Motif ID: SNAI1..3.p2

Z-value: 4.462


Transcription factors associated with SNAI1..3.p2:

Gene SymbolEntrez IDGene Name
SNAI1 6615 snail homolog 1 (Drosophila)
SNAI2 6591 snail homolog 2 (Drosophila)
SNAI3 333929 snail homolog 3 (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SNAI1chr20_+_48032918-0.543.0e-02Click!
SNAI3chr16_-_87280380-0.214.3e-01Click!
SNAI2chr8_-_49996353-0.097.5e-01Click!


Activity profile for motif SNAI1..3.p2.

activity profile for motif SNAI1..3.p2


Sorted Z-values histogram for motif SNAI1..3.p2

Sorted Z-values for motif SNAI1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SNAI1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_60053050 14.816 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr8_+_120289735 9.732 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr19_+_6415259 8.302 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr16_+_70217564 8.279 NM_001017967
NM_052858
MARVELD3

MARVEL domain containing 3

chr19_-_10558906 7.979 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr1_+_1971762 7.571 NM_002744
PRKCZ
protein kinase C, zeta
chr4_+_155884600 7.558 NM_004744
LRAT
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
chr19_+_7566698 7.441 NM_001080429
NM_020902
KIAA1543

KIAA1543

chr1_-_55039458 7.441 NM_001114108
NM_017904
TTC22

tetratricopeptide repeat domain 22

chr15_-_38332401 7.380 NM_001039905
C15orf56
chromosome 15 open reading frame 56
chr7_-_22363036 6.988 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr17_+_7225088 6.949 NM_003985
TNK1
tyrosine kinase, non-receptor, 1
chr1_-_27159462 6.553 NM_152365
C1orf172
chromosome 1 open reading frame 172
chr16_-_4927057 6.520 NM_002705
PPL
periplakin
chr17_+_71033339 6.127 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr11_-_407324 5.879 NM_001135053
NM_021805
SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

chr19_+_40431122 5.861 LSR
lipolysis stimulated lipoprotein receptor
chr4_+_155884564 5.811 LRAT
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
chr5_+_68824143 5.631 OCLN
occludin
chr7_+_139750311 5.447 NM_001008749
RAB19
RAB19, member RAS oncogene family
chr1_+_3360880 5.402 NM_014448
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr11_+_45900731 5.304 GYLTL1B
glycosyltransferase-like 1B
chr17_+_26839143 5.218 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr8_-_75396016 5.150 NM_020647
JPH1
junctophilin 1
chr6_-_30151526 5.078 NM_170769
NM_025236
RNF39

ring finger protein 39

chr14_-_60817621 5.060


chr15_+_38332640 5.058 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr20_+_48781457 4.952 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr3_-_123223658 4.844 NM_175924
ILDR1
immunoglobulin-like domain containing receptor 1
chr1_+_116181927 4.811 NHLH2
nescient helix loop helix 2
chr12_-_32940931 4.732 NM_001005242
NM_004572
PKP2

plakophilin 2

chr11_+_120828058 4.711 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr17_-_37196463 4.709 NM_002230
NM_021991
JUP

junction plakoglobin

chr15_+_48261649 4.709 NM_001159629
NM_003645
SLC27A2

solute carrier family 27 (fatty acid transporter), member 2

chr10_+_71060008 4.674 NM_145306
C10orf35
chromosome 10 open reading frame 35
chr14_-_70345485 4.672 NM_033141
MAP3K9
mitogen-activated protein kinase kinase kinase 9
chr5_-_60175798 4.568 NM_001104558
NM_024930
ELOVL7

