Motif ID: NKX3-2.p2

Z-value: 1.566


Transcription factors associated with NKX3-2.p2:

Gene SymbolEntrez IDGene Name
NKX3-2 579 NK3 homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX3-2chr4_-_13155135-0.214.4e-01Click!


Activity profile for motif NKX3-2.p2.

activity profile for motif NKX3-2.p2


Sorted Z-values histogram for motif NKX3-2.p2

Sorted Z-values for motif NKX3-2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_17585462 2.376 VSNL1
visinin-like 1
chr1_+_107484151 1.924 NM_001113226
NM_001113228
NM_014917
NTNG1


netrin G1


chr12_+_4253143 1.799 NM_001759
CCND2
cyclin D2
chr2_+_17585287 1.577 NM_003385
VSNL1
visinin-like 1
chr14_+_30098079 1.491 NM_017769
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr20_-_42249631 1.437 NM_020433
NM_175913
JPH2

junctophilin 2

chr20_+_51023159 1.358 TSHZ2
teashirt zinc finger homeobox 2
chr18_+_40514772 1.270 NM_015559
SETBP1
SET binding protein 1
chr2_-_24123726 1.209 NM_001142319
NM_025203
C2orf44

chromosome 2 open reading frame 44

chr2_-_70634129 1.200 NM_001099691
NM_003236
TGFA

transforming growth factor, alpha

chr1_+_107485071 1.114 NTNG1
netrin G1
chr5_+_56507029 1.090 NM_001127235
GPBP1
GC-rich promoter binding protein 1
chr2_+_201099093 1.062 NM_001160033
NM_001160046
NM_152524
SGOL2


shugoshin-like 2 (S. pombe)


chr14_-_22840249 1.058


chr14_+_22422270 1.057 NM_173527
REM2
RAS (RAD and GEM)-like GTP binding 2
chr8_+_120289735 1.024 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr4_-_84475328 0.980 NM_001166498
NM_006665
HPSE

heparanase

chr2_+_61986287 0.974 NM_152516
COMMD1
copper metabolism (Murr1) domain containing 1
chr9_-_205892 0.943 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr11_-_119499188 0.911 TRIM29
tripartite motif containing 29
chr2_+_63131466 0.879 NM_014562
OTX1
orthodenticle homeobox 1
chr11_+_116520181 0.862 NM_001184746
NM_001184747
NM_001184748
NM_002572
PAFAH1B2



platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)



chr2_-_220144254 0.860 OBSL1
obscurin-like 1
chr6_+_54819527 0.850 NM_001010872
FAM83B
family with sequence similarity 83, member B
chr10_+_96295511 0.841 NM_018063
HELLS
helicase, lymphoid-specific
chr20_-_33793507 0.839 RBM39
RNA binding motif protein 39
chr6_+_27464461 0.838 NM_001076781
ZNF391
zinc finger protein 391
chr2_-_220144511 0.827 NM_001173408
NM_001173431
NM_015311
OBSL1


obscurin-like 1


chr2_+_85665041 0.823 NM_006634
VAMP5
vesicle-associated membrane protein 5 (myobrevin)
chr3_-_137395966 0.820 NM_001145417
MSL2
male-specific lethal 2 homolog (Drosophila)
chr2_-_220144427 0.819 OBSL1
obscurin-like 1
chr14_-_23878871 0.808 NM_006871
RIPK3
receptor-interacting serine-threonine kinase 3
chr2_-_201082978 0.807 NM_152387
KCTD18
potassium channel tetramerisation domain containing 18
chr6_+_111409933 0.797 NM_032194
RPF2
ribosome production factor 2 homolog (S. cerevisiae)
chr2_+_101981888 0.782 NM_173343
IL1R2
interleukin 1 receptor, type II
chr20_+_2309553 0.775 NM_198994
TGM6
transglutaminase 6
chr19_-_10489111 0.759 NM_030760
S1PR5
sphingosine-1-phosphate receptor 5
chr19_-_6671585 0.757 NM_000064
C3
complement component 3
chr1_-_158182006 0.756 NM_001135050
NM_020789
IGSF9

