Motif ID: FOXL1.p2

Z-value: 1.677


Transcription factors associated with FOXL1.p2:

Gene SymbolEntrez IDGene Name
FOXL1 2300 forkhead box L1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXL1chr16_+_85169615-0.194.7e-01Click!


Activity profile for motif FOXL1.p2.

activity profile for motif FOXL1.p2


Sorted Z-values histogram for motif FOXL1.p2

Sorted Z-values for motif FOXL1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXL1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_45899080 1.995 IGFBP1
insulin-like growth factor binding protein 1
chr4_-_152368492 1.909 SH3D19
SH3 domain containing 19
chr7_+_45899621 1.905


chr7_-_107230867 1.848 NM_000111
SLC26A3
solute carrier family 26, member 3
chr5_+_140757787 1.816 NM_018925
NM_032099
PCDHGB5

protocadherin gamma subfamily B, 5

chr7_-_99312591 1.517 NM_001005276
OR2AE1
olfactory receptor, family 2, subfamily AE, member 1
chrX_+_21960841 1.502 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr7_+_142723340 1.463 NM_000083
CLCN1
chloride channel 1, skeletal muscle
chr5_+_140762551 1.391 NM_018921
NM_032089
PCDHGA9

protocadherin gamma subfamily A, 9

chr5_+_140772691 1.383 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr5_+_140719773 1.304 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr10_-_97190885 1.275 NM_001034954
NM_001034955
NM_001034956
NM_001034957
NM_006434
SORBS1




sorbin and SH3 domain containing 1




chr5_-_16561936 1.254 NM_019000
FAM134B
family with sequence similarity 134, member B
chrX_+_99726445 1.232 NM_022144
TNMD
tenomodulin
chr3_-_195601283 1.228 NM_004488
GP5
glycoprotein V (platelet)
chr17_-_15463742 1.225 NM_006382
CDRT1
CMT1A duplicated region transcript 1
chr3_-_150533948 1.213 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr6_+_132901119 1.211 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr7_+_134114701 1.209 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr10_+_90511142 1.207 NM_001102469
LIPN
lipase, family member N
chr7_+_142629251 1.188 NM_176882
TAS2R40
taste receptor, type 2, member 40
chr6_+_131613196 1.186 NM_004842
NM_138633
AKAP7

A kinase (PRKA) anchor protein 7

chr10_-_69095362 1.182 NM_001127384
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr1_+_181380837 1.170 LAMC1
laminin, gamma 1 (formerly LAMB2)
chr7_+_141054621 1.148 NM_001105558
WEE2
WEE1 homolog 2 (S. pombe)
chr15_-_68781662 1.137 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr4_+_88748704 1.131 NM_014208
DSPP
dentin sialophosphoprotein
chr7_+_94377145 1.113 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chrX_+_37750778 1.109 NM_001163335
NM_138780
SYTL5

synaptotagmin-like 5

chrX_+_41468351 1.090 NM_080817
GPR82
G protein-coupled receptor 82
chr3_+_153014550 1.057 NM_001086
AADAC
arylacetamide deacetylase (esterase)
chr1_+_246375072 1.043 NM_001004690
OR2M5
olfactory receptor, family 2, subfamily M, member 5
chr9_+_129066576 1.041 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr1_-_116185215 1.024 NM_005599
NHLH2
nescient helix loop helix 2
chr4_+_73123712 1.016 NM_001144756
NM_053036
NPFFR2