ELOVL family member 7, elongation of long chain fatty acids (yeast)

chr11_-_19219720 4.520 E2F8
E2F transcription factor 8
chr8_-_144887876 4.502 NM_198488
FAM83H
family with sequence similarity 83, member H
chr11_+_12987455 4.501 NM_001080521
RASSF10
Ras association (RalGDS/AF-6) domain family (N-terminal) member 10
chr17_-_7106497 4.466 CLDN7
claudin 7
chr8_+_102573837 4.458 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr18_-_72973750 4.454 NM_001025100
NM_001025101
MBP

myelin basic protein

chr10_-_62163083 4.410 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr8_+_144888275 4.327 LOC100128338
hypothetical LOC100128338
chr2_-_73350103 4.304 NM_001080410
FBXO41
F-box protein 41
chr4_-_11039600 4.214 NM_005114
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr8_+_102574012 4.188 GRHL2
grainyhead-like 2 (Drosophila)
chr11_+_120828275 3.984 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr14_-_60817663 3.925 TMEM30B
transmembrane protein 30B
chr16_-_52876390 3.892 IRX3
iroquois homeobox 3
chr10_+_8137356 3.879 GATA3
GATA binding protein 3
chr16_+_67236730 3.862 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr1_+_24518398 3.646 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr16_+_67328805 3.638 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr12_-_46585032 3.630 NM_000376
NM_001017535
VDR

vitamin D (1,25- dihydroxyvitamin D3) receptor

chr8_-_81246215 3.579 NM_001025253
NM_005079
TPD52

tumor protein D52

chr1_+_29086206 3.565 EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr21_-_42060266 3.519 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr11_+_129534983 3.481 ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr6_-_136913235 3.480 MAP7
microtubule-associated protein 7
chr21_-_42060334 3.475 RIPK4
receptor-interacting serine-threonine kinase 4
chr7_+_29570024 3.472 PRR15
proline rich 15
chr22_+_38720881 3.462 NM_138435
FAM83F
family with sequence similarity 83, member F
chr9_-_115901157 3.458 NM_138424
KIF12
kinesin family member 12
chr22_-_44751671 3.437 NM_058238
WNT7B
wingless-type MMTV integration site family, member 7B
chr17_+_9489578 3.423 NM_153210
USP43
ubiquitin specific peptidase 43
chr9_-_125070613 3.340 NM_018387
STRBP
spermatid perinuclear RNA binding protein
chr5_+_132176921 3.339 NM_175873
ANKRD43
ankyrin repeat domain 43
chr14_-_60817946 3.316


chr1_-_149955415 3.304 NM_001172648
NM_001172649
CELF3

CUGBP, Elav-like family member 3

chr16_+_67328715 3.301 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr18_-_72973698 3.292 MBP
myelin basic protein
chr9_-_125070675 3.279 NM_001171137
STRBP
spermatid perinuclear RNA binding protein
chr12_+_56435042 3.267 NM_138396
MARCH9
membrane-associated ring finger (C3HC4) 9
chr1_+_29086156 3.238 NM_001166005
NM_001166007
NM_004437
NM_203342
NM_203343
EPB41




erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)




chr1_+_24755152 3.230 NM_001010980
C1orf130
chromosome 1 open reading frame 130
chr11_+_119616112 3.228 NM_014352
POU2F3
POU class 2 homeobox 3
chr15_+_38923470 3.200 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr8_+_95722448 3.160 ESRP1
epithelial splicing regulatory protein 1
chr8_+_346933 3.153 FBXO25
F-box protein 25
chr17_+_36647795 3.138 NM_031963
KRTAP9-8
keratin associated protein 9-8
chr9_-_111300350 3.136 NM_001145368
NM_002829
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr1_-_40140126 3.118 NM_001033081
NM_001033082
NM_005376
MYCL1


v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)


chr14_-_60818263 3.099 NM_001017970
TMEM30B
transmembrane protein 30B
chr13_-_19665100 3.095 NM_004004
GJB2
gap junction protein, beta 2, 26kDa
chr1_-_17318452 3.093 NM_007365
PADI2
peptidyl arginine deiminase, type II
chr14_+_104402626 3.087 NM_001112726
NM_015005
KIAA0284

