Motif ID: SRF.p3

Z-value: 1.618


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SRFchr6_+_43247179-0.572.1e-02Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_32875040 3.907 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr10_-_64246129 2.936 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr10_-_64246080 2.611 EGR2
early growth response 2
chr10_-_131652364 2.262 EBF3
early B-cell factor 3
chr9_+_91409746 2.078 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr19_-_50517971 2.072 CKM
creatine kinase, muscle
chr5_+_149526533 1.992 NM_001804
CDX1
caudal type homeobox 1
chr20_+_34603290 1.904 NM_006097
NM_181526
MYL9

myosin, light chain 9, regulatory

chr9_+_36126667 1.896 GLIPR2
GLI pathogenesis-related 2
chr17_-_44026042 1.837 NM_002147
HOXB5
homeobox B5
chr9_+_36126710 1.790 NM_022343
GLIPR2
GLI pathogenesis-related 2
chr2_+_42128521 1.675 NM_138370
PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr2_-_128149112 1.481 NM_001136037
NM_001161403
LIMS2

LIM and senescent cell antigen-like domains 2

chr20_+_34603311 1.441 MYL9
myosin, light chain 9, regulatory
chr17_-_44026321 1.345 HOXB5
homeobox B5
chr19_-_50518072 1.218 NM_001824
CKM
creatine kinase, muscle
chr19_-_15204767 1.059 NM_001142886
EPHX3
epoxide hydrolase 3
chr4_+_81337663 1.056 NM_001099403
PRDM8
PR domain containing 8
chr11_-_2118743 1.026 IGF2
insulin-like growth factor 2 (somatomedin A)
chr2_+_88148413 0.993 NM_198274
SMYD1
SET and MYND domain containing 1
chr6_-_123999640 0.978 NM_006073
TRDN
triadin
chr9_+_139892049 0.971 NM_000718
CACNA1B
calcium channel, voltage-dependent, N type, alpha 1B subunit
chr5_-_33928049 0.969 ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr6_+_151602787 0.944 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr1_-_152431175 0.941 NM_152263
TPM3
tropomyosin 3
chr2_-_30883775 0.941 NM_144575
CAPN13
calpain 13
chr12_-_11439752 0.918 NM_006248
PRB1
PRB2
proline-rich protein BstNI subfamily 1
proline-rich protein BstNI subfamily 2
chr17_+_39990124 0.880 NM_001466
FZD2
frizzled homolog 2 (Drosophila)
chr1_-_16217025 0.814 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr7_-_44147436 0.795 NM_021223
MYL7
myosin, light chain 7, regulatory
chr11_-_57038891 0.794 NM_001198810
SLC43A1
solute carrier family 43, member 1
chr5_-_33927724 0.793 NM_030955
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr2_-_105381855 0.786 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr9_-_78710698 0.772 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr10_+_88418147 0.729 NM_001171610
LDB3
LIM domain binding 3
chr15_+_43193810 0.717 NM_207581
DUOXA2
dual oxidase maturation factor 2
chr2_-_160765008 0.716 ITGB6
integrin, beta 6
chr11_-_47330797 0.687 NM_000256
MYBPC3
myosin binding protein C, cardiac
chr1_+_165866127 0.686 RCSD1
RCSD domain containing 1
chr15_-_63147350 0.672 NM_016563
RASL12
RAS-like, family 12
chr5_+_92944680 0.672 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr5_+_88220846 0.646


chr19_+_53650577 0.642 NM_013348
KCNJ14
potassium inwardly-rectifying channel, subfamily J, member 14
chr6_-_105691675 0.633 BVES
blood vessel epicardial substance
chr1_+_165865953 0.596 NM_052862
RCSD1
RCSD domain containing 1
chr6_+_151603201 0.559 AKAP12
A kinase (PRKA) anchor protein 12
chr15_-_43193637 0.556 NM_014080
DUOX2
dual oxidase 2
chrX_-_11194015 0.552 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr2_-_40593074 0.549 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr20_-_42249146 0.510 JPH2
junctophilin 2
chr12_+_50731457 0.504 NM_002135
NM_173157
NR4A1

nuclear receptor subfamily 4, group A, member 1

chr2_+_107969410 0.503 NM_021815
SLC5A7
solute carrier family 5 (choline transporter), member 7
chr11_-_75599433 0.490 WNT11
wingless-type MMTV integration site family, member 11
chr7_-_121731721 0.489 NM_001024613
NM_001160264
FEZF1