neuropeptide FF receptor 2

chr11_-_13474101 1.013 NM_000315
PTH
parathyroid hormone
chr12_+_79625538 1.012 NM_002469
MYF6
myogenic factor 6 (herculin)
chr3_-_148607096 1.008 NM_032153
ZIC4
Zic family member 4
chr17_-_8004671 1.006 VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr1_-_150328153 0.996 NM_001008536
TCHHL1
trichohyalin-like 1
chr16_+_24174374 0.996 NM_006539
CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr5_+_139485703 0.979 NM_001007189
C5orf53
chromosome 5 open reading frame 53
chr7_+_89681069 0.968 NM_001040666
STEAP2
six transmembrane epithelial antigen of the prostate 2
chr7_+_134114912 0.952 CALD1
caldesmon 1
chr6_-_25834733 0.951 NM_170745
HIST1H2AA
histone cluster 1, H2aa
chr7_-_113346284 0.948 NM_002711
PPP1R3A
protein phosphatase 1, regulatory (inhibitor) subunit 3A
chr8_+_50147455 0.934 NM_001007176
C8orf22
chromosome 8 open reading frame 22
chr1_+_234748187 0.932 NM_201545
LGALS8
lectin, galactoside-binding, soluble, 8
chr7_+_143263191 0.924 NM_001004685
OR2F2
olfactory receptor, family 2, subfamily F, member 2
chr1_+_158603480 0.923 NM_005598
NHLH1
nescient helix loop helix 1
chr3_+_129117007 0.914 KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr7_-_130021845 0.912 NM_052933
TSGA13
testis specific, 13
chr4_+_3341521 0.910 NM_198227
RGS12
regulator of G-protein signaling 12
chr5_+_156628929 0.909 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr19_-_14030970 0.901 NM_001145028
PALM3
paralemmin 3
chr2_+_158666627 0.895 NM_173355
UPP2
uridine phosphorylase 2
chr1_-_177106702 0.891 NM_004673
ANGPTL1
angiopoietin-like 1
chr2_+_64540843 0.888 HSPC159
galectin-related protein
chr4_+_71492581 0.886 NM_016519
AMBN
ameloblastin (enamel matrix protein)
chr16_+_70646008 0.885 NM_001126102
NM_005143
HP

haptoglobin

chr7_+_142850667 0.882 NM_177437
TAS2R60
taste receptor, type 2, member 60
chrX_-_50403412 0.880 SHROOM4
shroom family member 4
chr8_-_27997306 0.866 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr5_+_156540425 0.864 NM_005546
ITK
IL2-inducible T-cell kinase
chr4_+_88939725 0.863 NM_004967
IBSP
integrin-binding sialoprotein
chr1_+_246195157 0.855 NM_001004491
OR2AK2
olfactory receptor, family 2, subfamily AK, member 2
chr18_+_50409387 0.842 NM_173629
C18orf26
chromosome 18 open reading frame 26
chr13_+_110653407 0.841 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr1_-_153107084 0.837


chr11_+_7574992 0.832 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr16_-_11277806 0.823 NM_002762
PRM2
protamine 2
chr3_-_49204294 0.815 NM_001080528
LOC646498
hypothetical protein LOC646498
chr17_+_63367052 0.804 BPTF
bromodomain PHD finger transcription factor
chr17_-_36209672 0.799 NM_181535
KRT28
keratin 28
chr1_+_200775864 0.796 NM_001197131
PPP1R12B
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr11_-_6148131 0.792 NM_001004052
OR52B2
olfactory receptor, family 52, subfamily B, member 2
chr12_-_7547552 0.781 NM_004244
NM_203416
CD163

CD163 molecule

chrX_-_15593074 0.780 NM_020665
TMEM27
transmembrane protein 27
chr10_+_114033403 0.780 NM_058222
TECTB
tectorin beta
chr14_-_56346849 0.778 NM_021728
OTX2
orthodenticle homeobox 2
chr1_+_242281199 0.775 ZNF238
zinc finger protein 238
chr1_+_65503011 0.770 NM_014787
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr20_+_56455866 0.769 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr11_+_123315459 0.758 NM_001001965
OR4D5
olfactory receptor, family 4, subfamily D, member 5
chr11_+_124294355 0.758 NM_001037558
HEPN1
hepatocellular carcinoma, down-regulated 1
chr22_-_14829803 0.757 NM_001005239
OR11H1
olfactory receptor, family 11, subfamily H, member 1
chr5_+_76470829 0.751


