B
chr2_+_33213111 1.262 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr2_+_46378405 1.240 EPAS1
endothelial PAS domain protein 1
chr17_-_36915329 1.116 NM_002274
NM_153490
KRT13

keratin 13

chrX_-_128616594 1.114 NM_017413
APLN
apelin
chr6_+_18495559 1.093 NM_182757
RNF144B
ring finger protein 144B
chr1_-_184916044 1.058 NM_000963
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr10_-_21847126 1.045


chr15_+_55455994 1.018 NM_032866
CGNL1
cingulin-like 1
chr4_+_187227302 1.008 NM_003265
TLR3
toll-like receptor 3
chr10_+_69539255 0.988 NM_032578
MYPN
myopalladin
chr7_+_95239753 0.977 NM_001135556
NM_001135557
NM_004411
DYNC1I1


dynein, cytoplasmic 1, intermediate chain 1


chr7_-_107558021 0.969 NM_007356
LAMB4
laminin, beta 4
chr20_+_1194959 0.949 NM_014723
SNPH
syntaphilin
chr4_+_166519392 0.929 NM_001873
CPE
carboxypeptidase E
chr7_-_84654106 0.918 SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr10_+_123862430 0.916 TACC2
transforming, acidic coiled-coil containing protein 2
chr1_+_144260565 0.897 NM_144698
ANKRD35
ankyrin repeat domain 35
chr12_-_87498225 0.895 NM_000899
NM_003994
KITLG

KIT ligand

chr1_-_33669190 0.879 PHC2
polyhomeotic homolog 2 (Drosophila)
chr21_+_42807052 0.878 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr1_-_24342158 0.863 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr1_+_18680010 0.862 NM_152375
KLHDC7A
kelch domain containing 7A
chr14_+_62740878 0.851 NM_020663
RHOJ
ras homolog gene family, member J
chr21_-_44803049 0.851 NM_198696
KRTAP10-3
keratin associated protein 10-3
chr5_+_140848905 0.836 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr6_+_31059463 0.834 NM_001010909
MUC21
mucin 21, cell surface associated
chr1_+_245720992 0.830 NM_001004698
OR2W5
olfactory receptor, family 2, subfamily W, member 5
chr5_-_58607673 0.828 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr8_-_49996353 0.823 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr11_-_85115105 0.812 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr3_-_69381995 0.806 FRMD4B
FERM domain containing 4B
chr12_+_12935759 0.788 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr12_+_12935222 0.747 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr17_+_65677255 0.732 NM_000891
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr1_+_9338531 0.722


chr14_-_64638974 0.709 NM_002382
NM_145112
NM_145113
NM_145114
NM_145116
NM_197957
MAX





MYC associated factor X





chr10_+_85994788 0.707 NM_001012720
NM_001012722
NM_002921
RGR


retinal G protein coupled receptor


chr2_+_46377952 0.699 NM_001430
EPAS1
endothelial PAS domain protein 1
chr19_-_54557450 0.699 NM_003598
TEAD2
TEA domain family member 2
chr14_-_64638809 0.699 MAX
MYC associated factor X
chr8_+_94999167 0.698 NM_001161778
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr2_+_234333653 0.692 NM_000463
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr3_+_69871252 0.682 NM_198159
MITF
microphthalmia-associated transcription factor
chr4_+_3341521 0.672 NM_198227
RGS12
regulator of G-protein signaling 12
chr17_-_36594652 0.664 NM_033060
KRTAP4-1
keratin associated protein 4-1
chr6_-_38671741 0.658 NM_001172418
NM_152733
BTBD9

BTB (POZ) domain containing 9

chr4_+_8935987 0.651 NM_001105662
USP17L2
USP17L6P
USP17
ubiquitin specific peptidase 17-like 2
ubiquitin specific peptidase 17-like 6 (pseudogene)
ubiquitin specific peptidase 17
chr12_-_46585032 0.642 NM_000376
NM_001017535
VDR

vitamin D (1,25- dihydroxyvitamin D3) receptor

chr1_+_151209751 0.641 NM_173080
SPRR4
small proline-rich protein 4
chr14_-_106149623 0.634


chr3_+_189353502 0.632 LPP
LIM domain containing preferred translocation partner in lipoma
chr16_-_56389176 0.628 NM_001130099
KIFC3
kinesin family member C3
chr7_+_69869099 0.626 AUTS2
autism susceptibility candidate 2
chr8_+_98950453 0.623 NM_002380
NM_030583
MATN2

matrilin 2

chrX_-_10495476 0.614 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr1_-_85816520 0.605 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr18_+_3439972 0.604 NM_173209
NM_173208
NM_003244
TGIF1


