Motif ID: ZBTB16.p2

Z-value: 1.859


Transcription factors associated with ZBTB16.p2:

Gene SymbolEntrez IDGene Name
ZBTB16 7704 zinc finger and BTB domain containing 16

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZBTB16chr11_+_113436438-0.439.4e-02Click!


Activity profile for motif ZBTB16.p2.

activity profile for motif ZBTB16.p2


Sorted Z-values histogram for motif ZBTB16.p2

Sorted Z-values for motif ZBTB16.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZBTB16.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_10453409 2.826 NM_013431
KLRC4-KLRK1
KLRC4
KLRC4-KLRK1 read-through transcript
killer cell lectin-like receptor subfamily C, member 4
chr5_+_57823017 2.798 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr9_-_21340885 2.734 NM_021002
IFNA6
interferon, alpha 6
chr4_-_77176163 2.564 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr7_-_92693716 2.553 NM_001039372
HEPACAM2
HEPACAM family member 2
chr4_+_74520796 2.223 NM_001134
AFP
alpha-fetoprotein
chr4_-_38460983 2.174 NM_001017388
NM_001195106
NM_001195107
NM_001195108
NM_030956
TLR10




toll-like receptor 10




chr9_-_21375258 2.079 NM_000605
IFNA2
interferon, alpha 2
chr12_-_9987277 2.072 LOC100506159
hypothetical LOC100506159
chr18_+_59733724 2.057 NM_005024
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr7_+_99263571 2.027 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr2_-_135498716 1.997 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr5_-_176760242 1.995 NM_001029886
PFN3
profilin 3
chr16_-_70168449 1.942 NM_000353
TAT
tyrosine aminotransferase
chr17_+_29621352 1.877 NM_006273
CCL7
chemokine (C-C motif) ligand 7
chr14_+_28311740 1.862 C14orf23
chromosome 14 open reading frame 23
chr12_+_10351683 1.814 NM_002262
NM_007334
KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr4_-_90978469 1.791 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr9_+_21430439 1.725 NM_024013
IFNA1
interferon, alpha 1
chr15_-_72446979 1.637 NM_000781
CYP11A1
cytochrome P450, family 11, subfamily A, polypeptide 1
chr9_-_21218132 1.631 NM_021268
IFNA17
interferon, alpha 17
chr8_-_27997306 1.559 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr2_+_168383427 1.545 NM_020981
B3GALT1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr7_+_38984133 1.519 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr3_+_46370228 1.479 NM_001123041
NM_001123396
CCR2

chemokine (C-C motif) receptor 2

chr9_-_21295311 1.460 NM_002169
IFNA5
interferon, alpha 5
chr9_-_21229975 1.443 NM_002172
IFNA14
interferon, alpha 14
chr7_-_83108682 1.435 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr8_-_59575249 1.413 NM_000780
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr18_-_50777634 1.402 NM_025214
CCDC68
coiled-coil domain containing 68
chr4_+_141484046 1.389 NM_001153446
NM_001153635
NM_001153585
NM_001153690
SCOC



short coiled-coil protein



chr5_-_135259403 1.384 NM_000590
IL9
interleukin 9
chr1_+_195123766 1.374 NM_006684
CFHR4
complement factor H-related 4
chr8_+_104900591 1.366 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr9_-_21177529 1.362 NM_021068
IFNA4
interferon, alpha 4
chr19_-_5821546 1.279 NM_002034
FUT5
fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
chr4_-_47709717 1.253 NM_000087
CNGA1
cyclic nucleotide gated channel alpha 1
chr7_-_83116414 1.236 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr5_+_156540425 1.228 NM_005546
ITK
IL2-inducible T-cell kinase
chr2_+_204509698 1.225 NM_012092
ICOS
inducible T-cell co-stimulator
chr1_-_111771877 1.212 NM_002557
OVGP1
oviductal glycoprotein 1, 120kDa
chr15_+_26832300 1.211 LOC100289656
Dexi homolog (mouse) pseudogene
chr22_-_29231597 1.184 NM_001161368
NM_174977
SEC14L4