chr7_-_108311872 0.751 NM_001024607
C7orf66
chromosome 7 open reading frame 66
chr6_-_26038817 0.751 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr9_+_102380156 0.748 NM_001018116
MURC
muscle-related coiled-coil protein
chr3_-_139315011 0.744 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chrX_+_55666557 0.743 NM_198451
FOXR2
forkhead box R2
chr21_-_30614477 0.727 NM_203405
KRTAP26-1
keratin associated protein 26-1
chr5_+_140730014 0.727 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr8_-_7297296 0.727 NM_058206
NM_058207
SPAG11B

sperm associated antigen 11B

chr3_+_12367993 0.723 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr7_+_134114957 0.722 CALD1
caldesmon 1
chr9_+_42707229 0.702 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chrX_+_54963953 0.701 NM_001039705
NM_016157
NM_177556
TRO


trophinin


chr17_+_29707583 0.697 NM_005408
CCL13
chemokine (C-C motif) ligand 13
chr5_-_58918031 0.696 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr6_-_117256890 0.696 NM_148963
GPRC6A
G protein-coupled receptor, family C, group 6, member A
chr3_-_102194938 0.687 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr1_-_201321999 0.685 NM_002479
MYOG
myogenin (myogenic factor 4)
chr3_-_121445831 0.683 NM_001168271
NM_153002
GPR156

G protein-coupled receptor 156

chr7_+_128099581 0.680 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr1_-_75849350 0.678 NM_001130058
NM_152697
SLC44A5

solute carrier family 44, member 5

chr1_-_166779825 0.673 NM_003175
XCL1
XCL2
chemokine (C motif) ligand 1
chemokine (C motif) ligand 2
chr11_-_40271086 0.669 LRRC4C
leucine rich repeat containing 4C
chr1_+_116455898 0.665 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr22_+_27779877 0.665 ZNRF3
zinc and ring finger 3
chrX_-_11194015 0.664 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr3_-_115380539 0.661 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr1_-_150398327 0.657 NM_001122965
RPTN
repetin
chr2_-_180319013 0.653 NM_001113397
ZNF385B
zinc finger protein 385B
chr15_+_26832300 0.651 LOC100289656
Dexi homolog (mouse) pseudogene
chr7_+_123083096 0.650 NM_207163
LMOD2
leiomodin 2 (cardiac)
chr12_+_9713472 0.647 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr12_-_14858358 0.641 NM_001013698
C12orf69
chromosome 12 open reading frame 69
chr11_-_123758448 0.638 NM_001005468
OR8B2
olfactory receptor, family 8, subfamily B, member 2
chrX_+_135558001 0.627 NM_000074
CD40LG
CD40 ligand
chr1_-_161439248 0.623 NM_001195303
RGS5
regulator of G-protein signaling 5
chr8_+_24354387 0.620 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr1_+_103898844 0.619 NM_020978
AMY2B
amylase, alpha 2B (pancreatic)
chr8_-_134141586 0.614 NM_006748
SLA
Src-like-adaptor
chr1_+_151209751 0.608 NM_173080
SPRR4
small proline-rich protein 4
chr3_+_162697289 0.605 NM_001080440
OTOL1
otolin 1 homolog (zebrafish)
chr15_+_19883745 0.605 NM_001005241
OR4N4
olfactory receptor, family 4, subfamily N, member 4
chr7_+_143287952 0.605 NM_012369
OR2F1
olfactory receptor, family 2, subfamily F, member 1
chr6_+_155579788 0.604 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr7_-_50596238 0.603 NM_000790
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr4_+_14950657 0.602 NM_001135170
C1QTNF7
C1q and tumor necrosis factor related protein 7
chrX_+_10084984 0.600 NM_001830
CLCN4
chloride channel 4
chr8_+_67568044 0.596 NM_152765
C8orf46
chromosome 8 open reading frame 46
chr12_-_18134319 0.594 NM_024730
RERGL
RERG/RAS-like
chr3_-_15538164 0.594 NM_005677
NM_080539
COLQ

collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase

chrX_+_123062143 0.594 STAG2
stromal antigen 2
chr1_+_13903936 0.592 NM_012231
NM_015866
PRDM2

