Motif ID: HNF4A_NR2F1,2.p2

Z-value: 2.496


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
HNF4A 3172 hepatocyte nuclear factor 4, alpha
NR2F1 7025 nuclear receptor subfamily 2, group F, member 1
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NR2F2chr15_+_94677572-0.591.7e-02Click!
HNF4Achr20_+_424175020.476.8e-02Click!
NR2F1chr5_+_92944680-0.078.0e-01Click!


Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_33753218 1.844 NM_001004334
GPR179
G protein-coupled receptor 179
chr5_+_150008030 1.749 SYNPO
synaptopodin
chr7_+_142885087 1.603 NM_176883
TAS2R41
taste receptor, type 2, member 41
chr10_+_102722275 1.548 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr17_-_31353196 1.515 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr6_+_33280396 1.502 NM_014234
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr22_-_22970850 1.431 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr17_-_31219943 1.389 NM_152781
C17orf66
chromosome 17 open reading frame 66
chr7_-_150515410 1.337 NM_001142459
NM_001142460
ASB10

ankyrin repeat and SOCS box containing 10

chr17_+_75766875 1.286 NM_024110
CARD14
caspase recruitment domain family, member 14
chr3_-_42892195 1.213 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr22_+_20316968 1.156 NM_152612
CCDC116
coiled-coil domain containing 116
chr19_-_17432724 1.114 NM_138454
NXNL1
nucleoredoxin-like 1
chr17_-_44641741 1.105 NM_031498
NM_001198755
NM_001198756
GNGT2


guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2


chr1_-_24307514 1.090 MYOM3
myomesin family, member 3
chr19_-_47328399 1.060 NM_002698
POU2F2
POU class 2 homeobox 2
chr2_+_27573206 1.035 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr16_-_11277806 1.033 NM_002762
PRM2
protamine 2
chr8_+_22909305 1.029 NM_001160037
RHOBTB2
Rho-related BTB domain containing 2
chr22_+_20899155 1.007


chr11_-_6418705 1.004 NM_000613
HPX
hemopexin
chr5_+_67558217 1.003 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr11_+_118332217 0.997 NM_006760
UPK2
uroplakin 2
chr1_+_15941503 0.984 NM_001013641
TMEM82
transmembrane protein 82
chr19_+_46640902 0.961 NM_001130514
C19orf69
chromosome 19 open reading frame 69
chr22_+_18330049 0.944 NM_007310
COMT
catechol-O-methyltransferase
chr12_-_53065758 0.942 ZNF385A
zinc finger protein 385A
chr12_+_107797985 0.935 NM_001917
DAO
D-amino-acid oxidase
chr1_+_154386358 0.927 NM_001193301
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr16_+_68542126 0.927 NM_001136214
CLEC18A
C-type lectin domain family 18, member A
chr19_-_53558961 0.921 NM_018273
TMEM143
transmembrane protein 143
chr2_-_241480058 0.901 NM_024861
C2orf54
chromosome 2 open reading frame 54
chr3_-_52454082 0.900 NM_020163
SEMA3G
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr22_+_21559959 0.897 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr11_-_4893468 0.894 NM_001005238
OR51G2
olfactory receptor, family 51, subfamily G, member 2
chr1_-_202726068 0.856 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr6_-_31246159 0.854 NM_002701
POU5F1
POU5F1B
POU5F1P3
POU class 5 homeobox 1
POU class 5 homeobox 1B
POU class 5 homeobox 1 pseudogene 3
chr10_-_76529253 0.853 NM_016364
DUSP13
dual specificity phosphatase 13
chr20_-_62208627 0.838 NM_005286
NPBWR2
neuropeptides B/W receptor 2
chr16_-_66558197 0.832 NM_001145964
SLC12A4
solute carrier family 12 (potassium/chloride transporters), member 4
chr17_-_8588829 0.832 NM_001158261
NM_144681
CCDC42

coiled-coil domain containing 42

chr17_-_3766441 0.830 P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr5_+_159589014 0.824 NM_001445
FABP6
fatty acid binding protein 6, ileal
chr3_+_46514488 0.810 NM_031440
RTP3
receptor (chemosensory) transporter protein 3
chr16_-_87646856 0.805


