Motif ID: NHLH1,2.p2

Z-value: 2.342


Transcription factors associated with NHLH1,2.p2:

Gene SymbolEntrez IDGene Name
NHLH1 4807 nescient helix loop helix 1
NHLH2 4808 nescient helix loop helix 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NHLH2chr1_-_116185215-0.322.2e-01Click!
NHLH1chr1_+_1586034800.155.8e-01Click!


Activity profile for motif NHLH1,2.p2.

activity profile for motif NHLH1,2.p2


Sorted Z-values histogram for motif NHLH1,2.p2

Sorted Z-values for motif NHLH1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NHLH1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_1937711 3.316 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr16_+_155972 3.287 NM_001003938
HBM
hemoglobin, mu
chr8_-_24828134 3.246 NEFM
neurofilament, medium polypeptide
chr5_+_113726203 2.859 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr5_+_113725914 2.691 NM_021614
KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr14_-_103058568 2.563 CKB
creatine kinase, brain
chr2_-_6923215 2.517 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr3_-_62835601 2.488


chr13_-_71338144 2.364 DACH1
dachshund homolog 1 (Drosophila)
chr7_-_72822471 2.279 NM_001306
CLDN3
claudin 3
chr13_+_48692472 2.236 NM_001507
MLNR
motilin receptor
chr2_+_74595073 2.168 NM_016170
TLX2
T-cell leukemia homeobox 2
chr4_-_13155135 2.092 NM_001189
NKX3-2
NK3 homeobox 2
chr20_+_20296744 2.066 NM_002196
INSM1
insulinoma-associated 1
chr21_+_33364420 2.005 OLIG1
oligodendrocyte transcription factor 1
chrX_+_23262905 1.972 NM_173495
PTCHD1
patched domain containing 1
chr14_+_30413393 1.895 NM_001135058
NM_004086
COCH

coagulation factor C homolog, cochlin (Limulus polyphemus)

chr17_+_56832492 1.881 TBX2
T-box 2
chr2_+_208979800 1.824 NM_005048
PTH2R
parathyroid hormone 2 receptor
chr8_+_85258007 1.821 NM_001100392
NM_001100393
RALYL

RALY RNA binding protein-like

chr10_-_15801661 1.810 NM_003638
ITGA8
integrin, alpha 8
chr11_-_63440891 1.806 NM_173587
RCOR2
REST corepressor 2
chr3_-_73756668 1.786 NM_015009
PDZRN3
PDZ domain containing ring finger 3
chr8_+_56177567 1.783 NM_052898
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr17_-_77512346 1.781 NM_178493
NOTUM
notum pectinacetylesterase homolog (Drosophila)
chr17_+_7494964 1.768 NM_001678
ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr8_-_144862266 1.761 NM_001162914
LOC100130274
coiled-coil domain containing 121-like
chr6_+_133604203 1.682 EYA4
eyes absent homolog 4 (Drosophila)
chr10_+_94823636 1.649 NM_000783
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr11_-_74818685 1.634 KLHL35
kelch-like 35 (Drosophila)
chr8_+_85258056 1.629 NM_173848
RALYL
RALY RNA binding protein-like
chr3_+_161426322 1.626 LOC401097
hypothetical protein LOC401097
chr16_+_23754860 1.617 PRKCB
protein kinase C, beta
chr22_-_37569679 1.555


chr8_+_24827181 1.554 NEFM
neurofilament, medium polypeptide
chr1_-_92724181 1.553 NM_001127216
GFI1
growth factor independent 1 transcription repressor
chr8_+_24827173 1.531 NM_005382
NEFM
neurofilament, medium polypeptide
chr13_-_71338558 1.510 DACH1
dachshund homolog 1 (Drosophila)
chr15_+_90738108 1.497 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chrX_+_68641802 1.496 NM_015686
FAM155B
family with sequence similarity 155, member B
chr17_-_16335809 1.495 C17orf76
chromosome 17 open reading frame 76
chr3_-_62836052 1.494 NM_003716
NM_183393
NM_183394
CADPS


