Motif ID: NKX2-3_NKX2-5.p2

Z-value: 0.984


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-5chr5_-_1725946910.523.9e-02Click!
NKX2-3chr10_+_101282679-0.058.6e-01Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_27171673 1.876 NM_152739
HOXA9
homeobox A9
chrX_+_70682204 1.796 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr7_-_27171648 1.759 HOXA9
homeobox A9
chr7_-_27171600 1.664 HOXA9
homeobox A9
chr2_+_37282516 1.330 LOC100505876
hypothetical LOC100505876
chr5_+_71538456 1.285 MAP1B
microtubule-associated protein 1B
chrX_+_21960841 1.234 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr7_+_94135384 1.039 PEG10
paternally expressed 10
chrX_-_129347101 0.973 NM_178471
GPR119
G protein-coupled receptor 119
chr6_+_155579788 0.849 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chrX_+_66705407 0.849 NM_001011645
AR
androgen receptor
chr9_+_129066576 0.818 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr20_+_56919233 0.809 GNAS
GNAS complex locus
chrX_+_28515479 0.805 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr5_+_140772691 0.781 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr10_-_31328426 0.768 NM_001143769
ZNF438
zinc finger protein 438
chr17_-_46479127 0.751 SPAG9
sperm associated antigen 9
chr19_+_40632456 0.748 NM_005306
FFAR2
free fatty acid receptor 2
chr5_+_156628929 0.742 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr12_-_4358968 0.699 NM_020638
FGF23
fibroblast growth factor 23
chr3_-_15538164 0.679 NM_005677
NM_080539
COLQ

collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase

chr7_+_139175420 0.646 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr1_-_109957195 0.644 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr13_+_77213295 0.635 NM_144595
SLAIN1
SLAIN motif family, member 1
chrX_-_110541029 0.627 NM_000555
DCX
doublecortin
chr11_+_122936246 0.623 GRAMD1B
GRAM domain containing 1B
chr1_+_63861474 0.605 NM_001172818
PGM1
phosphoglucomutase 1
chr12_+_50342814 0.600 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr11_-_40272239 0.579 NM_020929
LRRC4C
leucine rich repeat containing 4C
chr1_-_205012348 0.579 NM_000572
IL10
interleukin 10
chr11_+_86710076 0.579 TMEM135
transmembrane protein 135
chr2_+_171280046 0.568 NM_001003845
SP5
Sp5 transcription factor
chr14_+_69307914 0.560 SRSF5
serine/arginine-rich splicing factor 5
chr12_-_52281050 0.539 NM_001130059
ATF7
activating transcription factor 7
chr22_-_16127520 0.539 CECR3
cat eye syndrome chromosome region, candidate 3
chr4_+_71142893 0.529 NM_005212
CSN3
casein kappa
chr1_+_84402962 0.529 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr9_+_109131814 0.526 RAD23B
RAD23 homolog B (S. cerevisiae)
chr21_-_32879617 0.519 NM_144659
TCP10L
t-complex 10 (mouse)-like
chr1_-_153109349 0.516 NM_002249
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chrX_+_111005934 0.514 NM_001195576
NM_001195578
LOC100329135

hypothetical LOC100329135

chr3_-_11598829 0.509 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr4_-_153493133 0.507 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr6_+_16251260 0.501 MYLIP
myosin regulatory light chain interacting protein
chr5_+_140703784 0.499 NM_018916
NM_032011
PCDHGA3

protocadherin gamma subfamily A, 3

chr7_-_112513379 0.499 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr5_-_88155360 0.497 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chrX_+_115481774 0.495 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr7_-_36991189 0.494 NM_001039459
ELMO1
engulfment and cell motility 1
chr13_+_34948977 0.488 NBEA
neurobeachin
chr7_-_115458047 0.483 TFEC
transcription factor EC
chr12_+_40117751 0.482 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr5_+_175041069 0.472 NM_022304
HRH2
histamine receptor H2
chr6_+_41128917 0.465 NM_006789
APOBEC2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr1_-_201321999 0.463 NM_002479
MYOG
myogenin (myogenic factor 4)
chr7_-_27133163 0.455 NM_153631
HOXA3
homeobox A3
chr2_+_171280182 0.443