KIAA0284

chr10_-_134940315 3.023 NM_001109
NM_001164489
NM_001164490
ADAM8


ADAM metallopeptidase domain 8


chr19_+_40431359 3.017 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr15_+_38923914 3.004 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr1_+_24518501 3.002 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr11_+_129534922 2.999 ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr1_-_54256390 2.974 NM_001010978
LDLRAD1
low density lipoprotein receptor class A domain containing 1
chr18_+_27332024 2.973 NM_001943
DSG2
desmoglein 2
chr11_+_32808045 2.960 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr5_+_74197473 2.959 LOC441086
hypothetical LOC441086
chr16_+_67328737 2.952 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr12_-_70953461 2.951 LOC283392
hypothetical LOC283392
chr19_+_40431618 2.950 LSR
lipolysis stimulated lipoprotein receptor
chr8_-_101731068 2.946 NM_152628
SNX31
sorting nexin 31
chr13_+_112681626 2.941 NM_024979
MCF2L
MCF.2 cell line derived transforming sequence-like
chr14_-_60817709 2.940 TMEM30B
transmembrane protein 30B
chr6_-_10527772 2.931 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr4_-_78038025 2.887 NM_001029870
ANKRD56
ankyrin repeat domain 56
chr10_+_115988999 2.853 NM_198496
VWA2
von Willebrand factor A domain containing 2
chr13_-_19665036 2.840 GJB2
gap junction protein, beta 2, 26kDa
chr2_-_108972100 2.823 NM_022336
EDAR
ectodysplasin A receptor
chr11_+_73036241 2.801 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr5_-_168660293 2.790 NM_003062
SLIT3
slit homolog 3 (Drosophila)
chr8_+_27238979 2.783 NM_173175
PTK2B
PTK2B protein tyrosine kinase 2 beta
chr7_+_12576727 2.772 NM_001112706
SCIN
scinderin
chr16_+_67236699 2.770 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr9_+_17568952 2.753 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr13_-_113066366 2.744 NM_024719
GRTP1
growth hormone regulated TBC protein 1
chr17_+_35147697 2.705 NM_005310
GRB7
growth factor receptor-bound protein 7
chr4_-_40327396 2.685 RBM47
RNA binding motif protein 47
chr5_+_176744037 2.665 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chr4_+_85723080 2.652 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr5_+_68823874 2.636 NM_002538
OCLN
occludin
chr4_+_106693225 2.632 NM_017700
ARHGEF38
Rho guanine nucleotide exchange factor (GEF) 38
chr17_+_35147738 2.621 GRB7
growth factor receptor-bound protein 7
chr8_+_95722575 2.620 ESRP1
epithelial splicing regulatory protein 1
chr11_+_129534909 2.620 ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr8_+_95722516 2.587 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr1_+_24522116 2.587 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr8_+_21937533 2.584 NPM2
nucleophosmin/nucleoplasmin 2
chr16_+_67328693 2.581 NM_004360
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr16_+_29697090 2.550 ZG16
zymogen granule protein 16 homolog (rat)
chr1_+_199130571 2.538 NM_001142569
C1orf106
chromosome 1 open reading frame 106
chr17_-_7106987 2.506 NM_001185023
NM_001307
CLDN7

claudin 7

chr16_+_2954217 2.493 NM_024507
NM_172229
KREMEN2

kringle containing transmembrane protein 2

chr19_+_12810258 2.488 NM_014975
MAST1
microtubule associated serine/threonine kinase 1
chr1_+_175406685 2.475 FAM5B
family with sequence similarity 5, member B
chr2_+_231610438 2.452 NM_001144994
C2orf72
chromosome 2 open reading frame 72
chr15_-_81146188 2.447 AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr12_+_6289862 2.435 NM_018173
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr11_+_63864263 2.426 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr16_-_73365975 2.412 FA2H
fatty acid 2-hydroxylase
chr1_+_175407153 2.399 NM_021165
FAM5B
family with sequence similarity 5, member B
chr11_+_129534873 2.379 NM_021978
ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr19_-_7845325 2.343 NM_001190467
FLJ22184
hypothetical protein FLJ22184
chr9_+_128416542 2.307 NM_001174146
NM_001174147
NM_002316
LMX1B