Ca++-dependent secretion activator


chr10_+_134893766 1.473 NM_003577
UTF1
undifferentiated embryonic cell transcription factor 1
chr2_+_109112428 1.471 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr19_+_868285 1.468 NM_032551
KISS1R
KISS1 receptor
chr2_-_47650973 1.460 NM_022055
KCNK12
potassium channel, subfamily K, member 12
chr14_-_99695684 1.457 NM_206918
DEGS2
degenerative spermatocyte homolog 2, lipid desaturase (Drosophila)
chr18_+_74841262 1.448 NM_171999
SALL3
sal-like 3 (Drosophila)
chr2_-_72228427 1.444 NM_019885
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr11_-_74818858 1.432 KLHL35
kelch-like 35 (Drosophila)
chr17_-_44047299 1.428 NM_024016
HOXB8
homeobox B8
chr14_-_76807302 1.413 NM_021257
NGB
neuroglobin
chr14_+_37748345 1.408 SSTR1
somatostatin receptor 1
chr16_+_23754997 1.397 PRKCB
protein kinase C, beta
chr11_-_129803515 1.392 ADAMTS8
ADAM metallopeptidase with thrombospondin type 1 motif, 8
chr4_-_168392307 1.389 NM_001040159
NM_016950
SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr9_-_110969310 1.385 NM_014334
C9orf4
chromosome 9 open reading frame 4
chr2_-_233060774 1.384 NM_004826
ECEL1
endothelin converting enzyme-like 1
chr6_+_129245978 1.373 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr3_+_35656012 1.371 ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr18_+_65219114 1.370 NM_152721
DOK6
docking protein 6
chr9_-_83493415 1.365 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr20_-_21326046 1.365 NM_033176
NKX2-4
NK2 homeobox 4
chr2_+_137239583 1.346 THSD7B
thrombospondin, type I, domain containing 7B
chr11_-_617172 1.329 NM_021920
SCT
secretin
chr2_-_230287442 1.328 NM_139072
DNER
delta/notch-like EGF repeat containing
chr13_+_87122778 1.325 NM_015567
SLITRK5
SLIT and NTRK-like family, member 5
chr22_+_28206180 1.317 NM_021076
NEFH
neurofilament, heavy polypeptide
chr4_+_115739006 1.314 NM_001128174
UGT8
UDP glycosyltransferase 8
chr14_-_47213906 1.309 NM_001113498
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr5_+_115326035 1.300 NM_173800
AQPEP
laeverin
chr3_+_125786195 1.299 NM_007064
KALRN
kalirin, RhoGEF kinase
chr4_-_168392266 1.294 SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr17_+_56832255 1.269 TBX2
T-box 2
chr20_-_9767406 1.268 NM_020341
NM_177990
PAK7

p21 protein (Cdc42/Rac)-activated kinase 7

chr16_-_47872880 1.264


chr2_+_155263338 1.258 NM_002239
KCNJ3
potassium inwardly-rectifying channel, subfamily J, member 3
chr14_+_37748031 1.249 SSTR1
somatostatin receptor 1
chr17_+_14145051 1.247 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr4_-_154929657 1.244 NM_003013
SFRP2
secreted frizzled-related protein 2
chr17_-_16336204 1.242 NM_001113567
NM_207387
C17orf76

chromosome 17 open reading frame 76

chr12_+_101876151 1.240 ASCL1
achaete-scute complex homolog 1 (Drosophila)
chr11_-_65841077 1.239 NM_020404
CD248
CD248 molecule, endosialin
chr12_-_61615124 1.226 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr11_-_32413486 1.222 WT1
Wilms tumor 1
chr11_-_32413635 1.219 NM_000378
NM_024424
NM_024426
WT1