FEZ family zinc finger 1

chr11_+_66070949 0.486 NM_001104
ACTN3
actinin, alpha 3
chr19_+_12995782 0.479 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr5_-_58331515 0.474 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr11_-_118799058 0.456 THY1
Thy-1 cell surface antigen
chr20_+_60558104 0.454 NM_178463
C20orf166
chromosome 20 open reading frame 166
chr12_+_52713098 0.454 NM_018953
HOXC5
homeobox C5
chr11_+_59564323 0.453 NM_173801
PLAC1L
placenta-specific 1-like
chr5_+_169749068 0.445


chr10_+_88418243 0.444 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
LDB3




LIM domain binding 3




chr8_+_1937711 0.443 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr10_+_31650069 0.442 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr15_-_43193614 0.433 DUOX2
dual oxidase 2
chr19_+_16039170 0.423 NM_001145160
TPM4
tropomyosin 4
chr17_-_69869552 0.420 NM_001080466
BTBD17
BTB (POZ) domain containing 17
chrX_-_99873728 0.416 NM_001129896
SYTL4
synaptotagmin-like 4
chr12_-_48902692 0.409 NM_001113547
LIMA1
LIM domain and actin binding 1
chr3_-_71376919 0.405 FOXP1
forkhead box P1
chr20_-_1922701 0.401 NM_001190899
NM_001190898
NM_024411
PDYN


prodynorphin


chr1_-_227636462 0.398 NM_001100
ACTA1
actin, alpha 1, skeletal muscle
chr2_+_73973600 0.394 NM_001615
ACTG2
actin, gamma 2, smooth muscle, enteric
chr2_-_21120420 0.390 NM_000384
APOB
apolipoprotein B (including Ag(x) antigen)
chr17_+_29707583 0.385 NM_005408
CCL13
chemokine (C-C motif) ligand 13
chr3_-_124821868 0.381 MYLK
myosin light chain kinase
chr22_+_28206180 0.377 NM_021076
NEFH
neurofilament, heavy polypeptide
chr20_-_21442663 0.376 NM_002509
NKX2-2
NK2 homeobox 2
chr6_-_29635680 0.374 NM_006398
UBD
ubiquitin D
chr20_-_604443 0.371


chr12_-_46405477 0.362 NM_001172439
NM_001172440
NM_006025
ENDOU


endonuclease, polyU-specific


chr7_-_94123308 0.362 SGCE
sarcoglycan, epsilon
chr2_-_31659472 0.360 NM_000348
SRD5A2
steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
chr7_+_94123612 0.357 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr1_-_166373434 0.352 GPR161
G protein-coupled receptor 161
chr11_-_8982107 0.352 NM_020645
NRIP3
nuclear receptor interacting protein 3
chr6_+_12824873 0.351 PHACTR1
phosphatase and actin regulator 1
chr1_-_925332 0.346 NM_001142467
NM_021170
HES4

hairy and enhancer of split 4 (Drosophila)

chr4_+_156899575 0.342 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chrX_-_103386215 0.341 NM_153448
ESX1
ESX homeobox 1
chr4_+_24406182 0.339 NM_003102
SOD3
superoxide dismutase 3, extracellular
chr14_+_73775927 0.329 NM_182894
VSX2
visual system homeobox 2
chr5_+_140730014 0.320 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chrX_+_99726445 0.316 NM_022144
TNMD
tenomodulin
chr1_-_31618405 0.314 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr2_+_87536106 0.307 NCRNA00152
non-protein coding RNA 152
chr20_+_32610161 0.304 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr17_-_3129017 0.295 NM_002551
OR3A2
olfactory receptor, family 3, subfamily A, member 2
chr20_+_155898 0.291 NM_080831
DEFB129
defensin, beta 129
chr19_+_12996368 0.290 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr7_+_113842470 0.290 FOXP2
forkhead box P2
chr5_+_137829077 0.288 NM_001964
EGR1
early growth response 1
chr20_-_33706532 0.278 RBM12
RNA binding motif protein 12
chr2_-_215956429 0.275 FN1
fibronectin 1
chr7_-_94123413 0.274 NM_001099400
NM_001099401
NM_003919
SGCE


