Motif ID: PAX6.p2

Z-value: 0.498


Transcription factors associated with PAX6.p2:

Gene SymbolEntrez IDGene Name
PAX6 5080 paired box 6

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PAX6chr11_-_31796061-0.243.8e-01Click!


Activity profile for motif PAX6.p2.

activity profile for motif PAX6.p2


Sorted Z-values histogram for motif PAX6.p2

Sorted Z-values for motif PAX6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_70646008 0.807 NM_001126102
NM_005143
HP

haptoglobin

chr16_+_70654625 0.583 NM_020995
HPR
haptoglobin-related protein
chr2_+_39000007 0.511 NM_001145451
ARHGEF33
Rho guanine nucleotide exchange factor (GEF) 33
chr4_-_174557191 0.498 NM_007281
SCRG1
stimulator of chondrogenesis 1
chr12_-_68379331 0.384 NM_032735
BEST3
bestrophin 3
chr9_+_102380156 0.372 NM_001018116
MURC
muscle-related coiled-coil protein
chr3_-_15538164 0.308 NM_005677
NM_080539
COLQ

collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase

chrX_-_148604506 0.275 NM_001011544
MAGEA11
melanoma antigen family A, 11
chrX_+_2680092 0.270 NM_001141919
NM_001141920
NM_175569
XGPY2
XG


Xg pseudogene, Y-linked 2
Xg blood group


chr19_+_15920817 0.267 NM_001004465
OR10H4
olfactory receptor, family 10, subfamily H, member 4
chr6_+_155579788 0.262 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr1_-_6502655 0.225 NM_198681
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr1_-_12830728 0.225 NM_001146181
HNRNPCL1
LOC649330
heterogeneous nuclear ribonucleoprotein C-like 1
heterogeneous nuclear ribonucleoprotein C-like
chr19_-_56825400 0.202 NM_003830
SIGLEC5
sialic acid binding Ig-like lectin 5
chr4_+_77575276 0.192 NM_020859
SHROOM3
shroom family member 3
chr16_-_46823682 0.190 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr12_-_131725848 0.190 POLE
polymerase (DNA directed), epsilon
chr19_-_14800275 0.187 NM_017506
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr5_+_79651545 0.186 NM_032567
SPZ1
spermatogenic leucine zipper 1
chrX_-_13745134 0.185 GPM6B
glycoprotein M6B
chr4_+_77829634 0.183 SHROOM3
shroom family member 3
chr2_-_171631728 0.181 NM_001136555
TLK1
tousled-like kinase 1
chr11_+_55776251 0.174 NM_001004747
OR5T3
olfactory receptor, family 5, subfamily T, member 3
chr4_-_26100986 0.168 NM_000730
CCKAR
cholecystokinin A receptor
chrX_-_138742050 0.165 NM_001010986
NM_173694
ATP11C

ATPase, class VI, type 11C

chrX_-_15242589 0.159 NM_001012428
ASB11
ankyrin repeat and SOCS box containing 11
chr15_-_48192804 0.155 ATP8B4
ATPase, class I, type 8B, member 4
chr5_-_141318810 0.155 NM_016580
PCDH12
protocadherin 12
chr10_-_82039158 0.154 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr10_-_7699192 0.154 ITIH5
inter-alpha (globulin) inhibitor H5
chrX_-_52700674 0.139 NM_173358
SSX7
synovial sarcoma, X breakpoint 7
chr7_-_72761367 0.137 STX1A
syntaxin 1A (brain)
chr3_-_152585226 0.135 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr11_-_58099884 0.130 NM_004811
LPXN
leupaxin
chr10_+_35934343 0.125 NM_153368
GJD4
gap junction protein, delta 4, 40.1kDa
chr11_+_19328846 0.124 NM_001111018
NAV2
neuron navigator 2
chr19_+_59941785 0.121 NM_015868
KIR2DS2
KIR2DL3
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
chr2_+_178893216 0.119 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr1_+_35623688 0.115 ZMYM4
zinc finger, MYM-type 4
chr13_+_52500830 0.113 NM_006418
OLFM4
olfactomedin 4
chr12_+_55201854 0.109 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr1_-_54861656 0.106 NM_176782
FAM151A
family with sequence similarity 151, member A
chr16_-_11282595 0.105 NM_002761
PRM1
protamine 1
chr6_+_25760352 0.104 NM_006998
SCGN
secretagogin, EF-hand calcium binding protein
chr5_-_135259403 0.103 NM_000590
IL9
interleukin 9
chr3_-_58627509 0.102 NM_138805
FAM3D
family with sequence similarity 3, member D
chr4_-_170314382 0.100 SH3RF1
SH3 domain containing ring finger 1
chr1_+_93830106 0.098 LOC100129046
hypothetical LOC100129046
chr6_-_42270671 0.097 NM_002098
GUCA1B
guanylate cyclase activator 1B (retina)
chr5_-_125956996 0.097 ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr5_+_55182963 0.096 NM_139017
IL31RA
interleukin 31 receptor A
chr17_-_31528027 0.095 NM_001001417
TBC1D3B
TBC1D3C
TBC1D3G
TBC1D3F
TBC1 domain family, member 3B
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3F
chr3_-_150533948 0.093 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr13_-_109600709 0.092 COL4A1
collagen, type IV, alpha 1
chr11_+_111294868 0.092 C11orf52
chromosome 11 open reading frame 52
chr1_+_113038202 0.092 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr1_+_165564904 0.091 NM_001198783
POU2F1
POU class 2 homeobox 1
chrX_-_65176564 0.090 NM_001100431
NM_001184830
NM_001184831
NM_007268
VSIG4