immunoglobulin superfamily, member 9

chr1_+_199519202 0.751 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr6_-_49538810 0.745 NM_000255
MUT
methylmalonyl CoA mutase
chr2_+_218698980 0.724 NM_001557
CXCR2
chemokine (C-X-C motif) receptor 2
chr2_-_238861830 0.714 NM_022817
PER2
period homolog 2 (Drosophila)
chr8_-_122722674 0.714 NM_005328
HAS2
hyaluronan synthase 2
chr2_+_219141761 0.713 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr2_+_228386800 0.696 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr11_-_101906640 0.690 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr8_-_109868945 0.686 NM_153015
TMEM74
transmembrane protein 74
chr20_-_33793591 0.685 RBM39
RNA binding motif protein 39
chr11_-_64484184 0.676 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr14_-_20807346 0.673 NM_001077442
NM_001077443
NM_004500
NM_031314
HNRNPC



heterogeneous nuclear ribonucleoprotein C (C1/C2)



chr5_-_42847716 0.669 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr20_-_42249146 0.669 JPH2
junctophilin 2
chr1_+_156417302 0.661 CD1D
CD1d molecule
chr6_-_31658044 0.659 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr3_-_192063158 0.658 NM_001146686
GEMC1
geminin coiled-coil domain-containing protein 1
chr12_+_52618815 0.658 NM_017410
HOXC13
homeobox C13
chr2_+_183697327 0.657 NM_138285
NUP35
nucleoporin 35kDa
chr14_+_22305570 0.655 NM_005015
OXA1L
oxidase (cytochrome c) assembly 1-like
chr5_+_148501178 0.646 NM_014945
ABLIM3
actin binding LIM protein family, member 3
chr14_-_20636909 0.640 NM_001101672
ZNF219
zinc finger protein 219
chr1_+_216585298 0.637 NM_001135599
NM_003238
TGFB2

transforming growth factor, beta 2

chr8_+_102573837 0.636 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr6_-_134680888 0.626 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr2_-_27399405 0.621 NM_002437
MPV17
MpV17 mitochondrial inner membrane protein
chr17_-_57497380 0.620 NM_005121
MED13
mediator complex subunit 13
chr4_+_109761170 0.616 NM_000995
NM_033625
RPL34

ribosomal protein L34

chr18_+_50646616 0.610 NM_004163
RAB27B
RAB27B, member RAS oncogene family
chr2_+_54638957 0.609 NM_178313
SPTBN1
spectrin, beta, non-erythrocytic 1
chr1_+_78243181 0.608 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr1_+_234624266 0.606 NM_145861
EDARADD
EDAR-associated death domain
chr14_+_20636935 0.603 NM_001146683
C14orf176
chromosome 14 open reading frame 176
chr8_+_102574012 0.593 GRHL2
grainyhead-like 2 (Drosophila)
chr1_-_154665807 0.587 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr2_+_68445936 0.586 PLEK
pleckstrin
chr5_-_180563945 0.582 NM_203294
NM_203295
NM_203296
TRIM7


tripartite motif containing 7


chr16_+_11978002 0.582 NM_032167
RUNDC2A
RUN domain containing 2A
chr15_+_56217686 0.579 NM_020980
AQP9
aquaporin 9
chr10_-_5436781 0.578 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chr12_-_49708279 0.577 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr2_-_37752731 0.575 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr4_+_169789327 0.574 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr12_-_52980914 0.572 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr12_-_56447090 0.569 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr2_-_3360467 0.569 NM_003310
TSSC1
tumor suppressing subtransferable candidate 1
chr20_+_30161173 0.566 TM9SF4
transmembrane 9 superfamily protein member 4
chr14_-_20642214 0.563