Wilms tumor 1


chr4_-_2390050 1.216 NM_001172656
NM_001172657
NM_001172658
NM_020972
ZFYVE28



zinc finger, FYVE domain containing 28



chr9_-_90983195 1.206 SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr2_+_5750229 1.200 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr8_-_144583718 1.196 NM_201589
MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr16_+_23754772 1.194 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr16_-_47873183 1.189 NM_004352
CBLN1
cerebellin 1 precursor
chr9_-_85342868 1.183 NM_174938
FRMD3
FERM domain containing 3
chr4_+_156349230 1.177 NM_000910
NPY2R
neuropeptide Y receptor Y2
chr11_-_74819165 1.167 NM_001039548
KLHL35
kelch-like 35 (Drosophila)
chr20_+_34357604 1.163 DLGAP4
discs, large (Drosophila) homolog-associated protein 4
chr1_-_21868380 1.156 NM_001145657
NM_002885
RAP1GAP

RAP1 GTPase activating protein

chr17_-_29930431 1.147 NM_207454
C17orf102
chromosome 17 open reading frame 102
chrX_+_117992623 1.146 NM_001031855
NM_024778
LONRF3

LON peptidase N-terminal domain and ring finger 3

chr16_+_23754822 1.140 PRKCB
protein kinase C, beta
chr8_-_17315386 1.137 NM_004686
MTMR7
myotubularin related protein 7
chr8_-_140784416 1.133 NM_016601
KCNK9
potassium channel, subfamily K, member 9
chr1_+_63561632 1.127 FOXD3
forkhead box D3
chr4_+_61749540 1.121 LPHN3
latrophilin 3
chr10_-_120345148 1.120 NM_004248
PRLHR
prolactin releasing hormone receptor
chr3_-_10724715 1.112 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr1_+_229365296 1.105 NM_001004342
TRIM67
tripartite motif containing 67
chr8_-_139578246 1.097 NM_015912
FAM135B
family with sequence similarity 135, member B
chr7_+_98084531 1.095 NM_002523
NPTX2
neuronal pentraxin II
chr9_-_139183675 1.095


chr3_-_135097111 1.083 NM_016577
RAB6B
RAB6B, member RAS oncogene family
chr1_+_1062137 1.078 LOC254099
hypothetical protein LOC254099
chrX_-_99551926 1.077 NM_001105243
NM_001184880
NM_020766
PCDH19


protocadherin 19


chr11_+_13940715 1.074 SPON1
spondin 1, extracellular matrix protein
chr19_-_51856129 1.059 NM_145056
DACT3
dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
chr6_+_124166767 1.052 NM_001040214
NM_153355
NKAIN2

Na+/K+ transporting ATPase interacting 2

chr3_-_135096986 1.049 RAB6B
RAB6B, member RAS oncogene family
chr19_-_6453224 1.048 NM_006087
TUBB4
tubulin, beta 4
chr12_+_131705438 1.048 NM_012226
NM_016318
NM_170682
NM_170683
NM_174872
NM_174873
P2RX2





purinergic receptor P2X, ligand-gated ion channel, 2





chr8_+_31616809 1.045 NM_013962
NRG1
neuregulin 1
chr3_-_124650081 1.044 NM_183357
ADCY5
adenylate cyclase 5
chr16_-_47872973 1.043 CBLN1
cerebellin 1 precursor
chr8_+_35212505 1.042 NM_080872
UNC5D
unc-5 homolog D (C. elegans)
chr3_-_30911156 1.038 NM_207359
GADL1
glutamate decarboxylase-like 1
chr4_-_155631861 1.031 DCHS2
dachsous 2 (Drosophila)
chr19_-_14177980 1.029 NM_001008701
NM_014921
LPHN1

