Motif ID: NKX2-2,8.p2

Z-value: 1.303


Transcription factors associated with NKX2-2,8.p2:

Gene SymbolEntrez IDGene Name
NKX2-2 4821 NK2 homeobox 2
NKX2-8 26257 NK2 homeobox 8

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NKX2-2chr20_-_21442663-0.467.4e-02Click!
NKX2-8chr14_-_36121536-0.214.3e-01Click!


Activity profile for motif NKX2-2,8.p2.

activity profile for motif NKX2-2,8.p2


Sorted Z-values histogram for motif NKX2-2,8.p2

Sorted Z-values for motif NKX2-2,8.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-2,8.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_242281175 1.796 NM_205768
ZNF238
zinc finger protein 238
chr7_+_69869099 1.634 AUTS2
autism susceptibility candidate 2
chr17_-_3442871 1.412 NM_080706
TRPV1
transient receptor potential cation channel, subfamily V, member 1
chr1_+_242281199 1.386 ZNF238
zinc finger protein 238
chr1_-_177106702 1.264 NM_004673
ANGPTL1
angiopoietin-like 1
chr5_-_37220702 1.191 C5orf42
chromosome 5 open reading frame 42
chr8_-_133841988 1.191 NM_001145153
NM_144649
TMEM71

transmembrane protein 71

chr20_-_49747397 1.178 ATP9A
ATPase, class II, type 9A
chr12_-_103846186 1.172 NM_032148
SLC41A2
solute carrier family 41, member 2
chr1_+_144198658 1.104 LIX1L
Lix1 homolog (mouse)-like
chr10_+_74323344 1.071 NM_152635
OIT3
oncoprotein induced transcript 3
chr4_-_170314382 1.025 SH3RF1
SH3 domain containing ring finger 1
chr12_+_100394787 0.961 NM_152323
SPIC
Spi-C transcription factor (Spi-1/PU.1 related)
chr8_-_18710575 0.941 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr8_-_124613557 0.934 NM_148177
FBXO32
F-box protein 32
chr1_+_15862887 0.930


chr3_+_185253528 0.919 NM_130770
HTR3C
5-hydroxytryptamine (serotonin) receptor 3, family member C
chr9_+_129066576 0.908 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr22_-_16070778 0.898 NM_017424
CECR1
cat eye syndrome chromosome region, candidate 1
chr1_-_67039518 0.897 NM_005478
INSL5
insulin-like 5
chr3_-_152403636 0.893 NM_013308
GPR171
G protein-coupled receptor 171
chr9_+_102380156 0.883 NM_001018116
MURC
muscle-related coiled-coil protein
chr5_+_67558217 0.863 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr7_-_111216180 0.850 DOCK4
dedicator of cytokinesis 4
chr12_+_10054492 0.833 NM_001129998
NM_205852
CLEC12B

