Motif ID: SRF.p3

Z-value: 1.618


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SRFchr6_+_43247179-0.572.1e-02Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_32875040 3.907 NM_005159
 ACTC1
actin, alpha, cardiac muscle 1
chr10_-_64246129 2.936 NM_000399
NM_001136177
NM_001136179
 EGR2


early growth response 2


chr10_-_64246080 2.611 EGR2
early growth response 2
chr10_-_131652364 2.262 EBF3
early B-cell factor 3
chr9_+_91409746 2.078 NM_006705
 GADD45G
growth arrest and DNA-damage-inducible, gamma
chr19_-_50517971 2.072 CKM
creatine kinase, muscle
chr5_+_149526533 1.992 NM_001804
 CDX1
caudal type homeobox 1
chr20_+_34603290 1.904 NM_006097
NM_181526
 MYL9

myosin, light chain 9, regulatory

chr9_+_36126667 1.896 GLIPR2
GLI pathogenesis-related 2
chr17_-_44026042 1.837 NM_002147
 HOXB5
homeobox B5
chr9_+_36126710 1.790 NM_022343
 GLIPR2
GLI pathogenesis-related 2
chr2_+_42128521 1.675 NM_138370
 PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr2_-_128149112 1.481 NM_001136037
NM_001161403
 LIMS2

LIM and senescent cell antigen-like domains 2

chr20_+_34603311 1.441 MYL9
myosin, light chain 9, regulatory
chr17_-_44026321 1.345 HOXB5
homeobox B5
chr19_-_50518072 1.218 NM_001824
 CKM
creatine kinase, muscle
chr19_-_15204767 1.059 NM_001142886
 EPHX3
epoxide hydrolase 3
chr4_+_81337663 1.056 NM_001099403
 PRDM8
PR domain containing 8
chr11_-_2118743 1.026 IGF2
insulin-like growth factor 2 (somatomedin A)
chr2_+_88148413 0.993 NM_198274
 SMYD1
SET and MYND domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 31 entries
enrichment   p-value GO term description
16.70 2.56e-06 GO:0030049 muscle filament sliding
16.70 2.56e-06 GO:0033275 actin-myosin filament sliding
16.26 3.31e-06 GO:0070252 actin-mediated cell contraction
14.81 1.65e-07 GO:0030048 actin filament-based movement
8.26 1.96e-09 GO:0006936 muscle contraction
7.59 9.05e-09 GO:0003012 muscle system process
5.33 2.22e-02 GO:0060537 muscle tissue development
5.23 6.10e-04 GO:0007517 muscle organ development
4.56 1.13e-04 GO:0030029 actin filament-based process
3.98 7.32e-03 GO:0061061 muscle structure development
3.19 6.36e-03 GO:0072358 cardiovascular system development
3.19 6.36e-03 GO:0072359 circulatory system development
2.59 3.65e-02 GO:0010628 positive regulation of gene expression
2.50 2.10e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
2.12 2.45e-02 GO:0009893 positive regulation of metabolic process
2.12 4.46e-02 GO:0031325 positive regulation of cellular metabolic process
2.11 1.90e-04 GO:0048513 organ development
1.95 2.10e-03 GO:0030154 cell differentiation
1.90 4.79e-03 GO:0048869 cellular developmental process
1.89 1.14e-06 GO:0007275 multicellular organismal development

Gene overrepresentation in compartment category:

Showing 1 to 16 of 16 entries
enrichment   p-value GO term description
26.41 1.53e-04 GO:0031672 A band
19.07 9.61e-04 GO:0005859 muscle myosin complex
17.17 1.70e-03 GO:0016460 myosin II complex
14.71 5.40e-04 GO:0001725 stress fiber
14.57 8.26e-05 GO:0042641 actomyosin
13.73 8.30e-04 GO:0032432 actin filament bundle
10.94 9.95e-12 GO:0044449 contractile fiber part
10.73 5.74e-06 GO:0016459 myosin complex
10.51 2.46e-09 GO:0030017 sarcomere
10.10 2.58e-02 GO:0005884 actin filament
10.06 2.10e-10 GO:0030016 myofibril
10.05 4.54e-11 GO:0043292 contractile fiber
8.59 1.38e-02 GO:0031674 I band
6.00 1.55e-10 GO:0015629 actin cytoskeleton
2.12 1.40e-02 GO:0044430 cytoskeletal part
1.99 2.79e-03 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
12.78 3.78e-05 GO:0008307 structural constituent of muscle
6.11 1.12e-02 GO:0003704 specific RNA polymerase II transcription factor activity
4.42 4.77e-02 GO:0003774 motor activity
3.91 2.13e-04 GO:0003779 actin binding
2.79 5.41e-03 GO:0008092 cytoskeletal protein binding
2.55 6.36e-03 GO:0043565 sequence-specific DNA binding
2.35 1.42e-03 GO:0001071 nucleic acid binding transcription factor activity
2.35 1.42e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
2.31 2.09e-03 GO:0030528 transcription regulator activity
1.29 4.31e-02 GO:0005515 protein binding
1.19 1.24e-03 GO:0005488 binding