latrophilin 1

chr12_+_5023345 1.026 NM_002234
KCNA5
potassium voltage-gated channel, shaker-related subfamily, member 5
chr21_+_18539016 1.025 NM_024944
CHODL
chondrolectin
chr16_+_270606 1.023 NM_001176
ARHGDIG
Rho GDP dissociation inhibitor (GDI) gamma
chrX_+_12066505 1.020 NM_014728
FRMPD4
FERM and PDZ domain containing 4
chr22_+_28446288 1.017 NM_182527
CABP7
calcium binding protein 7
chr14_-_60185659 1.002 NM_005982
SIX1
SIX homeobox 1
chr10_+_23521464 0.995 NM_178161
PTF1A
pancreas specific transcription factor, 1a
chr17_-_7106497 0.994 CLDN7
claudin 7
chr22_+_42138034 0.994 MPPED1
metallophosphoesterase domain containing 1
chr17_-_17340219 0.993 NM_016084
RASD1
RAS, dexamethasone-induced 1
chrX_+_21302317 0.992 NM_001168647
NM_001168648
NM_001168649
NM_014927
CNKSR2



connector enhancer of kinase suppressor of Ras 2



chr22_+_16973399 0.989 NM_001193414
NM_018943
TUBA8

tubulin, alpha 8

chr14_-_37795290 0.979 NM_175060
CLEC14A
C-type lectin domain family 14, member A
chr7_-_45927263 0.979 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr5_+_80292313 0.974 NM_006909
RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr20_+_13150417 0.970 NM_080826
ISM1
isthmin 1 homolog (zebrafish)
chr4_+_177223978 0.970 NM_170710
NM_181265
WDR17

WD repeat domain 17

chr3_-_69064364 0.969 NM_001005527
NM_182522
FAM19A4

family with sequence similarity 19 (chemokine (C-C motif)-like), member A4

chr10_-_99521701 0.962 NM_003015
SFRP5
secreted frizzled-related protein 5
chr11_+_14621972 0.960 PDE3B
phosphodiesterase 3B, cGMP-inhibited
chr7_-_30688626 0.959 NM_001883
CRHR2
corticotropin releasing hormone receptor 2
chr13_+_95541093 0.958 NM_153456
HS6ST3
heparan sulfate 6-O-sulfotransferase 3
chr9_+_94987032 0.957 NM_006648
WNK2
WNK lysine deficient protein kinase 2
chr2_-_128792515 0.954 NM_004807
HS6ST1
heparan sulfate 6-O-sulfotransferase 1
chr10_+_115793795 0.951 NM_000684
ADRB1
adrenergic, beta-1-, receptor
chr2_+_185171480 0.949 ZNF804A
zinc finger protein 804A
chr8_-_17315171 0.949 MTMR7
myotubularin related protein 7
chr10_+_105026773 0.945 NM_032727
INA
internexin neuronal intermediate filament protein, alpha
chr19_-_44386731 0.944 NM_001080468
SYCN
syncollin
chr20_-_42872295 0.937 NM_182970
RIMS4
regulating synaptic membrane exocytosis 4
chr10_-_135000358 0.936 CALY
calcyon neuron-specific vesicular protein
chr19_-_7845325 0.931 NM_001190467
FLJ22184
hypothetical protein FLJ22184
chr18_+_53170718 0.925 NM_015879
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr4_-_85638410 0.924 NM_006168
NKX6-1
NK6 homeobox 1
chr20_+_19141364 0.924 SLC24A3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr5_+_170779664 0.920 FGF18
fibroblast growth factor 18
chr17_+_29931880 0.917 NM_207313
TMEM132E
transmembrane protein 132E
chr4_+_177224142 0.904 WDR17
WD repeat domain 17
chr3_-_124228999 0.903 SEMA5B
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
chr11_-_18769703 0.900 NM_001039970
NM_006906
NM_032781
PTPN5


protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)


chr22_-_29231597 0.896 NM_001161368
NM_174977
SEC14L4

SEC14-like 4 (S. cerevisiae)

