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• Activity deltas table
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• Motifs sorted by significance (text)
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Motif ID: SREBF1,2.p2

Z-value: 0.866

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr13_+_48582389	1.800	NM_014923	FNDC3A	fibronectin type III domain containing 3A
chr2_+_234333653	1.578	NM_000463	UGT1A1	UDP glucuronosyltransferase 1 family, polypeptide A1
chr2_+_227898163	1.445		MFF	mitochondrial fission factor
chr20_+_37024383	1.372	NM_001190809 NM_021931	DHX35	DEAH (Asp-Glu-Ala-His) box polypeptide 35
chr14_-_34253473	1.312	NM_138638	CFL2	cofilin 2 (muscle)
chr2_+_177785667	1.305	NM_194247	HNRNPA3P1 HNRNPA3	heterogeneous nuclear ribonucleoprotein A3 pseudogene 1 heterogeneous nuclear ribonucleoprotein A3
chr2_-_176575171	1.160	NM_030650	KIAA1715	KIAA1715
chr6_-_84994032	1.155	NM_014895	KIAA1009	KIAA1009
chr10_-_45410197	1.092	NM_001002265 NM_145021	MARCH8	membrane-associated ring finger (C3HC4) 8
chr17_-_44022595	1.070		HOXB3	homeobox B3
chr10_+_45542653	1.059	NM_001169106 NM_001169107 NM_015262	FAM21C FAM21A	family with sequence similarity 21, member C family with sequence similarity 21, member A
chr11_-_85457469	1.027		PICALM	phosphatidylinositol binding clathrin assembly protein
chr6_-_7258351	1.001	NM_003144	SSR1	signal sequence receptor, alpha
chr6_+_35852369	0.993	NM_207409	C6orf126	chromosome 6 open reading frame 126
chr11_+_85017269	0.990	NM_001193537 NM_001193538 NM_018480	TMEM126B	transmembrane protein 126B
chr14_-_67353046	0.978	NM_015346	ZFYVE26	zinc finger, FYVE domain containing 26
chr20_-_43953036	0.975	NM_080749	NEURL2	neuralized homolog 2 (Drosophila)
chr17_-_41018291	0.968
chr16_+_55580910	0.964	NM_032206	NLRC5	NLR family, CARD domain containing 5
chr20_+_43953428	0.909		CTSA	cathepsin A
chr2_-_131567458	0.884	NM_001009993	FAM168B	family with sequence similarity 168, member B
chr20_+_43953372	0.882		CTSA	cathepsin A
chr2_+_187266899	0.879	NM_177454	FAM171B	family with sequence similarity 171, member B
chr3_-_20202622	0.868	NM_001012409 NM_001012410 NM_001012411 NM_001012412 NM_001012413 NM_138484	SGOL1	shugoshin-like 1 (S. pombe)
chr6_-_169392771	0.867
chr10_+_69314714	0.860		SIRT1	sirtuin 1
chr11_+_125586828	0.858	NM_024556	FAM118B	family with sequence similarity 118, member B
chr2_+_176724583	0.851
chr2_-_27399405	0.848	NM_002437	MPV17	MpV17 mitochondrial inner membrane protein
chr3_-_11736946	0.845	NM_014667	VGLL4	vestigial like 4 (Drosophila)
chr6_+_160310118	0.843	NM_000876	IGF2R	insulin-like growth factor 2 receptor
chr6_+_127629677	0.828	NM_030963	RNF146	ring finger protein 146
chr7_-_44496703	0.824	NM_015332	NUDCD3	NudC domain containing 3
chr4_-_23500706	0.821	NM_013261	PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr2_+_241174803	0.816	NM_023083 NM_023085	CAPN10	calpain 10
chr20_+_33506322	0.808	NM_007186	CEP250	centrosomal protein 250kDa
chr1_+_224337937	0.807
