Motif ID: EVI1.p2

Z-value: 1.755


Transcription factors associated with EVI1.p2:

Gene SymbolEntrez IDGene Name
EVI1 2122 ecotropic viral integration site 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MECOMchr3_-_170348215-0.401.2e-01Click!


Activity profile for motif EVI1.p2.

activity profile for motif EVI1.p2


Sorted Z-values histogram for motif EVI1.p2

Sorted Z-values for motif EVI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EVI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_135558001 2.001 NM_000074
CD40LG
CD40 ligand
chr12_-_242255 1.858 NM_001190997
NM_016615
SLC6A13

solute carrier family 6 (neurotransmitter transporter, GABA), member 13

chr6_+_29732736 1.763 NM_001008228
NM_001008229
NM_001170418
NM_002433
NM_206809
NM_206810
NM_206811
NM_206812
NM_206814
MOG








myelin oligodendrocyte glycoprotein








chr8_-_27997306 1.661 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr2_-_135498716 1.651 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr11_-_8921155 1.581 NM_020646
ASCL3
achaete-scute complex homolog 3 (Drosophila)
chr5_+_140719773 1.553 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr16_-_27806978 1.466 NM_144675
GSG1L
GSG1-like
chr12_-_27126721 1.464 NM_001080406
C12orf71
chromosome 12 open reading frame 71
chr10_-_29794484 1.340 SVIL
supervillin
chr7_+_142053693 1.333 NM_001190487
MTRNR2L6
MT-RNR2-like 6
chrX_+_30169977 1.323 NM_002367
MAGEB4
melanoma antigen family B, 4
chr1_-_9040141 1.312 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr10_+_63950212 1.283 NM_199452
ZNF365
zinc finger protein 365
chr7_-_93027057 1.274 NM_001164738
CALCR
calcitonin receptor
chr5_-_137502975 1.250 NM_003551
NME5
non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
chr3_+_150065732 1.218 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr19_-_40673185 1.211 NM_207392
KRTDAP
keratinocyte differentiation-associated protein
chr7_-_75876830 1.151 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr1_-_150599105 1.148 NM_001014342
FLG2
filaggrin family member 2
chr6_-_50025115 1.128 NM_001166478
DEFB133
defensin, beta 133
chr4_-_52578542 1.095 NM_001024611
LRRC66
leucine rich repeat containing 66
chr3_-_58175437 1.074 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr11_-_47467094 1.067 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr5_+_72504778 1.057 NM_153217
TMEM174
transmembrane protein 174
chr15_-_88023576 1.045 NM_001145311
NM_002666
PLIN1

perilipin 1

chr15_-_79453472 1.025 NM_001080532
TMC3
transmembrane channel-like 3
chr4_-_9650931 1.004 NM_001001290
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr9_+_124590970 1.003 NM_001001923
OR5C1
olfactory receptor, family 5, subfamily C, member 1
chr8_+_134272463 0.999 NM_003882
NM_080838
WISP1

WNT1 inducible signaling pathway protein 1

chr1_-_202726068 0.999 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr11_-_85108030 0.996 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr5_+_139856688 0.979 ANKHD1
ankyrin repeat and KH domain containing 1
chr17_-_19592178 0.970 NM_000691
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr8_-_81155564 0.970 NM_001025252
TPD52
tumor protein D52
chr12_+_48310593 0.961 NM_001031698
PRPF40B
PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
chr1_-_111908085 0.953 NM_001081976
ADORA3
adenosine A3 receptor
chr15_+_60146467 0.948 NM_207322
C2CD4A
C2 calcium-dependent domain containing 4A
chr1_+_111573855 0.946 NM_001025199
CHI3L2
chitinase 3-like 2
chr7_+_44007012 0.945 NM_175064
SPDYE1
speedy homolog E1 (Xenopus laevis)
chr7_-_38279757 0.926 NM_001003799
NM_001003806
TARP