chrX_+_153101278 0.440 NM_000513
NM_001048181
OPN1MW
OPN1MW2
opsin 1 (cone pigments), medium-wave-sensitive
opsin 1 (cone pigments), medium-wave-sensitive 2
chr4_+_3341521 0.438 NM_198227
RGS12
regulator of G-protein signaling 12
chrX_+_105823723 0.437 NM_024539
RNF128
ring finger protein 128
chr1_-_181889070 0.435 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr2_+_161981046 0.423 TBR1
T-box, brain, 1
chr21_+_39117064 0.421 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr11_+_6176951 0.415 NM_001005178
OR52W1
olfactory receptor, family 52, subfamily W, member 1
chr14_+_75058518 0.412 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr1_+_556968 0.411


chr1_-_42156913 0.410


chr13_-_34948758 0.407 NM_005584
MAB21L1
mab-21-like 1 (C. elegans)
chr21_-_31175722 0.406 NM_175858
KRTAP11-1
keratin associated protein 11-1
chr10_+_86174665 0.403 FAM190B
family with sequence similarity 190, member B
chr1_-_42156957 0.400 HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr7_-_115458010 0.397 NM_001018058
NM_012252
TFEC

transcription factor EC

chr5_+_140762551 0.397 NM_018921
NM_032089
PCDHGA9

protocadherin gamma subfamily A, 9

chrX_-_131401319 0.388 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr8_-_110689396 0.388 SYBU
syntabulin (syntaxin-interacting)
chr7_+_141054621 0.386 NM_001105558
WEE2
WEE1 homolog 2 (S. pombe)
chr22_-_43987010 0.384 NM_015264
KIAA0930
KIAA0930
chr1_+_182040837 0.381 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr4_-_176970895 0.381 GPM6A
glycoprotein M6A
chr2_+_161981138 0.375 TBR1
T-box, brain, 1
chr1_+_84540921 0.375 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr13_+_34948885 0.374 NBEA
neurobeachin
chr1_+_242281199 0.368 ZNF238
zinc finger protein 238
chr7_-_96471544 0.365 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr6_+_29187565 0.365 NM_001005216
OR2J3
olfactory receptor, family 2, subfamily J, member 3
chr22_-_36836620 0.364 NM_025045
BAIAP2L2
BAI1-associated protein 2-like 2
chr1_+_242281175 0.360 NM_205768
ZNF238
zinc finger protein 238
chrX_+_102852492 0.356 NM_182541
TMEM31
transmembrane protein 31
chr1_+_166516901 0.355 NM_005149
TBX19
T-box 19
chr19_-_3723208 0.355 NM_032753
RAX2
retina and anterior neural fold homeobox 2
chr5_+_140848905 0.346 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr15_-_53996597 0.342 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr3_-_57209319 0.341 NM_003865
HESX1
HESX homeobox 1
chrX_-_18600108 0.340 NM_000330
RS1
retinoschisin 1
chr11_-_16454493 0.340 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr19_+_4442610 0.337 HDGFRP2
hepatoma-derived growth factor-related protein 2
chr12_+_32546243 0.334 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr8_+_42671718 0.332 NM_000749
CHRNB3
cholinergic receptor, nicotinic, beta 3
chr2_+_17861266 0.332 NM_001105569
MSGN1
mesogenin 1
chr15_-_59308708 0.330 RORA
RAR-related orphan receptor A
chr18_+_18989786 0.330 NM_138375
CABLES1
Cdk5 and Abl enzyme substrate 1
chr10_+_126620681 0.328 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr1_+_221168388 0.327 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr8_-_40874485 0.327 NM_001135731
NM_024645
ZMAT4