chr17_-_58237742 0.561 NM_001100875
MARCH10
membrane-associated ring finger (C3HC4) 10
chr2_+_220033777 0.556 NM_001173476
SPEG
SPEG complex locus
chr4_-_84475023 0.555 HPSE
heparanase
chr20_-_60435983 0.554 NM_080833
C20orf151
chromosome 20 open reading frame 151
chr6_+_122973240 0.554 PKIB
protein kinase (cAMP-dependent, catalytic) inhibitor beta
chr4_+_169654742 0.552 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr2_-_148495642 0.551 NM_181742
ORC4
origin recognition complex, subunit 4
chr1_+_216586199 0.546 TGFB2
transforming growth factor, beta 2
chr10_-_123343761 0.544 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr5_+_174084137 0.541 NM_002449
MSX2
msh homeobox 2
chr2_+_148495043 0.541 NM_018328
MBD5
methyl-CpG binding domain protein 5
chr16_-_14695930 0.537 NM_003561
PLA2G10
phospholipase A2, group X
chr4_-_84474919 0.535 HPSE
heparanase
chr3_+_46894239 0.532 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr20_-_16501911 0.531 NM_024704
KIF16B
kinesin family member 16B
chr11_+_129823667 0.530 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr5_+_66160359 0.529 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr20_-_33793593 0.528 NM_004902
NM_184234
RBM39

RNA binding motif protein 39

chr3_+_120375053 0.518 NM_006952
UPK1B
uroplakin 1B
chr14_+_38714111 0.518 NM_002687
PNN
pinin, desmosome associated protein
chr10_-_116154212 0.517 AFAP1L2
actin filament associated protein 1-like 2
chr6_-_46997579 0.517 NM_001098518
GPR116
G protein-coupled receptor 116
chr16_-_80602546 0.517 NM_145168
SDR42E1
short chain dehydrogenase/reductase family 42E, member 1
chr18_+_27332024 0.516 NM_001943
DSG2
desmoglein 2
chr22_+_35586950 0.515 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr2_-_104834344 0.513 LOC100506421
hypothetical LOC100506421
chr14_-_23781328 0.512 TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr2_-_197499584 0.512 NM_024989
PGAP1
post-GPI attachment to proteins 1
chr12_-_52980984 0.511 NM_001136023
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr6_+_146961828 0.510 NM_024694
C6orf103
chromosome 6 open reading frame 103
chr4_+_8935987 0.509 NM_001105662
USP17L2
USP17L6P
USP17
ubiquitin specific peptidase 17-like 2
ubiquitin specific peptidase 17-like 6 (pseudogene)
ubiquitin specific peptidase 17
chr17_+_19999784 0.507 NM_001033554
NM_001033555
SPECC1

sperm antigen with calponin homology and coiled-coil domains 1

chr14_-_24115268 0.506 NM_001911
CTSG
cathepsin G
chr11_-_57054756 0.503 NM_012456
TIMM10
translocase of inner mitochondrial membrane 10 homolog (yeast)
chr16_-_31054563 0.499 NM_002773
PRSS8
protease, serine, 8
chr14_+_34831355 0.494 PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr14_-_23623657 0.493 NM_006177
NRL
neural retina leucine zipper
chr5_-_159730196 0.493 NM_031908
C1QTNF2
C1q and tumor necrosis factor related protein 2
chr3_+_185762233 0.489 NM_004443
EPHB3
EPH receptor B3
chr8_+_22075112 0.488 NM_001172357
NM_001172410
NM_003018
SFTPC


