Motif ID: NFIX.p2

Z-value: 0.924


Transcription factors associated with NFIX.p2:

Gene SymbolEntrez IDGene Name
NFIX 4784 nuclear factor I/X (CCAAT-binding transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFIXchr19_+_129669700.674.2e-03Click!


Activity profile for motif NFIX.p2.

activity profile for motif NFIX.p2


Sorted Z-values histogram for motif NFIX.p2

Sorted Z-values for motif NFIX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFIX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr21_+_44818033 1.353 NM_198687
KRTAP10-4
keratin associated protein 10-4
chr12_+_50271283 0.991 NM_014191
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr3_-_46481346 0.961 NM_002343
LTF
lactotransferrin
chr12_+_48641545 0.943 NM_001651
AQP5
aquaporin 5
chr9_-_139183675 0.848


chr21_+_44941514 0.829 NM_198699
KRTAP10-12
keratin associated protein 10-12
chr1_+_43769065 0.817 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr1_+_226261374 0.804 NM_033131
WNT3A
wingless-type MMTV integration site family, member 3A
chr19_-_1188840 0.787 NM_152769
C19orf26
chromosome 19 open reading frame 26
chr5_+_169713458 0.737 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr1_+_43386180 0.731 NM_001101376
FAM183A
family with sequence similarity 183, member A
chr1_+_24701886 0.724 NM_013441
RCAN3
RCAN family member 3
chr21_-_44836811 0.702 NM_198688
KRTAP10-6
keratin associated protein 10-6
chr21_+_44844924 0.691 NM_198689
KRTAP10-7
keratin associated protein 10-7
chr7_+_65307816 0.690 TPST1
tyrosylprotein sulfotransferase 1
chr17_-_25587079 0.681 NM_001045
SLC6A4
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
chr21_+_44890758 0.641 NM_198692
KRTAP10-11
keratin associated protein 10-11
chr1_+_219026661 0.636 NM_022746
MOSC1
MOCO sulphurase C-terminal domain containing 1
chr4_+_3264509 0.626 RGS12
regulator of G-protein signaling 12
chr1_-_150232900 0.617 S100A10
S100 calcium binding protein A10
chr1_-_150232927 0.603 S100A10
S100 calcium binding protein A10
chr1_+_31658549 0.592 NM_178865
SERINC2
serine incorporator 2
chr19_+_4442610 0.582 HDGFRP2
hepatoma-derived growth factor-related protein 2
chrX_+_150482662 0.581 NM_173493
PASD1
PAS domain containing 1
chr3_-_46710137 0.576 NM_001190707
NM_147129
ALS2CL

ALS2 C-terminal like

chr15_+_61123327 0.575 TPM1
tropomyosin 1 (alpha)
chrX_-_135941498 0.574 NM_054021
GPR101
G protein-coupled receptor 101
chr21_+_44871467 0.574 NM_198690
KRTAP10-9
keratin associated protein 10-9
chr3_-_41978464 0.561 NM_017886
ULK4
unc-51-like kinase 4 (C. elegans)
chr11_-_67163600 0.547 NM_005995
TBX10
T-box 10
chr1_+_157408000 0.542 NM_021189
NM_001127173
CADM3

