• All motifs sorted by activity significance
• All samples sorted alphabetically
• Mean activities
• All promoters sorted by FOV

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
• Download the whole report

Motif ID: REST.p3

Z-value: 3.794

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr9_+_134447795	19.795	NM_020064	BARHL1	BarH-like homeobox 1
chr2_-_27384617	14.421	NM_003353	UCN	urocortin
chr3_+_9720509	13.523	NM_153635	CPNE9	copine family member IX
chr8_-_145530639	12.309	NM_031309	SCRT1	scratch homolog 1, zinc finger protein (Drosophila)
chr6_+_110406890	11.072	NM_005284	GPR6	G protein-coupled receptor 6
chr5_-_151284515	10.969	NM_000171 NM_001146040	GLRA1	glycine receptor, alpha 1
chr4_+_158361185	10.352	NM_000826 NM_001083619 NM_001083620	GRIA2	glutamate receptor, ionotropic, AMPA 2
chr5_+_71050745	10.229	NM_004291	CARTPT	CART prepropeptide
chr15_+_65904994	9.975	NM_001031807	SKOR1	SKI family transcriptional corepressor 1
chr7_+_154943466	9.089	NM_001427	EN2	engrailed homeobox 2
chr7_-_19778928	8.682	NM_152774	TMEM196	transmembrane protein 196
chr10_+_26545599	8.601		GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr8_-_57521065	8.543	NM_006211	PENK	proenkephalin
chr19_-_60383280	8.168	NM_003180	SYT5	synaptotagmin V
chr20_+_30019465	7.418	NM_001011718	XKR7	XK, Kell blood group complex subunit-related family, member 7
chr14_-_50631407	7.287		TRIM9	tripartite motif containing 9
chr12_-_3472245	7.271		LOC100129223	hypothetical LOC100129223
chr5_+_33972247	7.188	NM_016568	RXFP3	relaxin/insulin-like family peptide receptor 3
chr8_+_57520915	7.187
chr20_+_44091219	6.990	NM_020708	SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5
chr20_+_44091265	6.835		SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5
chr9_-_138236775	6.698	NM_178138	LHX3	LIM homeobox 3
chr3_-_133236447	6.563	NM_130808	CPNE4	copine IV
chr11_+_22316242	6.423	NM_020346	SLC17A6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr11_-_74819165	6.367	NM_001039548	KLHL35	kelch-like 35 (Drosophila)
chr11_-_74818858	6.367		KLHL35	kelch-like 35 (Drosophila)
chr3_-_48675321	6.330	NM_001407	CELSR3	cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr8_-_91164100	6.328	NM_004929	CALB1	calbindin 1, 28kDa
chr11_-_27698800	6.302	NM_001143805 NM_001143806 NM_170732	BDNF	brain-derived neurotrophic factor
chr11_+_627268	6.194	NM_000797	DRD4	dopamine receptor D4
chr2_+_207215386	6.121	NM_001102659	LOC200726	hCG1657980
chr1_-_149955870	5.910	NM_007185	CELF3	CUGBP, Elav-like family member 3
chr3_+_122109716	5.854	NM_014980	STXBP5L	syntaxin binding protein 5-like
chr20_-_10148137	5.839		LOC100131208	similar to hCG2045825
chr11_-_74818685	5.781		KLHL35	kelch-like 35 (Drosophila)
chr11_-_122357545	5.630	NM_001098169	BSX	brain-specific homeobox
chr17_+_1120607	5.552	NM_001164405	BHLHA9	basic helix-loop-helix family, member a9
chr14_+_92459197	5.440	NM_001275	CHGA	chromogranin A (parathyroid secretory protein 1)
chr14_-_73962557	5.318	NM_001105579	TMEM90A	transmembrane protein 90A