V-set and immunoglobulin domain containing 4



chr2_+_170074457 0.088 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr19_+_9064854 0.087 NM_001004456
OR1M1
olfactory receptor, family 1, subfamily M, member 1
chr10_+_18280773 0.086 NM_001145195
NM_152725
SLC39A12

solute carrier family 39 (zinc transporter), member 12

chr17_-_36294962 0.085 NM_019010
KRT20
keratin 20
chrX_-_13745234 0.084 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr1_+_246703249 0.084 NM_001005495
OR2T3
olfactory receptor, family 2, subfamily T, member 3
chr3_-_120861959 0.083 NM_022135
POPDC2
popeye domain containing 2
chr1_+_207944807 0.081 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr16_-_71650034 0.080 NM_001164766
ZFHX3
zinc finger homeobox 3
chr3_+_16949585 0.078 NM_015184
PLCL2
phospholipase C-like 2
chr1_-_209732881 0.077 NM_001164688
NM_183059
RD3

retinal degeneration 3

chrX_+_103243762 0.075 NM_001143978
ZCCHC18
zinc finger, CCHC domain containing 18
chr1_-_246804680 0.075 NM_001001821
OR2T34
olfactory receptor, family 2, subfamily T, member 34
chr10_+_114033403 0.074 NM_058222
TECTB
tectorin beta
chr1_+_93830169 0.074 LOC100129046
hypothetical LOC100129046
chr8_-_7710547 0.065 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chrX_-_130251068 0.062 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr17_-_31831093 0.061 NM_001123392
NM_032258
TBC1D3C
TBC1D3G
TBC1D3
TBC1D3H
TBC1D3F
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3
TBC1 domain family, member 3H
TBC1 domain family, member 3F
chr6_-_28591542 0.061 NM_182701
GPX6
glutathione peroxidase 6 (olfactory)
chr4_-_10295412 0.059 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr1_+_61697209 0.059 NFIA
nuclear factor I/A
chr20_+_31106797 0.058 NM_182658
C20orf185
chromosome 20 open reading frame 185
chrX_-_130250880 0.057 IGSF1
immunoglobulin superfamily, member 1
chrX_-_13745108 0.056 GPM6B
glycoprotein M6B
chr11_-_123130435 0.056 NM_001005188
OR6X1
olfactory receptor, family 6, subfamily X, member 1
chr6_-_50097606 0.054 NM_001037497
NM_001037728
DEFB110

defensin, beta 110 locus

chrX_+_48127911 0.053 NM_001034832
NM_001040612
NM_005636
NM_175729
SSX4B

SSX4

synovial sarcoma, X breakpoint 4B

synovial sarcoma, X breakpoint 4

chr6_-_152681171 0.053 NM_015293
SYNE1
spectrin repeat containing, nuclear envelope 1
chr12_+_10351683 0.052 NM_002262
NM_007334
KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr6_-_131333173 0.051 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chrX_+_52797004 0.049 NM_003147
NM_175698
NM_001164417
SSX2