SEC14-like 4 (S. cerevisiae)

chr10_-_100985548 1.182 NM_001166244
NM_001166245
NM_001166246
NM_021828
HPSE2



heparanase 2



chr19_-_20399601 1.176 ZNF826P
zinc finger protein 826, pseudogene
chr19_-_13478037 1.174 NM_000068
NM_001127221
NM_001127222
NM_001174080
NM_023035
CACNA1A




calcium channel, voltage-dependent, P/Q type, alpha 1A subunit




chr11_-_89181390 1.170 NM_020358
TRIM49
tripartite motif containing 49
chr6_+_130799954 1.162 NM_052913
TMEM200A
transmembrane protein 200A
chr9_-_21156609 1.148 NM_002175
IFNA21
interferon, alpha 21
chr8_+_24354387 1.147 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr12_-_21379098 1.144 NM_021094
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr15_-_74091817 1.139 NM_138573
NRG4
neuregulin 4
chr12_+_63510481 1.135


chr12_-_119249938 1.130 NM_000928
PLA2G1B
phospholipase A2, group IB (pancreas)
chr5_-_88004891 1.130 LOC645323
hypothetical LOC645323
chr17_+_23818922 1.129


chr9_-_21192201 1.122 NM_021057
IFNA7
interferon, alpha 7
chr6_+_28032997 1.106 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr9_-_21207303 1.097 NM_002173
IFNA16
interferon, alpha 16
chr6_+_105511615 1.095 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr2_-_38156769 1.091 CYP1B1
cytochrome P450, family 1, subfamily B, polypeptide 1
chr14_-_20098929 1.089 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chr4_-_185963859 1.087 ACSL1
acyl-CoA synthetase long-chain family member 1
chr6_-_46811388 1.087 NM_001168357
PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr15_+_70477707 1.075 NM_001080462
TMEM202
transmembrane protein 202
chr3_+_99733432 1.068 NM_005290
GPR15
G protein-coupled receptor 15
chr8_-_81155564 1.058 NM_001025252
TPD52
tumor protein D52
chr11_+_71221893 1.048 NM_001002035
DEFB108B
defensin, beta 108B
chr19_-_45141473 1.046 LOC440525
PRR13
proline rich 13 pseudogene
proline rich 13
chr8_+_18072250 1.046 NM_001160179
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr12_+_53178834 1.042 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr13_-_38462857 1.041 NM_001144033
NM_145286
STOML3

stomatin (EPB72)-like 3

chr6_-_132980901 1.036 NM_014626
TAAR2
trace amine associated receptor 2
chr9_-_21358005 1.035 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr9_-_21197141 1.027 NM_002171
IFNA10
interferon, alpha 10
chr19_+_53656317 1.026 NM_170720
KCNJ14
potassium inwardly-rectifying channel, subfamily J, member 14
chr10_-_69125932 1.020 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr11_-_7906784 1.015 NM_001004461
OR10A6
olfactory receptor, family 10, subfamily A, member 6
chr3_+_46258875 1.013 NM_001164680
NM_001837
NM_178328
NM_178329
CCR3



chemokine (C-C motif) receptor 3



chr19_+_4104593 1.012 NM_032607
CREB3L3
cAMP responsive element binding protein 3-like 3
chrX_-_108611940 1.004 NM_001522
GUCY2F
guanylate cyclase 2F, retinal
chr10_+_111755715 0.994 NM_019903
ADD3
adducin 3 (gamma)
chr6_-_44341296 0.992 NM_004556
NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr6_-_136829705 0.991 NM_001198615
MAP7
microtubule-associated protein 7
chr5_+_147672181 0.973 NM_032566
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr3_-_126412882 0.972 NM_001195483
SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr7_+_139750311 0.968 NM_001008749
RAB19
RAB19, member RAS oncogene family
chr15_-_48192804 0.960 ATP8B4
ATPase, class I, type 8B, member 4
chr2_-_38156811 0.957 NM_000104
CYP1B1
cytochrome P450, family 1, subfamily B, polypeptide 1
chr3_+_131175803 0.955 NM_007117
TRH
thyrotropin-releasing hormone
chr11_-_104332631 0.955 NM_033306
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr9_+_5880801 0.945 NM_005511
MLANA
melan-A
chr1_+_149275652 0.928 NM_001159642
NM_138278
BNIPL