chr7_-_134845363	0.802	NM_001008225 NM_001190847 NM_001190848 NM_001190849 NM_001190850 NM_013316	CNOT4	CCR4-NOT transcription complex, subunit 4
chr2_+_176724358	0.779	NM_014621	HOXD4	homeobox D4
chr2_+_85676347	0.777	NM_016494	RNF181	ring finger protein 181
chr16_+_68542126	0.774	NM_001136214	CLEC18A	C-type lectin domain family 18, member A
chr6_+_139391511	0.773	NM_021243	C6orf115	chromosome 6 open reading frame 115
chr20_+_43953331	0.768		CTSA	cathepsin A
chr13_+_112999590	0.760		LAMP1	lysosomal-associated membrane protein 1
chr22_+_34107087	0.749		HMOX1	heme oxygenase (decycling) 1
chr1_-_152797820	0.748		UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1
chr5_+_41940216	0.730	NM_175921	C5orf51	chromosome 5 open reading frame 51
chr16_+_68542310	0.724	NM_182619	CLEC18C CLEC18A CLEC18B	C-type lectin domain family 18, member C C-type lectin domain family 18, member A C-type lectin domain family 18, member B
chr13_-_78131259	0.704	NM_024546	RNF219	ring finger protein 219
chr1_+_76312962	0.700	NM_001160011 NM_152996	ST6GALNAC3	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr16_-_1465007	0.686		CLCN7	chloride channel 7
chr16_-_1465041	0.685	NM_001114331 NM_001287	CLCN7	chloride channel 7
chr6_+_7671267	0.684		BMP6	bone morphogenetic protein 6
chr1_+_159550789	0.683	NM_001035511 NM_001035512 NM_001035513 NM_003001	SDHC	succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
chr20_+_33823318	0.676	NM_016436	PHF20	PHD finger protein 20
chr1_-_152797707	0.673	NM_017582	UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1
chr19_+_10626106	0.668		ILF3	interleukin enhancer binding factor 3, 90kDa
chr11_-_85457736	0.662		PICALM	phosphatidylinositol binding clathrin assembly protein
chr11_-_85457753	0.658	NM_001008660 NM_007166	PICALM	phosphatidylinositol binding clathrin assembly protein
chr6_+_151815298	0.655		C6orf211	chromosome 6 open reading frame 211
chr16_+_5023672	0.647		LOC100507589	hypothetical LOC100507589
chr4_+_17225344	0.644	NM_025205	MED28	mediator complex subunit 28
chr1_-_152797760	0.639		UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1
chr6_+_139391570	0.639		C6orf115	chromosome 6 open reading frame 115
chr5_+_133735004	0.635		UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)
chr20_-_32877029	0.635	NM_014071	NCOA6	nuclear receptor coactivator 6
chr16_-_15644465	0.627	NM_001184998 NM_001184999 NM_014647	KIAA0430	KIAA0430
chr1_-_152797767	0.621		UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1
chr20_+_46971618	0.615	NM_006420	ARFGEF2	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr16_-_5023562	0.614		NAGPA	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr16_-_1464927	0.595		CLCN7	chloride channel 7
chr6_-_163754903	0.594		LOC100526820	hypothetical LOC100526820
chr7_+_27190688	0.594
chr7_-_135083906	0.592	NM_205855	FAM180A	family with sequence similarity 180, member A
chr16_+_28893525	0.592	NM_001142448 NM_001142449 NM_001142450 NM_001142451 NM_032038	SPIN1 SPNS1	spindlin 1 spinster homolog 1 (Drosophila)
