Motif ID: TCF4_dimer.p2

Z-value: 2.112


Transcription factors associated with TCF4_dimer.p2:

Gene SymbolEntrez IDGene Name
TCF4 6925 transcription factor 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF4chr18_-_51406841-0.116.9e-01Click!


Activity profile for motif TCF4_dimer.p2.

activity profile for motif TCF4_dimer.p2


Sorted Z-values histogram for motif TCF4_dimer.p2

Sorted Z-values for motif TCF4_dimer.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF4_dimer.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_20068039 3.384 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr22_-_20235372 3.371 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr11_+_70926718 3.326 NM_021046
KRTAP5-8
keratin associated protein 5-8
chr7_-_130891861 3.016 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr2_+_85834111 2.581 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr17_+_36493927 2.387 NM_033061
KRTAP4-7
keratin associated protein 4-7
chr9_-_96441409 2.322 FBP1
fructose-1,6-bisphosphatase 1
chr15_+_81567327 2.161 NM_001144903
NM_023003
TM6SF1

transmembrane 6 superfamily member 1

chr15_-_53822468 2.103 NM_173814
PRTG
protogenin
chr2_-_241484245 2.010 NM_001085437
C2orf54
chromosome 2 open reading frame 54
chr13_+_30378311 1.962 NM_032849
C13orf33
chromosome 13 open reading frame 33
chr9_-_96441654 1.810 NM_000507
FBP1
fructose-1,6-bisphosphatase 1
chr8_+_37773991 1.769 GPR124
G protein-coupled receptor 124
chr17_-_36594652 1.751 NM_033060
KRTAP4-1
keratin associated protein 4-1
chr17_+_4348877 1.738 NM_001124758
SPNS2
spinster homolog 2 (Drosophila)
chr19_+_43446937 1.689 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chrX_-_50573759 1.664 NM_020717
SHROOM4
shroom family member 4
chr12_-_89873081 1.654 NM_152638
C12orf12
chromosome 12 open reading frame 12
chr15_-_42274529 1.643 NM_032892
FRMD5
FERM domain containing 5
chr14_+_76298693 1.636 VASH1
vasohibin 1
chr16_-_73798539 1.629 NM_001025200
CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr21_+_36429079 1.602 NM_001236
CBR3
carbonyl reductase 3
chr19_+_43447078 1.598 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_+_43447262 1.597 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr1_-_27211913 1.551 NM_052943
FAM46B
family with sequence similarity 46, member B
chr2_-_241270982 1.528 NM_001102467
AQP12A
AQP12B
aquaporin 12A
aquaporin 12B
chr6_+_18495559 1.524 NM_182757
RNF144B
ring finger protein 144B
chr1_-_40140126 1.495 NM_001033081
NM_001033082
NM_005376
MYCL1


v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)


chr6_+_96570565 1.492 NM_006581
FUT9
fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
chr11_+_113436438 1.463 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr8_-_143692814 1.449 NM_015193
ARC
activity-regulated cytoskeleton-associated protein
chr2_+_33213111 1.430 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr17_-_7106987 1.417 NM_001185023
NM_001307
CLDN7

claudin 7

chr15_-_42274760 1.398 FRMD5
FERM domain containing 5
chrX_-_13866366 1.360


chr2_+_241279934 1.321 NM_198998
AQP12A
AQP12B
aquaporin 12A
aquaporin 12B
chr16_-_87570716 1.320 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr17_+_45008175 1.319 NM_007225
NXPH3
neurexophilin 3
chr9_-_96441567 1.319 FBP1
fructose-1,6-bisphosphatase 1
chr22_+_19660361 1.316 AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr17_+_36515166 1.292 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr11_+_76516957 1.290 NM_000260
NM_001127179
NM_001127180
MYO7A


myosin VIIA


chr7_-_143731718 1.286 NM_001080413
NOBOX
NOBOX oogenesis homeobox
chr19_+_18655487 1.257 CRTC1
CREB regulated transcription coactivator 1
chr11_-_6298284 1.254 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chrX_+_110074124 1.254 NM_001128166
NM_001128167
PAK3

p21 protein (Cdc42/Rac)-activated kinase 3

chr15_+_55455994 1.249 NM_032866
CGNL1
cingulin-like 1
chr5_-_159672060 1.244 NM_024565
CCNJL
cyclin J-like
chrX_-_128616594 1.234 NM_017413
APLN
apelin
chr2_+_27358800 1.206 NM_032546
NM_187841
TRIM54