SSX2B
synovial sarcoma, X breakpoint 2

synovial sarcoma, X breakpoint 2B
chr21_+_38566298 0.049 NM_170737
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr13_+_23742846 0.048 SPATA13
spermatogenesis associated 13
chr11_+_76561471 0.047 MYO7A
myosin VIIA
chr18_+_17076166 0.047 NM_001142966
GREB1L
growth regulation by estrogen in breast cancer-like
chr11_+_111294810 0.047 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr3_-_14558591 0.045 NM_001080423
GRIP2
glutamate receptor interacting protein 2
chr1_+_145841569 0.043 NM_005267
GJA8
gap junction protein, alpha 8, 50kDa
chr2_-_138762909 0.043


chr17_-_8602601 0.042 NM_001128076
SPDYE4
speedy homolog E4 (Xenopus laevis)
chr16_+_52037186 0.042 RBL2
retinoblastoma-like 2 (p130)
chr7_+_45033757 0.042 NM_001029835
CCM2
cerebral cavernous malformation 2
chr10_-_79298876 0.041 DLG5
discs, large homolog 5 (Drosophila)
chr5_-_79982584 0.040 NM_001190470
MTRNR2L2
MT-RNR2-like 2
chr1_+_97033103 0.040


chr21_+_38550739 0.039 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr8_-_62764839 0.038 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr15_+_27001131 0.037 NM_001130414
NM_005503
APBA2

amyloid beta (A4) precursor protein-binding, family A, member 2

chr17_-_33602374 0.037 NM_032258
TBC1D3C
TBC1D3G
TBC1D3
TBC1D3F
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3
TBC1 domain family, member 3F
chr11_+_117452995 0.037 TMPRSS4
transmembrane protease, serine 4
chr2_+_119416214 0.037 NM_006770
MARCO
macrophage receptor with collagenous structure
chr5_+_147672181 0.036 NM_032566
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr8_-_27525084 0.035 NM_001171138
CLU
clusterin
chr8_+_7340777 0.035 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr11_-_117252541 0.035 FXYD6
FXYD domain containing ion transport regulator 6
chrX_-_48156287 0.035 NM_001034832
NM_001040612
NM_005636
NM_175729
SSX4B

SSX4

synovial sarcoma, X breakpoint 4B

synovial sarcoma, X breakpoint 4

chr15_-_23204887 0.035 NM_000462
UBE3A
ubiquitin protein ligase E3A
chr1_-_13263334 0.034 NM_001012276
PRAMEF8
PRAMEF7
PRAME family member 8
PRAME family member 7
chr20_-_45360903 0.034 ZMYND8
zinc finger, MYND-type containing 8
chr12_-_55790355 0.034 NM_001178079
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr3_-_196792059 0.034 APOD
apolipoprotein D
chr7_+_72913424 0.033 NM_182504
WBSCR28
Williams-Beuren syndrome chromosome region 28
chr5_-_114965959 0.033 NM_021649
TICAM2
toll-like receptor adaptor molecule 2
chrX_-_13744933 0.032 GPM6B
glycoprotein M6B
chr9_+_130485754 0.030 NM_001122821
SET
SET nuclear oncogene
chr11_-_11331411 0.030 CSNK2A1P
casein kinase 2, alpha 1 polypeptide pseudogene
chr8_-_93181091 0.030 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr16_-_27806978 0.030 NM_144675
GSG1L
GSG1-like
chr12_-_69317441 0.029 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr3_+_52212969 0.028 ALAS1
aminolevulinate, delta-, synthase 1
chr2_-_18634257 0.028 NM_001002006
NM_033253
NT5C1B-RDH14
NT5C1B

NT5C1B-RDH14 readthrough
5'-nucleotidase, cytosolic IB

chr1_+_78888064 0.028 NM_006417
IFI44
interferon-induced protein 44
chr10_-_45350804 0.028 NM_001002266
MARCH8
membrane-associated ring finger (C3HC4) 8
chr5_+_121493113 0.028 NM_207317
ZNF474
zinc finger protein 474
chr5_-_58918031 0.027 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr21_-_38792173 0.026 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr9_+_122923864 0.025 CEP110
centrosomal protein 110kDa
chr15_+_63124760 0.025 NM_178859
OSTBETA
organic solute transporter beta
chr17_-_31616071 0.024 NM_001001418
NM_032258
TBC1D3B
TBC1D3C
TBC1D3G
TBC1D3F
TBC1 domain family, member 3B
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3F
chrX_+_50670474 0.024 NM_005448
BMP15
bone morphogenetic protein 15
chr2_-_133256097 0.023 NCKAP5
NCK-associated protein 5
chr3_-_121117647 0.022 GSK3B
glycogen synthase kinase 3 beta
chr17_+_22982344 0.021 LGALS9
lectin, galactoside-binding, soluble, 9
chr8_+_18123456 0.020 NM_001160174
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr5_+_42792676 0.018 NM_001134848
CCDC152
coiled-coil domain containing 152
chr12_+_8557402 0.018 NM_080387
CLEC4D
C-type lectin domain family 4, member D
chrX_-_76823813 0.018