zinc finger, matrin-type 4

chr1_+_17817397 0.324 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr11_+_33306652 0.323 HIPK3
homeodomain interacting protein kinase 3
chr5_-_88235624 0.322 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr12_-_6103945 0.322 NM_000552
VWF
von Willebrand factor
chr14_+_75058591 0.320 BATF
basic leucine zipper transcription factor, ATF-like
chr2_-_127817143 0.319 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr4_+_160408447 0.319 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr10_+_86121526 0.314 FAM190B
family with sequence similarity 190, member B
chr22_-_36836478 0.313 BAIAP2L2
BAI1-associated protein 2-like 2
chr19_-_46504831 0.313


chr3_+_63859114 0.313 NM_001177387
ATXN7
ataxin 7
chr3_+_46894239 0.310 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr1_-_166149867 0.309 NM_001167749
NM_018417
ADCY10

adenylate cyclase 10 (soluble)

chr14_+_99633570 0.308 EVL
Enah/Vasp-like
chr17_-_36209672 0.307 NM_181535
KRT28
keratin 28
chr1_+_35623688 0.306 ZMYM4
zinc finger, MYM-type 4
chr13_+_97856148 0.305


chr10_+_69539255 0.304 NM_032578
MYPN
myopalladin
chr17_+_24394281 0.303 PIPOX
pipecolic acid oxidase
chr1_-_201321711 0.302 MYOG
myogenin (myogenic factor 4)
chr13_+_112746908 0.302 MCF2L
MCF.2 cell line derived transforming sequence-like
chr7_+_128802719 0.301 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr12_-_51173238 0.300 NM_005554
KRT6A
keratin 6A
chr4_-_186970366 0.300 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr6_+_143971009 0.298 NM_001100166
NM_014721
PHACTR2

phosphatase and actin regulator 2

chr3_+_14835472 0.298 NM_152536
FGD5
FYVE, RhoGEF and PH domain containing 5
chr6_-_114490701 0.297 NM_153612
HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chrX_-_10495476 0.293 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr2_+_161980865 0.293 NM_006593
TBR1
T-box, brain, 1
chr7_+_147918589 0.293 NM_145304
C7orf33
chromosome 7 open reading frame 33
chrX_-_21686079 0.293 NM_014332
SMPX
small muscle protein, X-linked
chr21_-_36774257 0.291 NM_001146079
NM_144492
CLDN14

claudin 14

chr11_-_83071084 0.291 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr21_-_30836051 0.287 NM_181612
KRTAP19-6
keratin associated protein 19-6
chr6_+_12824873 0.287 PHACTR1
phosphatase and actin regulator 1
chr4_+_2853434 0.286 ADD1
adducin 1 (alpha)
chr3_+_16191159 0.286 NM_054110
GALNTL2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
chr1_-_154041393 0.286 GON4L
gon-4-like (C. elegans)
chr16_+_7322751 0.285 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr7_-_26198673 0.285 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr2_+_48649662 0.284 NM_172311
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr22_+_21006814 0.281


chr3_+_39484073 0.280 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr13_-_102517196 0.279 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chrX_+_68752635 0.279 NM_001005609
NM_001005610
NM_001005612
NM_001005613
NM_001399
EDA




ectodysplasin A




chr4_+_88939725 0.279 NM_004967
IBSP
integrin-binding sialoprotein
chr4_-_40631397 0.277 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr1_-_32157845 0.277 NM_001195100
NM_001195101
PTP4A2

protein tyrosine phosphatase type IVA, member 2

chr2_+_28892366 0.276 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr7_+_129771865 0.275 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chrX_+_44588192 0.273 NM_022076
DUSP21
dual specificity phosphatase 21
chr7_+_104539548 0.273 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr10_-_75071205 0.273 MYOZ1
myozenin 1
chr11_+_122936145 0.270 GRAMD1B
GRAM domain containing 1B
chr2_-_210726539 0.268 C2orf67
chromosome 2 open reading frame 67
chrX_+_100111352 0.268 NM_001012990
NM_001162490
NM_001162491
ARL13A


