Motif ID: E2F1..5.p2

Z-value: 1.931


Transcription factors associated with E2F1..5.p2:

Gene SymbolEntrez IDGene Name
E2F1 1869 E2F transcription factor 1
E2F2 1870 E2F transcription factor 2
E2F3 1871 E2F transcription factor 3
E2F4 1874 E2F transcription factor 4, p107/p130-binding
E2F5 1875 E2F transcription factor 5, p130-binding

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
E2F4chr16_+_657835990.505.0e-02Click!
E2F3chr6_+_205100190.273.2e-01Click!
E2F5chr8_+_86287161-0.263.4e-01Click!
E2F2chr1_-_237298710.204.7e-01Click!
E2F1chr20_-_317377310.185.0e-01Click!


Activity profile for motif E2F1..5.p2.

activity profile for motif E2F1..5.p2


Sorted Z-values histogram for motif E2F1..5.p2

Sorted Z-values for motif E2F1..5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F1..5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_131652007 2.091 NM_001005463
EBF3
early B-cell factor 3
chr4_+_72271218 1.991 NM_001098484
NM_001134742
SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr6_+_135544214 1.920 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr10_+_124885556 1.787 NM_001105574
HMX3
H6 family homeobox 3
chr10_-_131652364 1.679 EBF3
early B-cell factor 3
chr8_+_31616809 1.470 NM_013962
NRG1
neuregulin 1
chr19_-_62043867 1.319 NM_001146326
NM_001146327
NM_015363
NM_001146184
NM_001146185
NM_001146187
NM_006210
ZIM2


PEG3



zinc finger, imprinted 2


paternally expressed 3



chr7_+_98084531 1.292 NM_002523
NPTX2
neuronal pentraxin II
chr7_+_113513600 1.282 FOXP2
forkhead box P2
chr18_-_68361742 1.263 CBLN2
cerebellin 2 precursor
chr6_+_135544170 1.259 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr7_+_50314801 1.257 NM_006060
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr17_-_44042924 1.256 HOXB7
homeobox B7
chr6_+_135544138 1.219 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr3_-_124650081 1.203 NM_183357
ADCY5
adenylate cyclase 5
chr14_+_50776635 1.196 NM_030755
TMX1
thioredoxin-related transmembrane protein 1
chr8_+_65656164 1.179 BHLHE22
basic helix-loop-helix family, member e22
chr3_+_148609841 1.145 NM_003412
ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr9_-_103540682 1.132 NM_133445
GRIN3A
glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
chr15_+_64782468 1.119 SMAD6
SMAD family member 6
chr19_-_12807221 1.112 NM_031429
RTBDN
retbindin
chr2_+_171280046 1.105 NM_001003845
SP5
Sp5 transcription factor
chr14_+_20608179 1.096 NM_018071
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr16_+_1979959 1.094 NM_004209
SYNGR3
synaptogyrin 3
chr16_-_60627536 1.094 NM_001796
CDH8
cadherin 8, type 2
chr5_-_101659864 1.083 NM_180991
SLCO4C1
solute carrier organic anion transporter family, member 4C1
chr6_+_72949092 1.073 RIMS1
regulating synaptic membrane exocytosis 1
chr2_+_171280182 1.060


chr13_-_78075683 1.056 NM_006237
POU4F1
POU class 4 homeobox 1
chr8_-_144583718 1.054 NM_201589
MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr10_-_73518269 1.042 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr17_-_44043361 1.031 NM_004502
HOXB7
homeobox B7
chr10_-_73518284 1.028 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chrX_-_131919896 1.024 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr11_-_31789334 1.022 PAX6
paired box 6
chr9_-_121171400 1.018 NM_014618
DBC1
deleted in bladder cancer 1
chr4_-_104860277 1.009 NM_001059
TACR3
tachykinin receptor 3
chr16_+_71256497 1.002


chr20_-_5048443 0.999 NM_182649
PCNA
proliferating cell nuclear antigen
chr2_-_50428395 0.996 NM_138735
NRXN1
neurexin 1
chr8_-_132122016 0.980 NM_001115
ADCY8
adenylate cyclase 8 (brain)
chr17_-_44043278 0.961 HOXB7
homeobox B7
chr11_-_31789360 0.959 PAX6
paired box 6
chr12_-_123965099 0.948 UBC
ubiquitin C
chr11_-_31789431 0.938 NM_000280
NM_001604
PAX6