cell adhesion molecule 3

chr21_-_44795769 0.539 NM_198693
KRTAP10-2
keratin associated protein 10-2
chr7_+_65307691 0.539 NM_003596
TPST1
tyrosylprotein sulfotransferase 1
chr4_-_85638410 0.528 NM_006168
NKX6-1
NK6 homeobox 1
chr7_-_100262971 0.523 NM_004444
EPHB4
EPH receptor B4
chr7_-_100630912 0.515 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chrX_-_101658297 0.508 NM_021992
TMSB15A
TMSB15B
thymosin beta 15a
thymosin beta 15B
chr8_-_41286088 0.504 NM_003012
SFRP1
secreted frizzled-related protein 1
chr4_-_99798563 0.501 NM_005723
TSPAN5
tetraspanin 5
chr21_+_44881700 0.491 NM_181688
KRTAP10-10
keratin associated protein 10-10
chr21_-_44803049 0.482 NM_198696
KRTAP10-3
keratin associated protein 10-3
chr1_+_226741665 0.479 NM_001010858
RNF187
ring finger protein 187
chr1_+_44357108 0.458 NM_173484
KLF17
Kruppel-like factor 17
chrX_+_10084984 0.454 NM_001830
CLCN4
chloride channel 4
chr19_-_15869870 0.454 NM_001082
CYP4F2
cytochrome P450, family 4, subfamily F, polypeptide 2
chr15_+_65217412 0.445 NM_001145103
SMAD3
SMAD family member 3
chr1_-_150233337 0.441 NM_002966
S100A10
S100 calcium binding protein A10
chr1_-_1840564 0.425 NM_178545
TMEM52
transmembrane protein 52
chr1_+_891739 0.425 NM_001160184
NM_032129
PLEKHN1

pleckstrin homology domain containing, family N member 1

chr1_+_41022066 0.421 NM_004700
NM_172163
KCNQ4

potassium voltage-gated channel, KQT-like subfamily, member 4

chr3_+_32408346 0.417 CMTM7
CKLF-like MARVEL transmembrane domain containing 7
chr1_+_31659246 0.409 NM_001199039
NM_018565
SERINC2

serine incorporator 2

chr19_-_51829778 0.407 NM_033258
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr17_-_77868659 0.405 NM_006137
CD7
CD7 molecule
chr14_-_99842519 0.398 NM_001039355
SLC25A29
solute carrier family 25, member 29
chr21_+_32706615 0.386 NM_058187
C21orf63
chromosome 21 open reading frame 63
chrX_+_71047344 0.384 NM_001013627
NHSL2
NHS-like 2
chr5_-_38592439 0.381 NM_001127671
LIFR
leukemia inhibitory factor receptor alpha
chr15_+_72253940 0.377 NM_201526
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr8_+_22465368 0.365 SORBS3
sorbin and SH3 domain containing 3
chr10_-_14856901 0.365 NM_031453
FAM107B
family with sequence similarity 107, member B
chr3_-_162305319 0.364 NM_033169
NM_001038628
NM_003781
NM_033167
NM_033168
B3GALNT1




beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)




chr15_+_61122957 0.364 TPM1
tropomyosin 1 (alpha)
chr4_+_146622154 0.357 NM_005900
SMAD1
SMAD family member 1
chr19_-_2979901 0.354 NM_003260
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr7_-_71439678 0.349 CALN1
calneuron 1
chr4_+_156899575 0.343 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr9_-_38059082 0.335 SHB
Src homology 2 domain containing adaptor protein B
chr1_-_205272619 0.330 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr12_+_62523648 0.330


chr10_+_73393998 0.328 NM_004273
CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
chr1_+_208569262 0.325 NM_001170580
HHAT
hedgehog acyltransferase
chr16_+_3010311 0.324 NM_016639
TNFRSF12A
tumor necrosis factor receptor superfamily, member 12A
chr3_+_139550368 0.320 MRAS
muscle RAS oncogene homolog
chr14_-_77034853 0.317 NM_182509
NM_199296
ISM2

isthmin 2 homolog (zebrafish)

chr12_-_51281482 0.317 NM_001146225
NM_001146226
NM_080747
KRT72


keratin 72


chr21_-_44784499 0.315 NM_198691
KRTAP10-1
keratin associated protein 10-1
chr4_+_77446700 0.309 NM_003943
STBD1
starch binding domain 1
chr5_+_34692124 0.309 NM_001145522
NM_015577
RAI14

retinoic acid induced 14

chr1_+_229365296 0.308 NM_001004342
TRIM67
tripartite motif containing 67
chr1_+_24701363 0.308 RCAN3
RCAN family member 3
chr11_-_117200618 0.307 NM_001127489
NM_001680
FXYD2

