Motif ID: EOMES.p2

Z-value: 1.405


Transcription factors associated with EOMES.p2:

Gene SymbolEntrez IDGene Name
EOMES 8320 eomesodermin

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EOMESchr3_-_27739201-0.175.3e-01Click!


Activity profile for motif EOMES.p2.

activity profile for motif EOMES.p2


Sorted Z-values histogram for motif EOMES.p2

Sorted Z-values for motif EOMES.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EOMES.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_150958621 1.662 NM_001024679
C1orf68
chromosome 1 open reading frame 68
chr15_-_50270856 1.311 NM_016194
GNB5
guanine nucleotide binding protein (G protein), beta 5
chr1_+_224477941 1.183 NM_031944
MIXL1
Mix1 homeobox-like 1 (Xenopus laevis)
chr1_+_24522116 1.126 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr5_-_34078991 1.102 NM_030945
NM_181435
C1QTNF3

C1q and tumor necrosis factor related protein 3

chr16_+_31105579 1.066


chr1_+_17719405 1.048 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr17_+_22823151 1.000 NM_014238
KSR1
kinase suppressor of ras 1
chr7_+_110518297 0.967 NM_001099658
NM_001099660
NM_018334
LRRN3


leucine rich repeat neuronal 3


chr5_-_35974493 0.967 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr7_+_142723340 0.928 NM_000083
CLCN1
chloride channel 1, skeletal muscle
chr6_-_112147946 0.912 NM_153047
FYN
FYN oncogene related to SRC, FGR, YES
chr5_-_39306465 0.834 FYB
FYN binding protein
chr1_-_199259133 0.833 KIF21B
kinesin family member 21B
chr12_+_56435042 0.818 NM_138396
MARCH9
membrane-associated ring finger (C3HC4) 9
chr3_+_10832867 0.805 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr7_-_27108826 0.799 NM_006735
HOXA2
homeobox A2
chr12_-_66839589 0.785 NM_000619
IFNG
interferon, gamma
chr17_-_59349867 0.777 NM_000515
NM_022559
NM_022560
NM_022561
NM_022562
GH1




growth hormone 1




chr11_+_122214415 0.774 NM_019604
CRTAM
cytotoxic and regulatory T cell molecule
chr4_-_186815116 0.774 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chrX_+_70360184 0.771 GJB1
gap junction protein, beta 1, 32kDa
chr4_+_8633116 0.771 NM_080819
GPR78
G protein-coupled receptor 78
chr21_-_38792173 0.761 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr8_-_42353719 0.750 NM_014420
DKK4
dickkopf homolog 4 (Xenopus laevis)
chr1_-_116112684 0.736 CASQ2
calsequestrin 2 (cardiac muscle)
chr7_-_16471817 0.721 NM_015464
SOSTDC1
sclerostin domain containing 1
chr5_-_14706486 0.709


chr1_+_26973804 0.706 ARID1A
AT rich interactive domain 1A (SWI-like)
chr1_+_210848726 0.706 ATF3
activating transcription factor 3
chr1_-_44255583 0.688 NM_006934
NM_201649
SLC6A9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr8_+_22075112 0.682 NM_001172357
NM_001172410
NM_003018
SFTPC


surfactant protein C


chr15_+_63701322 0.680 NM_004727
SLC24A1
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr15_+_70477707 0.668 NM_001080462
TMEM202
transmembrane protein 202
chr1_+_89602023 0.659 NM_198460
GBP6
guanylate binding protein family, member 6
chr12_-_192752 0.649 NM_003044
SLC6A12
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr21_+_39745649 0.649 NM_007341
SH3BGR
SH3 domain binding glutamic acid-rich protein
chr5_-_1935764 0.635 NM_016358
IRX4
iroquois homeobox 4
chr11_+_73037382 0.621 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr1_+_32992131 0.616


chr1_-_11830328 0.614 NM_006172
NPPA
natriuretic peptide A
chr11_+_6216905 0.611 NM_001037329
CNGA4
cyclic nucleotide gated channel alpha 4
chr12_+_48630790 0.609 NM_000486
AQP2
aquaporin 2 (collecting duct)
chr11_+_73036241 0.608 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr1_+_210848592 0.598 NM_001040619
NM_001674
ATF3

activating transcription factor 3

chr19_+_55405635 0.595 MYH14
myosin, heavy chain 14, non-muscle
chr5_+_150020595 0.590 NM_001122853
NM_133371
MYOZ3