tripartite motif containing 54

chrX_-_106905545 1.199 TSC22D3
TSC22 domain family, member 3
chr17_-_36507900 1.198 NM_031960
KRTAP4-8
keratin associated protein 4-8
chrX_+_100361588 1.188 NM_001171184
NM_001939
DRP2

dystrophin related protein 2

chr7_-_28186867 1.185 NM_175061
JAZF1
JAZF zinc finger 1
chr16_+_56230707 1.181 NM_001145774
GPR56
G protein-coupled receptor 56
chr2_+_109112428 1.166 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr21_+_46355797 1.152 COL6A2
collagen, type VI, alpha 2
chr19_-_61874934 1.151 ZNF835
zinc finger protein 835
chr22_-_37858871 1.151 CBX7
chromobox homolog 7
chr6_-_39398293 1.138 NM_001135105
NM_001135106
NM_001135107
NM_032115
KCNK16



potassium channel, subfamily K, member 16



chr9_+_37640996 1.134 NM_014907
FRMPD1
FERM and PDZ domain containing 1
chr17_-_39700960 1.127 NM_000342
SLC4A1
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
chr19_-_60587414 1.119 NM_001190764
LOC388564
hypothetical protein LOC388564
chr17_-_24077246 1.115 NM_138463
TLCD1
TLC domain containing 1
chr8_-_145609737 1.110 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr11_+_70915960 1.103 NM_001012503
KRTAP5-7
keratin associated protein 5-7
chr16_+_68765428 1.102 NM_173619
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chr19_+_40224480 1.098 HPN
hepsin
chr19_-_56229808 1.095 NM_019598
NM_145894
NM_145895
KLK12


kallikrein-related peptidase 12


chr5_-_136862130 1.093 SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr15_-_49184764 1.088 NM_207381
TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr1_+_181259317 1.088


chr20_+_29870836 1.085 NM_033118
MYLK2
myosin light chain kinase 2
chr7_+_116099648 1.069 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr1_-_27212035 1.064 FAM46B
family with sequence similarity 46, member B
chr19_+_14405216 1.059 PKN1
protein kinase N1
chr16_-_15742883 1.057 MYH11
myosin, heavy chain 11, smooth muscle
chr14_-_105948734 1.054 LOC100126583
IGHV4-31
IGHA1
IGHA2
IGHG1
IGHG4
IGHM
hypothetical LOC100126583
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 4 (G4m marker)
immunoglobulin heavy constant mu
chr17_-_36559579 1.042 NM_033188
KRTAP4-5
keratin associated protein 4-5
chr9_-_135379888 1.041 NM_001080483
TMEM8C
transmembrane protein 8C
chr6_-_31188310 1.039 NM_014070
C6orf15
chromosome 6 open reading frame 15
chrX_-_106905657 1.039 NM_198057
TSC22D3
TSC22 domain family, member 3
chr19_-_51829778 1.039 NM_033258
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr16_+_68542310 1.038 NM_182619
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chrX_+_48221323 1.037 NM_177434
FTSJ1
FtsJ homolog 1 (E. coli)
chr17_+_36599664 1.036 NM_001190460
KRTAP9-1
keratin associated protein 9-1
chrX_-_13866451 1.032 GPM6B
glycoprotein M6B
chr1_+_199975271 1.030 NAV1
neuron navigator 1
chr11_+_61204392 1.029 NM_006133
DAGLA
diacylglycerol lipase, alpha
chr11_+_1816808 1.029 NM_003282
TNNI2
troponin I type 2 (skeletal, fast)
chr5_+_169465478 1.025 NM_012188
NM_144769
FOXI1

forkhead box I1

chr17_+_37694007 1.024 STAT5A
signal transducer and activator of transcription 5A
chr1_+_100776280 1.020 NM_022049
GPR88
G protein-coupled receptor 88
chr8_-_139578246 1.019 NM_015912
FAM135B
family with sequence similarity 135, member B
chr1_-_6585268 1.004 KLHL21
kelch-like 21 (Drosophila)
chr1_+_24614831 1.002 NM_020448
NIPAL3
NIPA-like domain containing 3
chr6_-_31977747 1.002 NM_181842
ZBTB12
zinc finger and BTB domain containing 12
chr15_-_88143721 0.995 ANPEP
alanyl (membrane) aminopeptidase
chr9_+_135389698 0.986 NM_014694
ADAMTSL2
ADAMTS-like 2
chr12_+_108690199 0.985 C12orf34
chromosome 12 open reading frame 34
chr4_+_151218862 0.969 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr12_+_47498778 0.968 NM_000725
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr7_-_120285245 0.967 TSPAN12
tetraspanin 12
chr15_-_58671929 0.962 NM_134262
RORA
RAR-related orphan receptor A
chr17_+_26060617 0.962