C-type lectin domain family 12, member B

chr11_-_47467094 0.824 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr6_+_155453114 0.818 NM_012454
TIAM2
T-cell lymphoma invasion and metastasis 2
chr3_-_42892195 0.810 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chrX_+_21960841 0.775 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr1_-_111908085 0.767 NM_001081976
ADORA3
adenosine A3 receptor
chr1_-_41398126 0.753 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr1_-_161379606 0.739 RGS5
regulator of G-protein signaling 5
chr4_-_152316105 0.738 NM_001128924
SH3D19
SH3 domain containing 19
chr3_-_153541468 0.717 NM_001123228
TMEM14E
transmembrane protein 14E
chr3_-_102194938 0.714 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr20_+_56919233 0.702 GNAS
GNAS complex locus
chr1_-_151630168 0.701 NM_002964
S100A8
S100 calcium binding protein A8
chr5_+_159589014 0.695 NM_001445
FABP6
fatty acid binding protein 6, ileal
chr1_+_169747788 0.694 PRRC2C
proline-rich coiled-coil 2C
chr5_+_156752739 0.692 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr11_-_102001259 0.678 NM_004771
MMP20
matrix metallopeptidase 20
chr7_+_93373755 0.668 NM_021955
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr12_+_50342814 0.668 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr7_-_93027057 0.665 NM_001164738
CALCR
calcitonin receptor
chr10_+_124660206 0.659 NM_001029888
FAM24A
family with sequence similarity 24, member A
chr11_+_123315459 0.653 NM_001001965
OR4D5
olfactory receptor, family 4, subfamily D, member 5
chr1_-_109957195 0.652 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr1_-_35143570 0.652 NM_001080418
DLGAP3
discs, large (Drosophila) homolog-associated protein 3
chr5_+_54491702 0.643 NM_001008397
GPX8
glutathione peroxidase 8 (putative)
chr10_+_63478974 0.634 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr1_+_190394214 0.632 NM_130782
RGS18
regulator of G-protein signaling 18
chr17_+_3324096 0.632 NM_001128085
ASPA
aspartoacylase
chr9_+_95273241 0.627 FAM120A
family with sequence similarity 120A
chr22_+_20929199 0.618 NM_007128
VPREB1
pre-B lymphocyte 1
chrX_-_55225668 0.614 NM_001190708
MTRNR2L10
MT-RNR2-like 10
chr5_+_145296313 0.610 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chrX_+_128966844 0.609 NM_021946
BCORL1
BCL6 corepressor-like 1
chr5_-_150501393 0.604 NM_001193544
ANXA6
annexin A6
chr21_+_34112456 0.594 ITSN1
intersectin 1 (SH3 domain protein)
chr15_-_74963246 0.590 NM_020843
SCAPER
S-phase cyclin A-associated protein in the ER
chr17_-_26648375 0.589 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr2_+_173394560 0.587 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr4_-_24590867 0.586 NM_173463
CCDC149
coiled-coil domain containing 149
chr5_+_127012611 0.583 NM_001048252
CTXN3
cortexin 3
chr7_-_107230867 0.571 NM_000111
SLC26A3
solute carrier family 26, member 3
chr1_-_155336223 0.568 NM_001004341
ETV3L
ets variant 3-like
chr18_-_18251808 0.561 NM_172241
CTAGE1
cutaneous T-cell lymphoma-associated antigen 1
chr5_-_121842680 0.561


chr5_+_6799100 0.559 NM_001171806
PAPD7
PAP associated domain containing 7
chr3_-_44464722 0.555


chr19_+_8814268 0.546 NM_145208
MBD3L1
methyl-CpG binding domain protein 3-like 1
chr2_-_217433018 0.529 NM_003284
TNP1
transition protein 1 (during histone to protamine replacement)
chr1_-_41399632 0.527 NM_001031694
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr6_-_138862271 0.524 NM_001144060
NHSL1
NHS-like 1
chr6_+_45404031 0.524 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr6_+_143971009 0.520 NM_001100166
NM_014721
PHACTR2

phosphatase and actin regulator 2

chr5_+_55098469 0.519 NM_001166534
DDX4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chrX_+_107174855 0.516 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr7_+_97199206 0.511 NM_003182
NM_013996
NM_013997
NM_013998
TAC1



tachykinin, precursor 1



chr6_+_88021644 0.510 ZNF292
zinc finger protein 292
chr3_-_33675484 0.509 CLASP2
cytoplasmic linker associated protein 2
chr5_-_16795336 0.505 MYO10
myosin X
chr1_-_115039614 0.505 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1

chr2_+_64540843 0.503 HSPC159
galectin-related protein
chr20_-_1298493 0.501 FKBP1A
FK506 binding protein 1A, 12kDa
chr21_+_36458708 0.500 NM_005128
DOPEY2
dopey family member 2
chr1_-_173979292 0.499 NM_003285
TNR
tenascin R (restrictin, janusin)
chr7_+_139175420 0.499 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr3_+_158637273 0.497 NM_002852
PTX3
pentraxin 3, long
chr3_+_37415971 0.494 NM_178339
NM_178342
C3orf35

chromosome 3 open reading frame 35

chr12_+_32578513 0.492 FGD4
FYVE, RhoGEF and PH domain containing 4
chr3_-_172227461 0.492 NM_000340
SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chrX_-_131401319 0.491 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chrX_-_19727828 0.490 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chrX_-_49008115 0.487 NM_001114377
NM_014009
FOXP3

forkhead box P3

chr3_-_122862391 0.485 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr9_-_14076901 0.484 NFIB
nuclear factor I/B
chr5_+_176955595 0.482


chr8_-_81155564 0.477 NM_001025252
TPD52
tumor protein D52
chr18_+_70352649 0.476 NM_032649
CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr17_-_19290745 0.473