TGFB-induced factor homeobox 1


chr11_-_8789457 0.597 NM_139157
ST5
suppression of tumorigenicity 5
chr16_+_10878539 0.586 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr3_+_66094324 0.582 NM_173471
SLC25A26
solute carrier family 25, member 26
chr15_+_99207555 0.582 LOC145757
hypothetical LOC145757
chr2_-_158439868 0.579 NM_001105
ACVR1
activin A receptor, type I
chr12_+_118100977 0.576 NM_014365
HSPB8
heat shock 22kDa protein 8
chr12_+_12935619 0.574 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr18_+_18989786 0.569 NM_138375
CABLES1
Cdk5 and Abl enzyme substrate 1
chr1_-_202595666 0.562 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr17_-_36409632 0.559 NM_031959
KRTAP3-2
keratin associated protein 3-2
chr2_+_8739563 0.553 NM_002166
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr6_+_73133152 0.552 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr6_+_136214495 0.552 NM_018945
PDE7B
phosphodiesterase 7B
chr3_-_129023850 0.551 NM_007283
MGLL
monoglyceride lipase
chr1_-_180297372 0.550 NM_001009992
ZNF648
zinc finger protein 648
chr4_-_83702123 0.545 NM_001080506
TMEM150C
transmembrane protein 150C
chr5_-_168204430 0.543


chr12_+_54612055 0.535 NM_201444
NM_201445
NM_201554
DGKA


diacylglycerol kinase, alpha 80kDa


chr22_+_23921072 0.535 KIAA1671
KIAA1671
chr2_+_66519949 0.533 MEIS1
Meis homeobox 1
chr4_+_167013859 0.527 NM_012464
TLL1
tolloid-like 1
chr21_+_33844793 0.526 SON
SON DNA binding protein
chr1_+_12958129 0.522 NM_001100631
PRAMEF22
PRAME family member 22
chr7_+_115637795 0.512 NM_015641
TES
testis derived transcript (3 LIM domains)
chr10_-_49483002 0.510 NM_021226
ARHGAP22
Rho GTPase activating protein 22
chr11_+_130745580 0.505 NM_001048209
NTM
neurotrimin
chr5_-_159730196 0.503 NM_031908
C1QTNF2
C1q and tumor necrosis factor related protein 2
chr7_-_16811131 0.503 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr3_-_56784634 0.498 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr12_-_69289889 0.495 NM_002837
PTPRB
protein tyrosine phosphatase, receptor type, B
chr12_+_38905053 0.494 NM_198578
LRRK2
leucine-rich repeat kinase 2
chr22_-_36212160 0.492 NM_001166343
NM_002405
MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr10_-_48010879 0.490 NM_002900
RBP3
retinol binding protein 3, interstitial
chr11_-_119504726 0.481 TRIM29
tripartite motif containing 29
chr6_-_108252200 0.481 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr2_-_1905508 0.479 MYT1L
myelin transcription factor 1-like
chr9_-_71476917 0.479 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr20_-_62071584 0.474 NM_020713
ZNF512B
zinc finger protein 512B
chr6_+_149763187 0.471 NM_001002255
SUMO4
SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)
chr3_+_67131416 0.463 NM_032505
KBTBD8
kelch repeat and BTB (POZ) domain containing 8
chr15_+_63124760 0.460 NM_178859
OSTBETA
organic solute transporter beta
chr9_-_129537372 0.458 NM_001085347
NM_001134430
NM_001134431
NM_130459
TOR2A



torsin family 2, member A



chr2_+_39000007 0.454 NM_001145451
ARHGEF33
Rho guanine nucleotide exchange factor (GEF) 33
chr11_-_123261549 0.450 NM_001013743
TMEM225
transmembrane protein 225
chr1_-_13350155 0.450 NM_001099850
NM_001099790
PRAMEF18
PRAMEF19
PRAME family member 18
PRAME family member 19
chr6_-_134680888 0.448 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr14_-_72430545 0.447 NM_012074
DPF3
D4, zinc and double PHD fingers, family 3
chr20_-_41788975 0.446 NM_001008901
NM_176791
GTSF1L