chr20_+_18066473	0.590	NM_001164811	PET117	cytochrome c oxidase assembly factor-like
chr6_-_21631992	0.587
chr15_-_71712605	0.587		NPTN	neuroplastin
chr14_-_23981493	0.585	NM_020195	SDR39U1	short chain dehydrogenase/reductase family 39U, member 1
chr3_+_87359088	0.573	NM_014043	CHMP2B	chromatin modifying protein 2B
chr6_-_26767892	0.570	NM_024639	ZNF322A	zinc finger protein 322A
chr8_+_98725505	0.570	NM_178812	MTDH	metadherin
chr17_-_44043361	0.569	NM_004502	HOXB7	homeobox B7
chr8_-_54918099	0.568	NM_213620	ATP6V1H	ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr17_-_43977273	0.564	NM_002145	HOXB2	homeobox B2
chr13_-_32757835	0.564	NM_178006	STARD13	StAR-related lipid transfer (START) domain containing 13
chr17_-_27210330	0.563	NM_018405	C17orf79	chromosome 17 open reading frame 79
chr16_+_80370426	0.558	NM_002661	PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr1_+_10015736	0.555		UBE4B	ubiquitination factor E4B (UFD2 homolog, yeast)
chr16_-_1465021	0.554		CLCN7	chloride channel 7
chr1_-_201162991	0.551	NM_021633	KLHL12	kelch-like 12 (Drosophila)
chr22_+_38903825	0.549	NM_001162501 NM_015088	TNRC6B	trinucleotide repeat containing 6B
chr1_+_234372454	0.544	NM_003272	GPR137B	G protein-coupled receptor 137B
chr2_+_46779827	0.541	NM_144949	SOCS5	suppressor of cytokine signaling 5
chr14_-_23752507	0.531		CHMP4A	chromatin modifying protein 4A
chr16_+_22124870	0.529	NM_013302	EEF2K	eukaryotic elongation factor-2 kinase
chr14_+_30161267	0.528	NM_016106 NM_182835	SCFD1	sec1 family domain containing 1
chr1_+_109221271	0.528		GPSM2	G-protein signaling modulator 2
chr3_+_150330060	0.527	NM_032383	HPS3	Hermansky-Pudlak syndrome 3
chr16_+_83618804	0.519	NM_014732	KIAA0513	KIAA0513
chr8_-_95343716	0.516	NM_005261 NM_181702	GEM	GTP binding protein overexpressed in skeletal muscle
chr3_-_126257425	0.515	NM_020733	HEG1	HEG homolog 1 (zebrafish)
chr17_-_40263124	0.514	NM_005497	GJC1	gap junction protein, gamma 1, 45kDa
chr10_+_69314347	0.511	NM_012238	SIRT1	sirtuin 1
chr1_+_109963982	0.510		AMPD2	adenosine monophosphate deaminase 2
chr2_-_200424140	0.509		LOC348751	hypothetical LOC348751
chr14_-_23752476	0.506		CHMP4A	chromatin modifying protein 4A
chr20_-_61317891	0.505	NM_017798	YTHDF1	YTH domain family, member 1
chr14_-_23752498	0.505		CHMP4A	chromatin modifying protein 4A
chr19_-_13088212	0.504	NM_001142554 NM_017722 NM_001136035	TRMT1	TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae)
chr4_-_84152985	0.499	NM_001115007	LIN54	lin-54 homolog (C. elegans)
chr17_-_44042924	0.498		HOXB7	homeobox B7
chr1_+_149750485	0.494	NM_020770	CGN	cingulin
chr6_-_31973418	0.493		EHMT2	euchromatic histone-lysine N-methyltransferase 2
chr1_+_181871830	0.491	NM_015149	RGL1	ral guanine nucleotide dissociation stimulator-like 1
chr9_-_130749604	0.490	NM_014908	DOLK	dolichol kinase
chr19_-_15436333	0.489	NM_022904	RASAL3	RAS protein activator like 3
chr17_+_52410466	0.489	NM_021626	SCPEP1	serine carboxypeptidase 1
chr2_-_148494732	0.488	NM_001190882 NM_001190879 NM_002552 NM_001190881 NM_181741	ORC4	origin recognition complex, subunit 4
