Motif ID: POU3F1..4.p2

Z-value: 1.228


Transcription factors associated with POU3F1..4.p2:

Gene SymbolEntrez IDGene Name
POU3F1 5453 POU class 3 homeobox 1
POU3F2 5454 POU class 3 homeobox 2
POU3F3 5455 POU class 3 homeobox 3
POU3F4 5456 POU class 3 homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU3F2chr6_+_993893000.371.6e-01Click!
POU3F3chr2_+_1048381770.253.5e-01Click!
POU3F1chr1_-_38285033-0.117.0e-01Click!
POU3F4chrX_+_826499240.087.6e-01Click!


Activity profile for motif POU3F1..4.p2.

activity profile for motif POU3F1..4.p2


Sorted Z-values histogram for motif POU3F1..4.p2

Sorted Z-values for motif POU3F1..4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU3F1..4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_66570683 1.541 PDE4B
phosphodiesterase 4B, cAMP-specific
chr3_+_150065732 1.357 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr12_+_54172413 1.250 NM_001005519
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr3_+_12367993 1.246 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr10_-_51678318 1.202 NM_001143974
NM_019893
ASAH2

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2

chr11_+_113280727 1.044 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr2_-_180319013 0.998 NM_001113397
ZNF385B
zinc finger protein 385B
chr1_+_176577228 0.916 NM_004841
RASAL2
RAS protein activator like 2
chr7_+_20621769 0.906 NM_001163941
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chrX_-_15530112 0.825 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr1_+_184532027 0.807 NM_001127708
NM_001127709
NM_001127710
NM_005807
PRG4



proteoglycan 4



chr8_-_20084892 0.765 NM_001135691
NM_001142324
NM_001142325
NM_003053
SLC18A1



solute carrier family 18 (vesicular monoamine), member 1



chr6_+_24465109 0.757 NM_181337
KAAG1
kidney associated antigen 1
chr6_+_49575629 0.755 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr11_-_35235325 0.741 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr2_+_151922350 0.740 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr2_+_135312655 0.731 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr12_-_94469357 0.697 NM_032147
USP44
ubiquitin specific peptidase 44
chr12_-_90029328 0.689 LUM
lumican
chr3_-_152529999 0.660 NM_176894
P2RY13
purinergic receptor P2Y, G-protein coupled, 13
chr2_+_108590032 0.659 NM_001193482
LIMS1
LIM and senescent cell antigen-like domains 1
chr5_-_41249270 0.656 NM_000065
C6
complement component 6
chrX_+_100692071 0.639 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr1_+_47037256 0.634 NM_000779
NM_001099772
CYP4B1

cytochrome P450, family 4, subfamily B, polypeptide 1

chr8_+_1980564 0.621 NM_003970
MYOM2
myomesin (M-protein) 2, 165kDa
chr18_+_59593591 0.612 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr11_-_85146691 0.603 NM_001162951
NM_001162953
SYTL2

synaptotagmin-like 2

chr12_-_107943227 0.595 NM_018711
SVOP
SV2 related protein homolog (rat)
chr1_+_50348052 0.585 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr12_+_50342814 0.583 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr2_+_166137091 0.577 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr13_+_42253685 0.573 NM_182508
C13orf30
chromosome 13 open reading frame 30
chr7_-_122627235 0.556 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr9_-_4142182 0.549 NM_152629
GLIS3
GLIS family zinc finger 3
chr6_-_114490701 0.534 NM_153612
HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr13_-_24644304 0.520 FAM123A
family with sequence similarity 123A
chr2_+_214984705 0.511 NM_001080500
VWC2L
von Willebrand factor C domain containing protein 2-like
chr10_-_69095362 0.507 NM_001127384
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr10_+_114033403 0.505 NM_058222
TECTB
tectorin beta
chr1_+_239882202 0.477 NM_144625
WDR64
WD repeat domain 64
chr9_-_21999270 0.476 NM_004936
NM_078487
CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

chr8_-_17624009 0.472 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr1_-_150353179 0.470 NM_007113
TCHH
trichohyalin
chr13_-_77390907 0.461 NM_001122659
NM_003991
EDNRB

endothelin receptor type B

chr11_+_59612712 0.460 NM_000139
MS4A2
membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
chrX_+_65300803 0.449 NM_001130860
NM_014799
HEPH

hephaestin

chr12_+_79127363 0.446 NM_173591
OTOGL
otogelin-like
chr12_+_10015274 0.437 NM_138337
NM_201623
CLEC12A