gametocyte specific factor 1-like

chr4_+_146622154 0.445 NM_005900
SMAD1
SMAD family member 1
chr11_-_76059435 0.444 NM_001128922
LRRC32
leucine rich repeat containing 32
chr17_+_3324096 0.443 NM_001128085
ASPA
aspartoacylase
chr11_+_111353218 0.441 NM_033425
DIXDC1
DIX domain containing 1
chr6_+_125346208 0.438 NM_152553
RNF217
ring finger protein 217
chr8_-_93181091 0.429 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr9_+_127550298 0.429 NM_001134778
PBX3
pre-B-cell leukemia homeobox 3
chr15_+_87540238 0.429 ABHD2
abhydrolase domain containing 2
chr1_-_20014180 0.428 NM_019062
RNF186
ring finger protein 186
chr6_-_28432026 0.427 NM_001135215
ZNF323
zinc finger protein 323
chr6_-_41781655 0.425 TFEB
transcription factor EB
chr20_-_49612574 0.425 NM_001136021
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr17_+_39213328 0.425 NM_001136483
C17orf105
chromosome 17 open reading frame 105
chrX_+_154650590 0.421 NM_005840
SPRY3
sprouty homolog 3 (Drosophila)
chr1_+_99884018 0.410 NM_017734
PALMD
palmdelphin
chr21_-_44795769 0.404 NM_198693
KRTAP10-2
keratin associated protein 10-2
chr1_-_148936123 0.403 NM_018178
GOLPH3L
golgi phosphoprotein 3-like
chr18_+_3443771 0.402 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr1_+_61697209 0.397 NFIA
nuclear factor I/A
chr5_+_157103280 0.396 NM_173491
LSM11
LSM11, U7 small nuclear RNA associated
chr1_-_42157077 0.395 NM_001127714
NM_024503
HIVEP3

human immunodeficiency virus type I enhancer binding protein 3

chr5_+_110587546 0.394 NM_001744
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr10_-_14856901 0.391 NM_031453
FAM107B
family with sequence similarity 107, member B
chr3_-_52694554 0.389 NM_018313
PBRM1
polybromo 1
chr7_+_21434818 0.389


chr3_-_46693902 0.388 NM_182775
ALS2CL
ALS2 C-terminal like
chr7_-_93357881 0.385 NM_006528
TFPI2
tissue factor pathway inhibitor 2
chr5_-_54317102 0.384 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr4_+_77214886 0.384 NM_001130016
NM_001179
ART3

ADP-ribosyltransferase 3

chr1_+_176330254 0.379 RASAL2
RAS protein activator like 2
chr10_-_73203202 0.379 NM_022153
C10orf54
chromosome 10 open reading frame 54
chr3_-_129024665 0.377 NM_001003794
MGLL
monoglyceride lipase
chr5_-_64813459 0.376 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr1_+_113734997 0.374 NM_001142782
NM_152900
MAGI3

membrane associated guanylate kinase, WW and PDZ domain containing 3

chr1_+_161305019 0.371 NM_001102445
RGS4
regulator of G-protein signaling 4
chr6_-_87861492 0.368 NM_000735
CGA
glycoprotein hormones, alpha polypeptide
chr6_-_33822659 0.368 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr6_-_41238899 0.365 NM_018965
TREM2
triggering receptor expressed on myeloid cells 2
chr18_+_19947314 0.363 TTC39C
tetratricopeptide repeat domain 39C
chr1_-_181889070 0.362 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chrX_-_43717864 0.362 NM_000266
NDP
Norrie disease (pseudoglioma)
chr3_+_161955980 0.360 PPM1L
protein phosphatase, Mg2+/Mn2+ dependent, 1L
chr1_+_154520693 0.360 NM_032323
TMEM79
transmembrane protein 79
chr2_-_172458970 0.360 NM_003705
SLC25A12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr4_-_186814852 0.360 SORBS2
sorbin and SH3 domain containing 2
chr11_-_83071084 0.352 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr3_-_192063158 0.351 NM_001146686
GEMC1
geminin coiled-coil domain-containing protein 1
chr19_-_56841819 0.348 NM_001098612
SIGLEC14
sialic acid binding Ig-like lectin 14
chr11_-_86343859 0.346 NM_012193
FZD4
frizzled homolog 4 (Drosophila)
chr16_+_56230707 0.346 NM_001145774
GPR56
G protein-coupled receptor 56
chr5_-_112852425 0.346 NM_001085377
MCC
mutated in colorectal cancers
chr6_+_29382381 0.346 NM_030946
OR14J1
olfactory receptor, family 14, subfamily J, member 1
chr11_-_5037432 0.346 NM_001005164
OR52E2
olfactory receptor, family 52, subfamily E, member 2
chr1_+_22251706 0.346 NM_001039802
NM_001791
NM_044472
CDC42