chr2_-_196744546	0.487	NM_004226	STK17B	serine/threonine kinase 17b
chr17_-_34263487	0.487	NM_000978	SNORA21 RPL23	small nucleolar RNA, H/ACA box 21 ribosomal protein L23
chr1_-_201162938	0.479		KLHL12	kelch-like 12 (Drosophila)
chr2_-_105312536	0.479	NM_001142621 NM_004257	TGFBRAP1	transforming growth factor, beta receptor associated protein 1
chr10_-_120504659	0.475	NM_153810	C10orf46	chromosome 10 open reading frame 46
chr6_-_43305156	0.475	NM_006443 NM_199184	C6orf108	chromosome 6 open reading frame 108
chr20_-_4743768	0.474	NM_170774	RASSF2	Ras association (RalGDS/AF-6) domain family member 2
chr1_-_77920914	0.472	NM_015534	ZZZ3	zinc finger, ZZ-type containing 3
chr20_+_43952997	0.472	NM_000308 NM_001127695 NM_001167594	CTSA	cathepsin A
chr2_+_46779553	0.468	NM_014011	SOCS5	suppressor of cytokine signaling 5
chr17_-_73636386	0.467	NM_001127198	TMC6	transmembrane channel-like 6
chr14_-_38971370	0.465	NM_203301	FBXO33	F-box protein 33
chr10_-_120504445	0.465		C10orf46	chromosome 10 open reading frame 46
chr12_-_47396724	0.463	NM_001240	CCNT1	cyclin T1
chr2_+_223625105	0.463	NM_080671	KCNE4	potassium voltage-gated channel, Isk-related family, member 4
chr20_+_18496068	0.461		LOC388789	hypothetical LOC388789
chr8_-_95343696	0.459		GEM	GTP binding protein overexpressed in skeletal muscle
chr11_-_125586733	0.458	NM_001144827 NM_032795	RPUSD4	RNA pseudouridylate synthase domain containing 4
chr22_+_34107051	0.456	NM_002133	HMOX1	heme oxygenase (decycling) 1
chr5_-_55564942	0.452	NM_024669	ANKRD55	ankyrin repeat domain 55
chr17_-_44043278	0.450		HOXB7	homeobox B7
chr8_-_81246215	0.447	NM_001025253 NM_005079	TPD52	tumor protein D52
chr16_+_80036275	0.447	NM_198390	CMIP	c-Maf-inducing protein
chr14_+_37746937	0.445	NM_001049	SSTR1	somatostatin receptor 1
chr6_-_31973434	0.444	NM_006709 NM_025256	EHMT2	euchromatic histone-lysine N-methyltransferase 2
chr17_-_33043514	0.443	NM_001163544 NM_001163545 NM_001163546 NM_001163547 NM_007247 NM_080550 NM_198882	SYNRG	synergin, gamma
chr10_+_101532544	0.441		ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr8_+_98725604	0.440		MTDH	metadherin
chr17_-_7078304	0.438		DVL2	dishevelled, dsh homolog 2 (Drosophila)
chr12_+_54396118	0.438		BLOC1S1	biogenesis of lysosomal organelles complex-1, subunit 1
chr7_+_97574054	0.437	NM_014916	LMTK2	lemur tyrosine kinase 2
chr2_-_210743622	0.436		C2orf67	chromosome 2 open reading frame 67
chr17_+_63252704	0.435		BPTF	bromodomain PHD finger transcription factor
chr6_+_87921980	0.434	NM_015021	ZNF292	zinc finger protein 292
chr5_+_122138636	0.432	NM_003100	SNX2	sorting nexin 2
chr5_-_172130766	0.430	NM_004417	DUSP1	dual specificity phosphatase 1
chr14_+_22860511	0.430		PABPN1	poly(A) binding protein, nuclear 1
chr6_-_44333002	0.429	NM_178148	SLC35B2	solute carrier family 35, member B2
chr4_-_152901542	0.428	NM_004564	PET112L	PET112-like (yeast)
chr11_-_1741680	0.428		CTSD	cathepsin D
chr17_-_73636362	0.427		TMC6	transmembrane channel-like 6