myozenin 3

chr3_-_95230143 0.580 NM_001001850
STX19
syntaxin 19
chr1_+_110795271 0.572 NM_032414
PROK1
prokineticin 1
chrX_+_69418746 0.571 NM_001032726
RAB41
RAB41, member RAS oncogene family
chr5_+_137447479 0.571 NM_058244
WNT8A
wingless-type MMTV integration site family, member 8A
chr4_-_186814852 0.571 SORBS2
sorbin and SH3 domain containing 2
chr16_-_20271530 0.568 NM_001008389
NM_003361
UMOD

uromodulin

chr2_-_160838397 0.567 RBMS1
RNA binding motif, single stranded interacting protein 1
chr14_+_20537253 0.566 NM_014579
SLC39A2
solute carrier family 39 (zinc transporter), member 2
chr2_-_113259441 0.564 NM_000575
IL1A
interleukin 1, alpha
chr1_+_35019376 0.557 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr1_-_239865724 0.557 NM_001821
CHML
choroideremia-like (Rab escort protein 2)
chr1_-_155053124 0.553 NM_001161441
NM_001161442
NM_001161444
NM_003975
SH2D2A



SH2 domain containing 2A



chr17_-_36475652 0.550 NM_033184
KRTAP2-4
keratin associated protein 2-4
chr1_+_180836050 0.550


chr7_+_69869099 0.548 AUTS2
autism susceptibility candidate 2
chr1_+_148511806 0.546 NM_024579
C1orf54
chromosome 1 open reading frame 54
chr5_+_125828685 0.534 NM_001146322
GRAMD3
GRAM domain containing 3
chr6_+_42896771 0.532 NM_015349
KIAA0240
KIAA0240
chr6_-_137857213 0.531 NM_175747
OLIG3
oligodendrocyte transcription factor 3
chr9_-_116307531 0.518 NM_001173425
NM_015404
DFNB31

deafness, autosomal recessive 31

chr1_+_158317967 0.512 NM_004983
KCNJ9
potassium inwardly-rectifying channel, subfamily J, member 9
chr5_-_16795336 0.511 MYO10
myosin X
chr22_-_36809094 0.510 NM_013356
SLC16A8
solute carrier family 16, member 8 (monocarboxylic acid transporter 3)
chr9_+_33740463 0.509 NM_001197097
NM_007343
NM_001197098
PRSS3


protease, serine, 3


chr5_+_67558217 0.508 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_+_210848763 0.506 ATF3
activating transcription factor 3
chr10_+_114144512 0.498 ACSL5
acyl-CoA synthetase long-chain family member 5
chr7_-_99365178 0.494 NM_181538
GJC3
gap junction protein, gamma 3, 30.2kDa
chr14_-_65550379 0.493


chr1_+_8928508 0.481 NM_001215
CA6
carbonic anhydrase VI
chr3_-_196792274 0.481 NM_001647
APOD
apolipoprotein D
chr6_+_31059463 0.480 NM_001010909
MUC21
mucin 21, cell surface associated
chrX_+_70359780 0.479 NM_000166
GJB1
gap junction protein, beta 1, 32kDa
chr19_+_41419165 0.479 ZNF146
zinc finger protein 146
chr13_-_35327798 0.477 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr22_-_37214480 0.477 NM_001098505
NM_030881
DDX17

DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

chr3_-_45812916 0.465 SLC6A20
solute carrier family 6 (proline IMINO transporter), member 20
chr12_+_53229443 0.463 NM_000924
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr17_+_8154864 0.462 NM_025014
ARHGEF15
Rho guanine nucleotide exchange factor (GEF) 15
chr1_+_54780515 0.462 ACOT11
acyl-CoA thioesterase 11
chr12_+_53229625 0.462 PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr1_+_148496792 0.457 NM_012113
CA14
carbonic anhydrase XIV
chr9_-_112010233 0.452 NM_001012993
C9orf152
chromosome 9 open reading frame 152
chr7_+_72034735 0.451 POM121
POM121 membrane glycoprotein
chr21_-_44824907 0.450 NM_198694
KRTAP10-5
keratin associated protein 10-5
chr1_+_63861474 0.440 NM_001172818
PGM1
phosphoglucomutase 1
chr1_+_559129 0.439


chr7_-_96471544 0.436 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr7_-_93027057 0.434 NM_001164738
CALCR
calcitonin receptor
chr3_+_139211639 0.432 NM_016369
CLDN18
claudin 18
chr3_+_52786642 0.431 NM_002215
ITIH1
inter-alpha (globulin) inhibitor H1
chr5_+_156752739 0.431 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr4_-_15686838 0.429 NM_001145849
NM_001145850
NM_001145851
NM_001145852
NM_006017
PROM1