chr17_-_24357014	5.195	NM_001098635 NM_178860	SEZ6	seizure related 6 homolog (mouse)
chr1_+_208178160	4.858	NM_001146261 NM_001146262 NM_001146264 NM_153262	SYT14	synaptotagmin XIV
chr14_-_50631794	4.847		TRIM9	tripartite motif containing 9
chr10_+_26545241	4.841	NM_000818 NM_001134366	GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr4_-_175986952	4.762	NM_001042543 NM_006529	GLRA3	glycine receptor, alpha 3
chr1_+_208178198	4.732		SYT14	synaptotagmin XIV
chr9_+_139153409	4.577	NM_000832 NM_001185090 NM_001185091 NM_007327 NM_021569	GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr14_+_92459244	4.562		CHGA	chromogranin A (parathyroid secretory protein 1)
chr19_-_45416043	4.534		TTC9B	tetratricopeptide repeat domain 9B
chr14_-_104142125	4.427	NM_207379	TMEM179	transmembrane protein 179
chr19_-_45416112	4.199	NM_152479	TTC9B	tetratricopeptide repeat domain 9B
chr6_+_154402135	3.834	NM_000914 NM_001008503 NM_001008504 NM_001008505 NM_001145282 NM_001145283 NM_001145285 NM_001145286 NM_001145284	OPRM1	opioid receptor, mu 1
chr7_-_100595552	3.784	NM_003378	VGF	VGF nerve growth factor inducible
chr7_+_8440541	3.759		NXPH1	neurexophilin 1
chr15_-_70399181	3.739		CELF6	CUGBP, Elav-like family member 6
chr3_-_188870799	3.669	NM_001048	SST	somatostatin
chr15_+_73074882	3.605	NM_001178111 NM_001178112 NM_138967	SCAMP5	secretory carrier membrane protein 5
chr11_+_45863774	3.479	NM_005456	MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1
chr4_+_8633116	3.425	NM_080819	GPR78	G protein-coupled receptor 78
chr2_-_51112743	3.421		NRXN1	neurexin 1
chr1_+_33124658	3.408	NM_002143	HPCA	hippocalcin
chr12_+_111714096	3.375		RPH3A	rabphilin 3A homolog (mouse)
chr1_-_102234959	3.314		OLFM3	olfactomedin 3
chr3_-_115380539	3.182	NM_000796 NM_033663	DRD3	dopamine receptor D3
chr16_+_66244314	3.123		RLTPR	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr5_-_135729062	3.114	NM_001167576 NM_001167577 NM_020389	TRPC7	transient receptor potential cation channel, subfamily C, member 7
chr7_+_8440109	3.107	NM_152745	NXPH1	neurexophilin 1
chr15_-_70399301	2.979	NM_001172684	CELF6	CUGBP, Elav-like family member 6
chr6_+_158877640	2.922		TMEM181	transmembrane protein 181
chr20_-_60228665	2.899	NM_007232	HRH3	histamine receptor H3
chr12_+_111713931	2.835	NM_001143854 NM_014954	RPH3A	rabphilin 3A homolog (mouse)
chr1_+_152806874	2.786	NM_000748	CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)
chr15_-_24570010	2.784	NM_021912	GABRB3	gamma-aminobutyric acid (GABA) A receptor, beta 3
chr12_-_97812633	2.763		ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B
chr18_-_39111243	2.719	NM_020783	SYT4	synaptotagmin IV
chr12_-_29828958	2.684	NM_175861	TMTC1	transmembrane and tetratricopeptide repeat containing 1
chr17_+_77925441	2.624	NM_018949	UTS2R	urotensin 2 receptor
chr20_-_61755145	2.560	NM_015894	STMN3	stathmin-like 3
chr19_-_44427446	2.438	NM_172139	IL28B	interleukin 28B (interferon, lambda 3)
chr1_-_102235377	2.419	NM_058170	OLFM3	olfactomedin 3