paired box 6

chr7_+_113513726 0.938 FOXP2
forkhead box P2
chr7_+_113513828 0.934 FOXP2
forkhead box P2
chr10_-_73518315 0.930 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr9_-_78710698 0.925 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr12_-_79855618 0.924 NM_004664
LIN7A
lin-7 homolog A (C. elegans)
chr10_+_96295511 0.917 NM_018063
HELLS
helicase, lymphoid-specific
chr14_+_74418345 0.915 NM_001933
DLST
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
chr2_+_219141761 0.907 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr20_-_21326046 0.903 NM_033176
NKX2-4
NK2 homeobox 4
chr15_+_45263517 0.894 NM_001198999
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr10_-_99521701 0.894 NM_003015
SFRP5
secreted frizzled-related protein 5
chr12_+_4788602 0.889 NM_002235
KCNA6
potassium voltage-gated channel, shaker-related subfamily, member 6
chr9_-_119217128 0.885 NM_014010
ASTN2
astrotactin 2
chr6_-_3102690 0.878 NM_001069
TUBB2A
tubulin, beta 2A
chr19_-_6453224 0.869 NM_006087
TUBB4
tubulin, beta 4
chr12_-_79855580 0.865 LIN7A
lin-7 homolog A (C. elegans)
chr14_+_37748345 0.863 SSTR1
somatostatin receptor 1
chr6_+_27941012 0.853 NM_003511
HIST1H2AI
HIST1H2AL
histone cluster 1, H2ai
histone cluster 1, H2al
chr14_-_20642214 0.844


chr13_+_48692472 0.840 NM_001507
MLNR
motilin receptor
chr12_-_1983845 0.838 NM_152640
DCP1B
DCP1 decapping enzyme homolog B (S. cerevisiae)
chr1_+_238321794 0.835 NM_020066
FMN2
formin 2
chr9_-_23811808 0.816 ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr18_+_48121067 0.808 DCC
deleted in colorectal carcinoma
chr9_-_23811842 0.804 NM_001171195
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chrX_-_135677022 0.803 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr1_-_29321599 0.794 NM_001171868
TMEM200B
transmembrane protein 200B
chr11_-_31789168 0.791 PAX6
paired box 6
chrX_-_139414890 0.788 NM_005634
SOX3
SRY (sex determining region Y)-box 3
chr15_+_39008822 0.785 NM_019074
DLL4
delta-like 4 (Drosophila)
chr9_-_119217147 0.783 ASTN2
astrotactin 2
chr2_-_667367 0.776 NM_152834
TMEM18
transmembrane protein 18
chr22_-_40194602 0.774 NM_032758
PHF5A
PHD finger protein 5A
chr11_-_117252541 0.774 FXYD6
FXYD domain containing ion transport regulator 6
chr7_-_19123765 0.763 TWIST1
twist homolog 1 (Drosophila)
chr6_-_27914095 0.762 NM_003510
HIST1H2AK
histone cluster 1, H2ak
chr8_-_95634845 0.752 NM_015496
NM_183009
KIAA1429

KIAA1429

chr3_+_140148765 0.750 NM_001040061
C3orf72
chromosome 3 open reading frame 72
chr1_+_93317374 0.748 NM_001164391
NM_001164392
NM_001164393
NM_007358
MTF2



metal response element binding transcription factor 2



chr19_-_44386731 0.748 NM_001080468
SYCN
syncollin
chr12_+_5411534 0.746 NM_001102654
NTF3
neurotrophin 3
chr2_-_139254273 0.745 NM_007226
NXPH2
neurexophilin 2
chr2_+_172658453 0.743 NM_001038493
NM_178120
DLX1