C-type lectin domain family 12, member A

chr11_+_110890719 0.427 NM_001100388
NM_207430
C11orf88

chromosome 11 open reading frame 88

chr9_-_92444886 0.426 NM_017594
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr12_-_10215942 0.424 NM_001172632
NM_001172633
NM_002543
OLR1


oxidized low density lipoprotein (lectin-like) receptor 1


chr3_+_25444753 0.423 NM_016152
RARB
retinoic acid receptor, beta
chr19_+_56049982 0.416 NM_001030047
NM_001030048
NM_001030050
NM_001648
KLK3



kallikrein-related peptidase 3



chr3_+_149930656 0.406 NM_032049
AGTR1
angiotensin II receptor, type 1
chr14_+_71468902 0.400 RGS6
regulator of G-protein signaling 6
chr4_-_152368492 0.396 SH3D19
SH3 domain containing 19
chr2_-_162808123 0.396 NM_004460
FAP
fibroblast activation protein, alpha
chr7_-_131983986 0.395 NM_181775
PLXNA4
plexin A4
chr12_-_69317441 0.387 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr11_+_22316242 0.385 NM_020346
SLC17A6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr20_-_49747397 0.377 ATP9A
ATPase, class II, type 9A
chrX_+_102471769 0.375 NM_152278
TCEAL7
transcription elongation factor A (SII)-like 7
chr5_+_147238466 0.373 NM_054023
SCGB3A2
secretoglobin, family 3A, member 2
chr3_-_152173475 0.369 NM_001195794
NM_174878
CLRN1

clarin 1

chr14_-_59167284 0.368 RTN1
reticulon 1
chr1_+_195503956 0.368 NM_001193640
NM_201253
CRB1

crumbs homolog 1 (Drosophila)

chr7_-_107230867 0.364 NM_000111
SLC26A3
solute carrier family 26, member 3
chr3_+_110024234 0.364 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr12_+_52806103 0.363 LOC400043
hypothetical LOC400043
chr3_-_115380539 0.354 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr20_+_43784401 0.352 NM_178455
SPINT4
serine peptidase inhibitor, Kunitz type 4
chr3_-_194579207 0.351 NM_198505
ATP13A5
ATPase type 13A5
chr13_-_77391525 0.348


chr1_+_169326641 0.345 NM_001002294
NM_006894
FMO3

flavin containing monooxygenase 3

chr3_+_99370233 0.343 NM_001005515
OR5H15
olfactory receptor, family 5, subfamily H, member 15
chr13_-_60887210 0.341 PCDH20
protocadherin 20
chr1_-_167663278 0.341 NM_021179
C1orf114
chromosome 1 open reading frame 114
chr2_-_206790871 0.337 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chr21_-_30855478 0.335 NM_181614
KRTAP19-7
keratin associated protein 19-7
chr3_+_25444837 0.330 NM_000965
RARB
retinoic acid receptor, beta
chrX_-_52913056 0.329 NM_130776
XAGE3
X antigen family, member 3
chr19_-_6991183 0.328 NM_001164419
MBD3L4
methyl-CpG-binding domain protein 3-like 4-like
chrX_+_41468351 0.325 NM_080817
GPR82
G protein-coupled receptor 82
chr7_+_100169184 0.324 NM_003386
NM_173059
ZAN

zonadhesin

chr18_+_65219114 0.321 NM_152721
DOK6
docking protein 6
chr3_+_28406990 0.320 NM_001040432
ZCWPW2
zinc finger, CW type with PWWP domain 2
chr12_+_8557402 0.318 NM_080387
CLEC4D
C-type lectin domain family 4, member D
chr4_+_71096830 0.317 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr12_+_70618892 0.316 NM_173353
TPH2
tryptophan hydroxylase 2
chrX_-_137649180 0.316 NM_033642
FGF13
fibroblast growth factor 13
chr1_-_68688219 0.316 NM_000329
RPE65
retinal pigment epithelium-specific protein 65kDa
chr7_+_39839337 0.314


chrX_-_135577102 0.313 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr1_+_157246305 0.307 NM_005531
IFI16
interferon, gamma-inducible protein 16
chr17_+_29606408 0.305 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr20_+_9406460 0.305 PLCB4
phospholipase C, beta 4
chr8_+_26206648 0.301 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr15_+_76171981 0.300 NM_001101404
SH2D7
SH2 domain containing 7
chr12_-_9123126 0.297 A2M
alpha-2-macroglobulin
chr1_-_171286634 0.297 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr13_+_23742846 0.296 SPATA13
spermatogenesis associated 13
chr4_+_155703581 0.296 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr2_-_37397669 0.293 NM_005813
PRKD3
protein kinase D3
chr1_-_7923464 0.290 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr8_-_13018123 0.288 NM_001164271
DLC1
deleted in liver cancer 1
chr5_+_34720368 0.287 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr9_+_674193 0.286