sarcoglycan, epsilon


chr3_+_189413414 0.266 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr7_-_94123362 0.263 SGCE
sarcoglycan, epsilon
chr7_+_94123672 0.263 PEG10
paternally expressed 10
chr1_-_925215 0.262 HES4
hairy and enhancer of split 4 (Drosophila)
chr14_+_74815233 0.258 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr17_+_55269974 0.257


chr1_+_6226838 0.257 NM_001024598
HES3
hairy and enhancer of split 3 (Drosophila)
chr2_-_21120398 0.256 APOB
apolipoprotein B (including Ag(x) antigen)
chr14_+_104338423 0.250 ZBTB42
zinc finger and BTB domain containing 42
chr1_-_150599105 0.250 NM_001014342
FLG2
filaggrin family member 2
chr10_+_112247614 0.241 NM_004419
DUSP5
dual specificity phosphatase 5
chr16_+_29984611 0.238 ALDOA
aldolase A, fructose-bisphosphate
chr16_+_29984647 0.235 ALDOA
aldolase A, fructose-bisphosphate
chr8_-_22606653 0.230 NM_004430
EGR3
early growth response 3
chr15_-_63147228 0.229 RASL12
RAS-like, family 12
chr2_+_73973640 0.219 ACTG2
actin, gamma 2, smooth muscle, enteric
chr3_-_46879883 0.217 NM_000258
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr7_-_107430566 0.214 NM_002291
LAMB1
laminin, beta 1
chr6_-_26216299 0.213 NM_005323
HIST1H1T
histone cluster 1, H1t
chr10_-_29963906 0.208 NM_021738
SVIL
supervillin
chr16_+_54247400 0.208 SLC6A2
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
chr15_+_94670160 0.207 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr3_+_25445071 0.193 RARB
retinoic acid receptor, beta
chr3_+_54131731 0.190 NM_018398
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr19_+_50109416 0.190 APOC1
apolipoprotein C-I
chr5_-_150264696 0.189 NM_001172831
NM_001172832
NM_052860
ZNF300


zinc finger protein 300


chr16_+_29984621 0.189 ALDOA
aldolase A, fructose-bisphosphate
chr16_+_29984591 0.186 ALDOA
aldolase A, fructose-bisphosphate
chr8_+_24827173 0.185 NM_005382
NEFM
neurofilament, medium polypeptide
chrX_+_153318662 0.185 GDI1
GDP dissociation inhibitor 1
chr3_-_158704056 0.184 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr2_-_105421661 0.181 NM_201557
FHL2
four and a half LIM domains 2
chr15_+_31390454 0.180 NM_001036
RYR3
ryanodine receptor 3
chr19_-_63550712 0.180 A1BG
alpha-1-B glycoprotein
chr15_-_99847395 0.178 PCSK6
proprotein convertase subtilisin/kexin type 6
chr11_-_30562324 0.177 MPPED2
metallophosphoesterase domain containing 2
chr11_+_43920385 0.173 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr1_-_166373351 0.172 GPR161
G protein-coupled receptor 161
chr7_+_113842284 0.172 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr16_+_29984544 0.169 NM_184041
ALDOA
aldolase A, fructose-bisphosphate
chr19_+_39402167 0.167 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr1_-_166373159 0.165 GPR161
G protein-coupled receptor 161
chr20_-_18425811 0.164 NM_006606
RBBP9
retinoblastoma binding protein 9
chr3_-_102888090 0.163 NM_000986
RPL24
ribosomal protein L24
chr2_-_27384617 0.161 NM_003353
UCN
urocortin
chr12_+_60940404 0.159 NM_006313
USP15
ubiquitin specific peptidase 15
chrX_-_37591760 0.158 NM_006520
DYNLT3
dynein, light chain, Tctex-type 3
chrX_+_82649924 0.156 NM_000307
POU3F4
POU class 3 homeobox 4
chr14_-_104507862 0.155 AHNAK2
AHNAK nucleoprotein 2
chr4_-_88669267 0.155 SPARCL1
SPARC-like 1 (hevin)
chr2_-_231697999 0.154 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr12_-_11313907 0.153 NM_006249
PRB3
proline-rich protein BstNI subfamily 3
chr3_-_124822113 0.151 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr17_-_3814334 0.148 NM_005173
NM_174953
NM_174954
NM_174955
NM_174956
NM_174957
NM_174958
ATP2A3