chr6_+_72653126 0.893 RIMS1
regulating synaptic membrane exocytosis 1
chr20_-_49852353 0.891 NM_020436
SALL4
sal-like 4 (Drosophila)
chr3_+_171619346 0.891 NM_005602
CLDN11
claudin 11
chr4_+_3738093 0.888 NM_000683
ADRA2C
adrenergic, alpha-2C-, receptor
chr10_-_135000464 0.886 NM_015722
CALY
calcyon neuron-specific vesicular protein
chr2_-_42573980 0.885 KCNG3
potassium voltage-gated channel, subfamily G, member 3
chr12_-_61614930 0.882 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr4_-_66218777 0.881 EPHA5
EPH receptor A5
chr4_-_5942818 0.874 CRMP1
collapsin response mediator protein 1
chr4_-_41849333 0.872 BEND4
BEN domain containing 4
chr14_-_37795001 0.868 CLEC14A
C-type lectin domain family 14, member A
chr13_+_27264779 0.867 NM_145657
GSX1
GS homeobox 1
chr4_+_147779492 0.864 NM_004575
POU4F2
POU class 4 homeobox 2
chr8_+_21937533 0.863 NPM2
nucleophosmin/nucleoplasmin 2
chr4_+_7245218 0.851 NM_020777
SORCS2
sortilin-related VPS10 domain containing receptor 2
chrX_-_74062005 0.851 NM_001008537
KIAA2022
KIAA2022
chr7_+_45580704 0.851 ADCY1
adenylate cyclase 1 (brain)
chr2_+_231610438 0.851 NM_001144994
C2orf72
chromosome 2 open reading frame 72
chr10_-_102978678 0.849 NM_006562
LBX1
ladybird homeobox 1
chr17_+_56831951 0.848 NM_005994
TBX2
T-box 2
chr17_-_64108529 0.844 NM_017565
FAM20A
family with sequence similarity 20, member A
chr2_-_278181 0.841 NM_001002919
FAM150B
family with sequence similarity 150, member B
chr4_+_93444572 0.839 NM_001510
GRID2
glutamate receptor, ionotropic, delta 2
chr14_+_28305922 0.831 NM_005249
FOXG1
forkhead box G1
chr11_-_44288188 0.830 NM_021926
ALX4
ALX homeobox 4
chr5_+_80292213 0.829 RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr16_+_1143738 0.828 CACNA1H
calcium channel, voltage-dependent, T type, alpha 1H subunit
chr5_-_134397740 0.826 NM_002653
PITX1
paired-like homeodomain 1
chr10_-_135088065 0.825 NM_001012508
SPRN
shadow of prion protein homolog (zebrafish)
chr13_+_77170470 0.824 NM_001040153
SLAIN1
SLAIN motif family, member 1
chr19_-_54267932 0.824 NM_031886
KCNA7
potassium voltage-gated channel, shaker-related subfamily, member 7
chr9_+_967386 0.823 DMRT3
doublesex and mab-3 related transcription factor 3
chr6_+_137285071 0.819 NM_001008783
SLC35D3
solute carrier family 35, member D3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.50 4.74e-19 GO:0007399 nervous system development
1.62 5.20e-12 GO:0030182 neuron differentiation
1.53 1.20e-11 GO:0022008 neurogenesis
1.53 4.17e-11 GO:0048699 generation of neurons
1.50 1.02e-10 GO:0048468 cell development
1.26 2.67e-10 GO:0048731 system development
1.23 1.03e-09 GO:0007275 multicellular organismal development
1.65 3.93e-09 GO:0007417 central nervous system development
1.23 5.69e-09 GO:0048856 anatomical structure development
1.30 1.07e-08 GO:0030154 cell differentiation
1.20 2.68e-08 GO:0032502 developmental process
1.28 5.18e-08 GO:0048869 cellular developmental process
1.56 1.50e-07 GO:0048666 neuron development
1.59 3.65e-07 GO:0000904 cell morphogenesis involved in differentiation
1.59 5.40e-07 GO:0031175 neuron projection development
1.07 9.99e-07 GO:0009987 cellular process
1.60 2.17e-06 GO:0048667 cell morphogenesis involved in neuron differentiation
1.59 4.27e-06 GO:0048812 neuron projection morphogenesis
1.65 5.35e-06 GO:0007420 brain development
1.10 7.10e-06 GO:0065007 biological regulation
1.58 1.68e-05 GO:0007409 axonogenesis
1.24 2.86e-05 GO:0065008 regulation of biological quality
1.52 3.54e-05 GO:0048858 cell projection morphogenesis
1.17 4.99e-05 GO:0023052 signaling
1.45 6.45e-05 GO:0030030 cell projection organization
1.50 6.86e-05 GO:0032990 cell part morphogenesis
1.28 7.83e-05 GO:0009653 anatomical structure morphogenesis
1.11 7.95e-05 GO:0050794 regulation of cellular process
1.46 9.57e-05 GO:0000902 cell morphogenesis
1.62 1.09e-04 GO:0007411 axon guidance
1.43 2.89e-04 GO:0032989 cellular component morphogenesis
1.10 4.06e-04 GO:0050789 regulation of biological process
1.29 4.38e-04 GO:0051239 regulation of multicellular organismal process
1.32 4.68e-04 GO:0010646 regulation of cell communication
1.22 2.04e-03 GO:0048513 organ development
1.22 2.28e-03 GO:0007166 cell surface receptor linked signaling pathway
1.15 2.67e-03 GO:0007165 signal transduction
1.35 3.94e-03 GO:2000026 regulation of multicellular organismal development
1.31 6.24e-03 GO:0050793 regulation of developmental process
1.23 6.48e-03 GO:0023051 regulation of signaling
1.54 6.69e-03 GO:0007610 behavior
1.13 1.19e-02 GO:0051716 cellular response to stimulus
4.07 1.24e-02 GO:0014061 regulation of norepinephrine secretion
1.47 1.78e-02 GO:0090066 regulation of anatomical structure size
1.28 1.97e-02 GO:0009605 response to external stimulus
1.18 2.12e-02 GO:0042221 response to chemical stimulus
1.68 3.12e-02 GO:0030900 forebrain development
1.30 3.73e-02 GO:0051128 regulation of cellular component organization
1.62 3.84e-02 GO:0045664 regulation of neuron differentiation
1.33 4.00e-02 GO:0045595 regulation of cell differentiation
1.49 4.40e-02 GO:0060284 regulation of cell development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.08 1.46e-04 GO:0005737 cytoplasm
1.05 9.20e-04 GO:0044424 intracellular part
1.18 2.36e-03 GO:0044459 plasma membrane part
1.05 5.20e-03 GO:0005622 intracellular
1.41 1.18e-02 GO:0045202 synapse

