Motif ID: E2F1..5.p2

Z-value: 1.931


Transcription factors associated with E2F1..5.p2:

Gene SymbolEntrez IDGene Name
E2F1 1869 E2F transcription factor 1
E2F2 1870 E2F transcription factor 2
E2F3 1871 E2F transcription factor 3
E2F4 1874 E2F transcription factor 4, p107/p130-binding
E2F5 1875 E2F transcription factor 5, p130-binding

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
E2F4chr16_+_657835990.505.0e-02Click!
E2F3chr6_+_205100190.273.2e-01Click!
E2F5chr8_+_86287161-0.263.4e-01Click!
E2F2chr1_-_237298710.204.7e-01Click!
E2F1chr20_-_317377310.185.0e-01Click!


Activity profile for motif E2F1..5.p2.

activity profile for motif E2F1..5.p2


Sorted Z-values histogram for motif E2F1..5.p2

Sorted Z-values for motif E2F1..5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F1..5.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_131652007 2.091 NM_001005463
 EBF3
early B-cell factor 3
chr4_+_72271218 1.991 NM_001098484
NM_001134742
 SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr6_+_135544214 1.920 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr10_+_124885556 1.787 NM_001105574
 HMX3
H6 family homeobox 3
chr10_-_131652364 1.679 EBF3
early B-cell factor 3
chr8_+_31616809 1.470 NM_013962
 NRG1
neuregulin 1
chr19_-_62043867 1.319 NM_001146326
NM_001146327
NM_015363
NM_001146184
NM_001146185
NM_001146187
NM_006210
 ZIM2


PEG3



zinc finger, imprinted 2


paternally expressed 3



chr7_+_98084531 1.292 NM_002523
 NPTX2
neuronal pentraxin II
chr7_+_113513600 1.282 FOXP2
forkhead box P2
chr18_-_68361742 1.263 CBLN2
cerebellin 2 precursor
chr6_+_135544170 1.259 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr7_+_50314801 1.257 NM_006060
 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr17_-_44042924 1.256 HOXB7
homeobox B7
chr6_+_135544138 1.219 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
 MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr3_-_124650081 1.203 NM_183357
 ADCY5
adenylate cyclase 5
chr14_+_50776635 1.196 NM_030755
 TMX1
thioredoxin-related transmembrane protein 1
chr8_+_65656164 1.179 BHLHE22
basic helix-loop-helix family, member e22
chr3_+_148609841 1.145 NM_003412
 ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr9_-_103540682 1.132 NM_133445
 GRIN3A
glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
chr15_+_64782468 1.119 SMAD6
SMAD family member 6

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 112 entries
enrichment   p-value GO term description
5.37 3.65e-02 GO:2000104 negative regulation of DNA-dependent DNA replication
5.19 1.75e-02 GO:0090329 regulation of DNA-dependent DNA replication
5.12 2.48e-03 GO:0006271 DNA strand elongation involved in DNA replication
4.78 6.01e-03 GO:0022616 DNA strand elongation
3.92 1.32e-05 GO:0006261 DNA-dependent DNA replication
3.51 2.91e-02 GO:0051053 negative regulation of DNA metabolic process
3.41 1.05e-05 GO:0031497 chromatin assembly
3.35 4.83e-06 GO:0065004 protein-DNA complex assembly
3.28 4.67e-06 GO:0071824 protein-DNA complex subunit organization
3.22 2.76e-02 GO:0031124 mRNA 3'-end processing
3.21 2.66e-04 GO:0006334 nucleosome assembly
3.01 5.85e-04 GO:0034728 nucleosome organization
2.99 3.12e-05 GO:0006323 DNA packaging
2.95 3.49e-02 GO:0000956 nuclear-transcribed mRNA catabolic process
2.88 4.98e-05 GO:0006333 chromatin assembly or disassembly
2.88 3.05e-02 GO:0006402 mRNA catabolic process
2.83 9.75e-07 GO:0006260 DNA replication
2.82 2.32e-03 GO:0051320 S phase
2.81 3.73e-05 GO:0071103 DNA conformation change
2.76 5.65e-03 GO:0000084 S phase of mitotic cell cycle

Gene overrepresentation in compartment category:

Showing 1 to 20 of 35 entries
enrichment   p-value GO term description
3.85 3.14e-05 GO:0000786 nucleosome
3.32 6.15e-06 GO:0032993 protein-DNA complex
2.87 8.65e-03 GO:0071013 catalytic step 2 spliceosome
2.78 4.99e-05 GO:0005681 spliceosomal complex
2.56 1.62e-07 GO:0000785 chromatin
2.55 6.37e-07 GO:0016604 nuclear body
2.45 9.27e-03 GO:0016607 nuclear speck
2.39 3.46e-05 GO:0000228 nuclear chromosome
2.37 8.34e-15 GO:0005694 chromosome
2.29 8.85e-11 GO:0044427 chromosomal part
2.25 4.51e-03 GO:0044454 nuclear chromosome part
2.02 5.61e-22 GO:0005654 nucleoplasm
2.00 3.15e-07 GO:0030529 ribonucleoprotein complex
1.94 5.75e-27 GO:0031981 nuclear lumen
1.92 4.13e-09 GO:0044451 nucleoplasm part
1.89 3.85e-30 GO:0044428 nuclear part
1.76 3.10e-23 GO:0070013 intracellular organelle lumen
1.75 1.13e-03 GO:0005730 nucleolus
1.74 2.08e-22 GO:0043233 organelle lumen
1.73 3.58e-22 GO:0031974 membrane-enclosed lumen

Gene overrepresentation in function category:

Showing 1 to 16 of 16 entries
enrichment   p-value GO term description
9.95 1.51e-02 GO:0032135 DNA insertion or deletion binding
4.59 1.62e-02 GO:0003887 DNA-directed DNA polymerase activity
4.53 7.39e-03 GO:0034061 DNA polymerase activity
3.26 5.37e-04 GO:0003729 mRNA binding
2.65 3.61e-04 GO:0003690 double-stranded DNA binding
2.39 3.05e-04 GO:0043566 structure-specific DNA binding
1.79 5.74e-06 GO:0043565 sequence-specific DNA binding
1.74 3.67e-08 GO:0001071 nucleic acid binding transcription factor activity
1.74 3.67e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
1.73 2.56e-06 GO:0003723 RNA binding
1.65 6.99e-18 GO:0003677 DNA binding
1.63 6.30e-06 GO:0030528 transcription regulator activity
1.60 7.71e-24 GO:0003676 nucleic acid binding
1.30 3.90e-03 GO:0000166 nucleotide binding
1.25 2.53e-13 GO:0005515 protein binding
1.14 7.47e-15 GO:0005488 binding