chr1_+_10015577	0.424	NM_001105562 NM_006048	UBE4B	ubiquitination factor E4B (UFD2 homolog, yeast)
chr14_-_34661190	0.423	NM_017917	PPP2R3C	protein phosphatase 2, regulatory subunit B'', gamma
chr17_+_63252087	0.423	NM_004459 NM_182641	BPTF	bromodomain PHD finger transcription factor
chr16_+_15644624	0.422	NM_001143979	NDE1	nudE nuclear distribution gene E homolog 1 (A. nidulans)
chr17_-_71362971	0.419	NM_012478	WBP2	WW domain binding protein 2
chr1_+_109963950	0.419	NM_139156	AMPD2	adenosine monophosphate deaminase 2
chr6_+_151815114	0.419	NM_024573	C6orf211	chromosome 6 open reading frame 211
chr16_+_4837912	0.419	NM_001079514	UBN1	ubinuclein 1
chr6_-_33822659	0.418	NM_001142883 NM_054111	IP6K3	inositol hexakisphosphate kinase 3
chr16_+_80370400	0.417		PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr3_+_4996096	0.417	NM_003670	BHLHE40	basic helix-loop-helix family, member e40
chr18_-_20231709	0.415		OSBPL1A	oxysterol binding protein-like 1A
chr1_+_36462583	0.412	NM_005119	THRAP3	thyroid hormone receptor associated protein 3
chr16_-_57276108	0.412	NM_018231	SLC38A7	solute carrier family 38, member 7
chr10_+_101532450	0.410	NM_000392	ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr9_-_124707314	0.409	NM_001100588 NM_018835	RC3H2	ring finger and CCCH-type domains 2
chr20_-_34102250	0.407		LOC647979	hypothetical LOC647979
chr11_-_8849485	0.406		ST5	suppression of tumorigenicity 5
chr6_-_152664906	0.406		SYNE1	spectrin repeat containing, nuclear envelope 1
chr9_-_139128777	0.405		DPP7	dipeptidyl-peptidase 7
chr14_-_93512818	0.404		ASB2	ankyrin repeat and SOCS box containing 2
chr14_-_34661156	0.403		PPP2R3C	protein phosphatase 2, regulatory subunit B'', gamma
chr2_-_175741096	0.402	NM_001880	ATF2	activating transcription factor 2
chr12_-_119826073	0.400		SPPL3	signal peptide peptidase 3
chr2_+_68238490	0.398	NM_020143	PNO1	partner of NOB1 homolog (S. cerevisiae)
chr2_-_215605054	0.396	NM_015657	ABCA12	ATP-binding cassette, sub-family A (ABC1), member 12
chr16_-_87450734	0.395		GALNS	galactosamine (N-acetyl)-6-sulfate sulfatase
chr11_+_66915997	0.393	NM_004584	RAD9A	RAD9 homolog A (S. pombe)
chr9_-_135379888	0.392	NM_001080483	TMEM8C	transmembrane protein 8C
chr12_+_70519753	0.391	NM_001146213 NM_001146214 NM_022771	TBC1D15	TBC1 domain family, member 15
chr16_+_66855827	0.389	NM_001076785 NM_003983	SLC7A6	solute carrier family 7 (cationic amino acid transporter, y+ system), member 6
chr10_-_120504267	0.389
chr1_+_36462625	0.387		THRAP3	thyroid hormone receptor associated protein 3
chr1_-_154532019	0.387	NM_144580	C1orf85	chromosome 1 open reading frame 85
chr5_+_122138661	0.387		SNX2	sorting nexin 2
chr17_+_46599081	0.386	NM_001018138	NME2	non-metastatic cells 2, protein (NM23B) expressed in
chr16_+_11669736	0.386	NM_003498	SNN	stannin
chr15_-_32398220	0.383	NM_005135	SLC12A6	solute carrier family 12 (potassium/chloride transporters), member 6
chr12_+_102982365	0.382	NM_013320	HCFC2	host cell factor C2
chr11_-_6597220	0.380		TPP1	tripeptidyl peptidase I