chrX_-_148484772 0.795 NM_001164415
NM_016153
HSFX2
HSFX1
heat shock transcription factor family, X linked 2
heat shock transcription factor family, X linked 1
chr6_-_32034607 0.794 NM_002904
RDBP
RD RNA binding protein
chr6_-_31953425 0.770 NM_001178045
SLC44A4
solute carrier family 44, member 4
chr3_-_46879883 0.767 NM_000258
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr6_+_32034767 0.766 SKIV2L
superkiller viralicidic activity 2-like (S. cerevisiae)
chr19_-_15451203 0.755 NM_052890
PGLYRP2
peptidoglycan recognition protein 2
chr16_+_56230707 0.753 NM_001145774
GPR56
G protein-coupled receptor 56
chr1_-_206263170 0.749 PLXNA2
plexin A2
chr22_+_21407066 0.748


chr7_+_128802719 0.746 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr6_+_29799095 0.734 NM_001098478
NM_001098479
NM_018950
HLA-F


major histocompatibility complex, class I, F


chrX_+_148663533 0.730 NM_001164415
NM_016153
HSFX2
HSFX1
heat shock transcription factor family, X linked 2
heat shock transcription factor family, X linked 1
chr16_-_86527608 0.728 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr22_+_20715340 0.724


chr1_+_226404037 0.723 NM_020435
GJC2
gap junction protein, gamma 2, 47kDa
chr12_+_48630790 0.721 NM_000486
AQP2
aquaporin 2 (collecting duct)
chr9_-_129557373 0.721 NM_001142534
NM_001142533
SH2D3C

SH2 domain containing 3C

chr2_-_74606819 0.720 NM_133637
DQX1
DEAQ box RNA-dependent ATPase 1
chr9_-_34554800 0.716 CNTFR
ciliary neurotrophic factor receptor
chr16_+_31312097 0.713 NM_005353
ITGAD
integrin, alpha D
chr19_+_53747233 0.712 NM_177973
SULT2B1
sulfotransferase family, cytosolic, 2B, member 1
chr1_-_20374273 0.707 NM_001105572
PLA2G2C
phospholipase A2, group IIC
chr1_+_144152864 0.706 TXNIP
thioredoxin interacting protein
chr17_+_24394281 0.699 PIPOX
pipecolic acid oxidase
chr1_-_181889070 0.695 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr22_-_35835548 0.693 TMPRSS6
transmembrane protease, serine 6
chr17_+_33867169 0.676 NM_020876
ARHGAP23
Rho GTPase activating protein 23
chr1_-_120285753 0.674 NOTCH2
notch 2
chr6_-_168222645 0.673 NM_024919
FRMD1
FERM domain containing 1
chr12_-_109842736 0.673 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr1_+_22200735 0.667 NM_005747
CELA3A
chymotrypsin-like elastase family, member 3A
chr19_+_18357966 0.667 NM_004864
GDF15
growth differentiation factor 15
chr13_-_25687062 0.663 RNF6
ring finger protein (C3H2C3 type) 6
chr7_+_142205266 0.662


chr4_-_9632192 0.658 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr6_-_31658044 0.655 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr12_-_192752 0.653 NM_003044
SLC6A12
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chrX_+_135079461 0.650 NM_001167819
FHL1
four and a half LIM domains 1
chr1_-_54861656 0.646 NM_176782
FAM151A
family with sequence similarity 151, member A
chr22_+_19651446 0.642 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr12_-_1791146 0.641 CACNA2D4
calcium channel, voltage-dependent, alpha 2/delta subunit 4
chr2_-_219404755 0.641 NM_017431
PRKAG3
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
chr7_-_72609458 0.637 BCL7B
B-cell CLL/lymphoma 7B
chr16_+_80086454 0.629 NM_030629
CMIP
c-Maf-inducing protein
chr7_-_72609804 0.625 BCL7B
B-cell CLL/lymphoma 7B
chr7_-_150352484 0.624 NM_173681
ATG9B
ATG9 autophagy related 9 homolog B (S. cerevisiae)
chr6_+_29799182 0.620 HLA-F
major histocompatibility complex, class I, F
chr1_-_23393808 0.617 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr6_+_30238961 0.616 NM_033229
TRIM15
tripartite motif containing 15
chr11_-_66245288 0.616 NM_006946
SPTBN2
spectrin, beta, non-erythrocytic 2
chrX_-_152844838 0.611 ARHGAP4
Rho GTPase activating protein 4
chr11_-_2517390 0.604


chrX_-_152844904 0.601 NM_001164741
NM_001666
ARHGAP4

Rho GTPase activating protein 4

chr6_+_29515694 0.601 NM_013941
OR10C1
olfactory receptor, family 10, subfamily C, member 1
chr20_-_7869068 0.600 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr7_-_42918013 0.599 NM_001099858
NM_024054
C7orf25