chr12_+_117903682	2.411	NM_194286	SRRM4	serine/arginine repetitive matrix 4
chr15_-_70399551	2.379	NM_052840	CELF6	CUGBP, Elav-like family member 6
chr11_-_125278296	2.303	NM_031307	PUS3	pseudouridylate synthase 3
chr7_+_145444385	2.293	NM_014141	CNTNAP2	contactin associated protein-like 2
chr17_+_70178911	2.281		RAB37	RAB37, member RAS oncogene family
chr12_-_29827952	2.196	NM_001193451	TMTC1	transmembrane and tetratricopeptide repeat containing 1
chr17_+_70178850	2.152	NM_175738	RAB37	RAB37, member RAS oncogene family
chr10_+_69990050	2.059	NM_030625	TET1	tet oncogene 1
chr15_-_70399523	2.039		CELF6	CUGBP, Elav-like family member 6
chr19_+_4720144	2.025		C19orf30	chromosome 19 open reading frame 30
chr12_+_46133	2.019	NM_001170738	IQSEC3	IQ motif and Sec7 domain 3
chr6_+_158877455	1.819	NM_020823	TMEM181	transmembrane protein 181
chr10_-_44200458	1.797	NM_000609 NM_001033886 NM_001178134 NM_199168	CXCL12	chemokine (C-X-C motif) ligand 12
chr19_+_45728270	1.792		SPTBN4	spectrin, beta, non-erythrocytic 4
chr1_-_239587090	1.679	NM_002924	RGS7	regulator of G-protein signaling 7
chr2_+_114916368	1.677	NM_020868	DPP10	dipeptidyl-peptidase 10 (non-functional)
chr17_-_3248453	1.660	NM_003553	OR1E1	olfactory receptor, family 1, subfamily E, member 1
chr9_-_73251639	1.635		TRPM3	transient receptor potential cation channel, subfamily M, member 3
chr8_-_145723209	1.627	NM_001024678	LRRC24	leucine rich repeat containing 24
chr5_+_175231098	1.555	NM_001008220	CPLX2	complexin 2
chr10_+_60607232	1.496	NM_001143774	PHYHIPL	phytanoyl-CoA 2-hydroxylase interacting protein-like
chrX_-_47364039	1.492
chr6_+_25760352	1.446	NM_006998	SCGN	secretagogin, EF-hand calcium binding protein
chr3_+_62279707	1.409		C3orf14	chromosome 3 open reading frame 14
chr5_+_175231170	1.393
chr7_+_8439762	1.346		NXPH1	neurexophilin 1
chr5_+_175231210	1.339		CPLX2	complexin 2
chrX_-_47364173	1.334	NM_006950 NM_133499	SYN1	synapsin I
chr16_+_2959362	1.282		PAQR4	progestin and adipoQ receptor family member IV
chr10_-_50640327	1.272	NM_001143996 NM_001143997 NM_018245	OGDHL	oxoglutarate dehydrogenase-like
chr19_+_45728207	1.239	NM_025213	SPTBN4	spectrin, beta, non-erythrocytic 4
chr11_-_1725924	1.239	NM_001170820	LOC402778	CD225 family protein FLJ76511
chr16_+_2959342	1.226	NM_152341	PAQR4	progestin and adipoQ receptor family member IV
chr10_-_102780840	1.223		PDZD7	PDZ domain containing 7
chr18_-_5187240	1.183	NM_001145194	LOC642597	hypothetical protein LOC642597
chr10_-_102780867	1.155	NM_001195263 NM_024895	PDZD7	PDZ domain containing 7
chr2_-_51113040	1.088	NM_001135659 NM_004801	NRXN1	neurexin 1
chr5_-_175969697	1.043	NM_052899	GPRIN1	G protein regulated inducer of neurite outgrowth 1
chr15_+_67009892	0.944	NM_145658 NM_001184780	SPESP1 NOX5	sperm equatorial segment protein 1 NADPH oxidase, EF-hand calcium binding domain 5
chr17_+_39741306	0.929	NM_001144825 NM_001144826 NM_006695	RUNDC3A	RUN domain containing 3A
chr6_+_153113624	0.923	NM_003381 NM_194435	VIP	vasoactive intestinal peptide