prominin 1




chr1_-_154665807 0.427 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr5_-_9683462 0.426 NM_019599
TAS2R1
taste receptor, type 2, member 1
chr17_-_31146660 0.419 NM_001032278
NM_024302
MMP28

matrix metallopeptidase 28

chr1_+_26609893 0.416 LIN28A
lin-28 homolog A (C. elegans)
chr6_-_21631992 0.415


chr9_+_109131814 0.413 RAD23B
RAD23 homolog B (S. cerevisiae)
chr11_-_65070625 0.412 LTBP3
latent transforming growth factor beta binding protein 3
chr17_-_20311411 0.412 NM_001042685
LGALS9B
lectin, galactoside-binding, soluble, 9B
chr14_-_23107106 0.411 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr5_-_172016174 0.410


chr4_-_171161486 0.409 NM_001009554
MFAP3L
microfibrillar-associated protein 3-like
chr6_-_29120930 0.407 NM_030903
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chr12_-_55134692 0.407 NM_012064
MIP
major intrinsic protein of lens fiber
chr1_+_46151845 0.404 MAST2
microtubule associated serine/threonine kinase 2
chr1_-_150328153 0.403 NM_001008536
TCHHL1
trichohyalin-like 1
chr1_+_42920755 0.402 YBX1
Y box binding protein 1
chr20_-_43949644 0.401 NM_080608
C20orf165
chromosome 20 open reading frame 165
chr21_-_44795769 0.400 NM_198693
KRTAP10-2
keratin associated protein 10-2
chr11_-_62508946 0.397 NM_004790
NM_153276
NM_153277
NM_153278
SLC22A6



solute carrier family 22 (organic anion transporter), member 6



chr4_-_90978469 0.395 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr12_-_192990 0.393 NM_001122847
SLC6A12
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr2_+_17861266 0.390 NM_001105569
MSGN1
mesogenin 1
chr1_+_2026014 0.389 NM_001033582
PRKCZ
protein kinase C, zeta
chr11_+_60727559 0.386 NM_001079807
PGA3
PGA4
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr4_+_160408447 0.386 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr5_+_140730014 0.380 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr14_+_18447521 0.369 NM_001013354
OR11H12
olfactory receptor, family 11, subfamily H, member 12
chr3_-_69381995 0.367 FRMD4B
FERM domain containing 4B
chr5_-_132228375 0.364 NM_005260
GDF9
growth differentiation factor 9
chr11_+_123945102 0.364 NM_001005194
OR8A1
olfactory receptor, family 8, subfamily A, member 1
chr12_+_10222823 0.362 NM_153022
C12orf59
chromosome 12 open reading frame 59
chr13_-_31784088 0.361 NM_001136571
ZAR1L
zygote arrest 1-like
chr15_-_70288071 0.360 PKM2
pyruvate kinase, muscle
chr1_+_42920718 0.360 YBX1
Y box binding protein 1
chr14_-_23106372 0.360 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr17_+_38247493 0.359 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr1_+_93072947 0.357 RPL5
ribosomal protein L5
chr5_+_149131695 0.355 NM_001172699
PPARGC1B
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr15_+_88120592 0.353 NM_001039958
MESP2
mesoderm posterior 2 homolog (mouse)
chr2_-_100125402 0.353 NM_002285
AFF3
AF4/FMR2 family, member 3
chrX_-_8729377 0.352 NM_001171186
NM_174951
FAM9A

family with sequence similarity 9, member A

chr12_-_66933492 0.352 NM_020525
IL22
interleukin 22
chr2_-_27187467 0.352 NM_001166241
CGREF1
cell growth regulator with EF-hand domain 1
chr3_-_102194938 0.352 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr19_-_7896974 0.350 NM_206833
CTXN1
cortexin 1
chr11_-_110755112 0.347 POU2AF1
POU class 2 associating factor 1
chr2_+_27652892 0.343 NM_032266
C2orf16
chromosome 2 open reading frame 16
chr17_+_40280804 0.342 NM_016438
HIGD1B
HIG1 hypoxia inducible domain family, member 1B
chr9_-_33455191 0.341 NOL6
nucleolar protein family 6 (RNA-associated)
chr10_+_50177192 0.340 NM_001135196
NM_199459
C10orf71

chromosome 10 open reading frame 71

chr11_+_45863774 0.333 NM_005456
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr3_+_38322430 0.332 NM_004803
SLC22A14
solute carrier family 22, member 14
chr12_-_60872814 0.330 NM_178539
FAM19A2
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chr19_+_52504914 0.329 NM_001736
C5AR1
complement component 5a receptor 1
chr1_-_246804680 0.329 NM_001001821
OR2T34
olfactory receptor, family 2, subfamily T, member 34
chr19_+_9132367 0.326