LIM homeobox transcription factor 1, beta


chr1_-_159257486 2.301 F11R
F11 receptor
chr1_+_199108705 2.283 NM_005298
GPR25
G protein-coupled receptor 25
chr16_-_73366200 2.281 NM_024306
FA2H
fatty acid 2-hydroxylase
chr16_+_56616782 2.279 NM_002428
MMP15
matrix metallopeptidase 15 (membrane-inserted)
chr19_-_14951349 2.273 SLC1A6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr17_+_35148084 2.271 NM_001030002
GRB7
growth factor receptor-bound protein 7
chr6_-_136913649 2.229 NM_001198616
NM_001198617
NM_003980
MAP7


microtubule-associated protein 7


chr12_-_60872814 2.227 NM_178539
FAM19A2
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chr9_+_35663852 2.221 NM_001216
CA9
carbonic anhydrase IX
chr12_-_10718157 2.213 NM_018423
STYK1
serine/threonine/tyrosine kinase 1
chr19_+_19183763 2.205 NM_004386
NCAN
neurocan
chr21_+_17807167 2.198 NM_001338
CXADR
coxsackie virus and adenovirus receptor
chr9_+_33740463 2.197 NM_001197097
NM_007343
NM_001197098
PRSS3


protease, serine, 3


chr17_+_7923477 2.177


chr22_+_49266836 2.175 NM_024866
ADM2
adrenomedullin 2
chr6_+_150505849 2.172 NM_030949
PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr12_+_6290127 2.155 PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr7_+_29569913 2.146 NM_175887
PRR15
proline rich 15
chr17_-_4410565 2.142 NM_001122890
NM_153338
GGT6

gamma-glutamyltransferase 6

chr4_-_40326603 2.132 NM_001098634
RBM47
RNA binding motif protein 47
chr11_-_18226743 2.122 NM_001127380
NM_030754
SAA2

serum amyloid A2

chr5_-_1935764 2.100 NM_016358
IRX4
iroquois homeobox 4
chr1_+_95355415 2.085 NM_152487
TMEM56
transmembrane protein 56
chr3_-_198767202 2.082 NM_004051
NM_203314
BDH1

3-hydroxybutyrate dehydrogenase, type 1

chr3_-_126414252 2.081 NM_024628
SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr6_+_54819527 2.073 NM_001010872
FAM83B
family with sequence similarity 83, member B
chr5_+_56146656 2.068 NM_005921
MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr19_+_41039649 2.054 NM_032123
NM_199179
NM_199180
KIRREL2


kin of IRRE like 2 (Drosophila)


chr19_+_40431678 2.052 LSR
lipolysis stimulated lipoprotein receptor
chr7_+_156491223 2.049 MNX1
motor neuron and pancreas homeobox 1
chr5_+_176717553 2.047


chr11_+_65536037 2.042 NM_001323
CST6
cystatin E/M
chr13_-_113066202 2.040 GRTP1
growth hormone regulated TBC protein 1
chr9_+_966963 2.025 NM_021240
DMRT3
doublesex and mab-3 related transcription factor 3
chr13_+_112671497 2.025 MCF2L
MCF.2 cell line derived transforming sequence-like
chr7_-_97868362 2.016 NM_018842
BAIAP2L1
BAI1-associated protein 2-like 1
chr7_+_156496360 2.011 LOC645249
hypothetical LOC645249
chr14_+_69415880 1.989 NM_001034852
NM_022137
SMOC1

