Motif ID: EGR1..3.p2

Z-value: 2.168


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EGR2chr10_-_642489320.821.1e-04Click!
EGR3chr8_-_226064010.485.7e-02Click!
EGR1chr5_+_137829065-0.146.0e-01Click!


Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_809879 4.839 NM_006651
 CPLX1
complexin 1
chr2_+_104838177 3.814 NM_006236
 POU3F3
POU class 3 homeobox 3
chr18_+_53253775 3.108 NM_004852
 ONECUT2
one cut homeobox 2
chr20_-_60074237 3.072 NM_003185
 TAF4
TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
chr1_+_41022066 2.874 NM_004700
NM_172163
 KCNQ4

potassium voltage-gated channel, KQT-like subfamily, member 4

chr15_+_22644448 2.846


chr2_+_42128521 2.608 NM_138370
 PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr7_-_526005 2.432 NM_002607
NM_033023
 PDGFA

platelet-derived growth factor alpha polypeptide

chr7_-_525556 2.395 PDGFA
platelet-derived growth factor alpha polypeptide
chr7_+_55922623 2.344 ZNF713
zinc finger protein 713
chr16_+_1143241 2.292 NM_001005407
NM_021098
 CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr2_+_10101081 2.052 NM_003597
NM_001177716
 KLF11

Kruppel-like factor 11

chr3_-_185461768 2.017 NM_033259
 CAMK2N2
calcium/calmodulin-dependent protein kinase II inhibitor 2
chr6_+_99389300 1.932 NM_005604
 POU3F2
POU class 3 homeobox 2
chr17_+_75366524 1.846 NM_005189
NM_032647
 CBX2

chromobox homolog 2

chr17_+_77582774 1.840 NM_005052
 RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr1_+_38032045 1.840 NM_001031740
NM_001113482
 MANEAL

mannosidase, endo-alpha-like

chr13_-_19633182 1.838 NM_021954
 GJA3
gap junction protein, alpha 3, 46kDa
chr6_+_99389318 1.814 POU3F2
POU class 3 homeobox 2
chr20_-_61933012 1.788 ZBTB46
zinc finger and BTB domain containing 46

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 209 entries
enrichment   p-value GO term description
3.53 4.13e-02 GO:0060993 kidney morphogenesis
3.42 2.94e-02 GO:0072073 kidney epithelium development
3.13 2.51e-05 GO:0001656 metanephros development
3.04 1.29e-02 GO:0072006 nephron development
2.69 7.25e-06 GO:0042472 inner ear morphogenesis
2.53 9.08e-06 GO:0042471 ear morphogenesis
2.50 3.86e-02 GO:0048663 neuron fate commitment
2.50 3.86e-02 GO:0060021 palate development
2.45 1.51e-02 GO:0090090 negative regulation of canonical Wnt receptor signaling pathway
2.42 5.77e-06 GO:0048839 inner ear development
2.40 5.70e-04 GO:2000027 regulation of organ morphogenesis
2.39 3.52e-07 GO:0043583 ear development
2.32 4.79e-09 GO:0045165 cell fate commitment
2.29 4.63e-05 GO:0030323 respiratory tube development
2.29 3.24e-02 GO:0001838 embryonic epithelial tube formation
2.26 1.69e-04 GO:0030324 lung development
2.26 3.03e-02 GO:0032409 regulation of transporter activity
2.25 4.77e-02 GO:0072175 epithelial tube formation
2.23 6.69e-03 GO:0016331 morphogenesis of embryonic epithelium
2.22 7.12e-08 GO:0048562 embryonic organ morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 41 entries
enrichment   p-value GO term description
2.78 9.85e-05 GO:0030672 synaptic vesicle membrane
2.47 3.35e-06 GO:0014069 postsynaptic density
2.44 3.58e-02 GO:0000118 histone deacetylase complex
2.38 5.06e-06 GO:0008021 synaptic vesicle
2.13 9.47e-04 GO:0008076 voltage-gated potassium channel complex
2.13 9.47e-04 GO:0034705 potassium channel complex
2.06 1.18e-13 GO:0044456 synapse part
2.00 3.34e-06 GO:0030136 clathrin-coated vesicle
2.00 1.22e-02 GO:0030665 clathrin coated vesicle membrane
1.96 8.53e-16 GO:0045202 synapse
1.96 1.37e-04 GO:0034703 cation channel complex
1.95 1.89e-02 GO:0016585 chromatin remodeling complex
1.86 6.57e-04 GO:0045211 postsynaptic membrane
1.78 7.84e-05 GO:0034702 ion channel complex
1.78 4.59e-03 GO:0005912 adherens junction
1.76 7.27e-15 GO:0030054 cell junction
1.75 7.85e-04 GO:0030425 dendrite
1.74 7.14e-04 GO:0030135 coated vesicle
1.73 5.87e-03 GO:0070161 anchoring junction
1.70 1.86e-04 GO:0005667 transcription factor complex

Gene overrepresentation in function category:

Showing 1 to 20 of 39 entries
enrichment   p-value GO term description
2.45 1.46e-07 GO:0005249 voltage-gated potassium channel activity
2.18 1.50e-07 GO:0022843 voltage-gated cation channel activity
2.18 1.64e-06 GO:0005267 potassium channel activity
2.10 6.10e-03 GO:0019199 transmembrane receptor protein kinase activity
2.06 1.20e-08 GO:0010843 promoter binding
2.03 1.76e-08 GO:0000975 regulatory region DNA binding
2.03 1.76e-08 GO:0001067 regulatory region nucleic acid binding
2.03 1.76e-08 GO:0044212 transcription regulatory region DNA binding
2.02 1.57e-02 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
1.94 2.85e-02 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
1.90 1.18e-05 GO:0005244 voltage-gated ion channel activity
1.90 1.18e-05 GO:0022832 voltage-gated channel activity
1.87 9.04e-10 GO:0016563 transcription activator activity
1.83 2.49e-20 GO:0043565 sequence-specific DNA binding
1.74 1.35e-05 GO:0005261 cation channel activity
1.67 2.67e-20 GO:0030528 transcription regulator activity
1.66 5.16e-05 GO:0022836 gated channel activity
1.64 2.80e-18 GO:0001071 nucleic acid binding transcription factor activity
1.64 2.80e-18 GO:0003700 sequence-specific DNA binding transcription factor activity
1.64 1.94e-04 GO:0008134 transcription factor binding