chr17_-_7106497 0.948 CLDN7
claudin 7
chr11_-_16992524 0.944 NM_175058
PLEKHA7
pleckstrin homology domain containing, family A member 7
chr15_-_72981595 0.943 C15orf17
chromosome 15 open reading frame 17
chr1_-_39871226 0.943 HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr7_-_135083906 0.940 NM_205855
FAM180A
family with sequence similarity 180, member A
chr14_+_76297885 0.939 NM_014909
VASH1
vasohibin 1
chr3_+_32255215 0.929 CMTM8
CKLF-like MARVEL transmembrane domain containing 8
chr2_+_233099113 0.918 NM_000751
CHRND
cholinergic receptor, nicotinic, delta
chr1_+_201364050 0.915 ADORA1
adenosine A1 receptor
chr3_+_32255158 0.914 NM_178868
CMTM8
CKLF-like MARVEL transmembrane domain containing 8
chr2_-_101134146 0.912 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr16_+_87232501 0.912 NM_013278
IL17C
interleukin 17C
chr22_+_29122932 0.911 NM_012429
NM_033382
SEC14L2

SEC14-like 2 (S. cerevisiae)

chr11_-_684842 0.906 DEAF1
deformed epidermal autoregulatory factor 1 (Drosophila)
chr11_+_817584 0.904 NM_173584
EFCAB4A
EF-hand calcium binding domain 4A
chr5_+_66160359 0.904 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr6_+_36754467 0.899 CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr3_+_141879555 0.889 NM_152616
TRIM42
tripartite motif containing 42
chr19_+_40224457 0.887 HPN
hepsin
chr6_+_7672009 0.886 NM_001718
BMP6
bone morphogenetic protein 6
chr16_+_971808 0.880 NM_014587
SOX8
SRY (sex determining region Y)-box 8
chr10_-_21847126 0.879


chr5_+_159276317 0.866 NM_000679
ADRA1B
adrenergic, alpha-1B-, receptor
chr2_+_128119908 0.866 NM_001161415
NM_001161416
NM_001161417
NM_005291
GPR17



G protein-coupled receptor 17



chr10_-_61819493 0.865 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr9_+_123544884 0.865 NM_138709
DAB2IP
DAB2 interacting protein
chr5_-_136862317 0.862 SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr11_-_65070625 0.859 LTBP3
latent transforming growth factor beta binding protein 3
chr12_+_129388543 0.859 PIWIL1
piwi-like 1 (Drosophila)
chr12_+_103675075 0.857 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr22_-_30071761 0.851 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr2_-_80384454 0.850 LRRTM1
leucine rich repeat transmembrane neuronal 1
chr2_+_176761552 0.848 NM_024501
HOXD1
homeobox D1
chr17_+_36665161 0.846 NM_030975
KRTAP9-9
keratin associated protein 9-9
chr9_-_129869211 0.845 NM_197956
NAIF1
nuclear apoptosis inducing factor 1
chr19_+_18655483 0.841 CRTC1
CREB regulated transcription coactivator 1
chr16_-_73012740 0.840 NM_001011880
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chrX_+_53095230 0.833 NM_018969
GPR173
G protein-coupled receptor 173
chr8_-_131483395 0.832 NM_018482
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr5_+_1254709 0.827 NM_001003841
SLC6A19
solute carrier family 6 (neutral amino acid transporter), member 19
chr5_+_71438796 0.823 NM_005909
MAP1B
microtubule-associated protein 1B
chr11_-_1026654 0.822 NM_005961
MUC6
mucin 6, oligomeric mucus/gel-forming
chr1_+_199975674 0.820 NAV1
neuron navigator 1
chr17_+_36636404 0.816 NM_031961
KRTAP9-2
keratin associated protein 9-2
chr20_+_42007949 0.813 NM_001098798
TOX2
TOX high mobility group box family member 2
chr17_-_70220605 0.809 NM_139018
CD300LF
CD300 molecule-like family member f
chr5_+_143171918 0.808 NM_021182
HMHB1
histocompatibility (minor) HB-1
chr15_-_23659329 0.803 NM_024490
ATP10A
ATPase, class V, type 10A
chr19_-_59495949 0.799 NM_001172654
NM_006865
LILRB2
LILRA3