FXYD domain containing ion transport regulator 2

chr10_-_42183441 0.305 LOC283027
hypothetical protein LOC283027
chr19_-_46048033 0.305 NM_000762
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr22_-_49041786 0.304 MAPK12
mitogen-activated protein kinase 12
chr1_-_38003391 0.301 NM_001099439
NM_173641
EPHA10

EPH receptor A10

chr1_+_18680010 0.299 NM_152375
KLHDC7A
kelch domain containing 7A
chr1_-_112083387 0.298 NM_019099
C1orf183
chromosome 1 open reading frame 183
chr14_+_102458745 0.297 NM_030943
AMN
amnionless homolog (mouse)
chr2_-_231498184 0.292 NM_005683
GPR55
G protein-coupled receptor 55
chr15_+_48261649 0.286 NM_001159629
NM_003645
SLC27A2

solute carrier family 27 (fatty acid transporter), member 2

chr1_-_20122638 0.286 NM_014589
PLA2G2E
phospholipase A2, group IIE
chr5_+_34692352 0.285 NM_001145520
RAI14
retinoic acid induced 14
chr9_-_129707392 0.284 LOC100131355
ST6GALNAC6
hypothetical protein LOC100131355
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chrX_-_43626537 0.280 NM_000898
MAOB
monoamine oxidase B
chr9_-_21549696 0.280 LOC554202
hypothetical LOC554202
chr1_+_156417302 0.279 CD1D
CD1d molecule
chr5_+_122452739 0.278 NM_001136239
PRDM6
PR domain containing 6
chr3_+_139550134 0.275 NM_001085049
MRAS
muscle RAS oncogene homolog
chr1_-_31484986 0.273 NKAIN1
Na+/K+ transporting ATPase interacting 1
chr5_-_176868483 0.273 DOK3
docking protein 3
chr1_-_21821597 0.270 RAP1GAP
RAP1 GTPase activating protein
chr3_+_32408155 0.266 NM_138410
NM_181472
CMTM7

CKLF-like MARVEL transmembrane domain containing 7

chr11_-_30564338 0.266 NM_001145399
MPPED2
metallophosphoesterase domain containing 2
chrX_-_107866262 0.265 NM_003604
IRS4
insulin receptor substrate 4
chr15_+_89570333 0.263 SV2B
synaptic vesicle glycoprotein 2B
chr7_+_117651947 0.262 NM_019644
ANKRD7
ankyrin repeat domain 7
chr16_+_88512769 0.261 MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chr3_+_35656012 0.258 ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr19_-_15906669 0.256 NM_001128932
NM_021187
CYP4F11

cytochrome P450, family 4, subfamily F, polypeptide 11

chr20_+_42777419 0.255 WISP2
WNT1 inducible signaling pathway protein 2
chr4_+_166097548 0.252 NM_153027
C4orf39
chromosome 4 open reading frame 39
chr5_+_34692239 0.252 RAI14
retinoic acid induced 14
chr17_+_21220260 0.251 NM_021012
KCNJ12
potassium inwardly-rectifying channel, subfamily J, member 12
chr1_-_206484258 0.251 NM_025179
PLXNA2
plexin A2
chr21_-_42247007 0.250 NM_015500
C2CD2
C2 calcium-dependent domain containing 2
chr10_+_102782151 0.250 SFXN3
sideroflexin 3
chr19_+_44838373 0.250 NM_001190441
LGALS16
beta-galactoside-binding lectin
chr6_+_3696224 0.249


chr10_-_124703683 0.248 NM_024942
C10orf88
chromosome 10 open reading frame 88
chr11_+_125262164 0.248 NM_001134793
HYLS1
hydrolethalus syndrome 1
chr10_+_69990050 0.247 NM_030625
TET1
tet oncogene 1
chr1_+_199975563 0.246 NM_001167738
NAV1
neuron navigator 1
chr4_-_2336328 0.245 NM_001172659
NM_001172660
ZFYVE28

zinc finger, FYVE domain containing 28

chr19_+_3659358 0.245 TJP3
tight junction protein 3 (zona occludens 3)
chr4_+_191229360 0.242 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr11_+_113280727 0.241 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr11_-_70837090 0.240 NM_001163817
NM_001360
DHCR7