chr1_-_89414310 0.284 NM_207398
GBP7
guanylate binding protein 7
chr14_-_59167193 0.284 NM_206852
RTN1
reticulon 1
chr1_-_229627412 0.283 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr1_+_185064654 0.280 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr10_+_124141808 0.280 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr8_-_124613557 0.278 NM_148177
FBXO32
F-box protein 32
chr1_-_202595666 0.278 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chrX_-_15312390 0.276 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr7_-_11838260 0.275 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chrX_+_47999740 0.275 NM_005635
SSX1
synovial sarcoma, X breakpoint 1
chr9_+_5880801 0.275 NM_005511
MLANA
melan-A
chr5_-_146441184 0.274 NM_181677
NM_181678
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr2_+_178893216 0.271 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr12_-_51494601 0.270 NM_002272
KRT4
keratin 4
chr13_-_46368968 0.270 NM_000621
NM_001165947
HTR2A

5-hydroxytryptamine (serotonin) receptor 2A

chrX_+_106758395 0.268 PRPS1
phosphoribosyl pyrophosphate synthetase 1
chr1_-_229071957 0.268 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr8_-_18710575 0.263 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr19_-_14800275 0.261 NM_017506
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr1_+_195123766 0.258 NM_006684
CFHR4
complement factor H-related 4
chr2_-_199922047 0.257 SATB2
SATB homeobox 2
chr12_+_50568010 0.256 NM_001130015
NM_182608
ANKRD33

ankyrin repeat domain 33

chr13_+_78068246 0.254 LOC780529
hypothetical LOC780529
chr6_-_133008834 0.251 NM_138327
TAAR1
trace amine associated receptor 1
chr8_+_49083522 0.248 NM_003350
UBE2V2
ubiquitin-conjugating enzyme E2 variant 2
chr21_-_33107813 0.247 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chr7_+_123036312 0.246 NM_080928
ASB15
ankyrin repeat and SOCS box containing 15
chr6_+_46869052 0.245 NM_005588
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr3_-_194755281 0.244 NM_032279
ATP13A4
ATPase type 13A4
chr6_-_117256890 0.242 NM_148963
GPRC6A
G protein-coupled receptor, family C, group 6, member A
chr13_+_28496746 0.242 NM_001033602
MTUS2
microtubule associated tumor suppressor candidate 2
chr10_+_15125900 0.240 NM_001039702
NM_018324
OLAH

oleoyl-ACP hydrolase

chr2_-_198248828 0.240 NM_144629
RFTN2
raftlin family member 2
chr1_+_66772393 0.239 NM_032291
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr18_-_55136673 0.236 NM_181654
CPLX4
complexin 4
chr5_+_40945374 0.236 C7
complement component 7
chr3_-_148604760 0.235 NM_001168378
ZIC4
Zic family member 4
chr17_-_45629401 0.234


chr1_+_15858950 0.231 NM_006511
RSC1A1
regulatory solute carrier protein, family 1, member 1
chr11_-_5037432 0.231 NM_001005164
OR52E2
olfactory receptor, family 52, subfamily E, member 2
chr12_-_242255 0.230 NM_001190997
NM_016615
SLC6A13

solute carrier family 6 (neurotransmitter transporter, GABA), member 13

chr1_+_195179533 0.229 NM_005666
CFHR2
complement factor H-related 2
chrX_-_105169370 0.228 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr12_-_10042956 0.227 NM_001099431
NM_016509
CLEC1B

C-type lectin domain family 1, member B

chr12_+_54106304 0.222 NM_001005183
OR6C76
olfactory receptor, family 6, subfamily C, member 76
chr19_-_59495949 0.220 NM_001172654
NM_006865
LILRB2
LILRA3

LILRA6
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chr6_-_41230003 0.219 NM_178174
TREML1
triggering receptor expressed on myeloid cells-like 1
chr1_+_190394214 0.219 NM_130782
RGS18
regulator of G-protein signaling 18
chr8_-_93181091 0.219 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr13_+_108046500 0.219 NM_015011
MYO16
myosin XVI
chr21_-_31041390 0.218 NM_181617
KRTAP21-2
keratin associated protein 21-2
chr1_+_190552744 0.218 NM_001039152
RGS21
regulator of G-protein signaling 21
chr9_-_110658030 0.217 NM_006686
ACTL7B
actin-like 7B
chr11_+_108040983 0.216 NM_004398
DDX10
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
chr13_+_108079570 0.216 NM_001198950
MYO16
myosin XVI
chr18_-_51219880 0.215 TCF4
transcription factor 4
chr11_-_123685871 0.215 NM_001002917
OR8D1
olfactory receptor, family 8, subfamily D, member 1
chr2_+_165804157 0.213 NM_001040142
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr8_+_104900591 0.213 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr5_+_40945315 0.213 NM_000587
C7
complement component 7
chr1_+_47305633 0.213 NM_178134
CYP4Z1
cytochrome P450, family 4, subfamily Z, polypeptide 1
chrX_+_114734074 0.211 NM_001136025
NM_001172335
PLS3