SPARC related modular calcium binding 1

chr1_-_159257567 1.989 F11R
F11 receptor
chr15_-_38953628 1.987 NM_133639
RHOV
ras homolog gene family, member V
chr10_-_116517945 1.985 ABLIM1
actin binding LIM protein 1
chr7_+_29569978 1.983 PRR15
proline rich 15
chr1_-_159257595 1.979 NM_016946
F11R
F11 receptor
chr13_-_78075683 1.964 NM_006237
POU4F1
POU class 4 homeobox 1
chr21_+_42512271 1.962 NM_004915
NM_016818
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr22_-_48793181 1.952 NM_001001694
IL17REL
interleukin 17 receptor E-like
chr8_+_27238964 1.950 NM_173176
PTK2B
PTK2B protein tyrosine kinase 2 beta
chr8_-_95720870 1.945 LOC100288748
hypothetical LOC100288748
chr1_-_111548440 1.941 DENND2D
DENN/MADD domain containing 2D
chr1_-_3556420 1.930 NM_017818
WDR8
WD repeat domain 8
chr15_+_38318528 1.925 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr18_-_45975163 1.920 NM_001080467
MYO5B
myosin VB
chr17_-_40839082 1.908 NM_001159330
ARHGAP27
Rho GTPase activating protein 27
chr5_+_89890366 1.900 NM_032119
GPR98
G protein-coupled receptor 98
chr1_+_172683834 1.899 NM_005684
GPR52
G protein-coupled receptor 52
chr11_+_65311104 1.895 NM_004561
OVOL1
ovo-like 1(Drosophila)
chr5_+_156625629 1.892 NM_001037333
NM_001037332
CYFIP2

cytoplasmic FMR1 interacting protein 2


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.11 2.64e-10 GO:0065007 biological regulation
1.18 2.36e-09 GO:0023052 signaling
1.11 7.65e-08 GO:0050789 regulation of biological process
1.18 9.11e-08 GO:0007165 signal transduction
1.11 1.56e-07 GO:0050794 regulation of cellular process
1.17 4.74e-06 GO:0048856 anatomical structure development
1.14 5.73e-05 GO:0032502 developmental process
1.20 2.36e-04 GO:0030154 cell differentiation
1.23 3.14e-04 GO:0007399 nervous system development
1.16 3.76e-04 GO:0048731 system development
1.05 3.79e-04 GO:0009987 cellular process
1.14 6.33e-04 GO:0007275 multicellular organismal development
1.19 6.76e-04 GO:0048869 cellular developmental process
1.18 9.17e-04 GO:0042221 response to chemical stimulus
1.29 1.40e-03 GO:0048468 cell development
1.20 1.57e-03 GO:0007166 cell surface receptor linked signaling pathway
1.12 2.49e-03 GO:0051716 cellular response to stimulus
1.13 2.79e-03 GO:0051179 localization
1.22 6.48e-03 GO:0051239 regulation of multicellular organismal process
1.27 9.70e-03 GO:0040011 locomotion
1.15 1.43e-02 GO:0048519 negative regulation of biological process
1.24 2.73e-02 GO:0007154 cell communication
1.26 3.44e-02 GO:0048699 generation of neurons
1.16 4.01e-02 GO:0048523 negative regulation of cellular process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.24 3.38e-09 GO:0044459 plasma membrane part
1.38 1.65e-05 GO:0030054 cell junction
1.12 1.05e-04 GO:0071944 cell periphery
1.12 1.53e-04 GO:0005886 plasma membrane
1.08 1.81e-04 GO:0016020 membrane
1.28 2.73e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.26 3.93e-03 GO:0031982 vesicle
1.27 4.12e-03 GO:0031988 membrane-bounded vesicle
1.27 4.74e-03 GO:0031410 cytoplasmic vesicle
1.20 5.08e-03 GO:0031226 intrinsic to plasma membrane
1.20 7.50e-03 GO:0005887 integral to plasma membrane
1.07 1.00e-02 GO:0044425 membrane part
1.45 2.30e-02 GO:0016323 basolateral plasma membrane
1.48 2.54e-02 GO:0005911 cell-cell junction
1.36 3.15e-02 GO:0048471 perinuclear region of cytoplasm
1.51 4.96e-02 GO:0070161 anchoring junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.23 1.09e-02 GO:0005102 receptor binding
1.07 1.76e-02 GO:0005515 protein binding