7-dehydrocholesterol reductase

chr1_-_31485320 0.237 NM_024522
NKAIN1
Na+/K+ transporting ATPase interacting 1
chr11_-_73700257 0.236 NM_182904
P4HA3
prolyl 4-hydroxylase, alpha polypeptide III
chr19_+_5406411 0.236 NM_181710
ZNRF4
zinc and ring finger 4
chr11_-_46678736 0.235 ARHGAP1
Rho GTPase activating protein 1
chr22_-_17517795 0.234 NM_005315
GSC2
goosecoid homeobox 2
chr4_+_77446906 0.233 STBD1
starch binding domain 1
chr11_-_2863536 0.233 NM_000076
NM_001122630
NM_001122631
CDKN1C


cyclin-dependent kinase inhibitor 1C (p57, Kip2)


chr22_+_37193961 0.233 NM_006855
NM_016657
KDELR3

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3

chrX_-_100070553 0.232 NM_212559
XKRX
XK, Kell blood group complex subunit-related, X-linked
chr1_+_20788027 0.231 NM_001785
CDA
cytidine deaminase
chr4_+_166097579 0.228 C4orf39
chromosome 4 open reading frame 39
chr13_+_112670757 0.228 NM_001112732
MCF2L
MCF.2 cell line derived transforming sequence-like
chr1_-_6448737 0.228 NM_001039664
NM_003790
NM_148965
NM_148966
NM_148967
NM_148970
TNFRSF25





tumor necrosis factor receptor superfamily, member 25





chr18_+_70352779 0.228 CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr3_+_10265169 0.227 NM_014760
TATDN2
TatD DNase domain containing 2
chr10_-_725522 0.227 NM_014974
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr3_+_50279993 0.225 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr11_-_46678715 0.225 ARHGAP1
Rho GTPase activating protein 1
chr6_+_150326802 0.225 NM_025218
ULBP1
UL16 binding protein 1
chr16_+_3002457 0.224 NM_020982
CLDN9
claudin 9
chr22_+_28446288 0.223 NM_182527
CABP7
calcium binding protein 7
chr22_+_21852699 0.223 BCR
breakpoint cluster region
chr11_-_75057299 0.222 MAP6
microtubule-associated protein 6
chr17_+_58908152 0.221 NM_000789
ACE
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr14_-_88948486 0.220 FOXN3
forkhead box N3
chr4_-_174492029 0.220 NM_001130688
NM_002129
HMGB2

high-mobility group box 2

chr1_+_47037256 0.220 NM_000779
NM_001099772
CYP4B1

cytochrome P450, family 4, subfamily B, polypeptide 1

chr4_+_14614462 0.219 CPEB2
cytoplasmic polyadenylation element binding protein 2
chr22_+_21870293 0.218


chr11_-_70837019 0.216 DHCR7
7-dehydrocholesterol reductase
chrX_-_68301974 0.215 NM_001032396
NM_022368
NM_145119
PJA1