chr2_+_131230252	0.907	NM_001105194 NM_001105195	FAM123C	family with sequence similarity 123C
chr3_+_52787478	0.878	NM_001166434	ITIH1	inter-alpha (globulin) inhibitor H1
chr1_+_152806924	0.859		CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)
chr15_-_29950070	0.854		OTUD7A	OTU domain containing 7A
chrX_-_152794478	0.832		L1CAM	L1 cell adhesion molecule
chr11_-_6633427	0.827	NM_003737	DCHS1	dachsous 1 (Drosophila)
chr10_+_102780974	0.813	NM_030971	SFXN3	sideroflexin 3
chr1_-_239587007	0.781		RGS7	regulator of G-protein signaling 7
chr11_-_1725662	0.742		LOC402778	CD225 family protein FLJ76511
chr16_+_24175173	0.728		CACNG3	calcium channel, voltage-dependent, gamma subunit 3
chr8_+_69027143	0.698	NM_024870 NM_025170	PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr8_+_69026895	0.675		PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr15_-_29950188	0.668		OTUD7A	OTU domain containing 7A
chr17_-_3283884	0.652	NM_003554	OR1E2	olfactory receptor, family 1, subfamily E, member 2
chr8_+_69027277	0.646		PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr19_-_50429306	0.641	NM_138568	EXOC3L2	exocyst complex component 3-like 2
chr8_+_80685859	0.630		STMN2	stathmin-like 2
chr1_-_33108876	0.618	NM_001171940 NM_153756	FNDC5	fibronectin type III domain containing 5
chr5_+_175231144	0.600		CPLX2	complexin 2
chr16_+_24174975	0.586		CACNG3	calcium channel, voltage-dependent, gamma subunit 3
chr12_+_112280757	0.574		PLBD2	phospholipase B domain containing 2
chr3_+_62280435	0.546	NM_020685	C3orf14	chromosome 3 open reading frame 14
chr1_-_151390050	0.499	NM_001014291	SPRR2G	small proline-rich protein 2G
chrX_-_152794592	0.498	NM_000425 NM_001143963 NM_024003	L1CAM	L1 cell adhesion molecule
chr11_-_123030091	0.483		SCN3B	sodium channel, voltage-gated, type III, beta
chrX_-_48943582	0.441	NM_003179	SYP	synaptophysin
chr18_+_55718171	0.423	NM_021127	PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1
chr20_+_5839973	0.415	NM_001819	CHGB	chromogranin B (secretogranin 1)
chr5_+_141283550	0.407	NM_001142603 NM_014773	KIAA0141	KIAA0141
chr6_+_35881048	0.393	NM_182548	LHFPL5	lipoma HMGIC fusion partner-like 5
chr20_+_35445350	0.322		SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr12_+_112280753	0.295	NM_001159727 NM_173542	PLBD2	phospholipase B domain containing 2
chr17_-_3546236	0.282	NM_002561 NM_175080 NM_175081	P2RX5-TAX1BP3 P2RX5	P2RX5-TAX1BP3 read-through transcript purinergic receptor P2X, ligand-gated ion channel, 5
chr17_-_7095622	0.266	NM_001143775	CTDNEP1	CTD nuclear envelope phosphatase 1
chr5_+_141283647	0.241		KIAA0141	KIAA0141
chr19_+_38867273	0.222	NM_022467	CHST8	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr19_+_51804260	0.155		CALM3	calmodulin 3 (phosphorylase kinase, delta)
chr19_-_50618599	0.139		ERCC1	excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr6_-_32121784	0.138	NM_032470	TNXB	tenascin XB
chr1_+_100777044	0.112		GPR88	G protein-coupled receptor 88
chr11_-_27677755	0.110	NM_170734	BDNF	brain-derived neurotrophic factor