distal-less homeobox 1

chr3_+_138965844 0.740 SOX14
SRY (sex determining region Y)-box 14
chr3_-_140148671 0.727 NM_023067
FOXL2
forkhead box L2
chr2_-_164300758 0.727 NM_018086
FIGN
fidgetin
chr13_+_102047286 0.725 NM_003291
TPP2
tripeptidyl peptidase II
chr17_-_47591691 0.724 CA10
carbonic anhydrase X
chr10_+_115793795 0.711 NM_000684
ADRB1
adrenergic, beta-1-, receptor
chr7_-_19123787 0.711 NM_000474
TWIST1
twist homolog 1 (Drosophila)
chr10_-_132999798 0.704 TCERG1L
transcription elongation regulator 1-like
chr13_+_44592647 0.691 GTF2F2
general transcription factor IIF, polypeptide 2, 30kDa
chr1_+_3558958 0.690 NM_005427
TP73
tumor protein p73
chr12_-_9492030 0.690 DDX11
DDX12
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12
chr3_+_135996990 0.687 EPHB1
EPH receptor B1
chr7_+_3307445 0.679 NM_152744
SDK1
sidekick homolog 1, cell adhesion molecule (chicken)
chr2_-_175754366 0.678 NM_001002258
NM_001190329
NM_001689
ATP5G3


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)


chr3_+_54131731 0.674 NM_018398
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr2_+_15998090 0.672 NM_005378
MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr16_-_2767129 0.672 NM_007108
NM_207013
TCEB2

transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)

chr10_+_60606352 0.671 NM_032439
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr10_-_60606195 0.667


chr17_+_40089270 0.666 NM_001145080
C17orf104
chromosome 17 open reading frame 104
chr2_+_15998010 0.665 MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr2_+_233206208 0.663 EFHD1
EF-hand domain family, member D1
chr4_-_56197115 0.657 NM_006681
NMU
neuromedin U
chr2_+_219532590 0.654 NM_003936
CDK5R2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr6_-_116681863 0.644 NM_021648
TSPYL4
TSPY-like 4
chr7_+_88226617 0.640 NM_181646
ZNF804B
zinc finger protein 804B
chr6_-_144370947 0.639 PLAGL1
pleiomorphic adenoma gene-like 1
chr15_+_43510054 0.634 NM_032413
NM_197955
C15orf48

chromosome 15 open reading frame 48

chr22_+_33983444 0.634 NM_001003681
HMGXB4
HMG box domain containing 4
chr22_+_34126104 0.633 NM_006739
MCM5
minichromosome maintenance complex component 5
chr8_+_128817658 0.631 MYC
v-myc myelocytomatosis viral oncogene homolog (avian)
chr12_-_43555607 0.623 NM_001145109
NELL2
NEL-like 2 (chicken)
chr22_+_34126154 0.623 MCM5
minichromosome maintenance complex component 5
chr2_+_233206181 0.610 EFHD1
EF-hand domain family, member D1
chrX_-_64171317 0.608 NM_001178032
ZC4H2
zinc finger, C4H2 domain containing
chr9_-_112840064 0.608 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chr4_+_55218663 0.604 NM_000222
NM_001093772
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr10_+_60606514 0.600 PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr3_+_54131613 0.598 CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr2_+_177785667 0.597 NM_194247
HNRNPA3P1
HNRNPA3
heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
heterogeneous nuclear ribonucleoprotein A3
chr20_+_2030527 0.595 NM_080836
STK35
serine/threonine kinase 35
chr17_+_26183074 0.591 NM_024857
ATAD5
ATPase family, AAA domain containing 5
chrX_+_82649924 0.591 NM_000307
POU3F4
POU class 3 homeobox 4
chr14_+_34521854 0.590 NM_001146282
NM_003136
SRP54

signal recognition particle 54kDa

chr14_+_34521945 0.587 SRP54
signal recognition particle 54kDa
chr17_-_47591123 0.577 NM_020178
CA10
carbonic anhydrase X
chr8_-_24869945 0.576 NM_006158
NEFL
neurofilament, light polypeptide
chr13_+_33290254 0.575 RFC3
replication factor C (activator 1) 3, 38kDa
chr2_-_144991386 0.574 ZEB2
zinc finger E-box binding homeobox 2
chr15_+_22751162 0.572 NM_003097
NM_022804
NM_005678
SNRPN
SNURF