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.29	3.99e-10	GO:0044237	cellular metabolic process
1.24	9.14e-09	GO:0008152	metabolic process
1.25	8.54e-08	GO:0044238	primary metabolic process
1.37	4.47e-06	GO:0006807	nitrogen compound metabolic process
1.30	8.01e-06	GO:0044260	cellular macromolecule metabolic process
1.36	1.31e-05	GO:0034641	cellular nitrogen compound metabolic process
1.39	3.11e-05	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.25	1.23e-04	GO:0043170	macromolecule metabolic process
1.40	6.51e-04	GO:0090304	nucleic acid metabolic process
1.38	6.63e-04	GO:0044249	cellular biosynthetic process
1.36	1.18e-03	GO:0009058	biosynthetic process
1.11	1.27e-03	GO:0009987	cellular process
4.13	3.82e-03	GO:0007033	vacuole organization
1.41	4.42e-03	GO:0010467	gene expression
1.42	6.74e-03	GO:0034645	cellular macromolecule biosynthetic process
2.03	7.88e-03	GO:0071495	cellular response to endogenous stimulus
1.41	1.35e-02	GO:0009059	macromolecule biosynthetic process
1.41	1.60e-02	GO:0006996	organelle organization
4.85	1.69e-02	GO:0015682	ferric iron transport
4.85	1.69e-02	GO:0033572	transferrin transport
1.48	2.83e-02	GO:0044248	cellular catabolic process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.18	7.04e-17	GO:0044424	intracellular part
1.17	8.13e-17	GO:0005622	intracellular
1.25	4.52e-16	GO:0043227	membrane-bounded organelle
1.24	5.36e-16	GO:0043231	intracellular membrane-bounded organelle
1.37	7.40e-16	GO:0044446	intracellular organelle part
1.36	1.36e-15	GO:0044422	organelle part
1.21	1.74e-14	GO:0043226	organelle
1.21	2.64e-14	GO:0043229	intracellular organelle
1.24	4.65e-13	GO:0005737	cytoplasm
1.60	5.08e-13	GO:0031974	membrane-enclosed lumen
1.31	1.13e-12	GO:0044444	cytoplasmic part
1.60	1.49e-12	GO:0043233	organelle lumen
1.60	2.92e-12	GO:0070013	intracellular organelle lumen
1.60	9.45e-12	GO:0044428	nuclear part
1.60	1.25e-09	GO:0031981	nuclear lumen
1.71	4.62e-09	GO:0005654	nucleoplasm
2.40	3.52e-07	GO:0005773	vacuole
1.24	5.80e-06	GO:0005634	nucleus
1.31	1.23e-05	GO:0032991	macromolecular complex
1.41	9.11e-05	GO:0005829	cytosol
2.17	5.40e-04	GO:0000323	lytic vacuole
2.17	5.40e-04	GO:0005764	lysosome
2.53	9.46e-04	GO:0044437	vacuolar part
1.66	9.71e-04	GO:0031967	organelle envelope
2.56	1.09e-03	GO:0005774	vacuolar membrane
1.46	1.62e-03	GO:0005739	mitochondrion
1.64	1.95e-03	GO:0031975	envelope
1.29	2.02e-03	GO:0043234	protein complex
1.63	3.02e-03	GO:0044451	nucleoplasm part
1.33	4.44e-03	GO:0031090	organelle membrane
1.75	1.12e-02	GO:0005768	endosome
1.58	2.14e-02	GO:0044429	mitochondrial part
2.05	2.41e-02	GO:0016604	nuclear body
2.30	3.43e-02	GO:0005769	early endosome

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.22	1.77e-08	GO:0005515	protein binding
1.11	9.65e-06	GO:0005488	binding
1.61	1.89e-03	GO:0003723	RNA binding
1.19	5.71e-03	GO:0003824	catalytic activity
1.29	3.28e-02	GO:0016787	hydrolase activity
2.74	4.97e-02	GO:0008238	exopeptidase activity

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