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.47 1.08e-05 GO:0008324 cation transmembrane transporter activity
1.36 2.53e-04 GO:0015075 ion transmembrane transporter activity
1.59 7.34e-04 GO:0005261 cation channel activity
1.32 8.31e-04 GO:0022891 substrate-specific transmembrane transporter activity
1.30 1.55e-03 GO:0022857 transmembrane transporter activity
1.35 2.73e-03 GO:0043565 sequence-specific DNA binding
1.43 7.76e-03 GO:0022838 substrate-specific channel activity
1.42 8.69e-03 GO:0015267 channel activity
1.43 9.50e-03 GO:0005216 ion channel activity
1.42 9.97e-03 GO:0022803 passive transmembrane transporter activity
1.49 1.11e-02 GO:0022836 gated channel activity
1.24 1.21e-02 GO:0005215 transporter activity
1.08 1.24e-02 GO:0005515 protein binding
1.26 1.30e-02 GO:0022892 substrate-specific transporter activity
1.29 3.85e-02 GO:0019899 enzyme binding
1.38 4.47e-02 GO:0019904 protein domain specific binding
1.24 4.87e-02 GO:0001071 nucleic acid binding transcription factor activity
1.24 4.87e-02 GO:0003700 sequence-specific DNA binding transcription factor activity