chromosome 7 open reading frame 25

chr16_+_82540172 0.598 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr1_+_3597092 0.598 NM_001126240
NM_001126241
NM_001126242
TP73


tumor protein p73


chr21_+_44818033 0.598 NM_198687
KRTAP10-4
keratin associated protein 10-4
chr19_-_14944729 0.595 NM_005071
SLC1A6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr3_-_184756101 0.593 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr3_-_140677990 0.593 NM_004164
RBP2
retinol binding protein 2, cellular
chr21_+_44530148 0.592 NM_000383
AIRE
autoimmune regulator
chr17_+_7753428 0.589 CHD3
chromodomain helicase DNA binding protein 3
chr1_+_43837096 0.589 PTPRF
protein tyrosine phosphatase, receptor type, F
chr12_+_52126131 0.586 PRR13
proline rich 13
chr17_+_3326045 0.585 NM_000049
ASPA
aspartoacylase
chr16_+_8722068 0.584 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr16_+_4546491 0.581 NM_001145011
LOC342346
hypothetical protein LOC342346
chr6_-_42798286 0.578 NM_000322
PRPH2
peripherin 2 (retinal degeneration, slow)
chr10_-_74384485 0.576 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr1_-_172153087 0.575 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr11_-_73397929 0.573 NM_003356
NM_022803
UCP3

uncoupling protein 3 (mitochondrial, proton carrier)

chr1_-_172153024 0.573 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr4_-_7487514 0.572 NM_001085382
PSAPL1
prosaposin-like 1 (gene/pseudogene)
chr7_+_150321771 0.572 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chr7_+_137411717 0.569 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr20_+_34937928 0.567 NM_080628
C20orf118
chromosome 20 open reading frame 118
chrX_+_152454773 0.566 NM_001001344
NM_021949
ATP2B3

ATPase, Ca++ transporting, plasma membrane 3

chr5_+_96237399 0.565 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr6_-_24985432 0.565 NM_015864
FAM65B
family with sequence similarity 65, member B
chr12_-_52015696 0.563 NM_152860
SP7
Sp7 transcription factor
chr17_+_35075124 0.561 NM_003673
TCAP
titin-cap (telethonin)
chr17_+_73638430 0.560 NM_152468
TMC8
transmembrane channel-like 8
chr8_+_22075112 0.560 NM_001172357
NM_001172410
NM_003018
SFTPC


surfactant protein C


chr11_+_4799126 0.559 NM_001004753
OR51F2
olfactory receptor, family 51, subfamily F, member 2
chr10_-_128199986 0.559 NM_001004298
C10orf90
chromosome 10 open reading frame 90
chr19_+_40716153 0.558 NM_014364
GAPDHS
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr14_-_59264044 0.556 NM_206857
RTN1
reticulon 1
chr11_+_73036241 0.554 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr8_-_142307854 0.553 NM_001080431
SLC45A4
solute carrier family 45, member 4
chrX_+_48803459 0.552 NM_001163322
NM_033626
NM_001163321
NM_001163323
CCDC120



coiled-coil domain containing 120



chr3_-_195553297 0.550 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr2_-_26717713 0.549 NM_001029881
CIB4
calcium and integrin binding family member 4
chr1_-_23567084 0.547 NM_030634
ZNF436
zinc finger protein 436
chr7_-_101059295 0.545 NM_138403
MYL10
myosin, light chain 10, regulatory
chr2_+_17861266 0.544 NM_001105569
MSGN1
mesogenin 1
chr4_-_185376012 0.544 NM_153343
ENPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr16_-_82830804 0.544 NM_172347
KCNG4
potassium voltage-gated channel, subfamily G, member 4
chr1_-_228916559 0.542 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr1_-_20122638 0.541 NM_014589
PLA2G2E
phospholipase A2, group IIE
chr11_-_62508946 0.541 NM_004790
NM_153276
NM_153277
NM_153278
SLC22A6



solute carrier family 22 (organic anion transporter), member 6



chr19_-_50506883 0.541 CKM
creatine kinase, muscle
chr2_+_95303947 0.541 PROM2
prominin 2
chr17_-_31332568 0.541 NM_004590
CCL16
chemokine (C-C motif) ligand 16
chr19_+_50086357 0.541 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr6_+_37081387 0.537 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr17_+_21249040 0.537 NM_001194958
KCNJ18
potassium inwardly-rectifying channel, subfamily J, member 18
chr22_+_35586950 0.536 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr1_+_1104939 0.535 NM_153254
TTLL10
tubulin tyrosine ligase-like family, member 10
chr19_+_4104593 0.532 NM_032607
CREB3L3
cAMP responsive element binding protein 3-like 3
chr5_-_9683462 0.531 NM_019599
TAS2R1
taste receptor, type 2, member 1
chr3_+_188043156 0.529 NM_001177800
NM_004797
ADIPOQ