TRGV9
TCR gamma alternate reading frame protein

T cell receptor gamma variable 9
chr3_+_185232025 0.924 NM_182537
HTR3D
5-hydroxytryptamine (serotonin) receptor 3 family member D
chr10_+_29617995 0.913 NM_032517
LYZL1
lysozyme-like 1
chr15_+_32048380 0.909 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chr5_+_156540425 0.901 NM_005546
ITK
IL2-inducible T-cell kinase
chrX_+_101388810 0.899 NM_022053
NXF2
nuclear RNA export factor 2
chr5_-_37220702 0.897 C5orf42
chromosome 5 open reading frame 42
chr3_-_49204294 0.883 NM_001080528
LOC646498
hypothetical protein LOC646498
chr1_+_169326641 0.873 NM_001002294
NM_006894
FMO3

flavin containing monooxygenase 3

chr2_+_204509698 0.853 NM_012092
ICOS
inducible T-cell co-stimulator
chr7_+_137411717 0.852 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr3_-_194755281 0.845 NM_032279
ATP13A4
ATPase type 13A4
chr7_-_122627235 0.842 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr3_-_139333813 0.835 NM_016161
A4GNT
alpha-1,4-N-acetylglucosaminyltransferase
chr17_+_18566060 0.827 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr9_-_111253484 0.823 NM_001145369
NM_001145370
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr11_-_64484184 0.789 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr12_-_47464143 0.785 NM_015270
ADCY6
adenylate cyclase 6
chr5_-_75954807 0.785 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr11_+_123625632 0.776 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr11_-_117589283 0.774 NM_153206
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr5_-_35266550 0.758 NM_000949
PRLR
prolactin receptor
chr11_+_22646229 0.757 NM_177553
GAS2
growth arrest-specific 2
chr3_-_152449591 0.755 NM_001081455
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr1_+_171871283 0.744 NM_001195190
LOC730159
hypothetical protein LOC730159
chr5_-_41249270 0.736 NM_000065
C6
complement component 6
chr3_+_44891101 0.735 NM_003241
TGM4
transglutaminase 4 (prostate)
chr22_-_16026176 0.732 NM_017829
CECR5
cat eye syndrome chromosome region, candidate 5
chr4_-_77042599 0.726 NM_006239
PPEF2
protein phosphatase, EF-hand calcium binding domain 2
chrX_-_74292800 0.725 NM_004299
ABCB7
ATP-binding cassette, sub-family B (MDR/TAP), member 7
chr10_+_35934343 0.718 NM_153368
GJD4
gap junction protein, delta 4, 40.1kDa
chr10_-_48426868 0.714 NM_001042357
NM_001042389
PTPN20B
PTPN20A
protein tyrosine phosphatase, non-receptor type 20B
protein tyrosine phosphatase, non-receptor type 20A
chr1_-_150044365 0.707 NM_001004432
LINGO4
leucine rich repeat and Ig domain containing 4
chr3_+_185232223 0.701 NM_001145143
HTR3D
5-hydroxytryptamine (serotonin) receptor 3 family member D
chr15_-_100280784 0.697 NM_001004195
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr3_+_148609841 0.697 NM_003412
ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr18_+_7221136 0.694 NM_001105581
LRRC30
leucine rich repeat containing 30
chr1_+_110795271 0.685 NM_032414
PROK1
prokineticin 1
chr7_-_150702629 0.682


chr11_+_125208420 0.676 NM_001144874
PATE4
prostate and testis expressed 4
chr8_-_95289945 0.674 NM_004063
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr10_+_77212524 0.668 NM_032024
C10orf11
chromosome 10 open reading frame 11
chr7_+_116182676 0.667