ATPase, Ca++ transporting, ubiquitous






chr14_-_73296643 0.145 NM_194278
C14orf43
chromosome 14 open reading frame 43
chr10_-_29963847 0.145


chr17_-_38385511 0.144 NM_025267
AARSD1
alanyl-tRNA synthetase domain containing 1
chr12_-_90029672 0.142 NM_002345
LUM
lumican
chr3_-_9809357 0.133 NM_006354
NM_133480
TADA3

transcriptional adaptor 3

chr2_-_49235059 0.132 NM_000145
NM_181446
FSHR

follicle stimulating hormone receptor

chr20_-_33783409 0.132 RBM39
RNA binding motif protein 39
chr20_+_2224612 0.130 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr11_+_74950893 0.129 SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chr5_-_169657360 0.128 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr14_+_95222506 0.128 NM_004918
NM_199206
TCL1B

T-cell leukemia/lymphoma 1B

chr6_+_158322904 0.127 SYNJ2
synaptojanin 2
chr14_-_105163301 0.124 IGHG4
immunoglobulin heavy constant gamma 4 (G4m marker)
chr2_-_96174502 0.122 DUSP2
dual specificity phosphatase 2
chr1_-_35097232 0.121 NM_001164824
C1orf212
chromosome 1 open reading frame 212
chrX_-_68301974 0.121 NM_001032396
NM_022368
NM_145119
PJA1


praja ring finger 1


chr12_+_48784057 0.119 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr14_-_105308720 0.118 IGHM
immunoglobulin heavy constant mu
chr17_-_10313600 0.118 NM_017533
MYH4
myosin, heavy chain 4, skeletal muscle
chr7_+_94123556 0.117 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr5_-_53642060 0.117 ARL15
ADP-ribosylation factor-like 15
chr2_-_151052391 0.117 NM_005168
RND3
Rho family GTPase 3
chrX_-_151370325 0.116 NM_000808
GABRA3
gamma-aminobutyric acid (GABA) A receptor, alpha 3
chr16_-_67943157 0.116 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr15_+_72006015 0.115 LOXL1
lysyl oxidase-like 1
chr19_+_2427122 0.114 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr2_+_87536174 0.114 NCRNA00152
non-protein coding RNA 152
chr19_-_9646717 0.113 ZNF562
zinc finger protein 562
chr6_+_126282078 0.112 NCOA7
nuclear receptor coactivator 7
chr20_+_60558369 0.111 C20orf166
chromosome 20 open reading frame 166
chr13_-_77447664 0.111 NM_000115
EDNRB
endothelin receptor type B
chr14_-_105280425 0.108 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chrX_-_142432884 0.107 NM_001009609
SPANXN3
SPANX family, member N3
chr7_+_113842407 0.107 FOXP2
forkhead box P2
chr5_-_178983281 0.104 NM_005520
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr19_-_9646750 0.102 NM_001130031
NM_001130032
NM_017656
ZNF562


zinc finger protein 562


chr19_-_12653698 0.100 DHPS
deoxyhypusine synthase
chr18_+_9698299 0.099 RAB31
RAB31, member RAS oncogene family
chr7_-_75280962 0.097 NM_002991
CCL24
chemokine (C-C motif) ligand 24
chr10_+_63950212 0.097 NM_199452
ZNF365
zinc finger protein 365