chr22_+_21053972 0.473


chr10_-_14856901 0.472 NM_031453
FAM107B
family with sequence similarity 107, member B
chr3_+_88270951 0.468 NM_018293
ZNF654
zinc finger protein 654
chr3_-_187744808 0.468 NM_017541
CRYGS
crystallin, gamma S
chr3_-_57301749 0.468 NM_001142733
ASB14
ankyrin repeat and SOCS box containing 14
chr1_+_61697209 0.467 NFIA
nuclear factor I/A
chrX_-_30505804 0.466 NM_025159
CXorf21
chromosome X open reading frame 21
chr5_+_71538456 0.464 MAP1B
microtubule-associated protein 1B
chr5_-_137876416 0.460 ETF1
eukaryotic translation termination factor 1
chr18_+_70352779 0.458 CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr13_-_32822759 0.455 STARD13
StAR-related lipid transfer (START) domain containing 13
chr6_-_39398293 0.454 NM_001135105
NM_001135106
NM_001135107
NM_032115
KCNK16



potassium channel, subfamily K, member 16



chr1_+_200698493 0.453 NM_032103
NM_032104
PPP1R12B

protein phosphatase 1, regulatory (inhibitor) subunit 12B

chr5_+_169713458 0.451 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr5_-_150663519 0.451 NM_001145017
NM_181774
SLC36A3

solute carrier family 36 (proton/amino acid symporter), member 3

chr2_+_11591692 0.450 NM_014668
GREB1
growth regulation by estrogen in breast cancer 1
chr8_+_92330691 0.449 NM_052832
NM_134266
SLC26A7

solute carrier family 26, member 7

chr2_+_28892366 0.449 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr21_+_41655786 0.448 NM_002463
LOC100131190
MX2
hypothetical protein LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr1_-_242073094 0.447 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chrX_-_19727775 0.443 SH3KBP1
SH3-domain kinase binding protein 1
chr1_-_224993498 0.441 NM_002221
ITPKB
inositol 1,4,5-trisphosphate 3-kinase B
chr6_+_31604717 0.440 NM_001011700
MCCD1
mitochondrial coiled-coil domain 1
chr12_-_105056577 0.440 NUAK1
NUAK family, SNF1-like kinase, 1
chr7_+_142978994 0.439 NM_001008747
CTAGE6P
CTAGE15P
CTAGE family, member 6, pseudogene
CTAGE family, member 15, pseudogene
chr2_-_61566477 0.436 XPO1
exportin 1 (CRM1 homolog, yeast)
chr7_+_143511480 0.435 NM_198495
CTAGE4
CTAGE8
CTAGE family, member 4
CTAGE family, member 8
chr21_-_26175068 0.432 APP
amyloid beta (A4) precursor protein
chr16_+_24475129 0.431 RBBP6
retinoblastoma binding protein 6
chr4_+_166519392 0.431 NM_001873
CPE
carboxypeptidase E
chr5_-_39306465 0.429 FYB
FYN binding protein
chr3_-_42892636 0.427 NM_004391
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr9_+_114671635 0.427 SNX30
sorting nexin family member 30
chr6_-_32247134 0.426 AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr8_+_22266256 0.424 PIWIL2
piwi-like 2 (Drosophila)
chr1_+_173303616 0.423 NM_022093
TNN
tenascin N
chr3_+_190990142 0.423 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr19_+_11837843 0.421 NM_152262
ZNF439
zinc finger protein 439
chr6_+_73133152 0.421 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr14_+_20537253 0.414 NM_014579
SLC39A2
solute carrier family 39 (zinc transporter), member 2
chr7_-_143597313 0.412 NM_198495
CTAGE4
CTAGE8
CTAGE family, member 4
CTAGE family, member 8
chr6_+_151603264 0.411


chr1_+_92405196 0.408 NM_015237
KIAA1107
KIAA1107
chr5_-_160044844 0.406 ATP10B
ATPase, class V, type 10B
chr6_-_50045296 0.406 NM_001037729
DEFB113
defensin, beta 113
chr6_-_11490487 0.403 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr3_+_46591048 0.400 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chr15_-_31147376 0.400 NM_001103184
FMN1
formin 1
chr8_+_17866373 0.399 PCM1
pericentriolar material 1
chr1_+_161305019 0.398 NM_001102445
RGS4
regulator of G-protein signaling 4
chr4_-_186934059 0.397 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr14_+_88130482 0.397 NM_207662
ZC3H14
zinc finger CCCH-type containing 14
chr3_+_153499883 0.396 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr6_+_151603201 0.394 AKAP12
A kinase (PRKA) anchor protein 12
chr15_-_53350383 0.388 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr14_-_88948486 0.384 FOXN3
forkhead box N3
chr8_-_110689396 0.377 SYBU
syntabulin (syntaxin-interacting)
chr8_+_38704860 0.375 NM_001146216
TACC1
transforming, acidic coiled-coil containing protein 1
chr9_+_126158935 0.374