BCL2/adenovirus E1B 19kD interacting protein like

chr7_-_38279757 0.925 NM_001003799
NM_001003806
TARP

TRGV9
TCR gamma alternate reading frame protein

T cell receptor gamma variable 9
chr18_-_68362702 0.920 NM_182511
CBLN2
cerebellin 2 precursor
chr3_-_152541129 0.918 NM_176876
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr1_-_150353179 0.918 NM_007113
TCHH
trichohyalin
chr2_-_219906142 0.909 NM_001007089
RESP18
regulated endocrine-specific protein 18 homolog (rat)
chr7_-_16888121 0.907 NM_176813
AGR3
anterior gradient homolog 3 (Xenopus laevis)
chr5_+_68823874 0.902 NM_002538
OCLN
occludin
chr6_+_49575629 0.896 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr10_-_45131061 0.894 NM_001004297
OR13A1
olfactory receptor, family 13, subfamily A, member 1
chr2_-_207291364 0.891 NM_001093730
DYTN
dystrotelin
chr6_+_46869052 0.886 NM_005588
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr9_-_115877104 0.882 AMBP
alpha-1-microglobulin/bikunin precursor
chr9_+_134843918 0.875 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr12_-_25597444 0.874 NM_152590
NM_001145728
NM_001145729
IFLTD1


intermediate filament tail domain containing 1


chr3_+_99699137 0.859 NM_001004737
OR5K2
olfactory receptor, family 5, subfamily K, member 2
chr10_+_90511142 0.859 NM_001102469
LIPN
lipase, family member N
chr11_-_13474101 0.857 NM_000315
PTH
parathyroid hormone
chr1_+_205328834 0.855 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr5_-_135318420 0.850 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr11_-_18018880 0.848 NM_004179
TPH1
tryptophan hydroxylase 1
chr5_-_177140071 0.845 NM_173663
FAM153A
FAM153C
family with sequence similarity 153, member A
family with sequence similarity 153, member C
chr11_-_8921155 0.840 NM_020646
ASCL3
achaete-scute complex homolog 3 (Drosophila)
chr8_+_12847521 0.839 NM_020844
KIAA1456
KIAA1456
chr11_-_5756472 0.832 NM_001001922
OR52N5
olfactory receptor, family 52, subfamily N, member 5
chr3_+_12367993 0.810 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr4_+_74566325 0.805 NM_001133
AFM
afamin
chr12_-_10850845 0.794 NM_023918
TAS2R8
taste receptor, type 2, member 8
chr9_-_70780574 0.792


chr6_-_76838944 0.792 NM_001563
IMPG1
interphotoreceptor matrix proteoglycan 1
chr8_-_120720200 0.790 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr14_-_98807307 0.789 BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)
chr17_+_41424665 0.787 MAPT
microtubule-associated protein tau
chr10_+_8137356 0.784 GATA3
GATA binding protein 3
chr1_-_142559339 0.783 NM_001123068
PPIAL4G
peptidylprolyl isomerase A (cyclophilin A)-like 4G
chr12_-_9777126 0.782 NM_172004
CLECL1
C-type lectin-like 1
chr12_+_9871343 0.780 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr10_+_63950212 0.780 NM_199452
ZNF365
zinc finger protein 365
chr11_+_26310253 0.777 NM_031418
ANO3
anoctamin 3
chr5_-_147142368 0.776 JAKMIP2
janus kinase and microtubule interacting protein 2
chr5_-_147142457 0.775 JAKMIP2
janus kinase and microtubule interacting protein 2
chr4_+_100651183 0.774 NM_032149
C4orf17
chromosome 4 open reading frame 17
chr6_-_117853710 0.761 NM_002944
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr4_+_71126376 0.757 NM_152997
C4orf7
chromosome 4 open reading frame 7
chr10_+_90552466 0.753 NM_001128215
LIPM
lipase, family member M
chr7_-_100630912 0.750 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr12_+_10222823 0.749 NM_153022
C12orf59
chromosome 12 open reading frame 59
chr2_+_109907623 0.747 NM_001037866
NM_001123363
NM_032260
RGPD6

