Motif ID: SREBF1,2.p2

Z-value: 0.866


Transcription factors associated with SREBF1,2.p2:

Gene SymbolEntrez IDGene Name
SREBF1 6720 sterol regulatory element binding transcription factor 1
SREBF2 6721 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SREBF1chr17_-_17681013-0.204.6e-01Click!
SREBF2chr22_+_40559083-0.097.5e-01Click!


Activity profile for motif SREBF1,2.p2.

activity profile for motif SREBF1,2.p2


Sorted Z-values histogram for motif SREBF1,2.p2

Sorted Z-values for motif SREBF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_48582389 1.800 NM_014923
 FNDC3A
fibronectin type III domain containing 3A
chr2_+_234333653 1.578 NM_000463
 UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr2_+_227898163 1.445 MFF
mitochondrial fission factor
chr20_+_37024383 1.372 NM_001190809
NM_021931
 DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr14_-_34253473 1.312 NM_138638
 CFL2
cofilin 2 (muscle)
chr2_+_177785667 1.305 NM_194247
 HNRNPA3P1
HNRNPA3
heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
heterogeneous nuclear ribonucleoprotein A3
chr2_-_176575171 1.160 NM_030650
 KIAA1715
KIAA1715
chr6_-_84994032 1.155 NM_014895
 KIAA1009
KIAA1009
chr10_-_45410197 1.092 NM_001002265
NM_145021
 MARCH8

membrane-associated ring finger (C3HC4) 8

chr17_-_44022595 1.070 HOXB3
homeobox B3
chr10_+_45542653 1.059 NM_001169106
NM_001169107
NM_015262
 FAM21C


FAM21A
family with sequence similarity 21, member C


family with sequence similarity 21, member A
chr11_-_85457469 1.027 PICALM
phosphatidylinositol binding clathrin assembly protein
chr6_-_7258351 1.001 NM_003144
 SSR1
signal sequence receptor, alpha
chr6_+_35852369 0.993 NM_207409
 C6orf126
chromosome 6 open reading frame 126
chr11_+_85017269 0.990 NM_001193537
NM_001193538
NM_018480
 TMEM126B


transmembrane protein 126B


chr14_-_67353046 0.978 NM_015346
 ZFYVE26
zinc finger, FYVE domain containing 26
chr20_-_43953036 0.975 NM_080749
 NEURL2
neuralized homolog 2 (Drosophila)
chr17_-_41018291 0.968


chr16_+_55580910 0.964 NM_032206
 NLRC5
NLR family, CARD domain containing 5
chr20_+_43953428 0.909 CTSA
cathepsin A

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
4.85 1.69e-02 GO:0015682 ferric iron transport
4.85 1.69e-02 GO:0033572 transferrin transport
4.13 3.82e-03 GO:0007033 vacuole organization
2.03 7.88e-03 GO:0071495 cellular response to endogenous stimulus
1.48 2.83e-02 GO:0044248 cellular catabolic process
1.42 6.74e-03 GO:0034645 cellular macromolecule biosynthetic process
1.41 4.42e-03 GO:0010467 gene expression
1.41 1.35e-02 GO:0009059 macromolecule biosynthetic process
1.41 1.60e-02 GO:0006996 organelle organization
1.40 6.51e-04 GO:0090304 nucleic acid metabolic process
1.39 3.11e-05 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.38 6.63e-04 GO:0044249 cellular biosynthetic process
1.37 4.47e-06 GO:0006807 nitrogen compound metabolic process
1.36 1.31e-05 GO:0034641 cellular nitrogen compound metabolic process
1.36 1.18e-03 GO:0009058 biosynthetic process
1.30 8.01e-06 GO:0044260 cellular macromolecule metabolic process
1.29 3.99e-10 GO:0044237 cellular metabolic process
1.25 8.54e-08 GO:0044238 primary metabolic process
1.25 1.23e-04 GO:0043170 macromolecule metabolic process
1.24 9.14e-09 GO:0008152 metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 34 entries
enrichment   p-value GO term description
2.56 1.09e-03 GO:0005774 vacuolar membrane
2.53 9.46e-04 GO:0044437 vacuolar part
2.40 3.52e-07 GO:0005773 vacuole
2.30 3.43e-02 GO:0005769 early endosome
2.17 5.40e-04 GO:0000323 lytic vacuole
2.17 5.40e-04 GO:0005764 lysosome
2.05 2.41e-02 GO:0016604 nuclear body
1.75 1.12e-02 GO:0005768 endosome
1.71 4.62e-09 GO:0005654 nucleoplasm
1.66 9.71e-04 GO:0031967 organelle envelope
1.64 1.95e-03 GO:0031975 envelope
1.63 3.02e-03 GO:0044451 nucleoplasm part
1.60 5.08e-13 GO:0031974 membrane-enclosed lumen
1.60 1.49e-12 GO:0043233 organelle lumen
1.60 2.92e-12 GO:0070013 intracellular organelle lumen
1.60 9.45e-12 GO:0044428 nuclear part
1.60 1.25e-09 GO:0031981 nuclear lumen
1.58 2.14e-02 GO:0044429 mitochondrial part
1.46 1.62e-03 GO:0005739 mitochondrion
1.41 9.11e-05 GO:0005829 cytosol

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
2.74 4.97e-02 GO:0008238 exopeptidase activity
1.61 1.89e-03 GO:0003723 RNA binding
1.29 3.28e-02 GO:0016787 hydrolase activity
1.22 1.77e-08 GO:0005515 protein binding
1.19 5.71e-03 GO:0003824 catalytic activity
1.11 9.65e-06 GO:0005488 binding