Motif ID: SPIB.p2

Z-value: 1.487


Transcription factors associated with SPIB.p2:

Gene SymbolEntrez IDGene Name
SPIB 6689 Spi-B transcription factor (Spi-1/PU.1 related)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SPIBchr19_+_55614006-0.165.7e-01Click!


Activity profile for motif SPIB.p2.

activity profile for motif SPIB.p2


Sorted Z-values histogram for motif SPIB.p2

Sorted Z-values for motif SPIB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPIB.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_64922420 1.990 NM_002758
 MAP2K6
mitogen-activated protein kinase kinase 6
chr6_-_159386007 1.460 NM_054114
NM_138810
NM_152133
 TAGAP


T-cell activation RhoGTPase activating protein


chr17_+_37693090 1.069 NM_003152
 STAT5A
signal transducer and activator of transcription 5A
chr6_+_130381408 1.064 NM_001007102
NM_032438
 L3MBTL3

l(3)mbt-like 3 (Drosophila)

chr2_+_183651531 1.041 NM_001142314
NM_080876
 DUSP19

dual specificity phosphatase 19

chr6_-_32742265 1.037 NM_002123
 HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr12_+_4253143 1.010 NM_001759
 CCND2
cyclin D2
chr14_+_22915772 1.006 NM_001037288
NM_138460
 CMTM5

CKLF-like MARVEL transmembrane domain containing 5

chr17_-_53847937 0.977 RNF43
ring finger protein 43
chr2_+_102401580 0.976 NM_003853
 IL18RAP
interleukin 18 receptor accessory protein
chr14_-_22658078 0.969 NM_001805
 CEBPE
CCAAT/enhancer binding protein (C/EBP), epsilon
chr2_-_175207521 0.894 NM_003387
 WIPF1
WAS/WASL interacting protein family, member 1
chr14_-_22127902 0.858 DAD1
defender against cell death 1
chr16_-_30841938 0.813 NCRNA00095
non-protein coding RNA 95
chr7_-_104440707 0.803 LOC100216545
hypothetical LOC100216545
chr2_-_55349818 0.800 NM_001005369
 MTIF2
mitochondrial translational initiation factor 2
chr17_+_35046843 0.784 NM_001165937
NM_001165938
NM_006804
 STARD3


StAR-related lipid transfer (START) domain containing 3


chr11_+_65026382 0.758


chr17_+_44643067 0.757 ABI3
ABI family, member 3
chr16_-_83703496 0.749 NM_198491
 FAM92B
family with sequence similarity 92, member B

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 53 entries
enrichment   p-value GO term description
2.16 3.35e-03 GO:0031294 lymphocyte costimulation
2.16 3.35e-03 GO:0031295 T cell costimulation
1.90 6.73e-03 GO:0050851 antigen receptor-mediated signaling pathway
1.82 6.16e-04 GO:0050870 positive regulation of T cell activation
1.78 1.48e-04 GO:0051251 positive regulation of lymphocyte activation
1.73 6.56e-04 GO:0050863 regulation of T cell activation
1.65 4.55e-03 GO:0050867 positive regulation of cell activation
1.65 4.57e-03 GO:0002696 positive regulation of leukocyte activation
1.64 1.19e-03 GO:0051249 regulation of lymphocyte activation
1.62 4.77e-02 GO:0006417 regulation of translation
1.60 1.18e-02 GO:0000375 RNA splicing, via transesterification reactions
1.60 1.55e-02 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
1.60 1.55e-02 GO:0000398 nuclear mRNA splicing, via spliceosome
1.60 2.61e-02 GO:0022411 cellular component disassembly
1.60 2.61e-02 GO:0071845 cellular component disassembly at cellular level
1.55 9.00e-03 GO:0002694 regulation of leukocyte activation
1.53 5.28e-03 GO:0010608 posttranscriptional regulation of gene expression
1.52 1.11e-04 GO:0006397 mRNA processing
1.52 3.31e-03 GO:0008380 RNA splicing
1.51 3.09e-03 GO:0006412 translation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 30 entries
enrichment   p-value GO term description
3.54 2.37e-02 GO:0035631 CD40 receptor complex
1.81 5.27e-04 GO:0016607 nuclear speck
1.56 1.90e-03 GO:0016604 nuclear body
1.45 5.58e-06 GO:0030529 ribonucleoprotein complex
1.39 5.68e-04 GO:0005730 nucleolus
1.32 2.52e-08 GO:0005654 nucleoplasm
1.30 3.29e-11 GO:0031981 nuclear lumen
1.28 7.14e-12 GO:0044428 nuclear part
1.27 8.27e-12 GO:0031974 membrane-enclosed lumen
1.27 4.11e-11 GO:0043233 organelle lumen
1.27 9.37e-11 GO:0070013 intracellular organelle lumen
1.27 1.54e-02 GO:0044451 nucleoplasm part
1.19 1.17e-04 GO:0005829 cytosol
1.17 2.96e-07 GO:0032991 macromolecular complex
1.17 5.62e-05 GO:0043228 non-membrane-bounded organelle
1.17 5.62e-05 GO:0043232 intracellular non-membrane-bounded organelle
1.16 7.01e-13 GO:0005634 nucleus
1.15 1.44e-11 GO:0044422 organelle part
1.15 4.74e-11 GO:0044446 intracellular organelle part
1.13 9.17e-03 GO:0043234 protein complex

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
1.94 1.16e-02 GO:0047485 protein N-terminus binding
1.40 6.73e-08 GO:0003723 RNA binding
1.18 3.13e-07 GO:0003676 nucleic acid binding
1.14 1.50e-15 GO:0005515 protein binding
1.06 1.38e-08 GO:0005488 binding