Motif ID: NHLH1,2.p2

Z-value: 2.342


Transcription factors associated with NHLH1,2.p2:

Gene SymbolEntrez IDGene Name
NHLH1 4807 nescient helix loop helix 1
NHLH2 4808 nescient helix loop helix 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NHLH2chr1_-_116185215-0.322.2e-01Click!
NHLH1chr1_+_1586034800.155.8e-01Click!


Activity profile for motif NHLH1,2.p2.

activity profile for motif NHLH1,2.p2


Sorted Z-values histogram for motif NHLH1,2.p2

Sorted Z-values for motif NHLH1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NHLH1,2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_1937711 3.316 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr16_+_155972 3.287 NM_001003938
 HBM
hemoglobin, mu
chr8_-_24828134 3.246 NEFM
neurofilament, medium polypeptide
chr5_+_113726203 2.859 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr5_+_113725914 2.691 NM_021614
 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr14_-_103058568 2.563 CKB
creatine kinase, brain
chr2_-_6923215 2.517 NM_207315
 CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr3_-_62835601 2.488


chr13_-_71338144 2.364 DACH1
dachshund homolog 1 (Drosophila)
chr7_-_72822471 2.279 NM_001306
 CLDN3
claudin 3
chr13_+_48692472 2.236 NM_001507
 MLNR
motilin receptor
chr2_+_74595073 2.168 NM_016170
 TLX2
T-cell leukemia homeobox 2
chr4_-_13155135 2.092 NM_001189
 NKX3-2
NK3 homeobox 2
chr20_+_20296744 2.066 NM_002196
 INSM1
insulinoma-associated 1
chr21_+_33364420 2.005 OLIG1
oligodendrocyte transcription factor 1
chrX_+_23262905 1.972 NM_173495
 PTCHD1
patched domain containing 1
chr14_+_30413393 1.895 NM_001135058
NM_004086
 COCH

coagulation factor C homolog, cochlin (Limulus polyphemus)

chr17_+_56832492 1.881 TBX2
T-box 2
chr2_+_208979800 1.824 NM_005048
 PTH2R
parathyroid hormone 2 receptor
chr8_+_85258007 1.821 NM_001100392
NM_001100393
 RALYL

RALY RNA binding protein-like


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 51 entries
enrichment   p-value GO term description
4.07 1.24e-02 GO:0014061 regulation of norepinephrine secretion
1.68 3.12e-02 GO:0030900 forebrain development
1.65 3.93e-09 GO:0007417 central nervous system development
1.65 5.35e-06 GO:0007420 brain development
1.62 5.20e-12 GO:0030182 neuron differentiation
1.62 1.09e-04 GO:0007411 axon guidance
1.62 3.84e-02 GO:0045664 regulation of neuron differentiation
1.60 2.17e-06 GO:0048667 cell morphogenesis involved in neuron differentiation
1.59 3.65e-07 GO:0000904 cell morphogenesis involved in differentiation
1.59 5.40e-07 GO:0031175 neuron projection development
1.59 4.27e-06 GO:0048812 neuron projection morphogenesis
1.58 1.68e-05 GO:0007409 axonogenesis
1.56 1.50e-07 GO:0048666 neuron development
1.54 6.69e-03 GO:0007610 behavior
1.53 1.20e-11 GO:0022008 neurogenesis
1.53 4.17e-11 GO:0048699 generation of neurons
1.52 3.54e-05 GO:0048858 cell projection morphogenesis
1.50 4.74e-19 GO:0007399 nervous system development
1.50 1.02e-10 GO:0048468 cell development
1.50 6.86e-05 GO:0032990 cell part morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
1.41 1.18e-02 GO:0045202 synapse
1.18 2.36e-03 GO:0044459 plasma membrane part
1.08 1.46e-04 GO:0005737 cytoplasm
1.05 9.20e-04 GO:0044424 intracellular part
1.05 5.20e-03 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
1.59 7.34e-04 GO:0005261 cation channel activity
1.49 1.11e-02 GO:0022836 gated channel activity
1.47 1.08e-05 GO:0008324 cation transmembrane transporter activity
1.43 7.76e-03 GO:0022838 substrate-specific channel activity
1.43 9.50e-03 GO:0005216 ion channel activity
1.42 8.69e-03 GO:0015267 channel activity
1.42 9.97e-03 GO:0022803 passive transmembrane transporter activity
1.38 4.47e-02 GO:0019904 protein domain specific binding
1.36 2.53e-04 GO:0015075 ion transmembrane transporter activity
1.35 2.73e-03 GO:0043565 sequence-specific DNA binding
1.32 8.31e-04 GO:0022891 substrate-specific transmembrane transporter activity
1.30 1.55e-03 GO:0022857 transmembrane transporter activity
1.29 3.85e-02 GO:0019899 enzyme binding
1.26 1.30e-02 GO:0022892 substrate-specific transporter activity
1.24 1.21e-02 GO:0005215 transporter activity
1.24 4.87e-02 GO:0001071 nucleic acid binding transcription factor activity
1.24 4.87e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.08 1.24e-02 GO:0005515 protein binding