praja ring finger 1


chr22_+_38720881 0.214 NM_138435
FAM83F
family with sequence similarity 83, member F
chr11_-_64582568 0.214 NM_005468
NAALADL1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr10_-_128884411 0.213 NM_001039762
FAM196A
family with sequence similarity 196, member A
chr17_-_68100537 0.213 LOC100499467
hypothetical LOC100499467
chr11_-_46678691 0.213 NM_004308
ARHGAP1
Rho GTPase activating protein 1
chr1_+_199975674 0.211 NAV1
neuron navigator 1
chr12_+_112344529 0.209 NM_138432
SDSL
serine dehydratase-like
chr4_-_24641404 0.208 NM_018176
LGI2
leucine-rich repeat LGI family, member 2
chr7_+_142723340 0.206 NM_000083
CLCN1
chloride channel 1, skeletal muscle
chr5_+_178300799 0.204 NM_001178089
NM_001178090
NM_182594
ZNF454


zinc finger protein 454


chr5_-_159478967 0.203 NM_001130864
NM_052927
PWWP2A

PWWP domain containing 2A

chr6_-_109437445 0.201 SESN1
sestrin 1
chr11_-_68537243 0.200 NM_001098515
NM_145015
MRGPRF

MAS-related GPR, member F

chr2_+_43919606 0.200 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr12_+_130761548 0.199 SFSWAP
splicing factor, suppressor of white-apricot homolog (Drosophila)
chr8_+_24827173 0.198 NM_005382
NEFM
neurofilament, medium polypeptide
chr2_-_241484245 0.197 NM_001085437
C2orf54
chromosome 2 open reading frame 54
chr1_+_77105709 0.196 ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr10_+_14960787 0.196 NM_001193424
NM_001193426
NM_001193425
NM_001193427
NM_024670
SUV39H2




suppressor of variegation 3-9 homolog 2 (Drosophila)




chr10_+_72749050 0.196 SLC29A3
solute carrier family 29 (nucleoside transporters), member 3
chr17_-_4589387 0.196 CXCL16
chemokine (C-X-C motif) ligand 16
chr15_+_65145215 0.194 SMAD3
SMAD family member 3
chr4_-_154900466 0.194


chr1_-_27565412 0.194 MAP3K6
mitogen-activated protein kinase kinase kinase 6
chr7_+_145444385 0.194 NM_014141
CNTNAP2
contactin associated protein-like 2
chrX_+_153423652 0.193 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr3_+_10265204 0.193 TATDN2
TatD DNase domain containing 2
chr1_+_35031185 0.193 NM_002060
GJA4
gap junction protein, alpha 4, 37kDa
chr17_+_19222651 0.192 MAPK7
mitogen-activated protein kinase 7
chr4_+_155707089 0.191 FGB
fibrinogen beta chain
chr7_+_156435163 0.191 NM_138400
NOM1
nucleolar protein with MIF4G domain 1
chr5_-_149809457 0.188 NM_001025070
NM_001025071
NM_005617
RPS14


ribosomal protein S14


chr1_+_6562681 0.188 ZBTB48
zinc finger and BTB domain containing 48
chr1_-_156800017 0.186 NM_001160325
OR6P1
olfactory receptor, family 6, subfamily P, member 1
chr12_-_112394259 0.186 NM_022363
LHX5
LIM homeobox 5
chr19_+_54722686 0.185 NM_020650
RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr3_+_156280129 0.184 NM_000902
MME
membrane metallo-endopeptidase
chr10_-_15170779 0.184 NM_001039844
ACBD7
acyl-CoA binding domain containing 7
chrX_-_151996613 0.183 NM_032882
PNMA6A
paraneoplastic antigen like 6A
chr5_-_149809424 0.183 RPS14
ribosomal protein S14
chr5_+_141283647 0.183 KIAA0141
KIAA0141

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.18 5.25e-04 GO:0044444 cytoplasmic part
1.12 7.38e-03 GO:0005737 cytoplasm
1.07 4.08e-02 GO:0005622 intracellular
1.08 4.28e-02 GO:0044424 intracellular part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.92 1.47e-02 GO:0005083 small GTPase regulator activity
7.48 2.87e-02 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity
2.90 3.56e-02 GO:0005089 Rho guanyl-nucleotide exchange factor activity