ADP-ribosylation factor-like 13A


chr5_-_168204430 0.266


chrX_-_133620103 0.265 NM_021796
PLAC1
placenta-specific 1
chr1_-_42157077 0.264 NM_001127714
NM_024503
HIVEP3

human immunodeficiency virus type I enhancer binding protein 3

chr10_-_98326435 0.262 TM9SF3
transmembrane 9 superfamily member 3
chr8_-_7275061 0.261 NM_018661
DEFB103B
defensin, beta 103B
chr12_+_100512877 0.260 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr12_-_121767272 0.260 NM_006018
GPR109B
G protein-coupled receptor 109B
chr4_-_2200755 0.258 NM_181808
POLN
polymerase (DNA directed) nu
chrX_-_128616594 0.257 NM_017413
APLN
apelin
chrX_+_70438352 0.257 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr17_-_36347197 0.254 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chrX_-_114158388 0.254 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr15_-_59308770 0.251 NM_134261
RORA
RAR-related orphan receptor A
chr4_-_83566045 0.251


chr15_-_68781662 0.251 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chrX_-_137649180 0.249 NM_033642
FGF13
fibroblast growth factor 13
chrX_-_102829621 0.248 NM_001142419
NM_001142420
NM_001142421
NM_001142422
NM_001142427
NM_001142428
NM_001142431
NM_001142432
MORF4L2







mortality factor 4 like 2







chr3_-_11585264 0.247 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr2_-_55090759 0.247 NM_007008
RTN4
reticulon 4
chr3_+_130730171 0.245 NM_000539
RHO
rhodopsin
chr4_+_94969064 0.245 NM_005172
ATOH1
atonal homolog 1 (Drosophila)
chrX_+_107174855 0.245 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr5_+_176744037 0.244 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chr10_+_124660206 0.244 NM_001029888
FAM24A
family with sequence similarity 24, member A
chr1_+_15862887 0.244


chrX_-_13247946 0.243 ATXN3L
ataxin 3-like
chr17_-_1195096 0.241 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr16_+_68238460 0.239 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chrX_+_144716619 0.239 NM_004709
CXorf1
chromosome X open reading frame 1
chr12_-_16650687 0.236 LMO3
LIM domain only 3 (rhombotin-like 2)
chr11_-_57275828 0.235 NM_001145101
BTBD18
BTB (POZ) domain containing 18
chr7_+_142053693 0.233 NM_001190487
MTRNR2L6
MT-RNR2-like 6
chr20_+_43784401 0.233 NM_178455
SPINT4
serine peptidase inhibitor, Kunitz type 4
chr11_+_4799126 0.230 NM_001004753
OR51F2
olfactory receptor, family 51, subfamily F, member 2
chr5_+_176494690 0.229 NSD1
nuclear receptor binding SET domain protein 1
chr8_+_67096344 0.229 NM_033105
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr10_-_75071498 0.228 NM_021245
MYOZ1
myozenin 1
chr2_-_80384454 0.228 LRRTM1
leucine rich repeat transmembrane neuronal 1
chr4_+_3285671 0.227 NM_002926
NM_198229
RGS12

regulator of G-protein signaling 12

chrX_+_47114925 0.227 NM_003446
ZNF157
zinc finger protein 157

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.33 5.37e-08 GO:0032501 multicellular organismal process
1.65 7.46e-07 GO:0003008 system process
1.24 8.73e-05 GO:0050896 response to stimulus
1.63 1.11e-04 GO:0050877 neurological system process
2.10 3.92e-04 GO:0007606 sensory perception of chemical stimulus
1.79 5.16e-04 GO:0007600 sensory perception
2.04 5.33e-03 GO:0007608 sensory perception of smell
1.28 9.70e-03 GO:0023052 signaling

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.29 9.69e-05 GO:0071944 cell periphery
1.28 2.40e-04 GO:0005886 plasma membrane
2.75 5.13e-04 GO:0005882 intermediate filament
2.46 2.87e-03 GO:0045111 intermediate filament cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.52 8.77e-05 GO:0004872 receptor activity
1.77 1.40e-04 GO:0004930 G-protein coupled receptor activity
2.14 3.33e-04 GO:0004984 olfactory receptor activity
1.55 1.07e-03 GO:0004888 transmembrane receptor activity
1.39 3.23e-03 GO:0004871 signal transducer activity
1.39 3.23e-03 GO:0060089 molecular transducer activity