adiponectin, C1Q and collagen domain containing

chr2_+_241193492 0.528 NM_001195381
NM_001195382
GPR35

G protein-coupled receptor 35

chr17_-_3766708 0.527 NM_002558
P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr2_+_73294852 0.526 NM_006062
SMYD5
SMYD family member 5
chr2_+_95326753 0.525 NM_013434
KCNIP3
Kv channel interacting protein 3, calsenilin
chr17_-_31369046 0.521 NM_005064
NM_145898
CCL23

chemokine (C-C motif) ligand 23

chr12_+_51783540 0.520 NM_003578
SOAT2
sterol O-acyltransferase 2
chr17_+_71229110 0.518 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr17_-_39822366 0.518 NM_000419
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr12_+_6424293 0.517 NM_001242
CD27
CD27 molecule
chr15_+_41672543 0.517 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr12_-_55637648 0.513 NM_003708
RDH16
retinol dehydrogenase 16 (all-trans)
chr16_+_29819647 0.512 NM_181718
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr2_-_25418856 0.511 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr19_-_56221681 0.510 NM_001136032
KLK11
kallikrein-related peptidase 11
chr13_+_112825113 0.510 NM_000504
F10
coagulation factor X
chr15_-_40173949 0.509 NM_178034
PLA2G4D
phospholipase A2, group IVD (cytosolic)
chr16_+_79829794 0.508 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr20_+_30831298 0.507 NM_175850
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta
chr10_-_101831579 0.506 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr12_+_51783554 0.505 SOAT2
sterol O-acyltransferase 2
chr1_-_41259973 0.505 NM_001168247
NM_144990
SLFNL1

schlafen-like 1

chr1_+_158352143 0.505 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr3_+_188397967 0.501 NM_153708
RTP1
receptor (chemosensory) transporter protein 1
chr20_+_29492071 0.500 NM_153324
DEFB123
defensin, beta 123
chr1_+_3531410 0.500 NM_182752
TPRG1L
tumor protein p63 regulated 1-like
chr12_+_50981915 0.500 NM_002284
KRT86
keratin 86
chr5_-_141318810 0.500 NM_016580
PCDH12
protocadherin 12
chr3_-_46481346 0.499 NM_002343
LTF
lactotransferrin
chr10_-_74384569 0.499 PLA2G12B
phospholipase A2, group XIIB
chr3_-_42892636 0.498 NM_004391
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr6_+_32034559 0.498 NM_006929
SKIV2L
superkiller viralicidic activity 2-like (S. cerevisiae)
chr11_+_112763722 0.497 NM_178510
ANKK1
ankyrin repeat and kinase domain containing 1
chr8_-_143820825 0.495 NM_020427
SLURP1
secreted LY6/PLAUR domain containing 1
chr17_+_24394043 0.494 NM_016518
PIPOX
pipecolic acid oxidase
chr11_-_116199145 0.494 NM_000482
APOA4
apolipoprotein A-IV
chr11_+_5024331 0.492 NM_001001916
OR52J3
olfactory receptor, family 52, subfamily J, member 3
chr15_+_72892205 0.490 NM_021819
LMAN1L
lectin, mannose-binding, 1 like
chr1_-_9008990 0.490 NM_207420
SLC2A7
solute carrier family 2 (facilitated glucose transporter), member 7
chr7_+_27191534 0.490 HOXA11-AS1
HOXA11 antisense RNA 1 (non-protein coding)
chr7_+_101704145 0.489 CUX1
cut-like homeobox 1
chr19_+_51492136 0.489 NM_152795
HIF3A
hypoxia inducible factor 3, alpha subunit
chr19_-_55156118 0.488 NM_001135163
NM_052884
SIGLEC11

sialic acid binding Ig-like lectin 11


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.24 1.62e-03 GO:0042221 response to chemical stimulus
3.68 2.02e-02 GO:0006942 regulation of striated muscle contraction
2.29 3.35e-02 GO:0009746 response to hexose stimulus
2.26 4.46e-02 GO:0034284 response to monosaccharide stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.45 3.17e-05 GO:0005626 insoluble fraction
1.44 5.68e-05 GO:0005624 membrane fraction
1.33 9.60e-04 GO:0000267 cell fraction
1.08 1.47e-02 GO:0016020 membrane

Nothing significant found in function category.