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
8.26 1.96e-09 GO:0006936 muscle contraction
7.59 9.05e-09 GO:0003012 muscle system process
14.81 1.65e-07 GO:0030048 actin filament-based movement
1.89 1.14e-06 GO:0007275 multicellular organismal development
1.64 2.07e-06 GO:0032501 multicellular organismal process
16.70 2.56e-06 GO:0030049 muscle filament sliding
16.70 2.56e-06 GO:0033275 actin-myosin filament sliding
16.26 3.31e-06 GO:0070252 actin-mediated cell contraction
1.78 1.02e-05 GO:0032502 developmental process
1.89 6.41e-05 GO:0048731 system development
1.82 9.24e-05 GO:0048856 anatomical structure development
4.56 1.13e-04 GO:0030029 actin filament-based process
2.11 1.90e-04 GO:0048513 organ development
5.23 6.10e-04 GO:0007517 muscle organ development
2.50 2.10e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.95 2.10e-03 GO:0030154 cell differentiation
1.35 2.44e-03 GO:0065007 biological regulation
1.64 4.12e-03 GO:0080090 regulation of primary metabolic process
1.90 4.79e-03 GO:0048869 cellular developmental process
3.19 6.36e-03 GO:0072358 cardiovascular system development
3.19 6.36e-03 GO:0072359 circulatory system development
3.98 7.32e-03 GO:0061061 muscle structure development
1.35 9.08e-03 GO:0050789 regulation of biological process
1.72 1.08e-02 GO:0051171 regulation of nitrogen compound metabolic process
1.60 1.34e-02 GO:0031323 regulation of cellular metabolic process
1.72 1.73e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.36 1.82e-02 GO:0050794 regulation of cellular process
5.33 2.22e-02 GO:0060537 muscle tissue development
2.12 2.45e-02 GO:0009893 positive regulation of metabolic process
2.59 3.65e-02 GO:0010628 positive regulation of gene expression
2.12 4.46e-02 GO:0031325 positive regulation of cellular metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
10.94 9.95e-12 GO:0044449 contractile fiber part
10.05 4.54e-11 GO:0043292 contractile fiber
6.00 1.55e-10 GO:0015629 actin cytoskeleton
10.06 2.10e-10 GO:0030016 myofibril
10.51 2.46e-09 GO:0030017 sarcomere
10.73 5.74e-06 GO:0016459 myosin complex
14.57 8.26e-05 GO:0042641 actomyosin
26.41 1.53e-04 GO:0031672 A band
14.71 5.40e-04 GO:0001725 stress fiber
13.73 8.30e-04 GO:0032432 actin filament bundle
19.07 9.61e-04 GO:0005859 muscle myosin complex
17.17 1.70e-03 GO:0016460 myosin II complex
1.99 2.79e-03 GO:0005856 cytoskeleton
8.59 1.38e-02 GO:0031674 I band
2.12 1.40e-02 GO:0044430 cytoskeletal part
10.10 2.58e-02 GO:0005884 actin filament

Gene overrepresentation in function category:

enrichment   p-value GO term description
12.78 3.78e-05 GO:0008307 structural constituent of muscle
3.91 2.13e-04 GO:0003779 actin binding
1.19 1.24e-03 GO:0005488 binding
2.35 1.42e-03 GO:0001071 nucleic acid binding transcription factor activity
2.35 1.42e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
2.31 2.09e-03 GO:0030528 transcription regulator activity
2.79 5.41e-03 GO:0008092 cytoskeletal protein binding
2.55 6.36e-03 GO:0043565 sequence-specific DNA binding
6.11 1.12e-02 GO:0003704 specific RNA polymerase II transcription factor activity
1.29 4.31e-02 GO:0005515 protein binding
4.42 4.77e-02 GO:0003774 motor activity