small nuclear ribonucleoprotein polypeptide N
SNRPN upstream reading frame

chr2_-_219566364 0.568 NM_005209
NM_057093
NM_057094
CRYBA2


crystallin, beta A2


chr16_+_65756138 0.568 HSF4
heat shock transcription factor 4
chr2_+_48395271 0.566 NM_002158
FOXN2
forkhead box N2
chr14_+_28306633 0.565 FOXG1
forkhead box G1
chr2_-_144991556 0.564 ZEB2
zinc finger E-box binding homeobox 2
chr10_+_22580992 0.564


chr1_-_25129354 0.563 NM_004350
RUNX3
runt-related transcription factor 3
chr16_+_69115225 0.560 SF3B3
splicing factor 3b, subunit 3, 130kDa
chr4_+_39734902 0.554 NM_018177
N4BP2
NEDD4 binding protein 2
chr14_-_20807346 0.553 NM_001077442
NM_001077443
NM_004500
NM_031314
HNRNPC



heterogeneous nuclear ribonucleoprotein C (C1/C2)



chr3_+_135996734 0.550 NM_004441
EPHB1
EPH receptor B1
chr16_-_87535106 0.550 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr20_+_34357604 0.549 DLGAP4
discs, large (Drosophila) homolog-associated protein 4
chr10_+_106391032 0.549 SORCS3
sortilin-related VPS10 domain containing receptor 3
chr9_+_831689 0.548 NM_021951
DMRT1
doublesex and mab-3 related transcription factor 1
chr17_-_47591949 0.543 CA10
carbonic anhydrase X
chrX_+_101792949 0.540 NM_001099410
NM_001099411
NM_014710
NM_001184727
GPRASP1



G protein-coupled receptor associated sorting protein 1



chr6_+_1336077 0.539


chr6_+_14033402 0.538 NM_001165033
RNF182
ring finger protein 182
chr3_-_134863316 0.538 NM_007027
TOPBP1
topoisomerase (DNA) II binding protein 1
chr17_+_62391216 0.537 NM_014405
CACNG4
calcium channel, voltage-dependent, gamma subunit 4
chr22_-_42589543 0.536 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr10_-_132999973 0.536 NM_174937
TCERG1L
transcription elongation regulator 1-like
chr16_+_69115189 0.534 NM_012426
SF3B3
splicing factor 3b, subunit 3, 130kDa
chr5_+_122452739 0.532 NM_001136239
PRDM6
PR domain containing 6
chr2_-_232037454 0.532 NCL
nucleolin
chr2_-_70848621 0.531 NM_001185055
NM_001617
NM_017482
NM_017488
ADD2



adducin 2 (beta)



chr16_-_23515104 0.526 NM_005003
NDUFAB1
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
chr15_+_42507123 0.526 CTDSPL2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr16_+_65756084 0.525 HSF4
heat shock transcription factor 4
chr5_-_132976121 0.525 NM_015082
FSTL4
follistatin-like 4
chr8_-_144862266 0.523 NM_001162914
LOC100130274
coiled-coil domain containing 121-like
chr16_+_85101605 0.520 NM_001451
FOXF1
forkhead box F1
chr13_+_99432258 0.517 NM_007129
ZIC2
Zic family member 2 (odd-paired homolog, Drosophila)
chr4_+_106287391 0.516 NM_001127208
NM_017628
TET2

tet oncogene family member 2

chr17_+_35277942 0.515 NM_198844
NM_199321
ZPBP2

zona pellucida binding protein 2

chr2_+_233206450 0.513 NM_025202
EFHD1
EF-hand domain family, member D1
chr6_+_99389300 0.513 NM_005604
POU3F2
POU class 3 homeobox 2
chr19_+_868285 0.506 NM_032551
KISS1R
KISS1 receptor
chr3_+_113180517 0.505 NM_018394
ABHD10
abhydrolase domain containing 10
chr2_-_202811459 0.500 NM_001005781
NM_001005782
NM_003352
SUMO1


SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)


chr3_+_144321286 0.498 NM_004267
CHST2
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
chr15_+_28705656 0.495 ARHGAP11B
Rho GTPase activating protein 11B
chr13_+_97426713 0.495 IPO5
importin 5
chr16_+_69115227 0.493 SF3B3
splicing factor 3b, subunit 3, 130kDa
chr16_+_85101734 0.490 FOXF1
forkhead box F1
chr12_-_123965539 0.489 NM_021009
UBC
ubiquitin C
chr12_-_61830882 0.487 AVPR1A
arginine vasopressin receptor 1A
chr20_-_39199936 0.482


chr19_-_53832381 0.481 NM_001352
DBP
D site of albumin promoter (albumin D-box) binding protein
chr16_+_65756179 0.479 HSF4
heat shock transcription factor 4
chr2_-_225615556 0.476 NM_014689
DOCK10
dedicator of cytokinesis 10
chr2_+_210344972 0.475 UNC80
unc-80 homolog (C. elegans)
chr5_-_95793618 0.472 NM_001177875
PCSK1
proprotein convertase subtilisin/kexin type 1
chr17_-_16197433 0.471 NM_181716
CENPV
centromere protein V
chr1_+_66230977 0.470 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr13_-_72254071 0.468 NM_001128226
NM_014953
DIS3

DIS3 mitotic control homolog (S. cerevisiae)

chr5_+_50714714 0.467 NM_002202
ISL1
ISL LIM homeobox 1
chrX_+_104953215 0.466 NRK
Nik related kinase
chr19_-_11531003 0.465 NM_032377
ELOF1
elongation factor 1 homolog (S. cerevisiae)
chr17_-_43977273 0.463 NM_002145
HOXB2
homeobox B2
chr18_+_11841388 0.461 NM_020412
CHMP1B
chromatin modifying protein 1B