chr16_+_14187965 0.666 MKL2
MKL/myocardin-like 2
chr10_-_91092410 0.666 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr22_+_21543671 0.661 IGLV4-3
immunoglobulin lambda variable 4-3
chr5_-_88004891 0.660 LOC645323
hypothetical LOC645323
chr3_-_15515382 0.660 NM_080538
COLQ
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr13_+_30207668 0.657 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr5_-_36337756 0.656 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chrX_-_10548458 0.655 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr12_-_94469357 0.653 NM_032147
USP44
ubiquitin specific peptidase 44
chr1_+_198263352 0.652 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr12_-_53044495 0.642 NM_020370
GPR84
G protein-coupled receptor 84
chr2_+_99344060 0.642 EIF5B
eukaryotic translation initiation factor 5B
chr10_+_90474280 0.638 NM_001080518
LIPK
lipase, family member K
chr3_-_38967055 0.633 NM_014139
SCN11A
sodium channel, voltage-gated, type XI, alpha subunit
chr1_-_20318578 0.633 NM_012400
PLA2G2D
phospholipase A2, group IID
chr4_-_111777651 0.628 PITX2
paired-like homeodomain 2
chrX_-_55225668 0.622 NM_001190708
MTRNR2L10
MT-RNR2-like 10
chr9_+_78305368 0.621 NM_001097636
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr11_+_59902598 0.615 MS4A7
membrane-spanning 4-domains, subfamily A, member 7
chr1_-_116112921 0.614 NM_001232
CASQ2
calsequestrin 2 (cardiac muscle)
chr17_-_31441390 0.610 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr2_+_38031099 0.609 NM_001170793
NM_144713
FAM82A1

family with sequence similarity 82, member A1

chr17_-_36418869 0.605 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr1_+_166812466 0.605 NM_002995
XCL1
chemokine (C motif) ligand 1
chr2_-_179623030 0.603 NM_173648
CCDC141
coiled-coil domain containing 141
chr11_+_59902530 0.603 NM_021201
NM_206938
NM_206939
NM_206940
MS4A7



membrane-spanning 4-domains, subfamily A, member 7



chr14_-_56346849 0.602 NM_021728
OTX2
orthodenticle homeobox 2
chr17_+_50698169 0.602 HLF
hepatic leukemia factor
chr12_+_55674496 0.600 NM_007264
GPR182
G protein-coupled receptor 182
chr6_-_132987106 0.596 NM_001033080
TAAR2
trace amine associated receptor 2
chr11_+_51371857 0.594 NM_001004703
OR4C46
olfactory receptor, family 4, subfamily C, member 46
chr3_+_58459131 0.594 NM_153331
KCTD6
potassium channel tetramerisation domain containing 6
chr3_+_23904086 0.593 UBE2E1
ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)
chr5_+_121493113 0.589 NM_207317
ZNF474
zinc finger protein 474
chrX_+_86659370 0.583 NM_019117
NM_057162
KLHL4

kelch-like 4 (Drosophila)

chr11_-_113935789 0.581 NM_152315
FAM55A
family with sequence similarity 55, member A
chr11_-_107087943 0.580 NM_003063
SLN
sarcolipin
chr19_+_53189719 0.574 NM_022142
ELSPBP1
epididymal sperm binding protein 1
chr11_+_58888460 0.573 NM_001004729
OR5AN1
olfactory receptor, family 5, subfamily AN, member 1
chr1_-_116112684 0.573 CASQ2
calsequestrin 2 (cardiac muscle)
chr12_-_11230809 0.568 NM_181429
TAS2R42
taste receptor, type 2, member 42
chr6_-_30188845 0.567 NM_007028
TRIM31
tripartite motif containing 31
chr17_-_25685175 0.566 NM_206832
TMIGD1
transmembrane and immunoglobulin domain containing 1
chr12_+_26096757 0.565 NM_001164746
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr12_-_7547552 0.563 NM_004244
NM_203416
CD163