chrX_+_152891184	0.100	NM_003492	TMEM187	transmembrane protein 187
chr1_-_20707103	0.096		MUL1	mitochondrial E3 ubiquitin protein ligase 1
chr1_-_20707196	0.072	NM_024544	MUL1	mitochondrial E3 ubiquitin protein ligase 1
chr10_+_73225533	0.066	NM_001171933 NM_001171934	CDH23	cadherin-related 23
chr8_-_94046891	0.054	NM_001191036	C8orf83	chromosome 8 open reading frame 83
chr11_-_72170533	0.054		STARD10	StAR-related lipid transfer (START) domain containing 10
chr2_-_96174502	0.049		DUSP2	dual specificity phosphatase 2
chr22_-_16636748	0.042	NM_197966	BID	BH3 interacting domain death agonist
chr11_+_64565118	0.025		SAC3D1	SAC3 domain containing 1
chr11_+_62136788	0.016	NM_000327	ROM1	retinal outer segment membrane protein 1

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
8.12	1.76e-11	GO:0007268	synaptic transmission
7.56	1.94e-11	GO:0019226	transmission of nerve impulse
7.56	1.94e-11	GO:0035637	multicellular organismal signaling
3.52	2.70e-09	GO:0003008	system process
3.91	3.22e-09	GO:0050877	neurological system process
4.92	1.32e-07	GO:0007267	cell-cell signaling
5.57	7.80e-07	GO:0007186	G-protein coupled receptor protein signaling pathway
4.02	1.25e-06	GO:0007154	cell communication
7.09	7.19e-06	GO:0007610	behavior
5.84	9.59e-06	GO:0046903	secretion
10.72	2.17e-05	GO:0031644	regulation of neurological system process
2.10	4.50e-05	GO:0023052	signaling
10.66	1.15e-04	GO:0051969	regulation of transmission of nerve impulse
1.80	2.04e-04	GO:0032501	multicellular organismal process
5.03	4.97e-04	GO:0055082	cellular chemical homeostasis
4.84	1.96e-03	GO:0006873	cellular ion homeostasis
11.06	2.24e-03	GO:0007626	locomotory behavior
5.56	3.23e-03	GO:0032940	secretion by cell
19.84	3.34e-03	GO:0051952	regulation of amine transport
7.11	3.43e-03	GO:0055074	calcium ion homeostasis
3.95	3.97e-03	GO:0048878	chemical homeostasis
6.85	4.63e-03	GO:0072507	divalent inorganic cation homeostasis
4.47	4.69e-03	GO:0050801	ion homeostasis
4.15	4.70e-03	GO:0019725	cellular homeostasis
9.70	5.36e-03	GO:0003001	generation of a signal involved in cell-cell signaling
9.70	5.36e-03	GO:0023061	signal release
5.22	5.89e-03	GO:0044057	regulation of system process
2.28	7.50e-03	GO:0065008	regulation of biological quality
9.18	7.70e-03	GO:0050804	regulation of synaptic transmission
26.69	9.23e-03	GO:0014073	response to tropane
26.69	9.23e-03	GO:0042220	response to cocaine
24.47	1.33e-02	GO:0060078	regulation of postsynaptic membrane potential
48.93	1.71e-02	GO:0010155	regulation of proton transport
22.59	1.85e-02	GO:0050433	regulation of catecholamine secretion
10.13	1.91e-02	GO:0001505	regulation of neurotransmitter levels
21.75	2.16e-02	GO:0045776	negative regulation of blood pressure
6.53	2.16e-02	GO:0006874	cellular calcium ion homeostasis
1.96	2.29e-02	GO:0051234	establishment of localization
4.97	2.34e-02	GO:0051046	regulation of secretion
6.32	2.73e-02	GO:0072503	cellular divalent inorganic cation homeostasis
6.29	2.84e-02	GO:0003013	circulatory system process