chr15_+_43331719 0.017 NM_004212
SLC28A2
solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
chr6_+_167624792 0.016 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr2_+_115538716 0.016 NM_001178037
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr19_-_59019240 0.016 NM_144687
NLRP12
NLR family, pyrin domain containing 12
chr1_+_165565006 0.014 POU2F1
POU class 2 homeobox 1
chr6_-_31954795 0.014 NM_001178044
NM_025257
SLC44A4

solute carrier family 44, member 4

chr1_-_161105174 0.014 NM_178550
C1orf110
chromosome 1 open reading frame 110
chr21_-_30855478 0.013 NM_181614
KRTAP19-7
keratin associated protein 19-7
chr2_-_157890400 0.013 NM_020711
ERMN
ermin, ERM-like protein
chr12_+_108035424 0.013


chr7_-_26198673 0.013 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr17_-_33552166 0.013 NM_001123391
NM_032258
TBC1D3C
TBC1D3G
TBC1D3
TBC1D3F
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3
TBC1 domain family, member 3F
chr19_+_56990222 0.013 NM_002030
FPR3
formyl peptide receptor 3
chr19_+_54299686 0.012 SNRNP70
small nuclear ribonucleoprotein 70kDa (U1)
chr21_-_30510113 0.012 NM_199328
CLDN8
claudin 8
chr17_-_34209671 0.012 NM_003559
PIP4K2B
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
chr12_+_18305740 0.012 NM_004570
PIK3C2G
phosphoinositide-3-kinase, class 2, gamma polypeptide
chr11_-_4827013 0.011 NM_001004758
OR51S1
olfactory receptor, family 51, subfamily S, member 1
chr1_+_202033273 0.011 NM_001174108
ZBED6
zinc finger, BED-type containing 6
chr4_+_100714995 0.011 MTTP
microsomal triglyceride transfer protein
chr17_+_22982372 0.010 LGALS9
lectin, galactoside-binding, soluble, 9
chr3_+_109498082 0.010 HHLA2
HERV-H LTR-associating 2
chr14_-_30927931 0.010 NM_015473
HEATR5A
HEAT repeat containing 5A
chr1_-_245902965 0.009 NM_001005487
OR13G1
olfactory receptor, family 13, subfamily G, member 1
chr4_+_89115825 0.009 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chrX_+_92815667 0.009 NM_001171109
NM_001171110
NM_001171111
NM_173698
FAM133A



family with sequence similarity 133, member A



chr1_-_87152372 0.008 SEP15
15 kDa selenoprotein
chr12_-_43555607 0.008 NM_001145109
NELL2
NEL-like 2 (chicken)
chr17_+_8154280 0.008 NM_173728
ARHGEF15
Rho guanine nucleotide exchange factor (GEF) 15
chrX_-_84250629 0.007 NM_001012980
SATL1
spermidine/spermine N1-acetyl transferase-like 1
chr5_-_142795269 0.007 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr14_-_87806913 0.007 NM_138318
KCNK10
potassium channel, subfamily K, member 10
chrX_+_49718954 0.007 NM_000084
CLCN5
chloride channel 5
chr19_-_62659665 0.006 NM_020633
VN1R1
vomeronasal 1 receptor 1
chr7_+_80105907 0.005 CD36
CD36 molecule (thrombospondin receptor)
chr2_+_214984705 0.004 NM_001080500
VWC2L
von Willebrand factor C domain containing protein 2-like
chr4_-_185963859 0.004 ACSL1
acyl-CoA synthetase long-chain family member 1
chr1_+_84382562 0.003 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr11_+_834445 0.002 NM_001025237
TSPAN4
tetraspanin 4
chr5_-_169657312 0.002 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr3_+_153499883 0.001 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr9_-_16860664 0.001 BNC2
basonuclin 2
chr12_-_43556220 0.001 NELL2
NEL-like 2 (chicken)
chr16_-_29514140 0.001


chr9_-_115901157 0.000 NM_138424
KIF12
kinesin family member 12

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.38 1.30e-03 GO:0046578 regulation of Ras protein signal transduction
12.46 4.42e-03 GO:0032313 regulation of Rab GTPase activity
12.46 4.42e-03 GO:0032483 regulation of Rab protein signal transduction

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
12.22 1.33e-03 GO:0005097 Rab GTPase activator activity
4.01 1.40e-02 GO:0005083 small GTPase regulator activity