CD163 molecule

chr10_-_69125932 0.563 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr22_+_34443863 0.562 NM_030642
APOL5
apolipoprotein L, 5
chr20_+_35445350 0.562 SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr19_+_10642648 0.561 ILF3
interleukin enhancer binding factor 3, 90kDa
chr6_-_53638464 0.554 NM_001003760
KLHL31
kelch-like 31 (Drosophila)
chr19_+_53656317 0.550 NM_170720
KCNJ14
potassium inwardly-rectifying channel, subfamily J, member 14
chr7_+_133862883 0.549 NM_020299
AKR1B10
aldo-keto reductase family 1, member B10 (aldose reductase)
chr12_-_14858358 0.549 NM_001013698
C12orf69
chromosome 12 open reading frame 69
chr4_-_72868598 0.549 NM_000583
GC
group-specific component (vitamin D binding protein)
chr9_-_113585593 0.548 NM_173521
C9orf84
chromosome 9 open reading frame 84
chr19_-_22744623 0.544 NM_001080409
ZNF99
zinc finger protein 99
chr5_+_125723686 0.543 NM_001146319
GRAMD3
GRAM domain containing 3
chr7_+_18296569 0.540 HDAC9
histone deacetylase 9
chr4_-_100284395 0.539 NM_000670
ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide
chr19_+_45973139 0.537 NM_006533
MIA
melanoma inhibitory activity
chr10_+_115929008 0.535 NM_198795
TDRD1
tudor domain containing 1
chr5_+_137231443 0.532 NM_001135940
NM_006790
MYOT

myotilin

chr7_-_100630912 0.529 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chrX_+_119379967 0.529 NM_001142447
NM_012069
ATP1B4

ATPase, Na+/K+ transporting, beta 4 polypeptide

chr2_-_26395420 0.528 NM_001145168
NM_001145169
GPR113

G protein-coupled receptor 113

chr3_+_123256902 0.524 NM_175862
CD86
CD86 molecule
chr15_+_71953020 0.524 NM_153356
TBC1D21
TBC1 domain family, member 21
chr1_+_200698493 0.522 NM_032103
NM_032104
PPP1R12B

protein phosphatase 1, regulatory (inhibitor) subunit 12B

chr8_-_91164100 0.522 NM_004929
CALB1
calbindin 1, 28kDa
chr1_-_92722088 0.522 GFI1
growth factor independent 1 transcription repressor
chr12_-_21649019 0.518 NM_021957
GYS2
glycogen synthase 2 (liver)
chr11_-_5523328 0.515 NM_001005289
OR52H1
olfactory receptor, family 52, subfamily H, member 1
chr5_-_35083996 0.513 NM_031900
AGXT2
alanine--glyoxylate aminotransferase 2
chr1_-_92721633 0.509 GFI1
growth factor independent 1 transcription repressor
chr6_-_32892705 0.508 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr1_-_144426918 0.508 NM_007053
CD160
CD160 molecule
chr9_+_1040367 0.506 DMRT2
doublesex and mab-3 related transcription factor 2
chr1_+_213245507 0.505 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr12_-_107943227 0.504 NM_018711
SVOP
SV2 related protein homolog (rat)
chrX_+_100692071 0.503 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr10_-_49792282 0.496 NM_001006939
LRRC18
leucine rich repeat containing 18
chr5_-_138842526 0.494 NM_198282
TMEM173
transmembrane protein 173
chr8_-_125649926 0.489 MTSS1
metastasis suppressor 1
chr19_-_45141473 0.489 LOC440525
PRR13
proline rich 13 pseudogene
proline rich 13
chr1_-_92721943 0.488 NM_001127215
GFI1
growth factor independent 1 transcription repressor
chr20_+_57966865 0.486 NM_177980
CDH26
cadherin 26
chr6_+_123142559 0.484 FABP7
fatty acid binding protein 7, brain
chr5_+_156752739 0.483 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr1_+_168898898 0.483 PRRX1
paired related homeobox 1
chr4_+_40032146 0.482 NM_017581
CHRNA9
cholinergic receptor, nicotinic, alpha 9
chr19_+_59820413 0.479 NM_006669
LILRB1
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr11_+_12917369 0.477 TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr7_+_94953148 0.477 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr8_-_110724594 0.477 NM_001099756
SYBU
syntabulin (syntaxin-interacting)
chr3_-_44464722 0.477