plastin 3

chr1_+_69998445 0.210 NM_020794
LRRC7
leucine rich repeat containing 7
chr11_-_77730573 0.210 NM_012296
GAB2
GRB2-associated binding protein 2
chr4_-_145281237 0.209 NM_002099
GYPA
glycophorin A (MNS blood group)
chr18_+_59726183 0.209 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr6_-_29635456 0.209 UBD
ubiquitin D
chr7_-_122422989 0.209 NM_016945
TAS2R16
taste receptor, type 2, member 16
chr18_+_59374372 0.207 NM_080474
SERPINB12
serpin peptidase inhibitor, clade B (ovalbumin), member 12
chr5_+_147672181 0.206 NM_032566
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr16_-_70591377 0.205 NM_181536
PKD1L3
polycystic kidney disease 1-like 3
chr3_+_116824840 0.201 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr3_+_185355909 0.200 DVL3
dishevelled, dsh homolog 3 (Drosophila)
chr1_+_75366706 0.200 NM_001001933
LHX8
LIM homeobox 8
chr22_+_16423147 0.199 NM_031481
SLC25A18
solute carrier family 25 (mitochondrial carrier), member 18
chr4_-_44348414 0.198 NM_182592
YIPF7
Yip1 domain family, member 7
chr8_+_50147455 0.197 NM_001007176
C8orf22
chromosome 8 open reading frame 22
chr12_-_10850845 0.196 NM_023918
TAS2R8
taste receptor, type 2, member 8
chr6_+_121798443 0.195 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr7_+_29486010 0.195 NM_001039936
CHN2
chimerin (chimaerin) 2
chr12_-_103846186 0.194 NM_032148
SLC41A2
solute carrier family 41, member 2
chrX_+_10084984 0.193 NM_001830
CLCN4
chloride channel 4
chr19_+_59820413 0.192 NM_006669
LILRB1
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr8_-_124818754 0.190 NM_001003954
NM_004306
ANXA13

annexin A13

chrX_-_131375217 0.190 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr1_+_117098579 0.189 NM_001767
CD2
CD2 molecule
chr5_-_119768430 0.189


chr14_-_94677807 0.189 NM_030621
DICER1
dicer 1, ribonuclease type III
chr8_+_67945537 0.188 NM_001136161
NM_173518
C8orf45

chromosome 8 open reading frame 45

chr11_-_57927457 0.186 NM_001005469
OR5B3
olfactory receptor, family 5, subfamily B, member 3
chr22_-_14829803 0.185 NM_001005239
OR11H1
olfactory receptor, family 11, subfamily H, member 1
chr7_+_143437539 0.185 NM_001005480
OR2A2
olfactory receptor, family 2, subfamily A, member 2
chr1_+_180685878 0.185 NM_001137669
RGSL1
regulator of G-protein signaling like 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.89 4.21e-09 GO:0007606 sensory perception of chemical stimulus
2.87 9.18e-08 GO:0007608 sensory perception of smell
1.78 6.27e-07 GO:0003008 system process
1.87 1.87e-06 GO:0050877 neurological system process
2.16 2.04e-06 GO:0007600 sensory perception
1.31 1.42e-05 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.55 6.78e-13 GO:0071944 cell periphery
1.55 1.50e-12 GO:0005886 plasma membrane
1.25 2.40e-06 GO:0016020 membrane
1.28 5.36e-06 GO:0044425 membrane part
1.31 2.84e-05 GO:0016021 integral to membrane
1.30 3.53e-05 GO:0031224 intrinsic to membrane
4.84 1.42e-03 GO:0031091 platelet alpha granule
1.71 1.35e-02 GO:0005626 insoluble fraction
4.50 1.69e-02 GO:0031983 vesicle lumen
1.68 3.67e-02 GO:0005624 membrane fraction
4.48 4.07e-02 GO:0031093 platelet alpha granule lumen
4.39 4.82e-02 GO:0034774 secretory granule lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.50 3.28e-12 GO:0004930 G-protein coupled receptor activity
1.92 9.37e-11 GO:0004872 receptor activity
1.81 9.69e-11 GO:0004871 signal transducer activity
1.81 9.69e-11 GO:0060089 molecular transducer activity
2.02 2.07e-09 GO:0004888 transmembrane receptor activity
2.95 1.49e-08 GO:0004984 olfactory receptor activity
6.55 2.84e-02 GO:0001608 nucleotide receptor activity, G-protein coupled
6.55 2.84e-02 GO:0045028 purinergic nucleotide receptor activity, G-protein coupled