chr4_-_77176163 0.326 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr1_+_32489426 0.325 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr2_-_37269193 0.324 NM_001032377
SULT6B1
sulfotransferase family, cytosolic, 6B, member 1
chr1_-_202449659 0.321 NM_198447
GOLT1A
golgi transport 1A
chr8_-_143830930 0.321 NM_205545
LYPD2
LY6/PLAUR domain containing 2
chr1_-_180908639 0.321 NM_001102450
NM_033345
RGS8

regulator of G-protein signaling 8

chr1_-_35143570 0.320 NM_001080418
DLGAP3
discs, large (Drosophila) homolog-associated protein 3
chr5_-_134810696 0.320 NM_130848
C5orf20
chromosome 5 open reading frame 20
chr11_+_113280727 0.319 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr1_+_42920692 0.319 YBX1
Y box binding protein 1
chr5_+_139869819 0.316


chr11_+_93394025 0.316 NM_001098672
HEPHL1
hephaestin-like 1
chr12_+_123339662 0.313 NM_181709
FAM101A
family with sequence similarity 101, member A
chr19_+_10242763 0.312 ICAM1
intercellular adhesion molecule 1
chr17_-_59304729 0.310 NM_020991
NM_022644
NM_022645
CSH2


chorionic somatomammotropin hormone 2


chr6_-_36915195 0.310 NM_020939
CPNE5
copine V
chr20_-_61669550 0.310 NM_033405
PRIC285
peroxisomal proliferator-activated receptor A interacting complex 285
chr19_-_49097774 0.309 LOC100505715
hypothetical LOC100505715
chr1_+_55237193 0.309 NM_057176
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr12_+_27740694 0.309 NM_001029874
REP15
RAB15 effector protein
chr6_+_88024152 0.307 ZNF292
zinc finger protein 292
chr9_+_107046811 0.305 SLC44A1
solute carrier family 44, member 1
chr8_-_28403652 0.303 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr19_-_6284561 0.303 NM_133492
ACER1
alkaline ceramidase 1
chr1_-_45862225 0.301 NM_001114938
NM_001190182
CCDC17

coiled-coil domain containing 17

chr1_-_202402043 0.300 NM_000537
REN
renin
chr9_+_108726257 0.300 ZNF462
zinc finger protein 462
chr16_+_75790849 0.298 NM_001129979
SYCE1L
synaptonemal complex central element protein 1-like
chr1_-_10964680 0.296 NM_001170754
C1orf127
chromosome 1 open reading frame 127
chr5_-_94250357 0.295 MCTP1
multiple C2 domains, transmembrane 1
chr11_-_46364681 0.294 NM_000741
CHRM4
cholinergic receptor, muscarinic 4
chr3_-_44464722 0.291


chr13_+_97856148 0.291


chr5_-_124108672 0.290 NM_020747
ZNF608
zinc finger protein 608
chr16_+_54263083 0.287 NM_001172502
SLC6A2
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
chr1_+_42920685 0.287 YBX1
Y box binding protein 1
chr5_+_179934143 0.286 CNOT6
CCR4-NOT transcription complex, subunit 6
chr5_+_35892747 0.285 NM_002185
IL7R
interleukin 7 receptor
chr18_-_3209846 0.285 MYOM1
myomesin 1, 185kDa
chr20_+_42776888 0.283 WISP2
WNT1 inducible signaling pathway protein 2
chr5_-_88016397 0.283 LOC645323
hypothetical LOC645323
chr15_+_38648783 0.280 RPUSD2
RNA pseudouridylate synthase domain containing 2
chr8_-_146173531 0.279 ZNF252
zinc finger protein 252
chr11_+_36354110 0.278 NM_001160168
NM_024841
PRR5L

proline rich 5 like


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.22 1.48e-03 GO:0032501 multicellular organismal process
1.28 1.61e-03 GO:0023052 signaling
1.61 2.50e-03 GO:0032879 regulation of localization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.70 4.21e-04 GO:0031988 membrane-bounded vesicle
1.69 6.92e-04 GO:0016023 cytoplasmic membrane-bounded vesicle
1.65 7.80e-04 GO:0031982 vesicle
1.63 2.27e-03 GO:0031410 cytoplasmic vesicle
1.92 1.12e-02 GO:0044433 cytoplasmic vesicle part
1.30 2.22e-02 GO:0044459 plasma membrane part
1.31 3.11e-02 GO:0005576 extracellular region
2.07 4.58e-02 GO:0030141 stored secretory granule
1.19 4.63e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.54 3.02e-03 GO:0005102 receptor binding
1.60 2.99e-02 GO:0005509 calcium ion binding