PR domain containing 2, with ZNF domain

chr8_-_82606104 0.591 NM_001105281
FABP12
fatty acid binding protein 12
chr3_+_143824955 0.589 NM_002670
PLS1
plastin 1
chr1_-_201583989 0.583 FMOD
fibromodulin
chr1_+_151081953 0.583 NM_001128600
LCE6A
late cornified envelope 6A
chr11_+_57547928 0.582 NM_001005212
OR9Q1
olfactory receptor, family 9, subfamily Q, member 1
chr15_+_66695932 0.580 NM_001190456
CORO2B
coronin, actin binding protein, 2B
chr1_+_17448179 0.576 NM_016233
PADI3
peptidyl arginine deiminase, type III
chr7_+_80069439 0.568 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr4_+_72321113 0.565 SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr10_-_21847126 0.564


chr17_-_36409632 0.563 NM_031959
KRTAP3-2
keratin associated protein 3-2
chr10_+_102111361 0.560 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr1_-_54256390 0.558 NM_001010978
LDLRAD1
low density lipoprotein receptor class A domain containing 1
chr1_+_207926172 0.556 NM_181755
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr11_+_123625632 0.555 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr1_-_161439487 0.552 NM_003617
RGS5
regulator of G-protein signaling 5
chr6_-_132987106 0.551 NM_001033080
TAAR2
trace amine associated receptor 2
chr1_-_227636462 0.548 NM_001100
ACTA1
actin, alpha 1, skeletal muscle
chrX_+_38096679 0.548 NM_000531
OTC
ornithine carbamoyltransferase
chr1_+_92405196 0.548 NM_015237
KIAA1107
KIAA1107
chrX_-_21686079 0.547 NM_014332
SMPX
small muscle protein, X-linked
chr1_-_181889070 0.547 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr7_-_96471544 0.547 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr18_+_28023984 0.546 NM_005925
MEP1B
meprin A, beta
chr4_+_71283383 0.544 NM_006685
SMR3B
submaxillary gland androgen regulated protein 3B
chr8_-_62764839 0.542 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr6_-_33268177 0.542 NM_001163771
NM_080679
NM_080680
NM_080681
COL11A2



collagen, type XI, alpha 2



chrX_-_57180782 0.537 NM_019003
SPIN2A
spindlin family, member 2A
chr8_-_42353719 0.537 NM_014420
DKK4
dickkopf homolog 4 (Xenopus laevis)
chrX_-_131089552 0.531 NM_194277
FRMD7
FERM domain containing 7
chr1_+_242281175 0.531 NM_205768
ZNF238
zinc finger protein 238
chr12_+_54172413 0.529 NM_001005519
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr1_+_181421984 0.528 LAMC2
laminin, gamma 2
chr10_-_30958631 0.527 NM_183058
LYZL2
lysozyme-like 2
chr10_-_61819493 0.526 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr11_-_85146691 0.525 NM_001162951
NM_001162953
SYTL2