RGPD5
RANBP2-like and GRIP domain containing 6

RANBP2-like and GRIP domain containing 5
chr15_-_48345453 0.747 NM_002112
HDC
histidine decarboxylase
chr19_+_61624 0.742 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr4_+_14950657 0.740 NM_001135170
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr12_-_10953427 0.730 NM_023920
TAS2R13
taste receptor, type 2, member 13
chr1_+_58899 0.728 NM_001005484
OR4F4
OR4F5
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 5
chr19_+_6415259 0.727 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr17_-_30909219 0.726 NM_001129820
SLFN14
schlafen family member 14
chr1_-_167969802 0.724 NM_000450
SELE
selectin E
chr15_+_56217686 0.719 NM_020980
AQP9
aquaporin 9
chr5_+_115415061 0.718 NM_001195581
LOC644100
hypothetical LOC644100
chr4_+_22303645 0.717 NM_001128432
NM_020973
GBA3

glucosidase, beta, acid 3 (cytosolic)

chr5_+_54434230 0.713 NM_006144
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr6_-_89984214 0.713 NM_002042
GABRR1
gamma-aminobutyric acid (GABA) receptor, rho 1
chr3_-_121445831 0.710 NM_001168271
NM_153002
GPR156

G protein-coupled receptor 156

chr12_+_52618815 0.707 NM_017410
HOXC13
homeobox C13
chr6_+_132933153 0.704 NM_175067
TAAR6
trace amine associated receptor 6
chr18_+_59405513 0.699 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr9_-_111253484 0.699 NM_001145369
NM_001145370
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr18_+_606671 0.699 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr1_+_198278339 0.696 NR5A2
nuclear receptor subfamily 5, group A, member 2
chr4_+_155707089 0.696 FGB
fibrinogen beta chain
chr7_-_124217978 0.694 NM_001024603
LOC154872
hypothetical protein LOC154872
chr4_+_40446670 0.693 NM_024677
NSUN7
NOP2/Sun domain family, member 7
chr1_+_119712918 0.692 NM_001005783
NM_016527
HAO2

hydroxyacid oxidase 2 (long chain)

chr7_+_28305464 0.692 NM_182899
CREB5
cAMP responsive element binding protein 5
chr11_-_70350292 0.680 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr4_-_157006827 0.680 NM_017419
ACCN5
amiloride-sensitive cation channel 5, intestinal
chr21_-_26867138 0.669 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr12_+_68028397 0.668 NM_000239
LYZ
lysozyme
chr8_+_24207524 0.665 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr8_+_62363078 0.663 NM_173519
CLVS1
clavesin 1
chr8_+_23157094 0.663 NM_152272
CHMP7
CHMP family, member 7
chr7_+_100169184 0.660 NM_003386
NM_173059
ZAN

zonadhesin

chr3_-_55489973 0.657 WNT5A
wingless-type MMTV integration site family, member 5A
chr21_+_30895276 0.656 NM_181620
KRTAP22-1
keratin associated protein 22-1
chr10_+_115514567 0.656 NM_182601
C10orf81
chromosome 10 open reading frame 81
chr9_-_116196505 0.650 NM_030767
AKNA
AT-hook transcription factor
chr14_-_60818263 0.650 NM_001017970
TMEM30B
transmembrane protein 30B
chr3_+_99288706 0.643 NM_054106
OR5AC2
olfactory receptor, family 5, subfamily AC, member 2
chr19_+_9984861 0.641 NM_015725
RDH8
retinol dehydrogenase 8 (all-trans)
chr8_+_24297742 0.638 NM_001145271
NM_001145272
NM_014479
ADAMDEC1