surfactant protein C


chr20_-_55719946 0.483 NM_199171
PMEPA1
prostate transmembrane protein, androgen induced 1
chr18_-_28304392 0.482 NM_022751
FAM59A
family with sequence similarity 59, member A
chr14_+_34831294 0.482 NM_002791
PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr22_-_22714230 0.477 NM_000853
GSTT1
glutathione S-transferase theta 1
chr2_-_223229006 0.471 NM_005687
FARSB
phenylalanyl-tRNA synthetase, beta subunit
chr3_+_77171938 0.470 NM_002942
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr15_+_38318528 0.470 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr1_-_17638797 0.470 NM_018715
RCC2
regulator of chromosome condensation 2
chr9_-_33437527 0.468 NM_004925
AQP3
aquaporin 3 (Gill blood group)
chr3_+_143797895 0.468 NM_001145319
PLS1
plastin 1
chr2_-_156897286 0.467 NM_006186
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr1_+_35020425 0.465 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr2_+_69093641 0.465 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr14_-_23874083 0.460 NM_001198568
NM_001198592
NM_139247
ADCY4


adenylate cyclase 4


chr7_+_134893185 0.458 NM_015135
NUP205
nucleoporin 205kDa
chr19_+_59061422 0.458 NM_001020820
MYADM
myeloid-associated differentiation marker
chr17_-_34575939 0.457 NM_001143968
ARL5C
ADP-ribosylation factor-like 5C
chr1_+_158636987 0.456 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr10_+_124310170 0.455 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr2_-_37727472 0.454 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr14_+_36200867 0.453 PAX9
paired box 9
chr5_+_118632316 0.452 NM_001077654
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr19_-_44214972 0.451 NM_178820
FBXO27
F-box protein 27
chr7_+_130445394 0.450 NM_001145354
MKLN1
muskelin 1, intracellular mediator containing kelch motifs
chr18_+_3584056 0.447 FLJ35776
hypothetical LOC649446
chr10_-_5035967 0.447 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr3_-_55490401 0.445 WNT5A
wingless-type MMTV integration site family, member 5A
chr2_-_158439868 0.444 NM_001105
ACVR1
activin A receptor, type I
chr4_-_171184003 0.442 NM_021647
MFAP3L
microfibrillar-associated protein 3-like
chr12_-_41269679 0.440 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr11_-_10630408 0.439 NM_001098579
MRVI1
murine retrovirus integration site 1 homolog
chr3_+_122769467 0.439 NM_001012659
ARGFX
arginine-fifty homeobox
chr2_+_32244406 0.438 NM_001193513
NM_001193514
NM_001193515
NM_017964
SLC30A6



solute carrier family 30 (zinc transporter), member 6



chr2_-_127694123 0.438 CYP27C1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr20_+_43531806 0.437 NM_006103
WFDC2
WAP four-disulfide core domain 2
chr2_-_178645718 0.433 NM_016953
PDE11A
phosphodiesterase 11A
chr6_+_49539049 0.432 NM_018132
CENPQ
centromere protein Q
chr6_-_52060327 0.432 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr4_-_84475024 0.431 HPSE
heparanase
chr2_+_68815416 0.428 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr6_-_157664464 0.427 C6orf35
chromosome 6 open reading frame 35
chr4_-_84475036 0.426 NM_001098540
HPSE
heparanase
chr11_+_93114365 0.425 NM_014039
C11orf54
chromosome 11 open reading frame 54
chr17_+_64922420 0.424 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr10_-_116154504 0.421 NM_001001936
NM_032550
AFAP1L2

actin filament associated protein 1-like 2

chr20_+_44083667 0.420 NM_001134771
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr6_+_26212082 0.417 NM_003542
HIST1H4C
histone cluster 1, H4c
chr2_-_201461945 0.416 NM_032472
NM_130906
PPIL3

peptidylprolyl isomerase (cyclophilin)-like 3

chr12_+_112071930 0.415 NM_001144872
CCDC42B
coiled-coil domain containing 42B
chr2_-_86418143 0.414 NM_001164731
NM_001164732
NM_022912
REEP1


receptor accessory protein 1


chr2_+_17861266 0.412 NM_001105569
MSGN1
mesogenin 1
chr2_+_201462294 0.410 NM_001136039
NM_001142355
NM_021824
NIF3L1