6.29	2.84e-02	GO:0008015	blood circulation
4.80	3.10e-02	GO:0055080	cation homeostasis
40.04	3.32e-02	GO:0032225	regulation of synaptic transmission, dopaminergic
1.93	4.05e-02	GO:0006810	transport
11.84	4.33e-02	GO:0007269	neurotransmitter secretion
36.70	4.41e-02	GO:0032413	negative regulation of ion transmembrane transporter activity
8.73	4.45e-02	GO:0006836	neurotransmitter transport
8.56	4.96e-02	GO:0008217	regulation of blood pressure

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
8.70	1.27e-09	GO:0044456	synapse part
6.84	1.62e-08	GO:0045202	synapse
17.07	4.22e-08	GO:0008021	synaptic vesicle
26.10	8.07e-08	GO:0030672	synaptic vesicle membrane
6.12	9.16e-07	GO:0043005	neuron projection
4.29	4.45e-06	GO:0016023	cytoplasmic membrane-bounded vesicle
4.21	6.07e-06	GO:0031988	membrane-bounded vesicle
4.04	1.20e-05	GO:0031410	cytoplasmic vesicle
13.82	1.44e-05	GO:0030665	clathrin coated vesicle membrane
9.18	1.78e-05	GO:0030136	clathrin-coated vesicle
3.91	2.03e-05	GO:0031982	vesicle
6.81	2.55e-05	GO:0030659	cytoplasmic vesicle membrane
6.58	3.68e-05	GO:0012506	vesicle membrane
4.39	3.79e-05	GO:0030054	cell junction
7.50	1.17e-04	GO:0030135	coated vesicle
10.22	1.49e-04	GO:0030662	coated vesicle membrane
5.65	1.84e-04	GO:0044433	cytoplasmic vesicle part
3.41	3.39e-04	GO:0042995	cell projection
6.87	2.83e-03	GO:0043025	neuronal cell body
6.68	3.48e-03	GO:0044297	cell body
2.16	3.83e-03	GO:0044459	plasma membrane part
6.22	5.79e-03	GO:0030425	dendrite
1.44	6.06e-03	GO:0016020	membrane
1.52	6.99e-03	GO:0044425	membrane part
8.90	7.51e-03	GO:0019717	synaptosome
6.95	8.77e-03	GO:0045211	postsynaptic membrane
1.56	1.35e-02	GO:0031224	intrinsic to membrane
1.56	1.63e-02	GO:0016021	integral to membrane
25.91	2.51e-02	GO:0032589	neuron projection membrane
73.39	3.52e-02	GO:0032590	dendrite membrane
1.64	3.79e-02	GO:0005886	plasma membrane

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
14.28	7.79e-05	GO:0005230	extracellular ligand-gated ion channel activity
18.74	1.01e-04	GO:0005231	excitatory extracellular ligand-gated ion channel activity
27.96	1.51e-03	GO:0005184	neuropeptide hormone activity
8.23	3.14e-03	GO:0015276	ligand-gated ion channel activity
8.23	3.14e-03	GO:0022834	ligand-gated channel activity
4.25	7.84e-03	GO:0005216	ion channel activity
8.90	7.91e-03	GO:0005179	hormone activity
4.18	9.02e-03	GO:0022838	substrate-specific channel activity
33.88	1.13e-02	GO:0016594	glycine binding
4.05	1.18e-02	GO:0015267	channel activity
4.04	1.21e-02	GO:0022803	passive transmembrane transporter activity
97.85	1.86e-02	GO:0001591	dopamine receptor activity, coupled via Gi/Go
7.17	2.63e-02	GO:0043176	amine binding
4.40	2.93e-02	GO:0022836	gated channel activity
2.46	3.20e-02	GO:0005215	transporter activity
73.39	3.71e-02	GO:0016933	extracellular-glycine-gated ion channel activity
73.39	3.71e-02	GO:0016934	extracellular-glycine-gated chloride channel activity
3.05	4.58e-02	GO:0005509	calcium ion binding

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