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.70 3.00e-23 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.76 5.50e-21 GO:0090304 nucleic acid metabolic process
1.45 3.93e-18 GO:0044260 cellular macromolecule metabolic process
1.56 7.01e-18 GO:0034641 cellular nitrogen compound metabolic process
1.53 1.42e-16 GO:0006807 nitrogen compound metabolic process
1.70 4.83e-13 GO:0016070 RNA metabolic process
1.15 5.19e-13 GO:0009987 cellular process
1.35 5.52e-13 GO:0043170 macromolecule metabolic process
1.29 1.21e-12 GO:0044237 cellular metabolic process
1.93 2.05e-12 GO:0007049 cell cycle
1.65 7.17e-12 GO:0010467 gene expression
2.10 6.56e-11 GO:0022403 cell cycle phase
1.48 2.06e-10 GO:0071841 cellular component organization or biogenesis at cellular level
1.97 4.39e-10 GO:0022402 cell cycle process
1.47 1.30e-09 GO:0071842 cellular component organization at cellular level
1.39 2.66e-09 GO:0071840 cellular component organization or biogenesis
1.25 2.72e-09 GO:0044238 primary metabolic process
1.39 3.40e-09 GO:0016043 cellular component organization
2.13 1.85e-08 GO:0016071 mRNA metabolic process
1.58 3.25e-08 GO:0034645 cellular macromolecule biosynthetic process
2.05 5.13e-08 GO:0000278 mitotic cell cycle
1.56 9.57e-08 GO:0009059 macromolecule biosynthetic process
1.69 1.15e-07 GO:0044085 cellular component biogenesis
1.20 1.96e-07 GO:0008152 metabolic process
1.97 2.69e-07 GO:0051276 chromosome organization
1.41 4.76e-07 GO:0031326 regulation of cellular biosynthetic process
2.24 6.09e-07 GO:0006397 mRNA processing
1.34 6.60e-07 GO:0080090 regulation of primary metabolic process
1.43 6.99e-07 GO:0044249 cellular biosynthetic process
1.93 7.36e-07 GO:0006396 RNA processing
1.43 7.68e-07 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.41 7.71e-07 GO:0008380 RNA splicing
2.83 9.75e-07 GO:0006260 DNA replication
1.40 1.00e-06 GO:0009889 regulation of biosynthetic process
1.33 1.05e-06 GO:0031323 regulation of cellular metabolic process
1.69 1.22e-06 GO:0022607 cellular component assembly
2.74 1.23e-06 GO:0000375 RNA splicing, via transesterification reactions
2.75 1.74e-06 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.75 1.74e-06 GO:0000398 nuclear mRNA splicing, via spliceosome
1.38 1.91e-06 GO:0051171 regulation of nitrogen compound metabolic process
1.34 2.21e-06 GO:0060255 regulation of macromolecule metabolic process
1.30 2.90e-06 GO:0019222 regulation of metabolic process
1.40 4.22e-06 GO:0010556 regulation of macromolecule biosynthetic process
2.32 4.35e-06 GO:0051325 interphase
3.28 4.67e-06 GO:0071824 protein-DNA complex subunit organization
1.38 4.71e-06 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.35 4.83e-06 GO:0065004 protein-DNA complex assembly
1.83 4.86e-06 GO:0065003 macromolecular complex assembly
1.39 8.58e-06 GO:0009058 biosynthetic process
3.41 1.05e-05 GO:0031497 chromatin assembly
1.68 1.17e-05 GO:0032774 RNA biosynthetic process
3.92 1.32e-05 GO:0006261 DNA-dependent DNA replication
1.38 1.32e-05 GO:0010468 regulation of gene expression
2.28 1.70e-05 GO:0051329 interphase of mitotic cell cycle
1.71 1.82e-05 GO:0006351 transcription, DNA-dependent
2.99 3.12e-05 GO:0006323 DNA packaging
1.71 3.17e-05 GO:0043933 macromolecular complex subunit organization
2.81 3.73e-05 GO:0071103 DNA conformation change
1.83 4.66e-05 GO:0051726 regulation of cell cycle
2.88 4.98e-05 GO:0006333 chromatin assembly or disassembly
2.10 5.86e-05 GO:0034622 cellular macromolecular complex assembly
1.85 6.62e-05 GO:0006259 DNA metabolic process
1.74 7.24e-05 GO:0071844 cellular component assembly at cellular level
1.47 8.90e-05 GO:0006996 organelle organization
1.38 1.02e-04 GO:0051252 regulation of RNA metabolic process
1.38 2.12e-04 GO:0006355 regulation of transcription, DNA-dependent
3.21 2.66e-04 GO:0006334 nucleosome assembly
1.17 2.77e-04 GO:0050794 regulation of cellular process
1.94 3.82e-04 GO:0000279 M phase
1.87 3.96e-04 GO:0034621 cellular macromolecular complex subunit organization
3.01 5.85e-04 GO:0034728 nucleosome organization
1.83 8.03e-04 GO:0006974 response to DNA damage stimulus
1.25 1.23e-03 GO:0032502 developmental process
2.00 1.61e-03 GO:0010564 regulation of cell cycle process
2.28 2.01e-03 GO:0000075 cell cycle checkpoint
2.25 2.07e-03 GO:0071156 regulation of cell cycle arrest
1.36 2.24e-03 GO:0048869 cellular developmental process
2.82 2.32e-03 GO:0051320 S phase
5.12 2.48e-03 GO:0006271 DNA strand elongation involved in DNA replication
1.43 3.08e-03 GO:0007399 nervous system development
1.14 4.33e-03 GO:0050789 regulation of biological process
2.76 5.65e-03 GO:0000084 S phase of mitotic cell cycle
4.78 6.01e-03 GO:0022616 DNA strand elongation
1.57 7.54e-03 GO:0033554 cellular response to stress
1.13 8.45e-03 GO:0065007 biological regulation
2.49 8.58e-03 GO:0000082 G1/S transition of mitotic cell cycle
1.24 9.19e-03 GO:0007275 multicellular organismal development
1.90 1.03e-02 GO:0007420 brain development
2.00 1.06e-02 GO:0000280 nuclear division
2.00 1.06e-02 GO:0007067 mitosis
1.34 1.11e-02 GO:0030154 cell differentiation
1.73 1.44e-02 GO:0007417 central nervous system development
5.19 1.75e-02 GO:0090329 regulation of DNA-dependent DNA replication
2.65 1.91e-02 GO:0051028 mRNA transport
1.25 2.00e-02 GO:0048856 anatomical structure development
1.94 2.32e-02 GO:0000087 M phase of mitotic cell cycle
1.51 2.51e-02 GO:0022008 neurogenesis
1.93 2.55e-02 GO:0048285 organelle fission
3.22 2.76e-02 GO:0031124 mRNA 3'-end processing
3.51 2.91e-02 GO:0051053 negative regulation of DNA metabolic process
2.53 3.03e-02 GO:0050657 nucleic acid transport
2.53 3.03e-02 GO:0050658 RNA transport
2.53 3.03e-02 GO:0051236 establishment of RNA localization
2.88 3.05e-02 GO:0006402 mRNA catabolic process
2.95 3.49e-02 GO:0000956 nuclear-transcribed mRNA catabolic process
5.37 3.65e-02 GO:2000104 negative regulation of DNA-dependent DNA replication
2.68 3.83e-02 GO:0007202 activation of phospholipase C activity
2.39 4.19e-02 GO:0006310 DNA recombination
1.85 4.44e-02 GO:0007389 pattern specification process
2.65 4.54e-02 GO:0010863 positive regulation of phospholipase C activity
1.71 4.77e-02 GO:0006325 chromatin organization
1.85 4.83e-02 GO:0006281 DNA repair