NIF3 NGG1 interacting factor 3-like 1 (S. pombe)


chr14_+_36200815 0.409 PAX9
paired box 9
chr5_+_118632403 0.407 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr17_+_78267868 0.406 NM_024619
FN3KRP
fructosamine 3 kinase related protein
chr17_-_57023322 0.406 NM_199290
NACA2
nascent polypeptide-associated complex alpha subunit 2
chr2_+_178986617 0.405


chr16_+_18903009 0.405 NM_001160364
TMC7
transmembrane channel-like 7
chr14_+_22633728 0.404 C14orf119
chromosome 14 open reading frame 119
chr12_+_52806103 0.404 LOC400043
hypothetical LOC400043
chr19_+_56766342 0.403 NM_007147
ZNF175
zinc finger protein 175
chr2_-_210798232 0.401 NM_001608
ACADL
acyl-CoA dehydrogenase, long chain
chr6_-_138935359 0.399 NM_020464
NHSL1
NHS-like 1
chr6_+_26359805 0.399 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr6_-_29824748 0.398 LOC285830
hypothetical LOC285830
chr21_+_42512271 0.398 NM_004915
NM_016818
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr20_-_57051231 0.397 NM_016045
SLMO2
slowmo homolog 2 (Drosophila)
chr2_+_28828332 0.396 PPP1CB
protein phosphatase 1, catalytic subunit, beta isozyme
chr18_+_27152049 0.396 NM_001942
DSG1
desmoglein 1
chr6_-_30820264 0.396 NM_003897
IER3
immediate early response 3
chr12_+_52689062 0.395 NM_022658
HOXC8
homeobox C8
chr3_-_172660545 0.395 NM_001161560
NM_001161561
NM_001161562
NM_001161563
NM_001161564
NM_001161565
NM_001161566
NM_015028
TNIK







TRAF2 and NCK interacting kinase







chr2_+_187163232 0.395 ITGAV
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.19 3.56e-07 GO:0044260 cellular macromolecule metabolic process
1.17 1.25e-06 GO:0043170 macromolecule metabolic process
1.08 3.01e-06 GO:0009987 cellular process
1.12 2.27e-05 GO:0008152 metabolic process
1.13 8.11e-05 GO:0044238 primary metabolic process
1.13 1.43e-04 GO:0044237 cellular metabolic process
1.23 2.69e-04 GO:0044267 cellular protein metabolic process
1.48 4.29e-03 GO:0016071 mRNA metabolic process
1.18 5.10e-03 GO:0019538 protein metabolic process
1.24 5.73e-03 GO:0010467 gene expression
1.27 2.63e-02 GO:0033036 macromolecule localization
1.21 3.77e-02 GO:0043412 macromolecule modification

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.09 3.31e-12 GO:0005622 intracellular
1.09 7.24e-12 GO:0044424 intracellular part
1.13 7.34e-10 GO:0005737 cytoplasm
1.09 8.39e-07 GO:0043229 intracellular organelle
1.09 1.04e-06 GO:0043226 organelle
1.10 2.83e-06 GO:0043231 intracellular membrane-bounded organelle
1.10 4.16e-06 GO:0043227 membrane-bounded organelle
1.14 6.41e-06 GO:0005634 nucleus
1.11 3.20e-03 GO:0044444 cytoplasmic part
1.15 3.99e-03 GO:0032991 macromolecular complex
1.25 1.50e-02 GO:0005654 nucleoplasm
1.15 1.90e-02 GO:0043234 protein complex
1.19 3.87e-02 GO:0031981 nuclear lumen
1.10 4.21e-02 GO:0044446 intracellular organelle part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 7.89e-09 GO:0005515 protein binding
1.06 2.18e-04 GO:0005488 binding
1.35 5.09e-03 GO:0003723 RNA binding