chr10_+_90336489 0.371 NM_001010939
LIPJ
lipase, family member J
chr4_-_152366970 0.370 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr1_+_110361634 0.367 AHCYL1
adenosylhomocysteinase-like 1
chr9_+_115303527 0.366 NM_130795
RGS3
regulator of G-protein signaling 3
chr18_+_30812205 0.365 NM_001143827
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chrX_-_37916138 0.361 SRPX
sushi-repeat containing protein, X-linked
chr8_-_57395794 0.361 NM_138969
SDR16C5
short chain dehydrogenase/reductase family 16C, member 5
chr5_+_139485703 0.358 NM_001007189
C5orf53
chromosome 5 open reading frame 53
chr1_+_84402962 0.353 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_-_156816312 0.352 NM_001004477
OR10X1
olfactory receptor, family 10, subfamily X, member 1
chrX_+_107569671 0.351 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr6_-_138862273 0.349


chr1_+_12728749 0.343 NM_152290
C1orf158
chromosome 1 open reading frame 158
chr10_+_86121526 0.342 FAM190B
family with sequence similarity 190, member B
chr3_+_153074118 0.342 NM_033050
SUCNR1
succinate receptor 1
chr12_-_51298599 0.340 NM_175068
KRT73
keratin 73
chr11_+_73037382 0.339 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr6_+_144654565 0.338 NM_007124
UTRN
utrophin
chrX_+_14813333 0.335 NM_001177475
MOSPD2
motile sperm domain containing 2
chr19_-_14771947 0.335 NM_198944
OR7C1
olfactory receptor, family 7, subfamily C, member 1
chrX_-_15243647 0.334 NM_080873
ASB11
ankyrin repeat and SOCS box containing 11
chr3_-_172227152 0.333 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr19_-_60458915 0.330 PPP6R1
protein phosphatase 6, regulatory subunit 1
chr3_+_120982020 0.328 NM_003889
NM_033013
NR1I2

nuclear receptor subfamily 1, group I, member 2

chr15_+_40484249 0.327 NM_173089
NM_173090
CAPN3

calpain 3, (p94)

chr5_-_58370693 0.327 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chrX_-_77111790 0.326 NM_001029891
PGAM4
phosphoglycerate mutase family member 4
chr4_+_77575276 0.326 NM_020859
SHROOM3
shroom family member 3
chr11_-_119514058 0.325 NM_012101
TRIM29
tripartite motif containing 29
chr9_-_70345549 0.321 NM_153237
C9orf71
chromosome 9 open reading frame 71
chr1_+_176577228 0.320 NM_004841
RASAL2
RAS protein activator like 2
chr1_+_103961476 0.320 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chrX_-_100801472 0.319 NM_014782
NM_177949
ARMCX2

armadillo repeat containing, X-linked 2

chr11_+_58967192 0.318 NM_001004728
OR5A1
olfactory receptor, family 5, subfamily A, member 1
chr7_-_143085704 0.317 NM_178561
CTAGE6P
CTAGE family, member 6, pseudogene
chr9_-_113561613 0.317 NM_001080551
C9orf84
chromosome 9 open reading frame 84
chr11_+_33520348 0.316 NM_012194
C11orf41
chromosome 11 open reading frame 41
chr10_-_98326435 0.316 TM9SF3
transmembrane 9 superfamily member 3
chr19_+_43847049 0.315


chr3_+_32408155 0.313 NM_138410
NM_181472
CMTM7

CKLF-like MARVEL transmembrane domain containing 7


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
7.09 3.01e-04 GO:0007602 phototransduction
6.27 3.91e-04 GO:0009583 detection of light stimulus
4.67 2.21e-03 GO:0009582 detection of abiotic stimulus
4.14 4.66e-03 GO:0009581 detection of external stimulus
3.11 3.52e-02 GO:0051606 detection of stimulus

Nothing significant found in compartment category.

Nothing significant found in function category.