synaptotagmin-like 2

chr21_-_30460841 0.524 NM_012131
CLDN17
claudin 17
chr9_+_124463665 0.523 NM_001005236
OR1L1
olfactory receptor, family 1, subfamily L, member 1
chr8_-_52884456 0.519 NM_144651
PXDNL
peroxidasin homolog (Drosophila)-like
chr5_+_180726874 0.518 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr1_-_199613406 0.516 TNNT2
troponin T type 2 (cardiac)
chr6_-_136888771 0.515 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr1_+_245818284 0.512 NM_001001915
OR2G2
olfactory receptor, family 2, subfamily G, member 2
chr3_+_42702014 0.509 NM_152393
KBTBD5
kelch repeat and BTB (POZ) domain containing 5
chr12_+_32546243 0.507 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr6_-_136889302 0.506 MAP7
microtubule-associated protein 7
chr10_-_116434102 0.505 ABLIM1
actin binding LIM protein 1
chr9_+_124321239 0.503 NM_001004452
OR1J4
olfactory receptor, family 1, subfamily J, member 4
chr6_-_134540666 0.502 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr4_+_120276386 0.502 NM_016599
MYOZ2
myozenin 2
chrX_-_142632181 0.496 NM_001009615
SPANXN2
SPANX family, member N2
chr6_-_132980901 0.496 NM_014626
TAAR2
trace amine associated receptor 2
chr9_-_21156609 0.493 NM_002175
IFNA21
interferon, alpha 21
chrX_-_131989963 0.493 NM_031907
USP26
ubiquitin specific peptidase 26
chr3_-_58175437 0.491 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr3_+_50291521 0.484 NM_153215
C3orf45
chromosome 3 open reading frame 45
chr1_-_156784518 0.484 NM_001005189
OR6Y1
olfactory receptor, family 6, subfamily Y, member 1
chr1_+_110795271 0.483 NM_032414
PROK1
prokineticin 1
chr1_-_157772420 0.481 NM_001004469
OR10J5
olfactory receptor, family 10, subfamily J, member 5
chr12_+_53901075 0.480 NM_001005280
OR10A7
olfactory receptor, family 10, subfamily A, member 7
chrX_-_24241352 0.479 NM_001136233
FAM48B2
family with sequence similarity 48, member B2
chr11_+_4976788 0.478 NM_001004755
OR51L1
olfactory receptor, family 51, subfamily L, member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.66 4.77e-35 GO:0007606 sensory perception of chemical stimulus
3.82 1.59e-34 GO:0007608 sensory perception of smell
2.68 8.71e-28 GO:0007600 sensory perception
2.13 7.20e-23 GO:0050877 neurological system process
1.95 2.54e-21 GO:0003008 system process
1.40 2.42e-16 GO:0032501 multicellular organismal process
1.25 8.38e-08 GO:0050896 response to stimulus
1.66 4.13e-03 GO:0006955 immune response
2.28 2.03e-02 GO:0007517 muscle organ development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.46 9.42e-18 GO:0071944 cell periphery
1.47 1.03e-17 GO:0005886 plasma membrane
1.60 5.99e-12 GO:0005576 extracellular region
1.86 1.29e-10 GO:0044421 extracellular region part
1.83 2.31e-07 GO:0005615 extracellular space
2.06 3.72e-04 GO:0005578 proteinaceous extracellular matrix
1.18 4.00e-03 GO:0016021 integral to membrane
1.15 4.05e-03 GO:0044425 membrane part
1.85 4.21e-03 GO:0031012 extracellular matrix
1.17 4.97e-03 GO:0031224 intrinsic to membrane
2.55 1.21e-02 GO:0044420 extracellular matrix part
9.37 1.55e-02 GO:0005579 membrane attack complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.01 2.44e-37 GO:0004984 olfactory receptor activity
2.82 3.93e-34 GO:0004930 G-protein coupled receptor activity
2.18 1.83e-24 GO:0004888 transmembrane receptor activity
1.85 2.34e-18 GO:0004872 receptor activity
1.72 1.02e-16 GO:0004871 signal transducer activity
1.72 1.02e-16 GO:0060089 molecular transducer activity
2.37 5.27e-04 GO:0005125 cytokine activity
2.95 1.42e-02 GO:0005201 extracellular matrix structural constituent
7.87 1.79e-02 GO:0003796 lysozyme activity