LILRA6
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chr1_+_18680010 0.797 NM_152375
KLHDC7A
kelch domain containing 7A
chr16_+_972064 0.795 SOX8
SRY (sex determining region Y)-box 8
chr12_+_6819635 0.793 NM_002075
GNB3
guanine nucleotide binding protein (G protein), beta polypeptide 3
chr22_-_36212160 0.791 NM_001166343
NM_002405
MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr6_+_138524717 0.790 NM_020340
KIAA1244
KIAA1244
chrX_+_69559605 0.787 NM_001171191
NM_001171192
NM_001171193
NM_017711
GDPD2



glycerophosphodiester phosphodiesterase domain containing 2



chr13_+_112789669 0.786 MCF2L
MCF.2 cell line derived transforming sequence-like
chr22_+_18081968 0.785 NM_002688
SEPT5
septin 5
chr2_+_56265260 0.782


chr6_+_167658563 0.779 NM_031949
TTLL2
tubulin tyrosine ligase-like family, member 2
chr5_+_148501178 0.779 NM_014945
ABLIM3
actin binding LIM protein family, member 3
chr19_+_51498695 0.765 NM_152794
HIF3A
hypoxia inducible factor 3, alpha subunit
chr14_-_105851580 0.764 IGHA1
IGHA2
IGHD
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
chr9_-_130980359 0.762 NM_203434
IER5L
immediate early response 5-like
chr2_-_183439515 0.762 NM_001463
FRZB
frizzled-related protein
chrX_+_70438352 0.757 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr9_-_139060285 0.756 NPDC1
neural proliferation, differentiation and control, 1
chr16_+_6473759 0.756 RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr17_+_45488330 0.754 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr1_-_23729871 0.748 E2F2
E2F transcription factor 2
chr4_-_191143017 0.747 NM_020040
TUBB4Q
tubulin, beta polypeptide 4, member Q
chr3_+_32123140 0.744 GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr2_-_216944911 0.742 NM_020814
MARCH4
membrane-associated ring finger (C3HC4) 4
chr15_+_66658626 0.740 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr8_+_31010319 0.740 NM_000553
WRN
Werner syndrome, RecQ helicase-like
chr1_+_46418786 0.738 TSPAN1
tetraspanin 1
chr1_+_242281175 0.735 NM_205768
ZNF238
zinc finger protein 238
chr9_-_115101140 0.732 NM_145051
RNF183
ring finger protein 183
chr11_+_113435640 0.731 NM_006006
ZBTB16
zinc finger and BTB domain containing 16
chr12_-_68379331 0.729 NM_032735
BEST3
bestrophin 3
chr1_-_6585485 0.728 NM_014851
KLHL21
kelch-like 21 (Drosophila)
chr10_-_116382089 0.727 ABLIM1
actin binding LIM protein 1
chr1_+_1104939 0.727 NM_153254
TTLL10
tubulin tyrosine ligase-like family, member 10
chr8_-_49996353 0.722 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr8_+_145138874 0.721 GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr17_+_45488356 0.721 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr1_+_199975563 0.721 NM_001167738
NAV1
neuron navigator 1
chr16_-_71549149 0.719 ZFHX3
zinc finger homeobox 3
chr11_-_63689780 0.716 MACROD1
MACRO domain containing 1
chr19_-_59438411 0.715 NM_024318
LILRB3
LILRA6
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chr14_-_105549177 0.714 IGHV4-31
IGHD
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr19_-_2259155 0.713 NM_001101391
LINGO3
leucine rich repeat and Ig domain containing 3
chr17_+_40192072 0.712 NM_002390
ADAM11
ADAM metallopeptidase domain 11
chr2_+_10101081 0.711 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr12_+_48630790 0.708 NM_000486
AQP2
aquaporin 2 (collecting duct)
chr9_-_139060377 0.707 NPDC1
neural proliferation, differentiation and control, 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.14 1.65e-04 GO:0007165 signal transduction
1.13 2.78e-04 GO:0023052 signaling
1.33 8.65e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.11 8.18e-03 GO:0051716 cellular response to stimulus
1.33 1.82e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.44 2.90e-02 GO:0061061 muscle structure development
1.54 3.05e-02 GO:0003012 muscle system process
1.19 3.71e-02 GO:0009966 regulation of signal transduction

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.87 6.23e-06 GO:0044449 contractile fiber part
1.80 2.15e-05 GO:0043292 contractile fiber
1.76 1.83e-04 GO:0030016 myofibril
1.81 3.42e-04 GO:0030017 sarcomere
1.42 3.45e-03 GO:0015629 actin cytoskeleton
1.06 5.21e-03 GO:0005737 cytoplasm
1.51 7.98e-03 GO:0030424 axon
1.27 1.26e-02 GO:0030054 cell junction
1.13 2.86e-02 GO:0005829 cytosol

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.08 1.74e-04 GO:0005515 protein binding
1.36 4.56e-02 GO:0003779 actin binding