Motif ID: REST.p3

Z-value: 3.794


Transcription factors associated with REST.p3:

Gene SymbolEntrez IDGene Name
REST 5978 RE1-silencing transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RESTchr4_+_574691220.495.2e-02Click!


Activity profile for motif REST.p3.

activity profile for motif REST.p3


Sorted Z-values histogram for motif REST.p3

Sorted Z-values for motif REST.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of REST.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 171 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_134447795 19.795 NM_020064
 BARHL1
BarH-like homeobox 1
chr2_-_27384617 14.421 NM_003353
 UCN
urocortin
chr3_+_9720509 13.523 NM_153635
 CPNE9
copine family member IX
chr8_-_145530639 12.309 NM_031309
 SCRT1
scratch homolog 1, zinc finger protein (Drosophila)
chr6_+_110406890 11.072 NM_005284
 GPR6
G protein-coupled receptor 6
chr5_-_151284515 10.969 NM_000171
NM_001146040
 GLRA1

glycine receptor, alpha 1

chr4_+_158361185 10.352 NM_000826
NM_001083619
NM_001083620
 GRIA2


glutamate receptor, ionotropic, AMPA 2


chr5_+_71050745 10.229 NM_004291
 CARTPT
CART prepropeptide
chr15_+_65904994 9.975 NM_001031807
 SKOR1
SKI family transcriptional corepressor 1
chr7_+_154943466 9.089 NM_001427
 EN2
engrailed homeobox 2
chr7_-_19778928 8.682 NM_152774
 TMEM196
transmembrane protein 196
chr10_+_26545599 8.601 GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr8_-_57521065 8.543 NM_006211
 PENK
proenkephalin
chr19_-_60383280 8.168 NM_003180
 SYT5
synaptotagmin V
chr20_+_30019465 7.418 NM_001011718
 XKR7
XK, Kell blood group complex subunit-related family, member 7
chr14_-_50631407 7.287 TRIM9
tripartite motif containing 9
chr12_-_3472245 7.271 LOC100129223
hypothetical LOC100129223
chr5_+_33972247 7.188 NM_016568
 RXFP3
relaxin/insulin-like family peptide receptor 3
chr8_+_57520915 7.187


chr20_+_44091219 6.990 NM_020708
 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 49 entries
enrichment   p-value GO term description
48.93 1.71e-02 GO:0010155 regulation of proton transport
40.04 3.32e-02 GO:0032225 regulation of synaptic transmission, dopaminergic
36.70 4.41e-02 GO:0032413 negative regulation of ion transmembrane transporter activity
26.69 9.23e-03 GO:0014073 response to tropane
26.69 9.23e-03 GO:0042220 response to cocaine
24.47 1.33e-02 GO:0060078 regulation of postsynaptic membrane potential
22.59 1.85e-02 GO:0050433 regulation of catecholamine secretion
21.75 2.16e-02 GO:0045776 negative regulation of blood pressure
19.84 3.34e-03 GO:0051952 regulation of amine transport
11.84 4.33e-02 GO:0007269 neurotransmitter secretion
11.06 2.24e-03 GO:0007626 locomotory behavior
10.72 2.17e-05 GO:0031644 regulation of neurological system process
10.66 1.15e-04 GO:0051969 regulation of transmission of nerve impulse
10.13 1.91e-02 GO:0001505 regulation of neurotransmitter levels
9.70 5.36e-03 GO:0003001 generation of a signal involved in cell-cell signaling
9.70 5.36e-03 GO:0023061 signal release
9.18 7.70e-03 GO:0050804 regulation of synaptic transmission
8.73 4.45e-02 GO:0006836 neurotransmitter transport
8.56 4.96e-02 GO:0008217 regulation of blood pressure
8.12 1.76e-11 GO:0007268 synaptic transmission

Gene overrepresentation in compartment category:

Showing 1 to 20 of 31 entries
enrichment   p-value GO term description
73.39 3.52e-02 GO:0032590 dendrite membrane
26.10 8.07e-08 GO:0030672 synaptic vesicle membrane
25.91 2.51e-02 GO:0032589 neuron projection membrane
17.07 4.22e-08 GO:0008021 synaptic vesicle
13.82 1.44e-05 GO:0030665 clathrin coated vesicle membrane
10.22 1.49e-04 GO:0030662 coated vesicle membrane
9.18 1.78e-05 GO:0030136 clathrin-coated vesicle
8.90 7.51e-03 GO:0019717 synaptosome
8.70 1.27e-09 GO:0044456 synapse part
7.50 1.17e-04 GO:0030135 coated vesicle
6.95 8.77e-03 GO:0045211 postsynaptic membrane
6.87 2.83e-03 GO:0043025 neuronal cell body
6.84 1.62e-08 GO:0045202 synapse
6.81 2.55e-05 GO:0030659 cytoplasmic vesicle membrane
6.68 3.48e-03 GO:0044297 cell body
6.58 3.68e-05 GO:0012506 vesicle membrane
6.22 5.79e-03 GO:0030425 dendrite
6.12 9.16e-07 GO:0043005 neuron projection
5.65 1.84e-04 GO:0044433 cytoplasmic vesicle part
4.39 3.79e-05 GO:0030054 cell junction

Gene overrepresentation in function category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
97.85 1.86e-02 GO:0001591 dopamine receptor activity, coupled via Gi/Go
73.39 3.71e-02 GO:0016933 extracellular-glycine-gated ion channel activity
73.39 3.71e-02 GO:0016934 extracellular-glycine-gated chloride channel activity
33.88 1.13e-02 GO:0016594 glycine binding
27.96 1.51e-03 GO:0005184 neuropeptide hormone activity
18.74 1.01e-04 GO:0005231 excitatory extracellular ligand-gated ion channel activity
14.28 7.79e-05 GO:0005230 extracellular ligand-gated ion channel activity
8.90 7.91e-03 GO:0005179 hormone activity
8.23 3.14e-03 GO:0015276 ligand-gated ion channel activity
8.23 3.14e-03 GO:0022834 ligand-gated channel activity
7.17 2.63e-02 GO:0043176 amine binding
4.40 2.93e-02 GO:0022836 gated channel activity
4.25 7.84e-03 GO:0005216 ion channel activity
4.18 9.02e-03 GO:0022838 substrate-specific channel activity
4.05 1.18e-02 GO:0015267 channel activity
4.04 1.21e-02 GO:0022803 passive transmembrane transporter activity
3.05 4.58e-02 GO:0005509 calcium ion binding
2.46 3.20e-02 GO:0005215 transporter activity