cell division cycle 42 (GTP binding protein, 25kDa)


chr7_-_131483925 0.346 PLXNA4
plexin A4
chr17_-_70053839 0.342 NM_006678
CD300C
CD300c molecule
chr5_-_94646033 0.341 NM_024717
MCTP1
multiple C2 domains, transmembrane 1
chr2_+_69055208 0.339 NM_019617
GKN1
gastrokine 1
chr1_+_84646621 0.338 NM_058248
DNASE2B
deoxyribonuclease II beta
chr10_-_116517945 0.337 ABLIM1
actin binding LIM protein 1
chr17_-_70053743 0.335 CD300C
CD300c molecule
chr12_+_8741746 0.333 NM_020734
RIMKLB
ribosomal modification protein rimK-like family member B
chr15_-_48192804 0.332 ATP8B4
ATPase, class I, type 8B, member 4
chrX_+_149612488 0.331 NM_003828
MTMR1
myotubularin related protein 1
chr4_+_101090648 0.330 LOC256880
hypothetical LOC256880
chr14_+_76362467 0.330 NM_194287
C14orf166B
chromosome 14 open reading frame 166B
chr12_-_51494601 0.328 NM_002272
KRT4
keratin 4
chr22_-_28564141 0.328 ASCC2
activating signal cointegrator 1 complex subunit 2
chr1_-_42156957 0.326 HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr17_-_36981830 0.326 NM_000226
KRT9
keratin 9
chr15_+_45797977 0.326 NM_020858
NM_024966
NM_153616
NM_153617
NM_153618
NM_153619
SEMA6D





sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D





chr2_+_152899837 0.322 NM_052905
FMNL2
formin-like 2
chrX_-_37964924 0.321 NM_001170750
NM_001170751
NM_001170752
NM_006307
SRPX



sushi-repeat containing protein, X-linked



chr16_-_30490452 0.321 ZNF688
zinc finger protein 688
chr3_+_185253528 0.319 NM_130770
HTR3C
5-hydroxytryptamine (serotonin) receptor 3, family member C
chr10_-_14412813 0.318 NM_018027
FRMD4A
FERM domain containing 4A
chr5_-_132140786 0.316 NM_001098811
NM_001098812
NM_015146
SEPT8


septin 8


chr12_+_51783554 0.315 SOAT2
sterol O-acyltransferase 2
chr11_+_20001130 0.314 NM_001111019
NAV2
neuron navigator 2
chr10_+_102113410 0.309


chr3_+_188043156 0.309 NM_001177800
NM_004797
ADIPOQ

adiponectin, C1Q and collagen domain containing

chr17_+_4348877 0.307 NM_001124758
SPNS2
spinster homolog 2 (Drosophila)
chr15_+_61123327 0.307 TPM1
tropomyosin 1 (alpha)
chr2_+_33514896 0.306 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr14_-_49543987 0.306 NM_001012706
C14orf182
chromosome 14 open reading frame 182
chr10_-_94247450 0.306 NM_001165946
IDE
insulin-degrading enzyme
chr11_+_89507465 0.305 NM_005467
NAALAD2
N-acetylated alpha-linked acidic dipeptidase 2
chr22_+_36531246 0.304 H1F0
H1 histone family, member 0
chr17_-_31146660 0.302 NM_001032278
NM_024302
MMP28

matrix metallopeptidase 28

chr17_+_19255083 0.302 NM_007148
RNF112
ring finger protein 112

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.35 3.36e-03 GO:0005912 adherens junction
2.27 3.86e-03 GO:0070161 anchoring junction
2.92 3.90e-03 GO:0045095 keratin filament
1.36 6.71e-03 GO:0005856 cytoskeleton
2.60 1.07e-02 GO:0005925 focal adhesion
2.49 1.46e-02 GO:0030055 cell-substrate junction
2.06 1.70e-02 GO:0045111 intermediate filament cytoskeleton
2.47 2.38e-02 GO:0005924 cell-substrate adherens junction
2.10 3.24e-02 GO:0005882 intermediate filament

Nothing significant found in function category.