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.56 1.83e-43 GO:0005634 nucleus
1.27 7.36e-31 GO:0043226 organelle
1.30 3.77e-30 GO:0043227 membrane-bounded organelle
1.89 3.85e-30 GO:0044428 nuclear part
1.26 5.03e-30 GO:0043229 intracellular organelle
1.30 1.74e-29 GO:0043231 intracellular membrane-bounded organelle
1.21 1.78e-28 GO:0044424 intracellular part
1.19 2.33e-27 GO:0005622 intracellular
1.94 5.75e-27 GO:0031981 nuclear lumen
1.76 3.10e-23 GO:0070013 intracellular organelle lumen
1.74 2.08e-22 GO:0043233 organelle lumen
1.73 3.58e-22 GO:0031974 membrane-enclosed lumen
2.02 5.61e-22 GO:0005654 nucleoplasm
1.37 1.44e-19 GO:0044446 intracellular organelle part
1.37 2.21e-19 GO:0044422 organelle part
2.37 8.34e-15 GO:0005694 chromosome
1.42 1.74e-12 GO:0032991 macromolecular complex
2.29 8.85e-11 GO:0044427 chromosomal part
1.45 1.95e-10 GO:0043228 non-membrane-bounded organelle
1.45 1.95e-10 GO:0043232 intracellular non-membrane-bounded organelle
1.92 4.13e-09 GO:0044451 nucleoplasm part
2.56 1.62e-07 GO:0000785 chromatin
1.05 1.73e-07 GO:0044464 cell part
1.05 1.80e-07 GO:0005623 cell
2.00 3.15e-07 GO:0030529 ribonucleoprotein complex
2.55 6.37e-07 GO:0016604 nuclear body
3.32 6.15e-06 GO:0032993 protein-DNA complex
3.85 3.14e-05 GO:0000786 nucleosome
2.39 3.46e-05 GO:0000228 nuclear chromosome
2.78 4.99e-05 GO:0005681 spliceosomal complex
1.27 9.55e-04 GO:0043234 protein complex
1.75 1.13e-03 GO:0005730 nucleolus
2.25 4.51e-03 GO:0044454 nuclear chromosome part
2.87 8.65e-03 GO:0071013 catalytic step 2 spliceosome
2.45 9.27e-03 GO:0016607 nuclear speck

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.60 7.71e-24 GO:0003676 nucleic acid binding
1.65 6.99e-18 GO:0003677 DNA binding
1.14 7.47e-15 GO:0005488 binding
1.25 2.53e-13 GO:0005515 protein binding
1.74 3.67e-08 GO:0001071 nucleic acid binding transcription factor activity
1.74 3.67e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
1.73 2.56e-06 GO:0003723 RNA binding
1.79 5.74e-06 GO:0043565 sequence-specific DNA binding
1.63 6.30e-06 GO:0030528 transcription regulator activity
2.39 3.05e-04 GO:0043566 structure-specific DNA binding
2.65 3.61e-04 GO:0003690 double-stranded DNA binding
3.26 5.37e-04 GO:0003729 mRNA binding
1.30 3.90e-03 GO:0000166 nucleotide binding
4.53 7.39e-03 GO:0034061 DNA polymerase activity
9.95 1.51e-02 GO:0032135 DNA insertion or deletion binding
4.59 1.62e-02 GO:0003887 DNA-directed DNA polymerase activity