ADAM-like, decysin 1


chr10_+_51219558 0.637 NM_002443
NM_138634
MSMB

microseminoprotein, beta-

chr17_-_36577949 0.637 NM_033187
KRTAP4-3
keratin associated protein 4-3
chr11_+_59920062 0.635 NM_001079692
NM_032597
MS4A14

membrane-spanning 4-domains, subfamily A, member 14

chr3_+_39346200 0.633 NM_005201
CCR8
chemokine (C-C motif) receptor 8
chr1_+_51340487 0.633 NM_001136508
C1orf185
chromosome 1 open reading frame 185
chr1_+_116181927 0.629 NHLH2
nescient helix loop helix 2
chrX_-_153903963 0.629 NM_000132
F8
coagulation factor VIII, procoagulant component
chr10_-_123343320 0.628 NM_001144913
NM_001144914
FGFR2

fibroblast growth factor receptor 2

chr8_-_37916803 0.623 NM_152413
GOT1L1
glutamic-oxaloacetic transaminase 1-like 1
chr1_-_244647333 0.622 NM_022743
SMYD3
SET and MYND domain containing 3
chr1_+_89602023 0.622 NM_198460
GBP6
guanylate binding protein family, member 6
chr8_+_86287161 0.621 NM_001083589
E2F5
E2F transcription factor 5, p130-binding
chr12_-_69434650 0.620 PTPRR
protein tyrosine phosphatase, receptor type, R
chr6_+_32114060 0.619 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr22_-_48866484 0.618 NM_015166
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr19_+_20138991 0.617 NM_052852
ZNF486
zinc finger protein 486
chr13_-_32678142 0.614 NM_052851
STARD13
StAR-related lipid transfer (START) domain containing 13
chr3_+_173954940 0.609 NM_018098
ECT2
epithelial cell transforming sequence 2 oncogene
chr10_+_106024638 0.608 GSTO2
glutathione S-transferase omega 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.44 2.26e-11 GO:0007606 sensory perception of chemical stimulus
2.47 2.43e-10 GO:0007608 sensory perception of smell
1.91 2.02e-08 GO:0007600 sensory perception
1.77 5.07e-05 GO:0006955 immune response
2.04 1.55e-04 GO:0051707 response to other organism
1.92 2.12e-04 GO:0009607 response to biotic stimulus
5.51 3.55e-04 GO:0060338 regulation of type I interferon-mediated signaling pathway
1.51 4.66e-04 GO:0050877 neurological system process
1.66 1.00e-03 GO:0006952 defense response
3.69 1.95e-03 GO:0060337 type I interferon-mediated signaling pathway
3.69 1.95e-03 GO:0071357 cellular response to type I interferon
2.56 2.42e-03 GO:0009615 response to virus
3.63 2.53e-03 GO:0034340 response to type I interferon
1.48 6.28e-03 GO:0002376 immune system process
1.85 6.30e-03 GO:0050776 regulation of immune response
1.17 6.64e-03 GO:0050896 response to stimulus
1.40 7.00e-03 GO:0003008 system process
1.98 1.21e-02 GO:0031347 regulation of defense response
1.87 2.35e-02 GO:0045087 innate immune response
3.28 4.22e-02 GO:0001959 regulation of cytokine-mediated signaling pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.77 1.33e-06 GO:0005615 extracellular space
1.27 7.29e-06 GO:0005886 plasma membrane
1.27 9.67e-06 GO:0071944 cell periphery
1.42 1.11e-05 GO:0005576 extracellular region
1.61 1.40e-05 GO:0044421 extracellular region part
1.14 9.74e-03 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.56 1.21e-11 GO:0004984 olfactory receptor activity
1.95 1.81e-10 GO:0004930 G-protein coupled receptor activity
1.67 1.95e-08 GO:0004888 transmembrane receptor activity
1.56 3.10e-08 GO:0004872 receptor activity
1.44 3.97e-06 GO:0004871 signal transducer activity
1.44 3.97e-06 GO:0060089 molecular transducer activity
11.12 7.49e-05 GO:0005132 interferon-alpha/beta receptor binding
2.34 1.39e-03 GO:0005126 cytokine receptor binding
2.24 2.80e-03 GO:0005125 cytokine activity