chr16_+_52037186 0.476 RBL2
retinoblastoma-like 2 (p130)
chrX_+_50044279 0.475 NM_033031
NM_033670
CCNB3

cyclin B3

chr1_-_33110668 0.474 NM_001171941
FNDC5
fibronectin type III domain containing 5
chr3_-_120861959 0.474 NM_022135
POPDC2
popeye domain containing 2
chr15_+_83467295 0.470 PDE8A
phosphodiesterase 8A
chr8_+_17440664 0.470 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr22_+_36008369 0.470 NM_013385
CYTH4
cytohesin 4
chr3_-_185578621 0.468 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr1_+_32777358 0.465 NM_001040441
ZBTB8A
zinc finger and BTB domain containing 8A
chr3_-_168854395 0.463 WDR49
WD repeat domain 49
chr10_-_17211795 0.463 NM_001081
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr12_-_45506001 0.462 NM_001143824
NM_018018
SLC38A4

solute carrier family 38, member 4

chr4_-_38460983 0.461 NM_001017388
NM_001195106
NM_001195107
NM_001195108
NM_030956
TLR10




toll-like receptor 10




chr8_+_133948384 0.461 NM_003235
TG
thyroglobulin
chr13_+_77007809 0.459 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr7_+_74962234 0.459 NM_001099435
SPDYE5
speedy homolog E5 (Xenopus laevis)
chr2_-_158008763 0.458 NM_004288
CYTIP
cytohesin 1 interacting protein
chr7_+_63410620 0.458 NM_001170905
ZNF736
zinc finger protein 736
chr4_+_41678469 0.458 NM_001029955
DCAF4L1
DDB1 and CUL4 associated factor 4-like 1
chr8_+_97575052 0.457 NM_002998
SDC2
syndecan 2
chr4_+_72321113 0.452 SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr12_-_9976173 0.452 NM_001130711
CLEC2A
C-type lectin domain family 2, member A

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.54 1.48e-10 GO:0007608 sensory perception of smell
2.42 2.67e-10 GO:0007606 sensory perception of chemical stimulus
1.84 1.81e-06 GO:0007600 sensory perception
1.23 7.38e-06 GO:0050896 response to stimulus
1.26 7.96e-06 GO:0032501 multicellular organismal process
1.52 1.84e-05 GO:0003008 system process
1.56 8.98e-05 GO:0050877 neurological system process
1.71 3.10e-04 GO:0006952 defense response
1.98 4.86e-04 GO:0050776 regulation of immune response
2.13 4.62e-03 GO:0050778 positive regulation of immune response
2.11 7.60e-03 GO:0006954 inflammatory response
1.56 1.95e-02 GO:0009611 response to wounding
1.81 3.16e-02 GO:0002684 positive regulation of immune system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.37 1.65e-10 GO:0071944 cell periphery
1.36 4.99e-10 GO:0005886 plasma membrane
1.47 6.67e-07 GO:0005576 extracellular region
1.23 5.28e-06 GO:0031224 intrinsic to membrane
1.21 6.58e-06 GO:0044425 membrane part
1.23 1.16e-05 GO:0016021 integral to membrane
1.14 1.65e-03 GO:0016020 membrane
1.53 1.60e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.13 1.32e-13 GO:0004930 G-protein coupled receptor activity
2.62 8.88e-12 GO:0004984 olfactory receptor activity
1.66 1.54e-10 GO:0004872 receptor activity
1.78 1.68e-10 GO:0004888 transmembrane receptor activity
1.54 4.36e-09 GO:0004871 signal transducer activity
1.54 4.36e-09 GO:0060089 molecular transducer activity