Motif ID: HIC1.p2

Z-value: 4.747


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIC1chr17_+_19062620.523.9e-02Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_1704661 8.107 NM_001080488
ONECUT3
one cut homeobox 3
chr9_+_94987032 7.901 NM_006648
WNK2
WNK lysine deficient protein kinase 2
chr12_-_131415854 7.591 NM_001122636
GALNT9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
chr5_+_76542461 7.174 NM_001029851
NM_001029852
NM_001029853
NM_001029854
NM_003719
PDE8B




phosphodiesterase 8B




chr18_+_74841262 6.541 NM_171999
SALL3
sal-like 3 (Drosophila)
chr16_+_162845 6.310 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr18_-_68361742 6.125 CBLN2
cerebellin 2 precursor
chr2_-_233501069 5.860 NM_001114090
NGEF
neuronal guanine nucleotide exchange factor
chr7_+_154943466 5.811 NM_001427
EN2
engrailed homeobox 2
chr11_+_359723 5.537 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr15_-_27650218 5.340 NM_015307
FAM189A1
family with sequence similarity 189, member A1
chr19_+_659766 5.316 NM_001040134
NM_002579
PALM

paralemmin

chr22_+_47263919 5.312 NM_001082967
FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr10_-_103525646 5.311 NM_006119
NM_033163
NM_033164
NM_033165
FGF8



fibroblast growth factor 8 (androgen-induced)



chr7_-_44331544 5.255 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr15_-_49174107 5.216 TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr8_+_1937711 4.938 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr19_+_1236766 4.895 NM_001405
EFNA2
ephrin-A2
chr4_-_41848874 4.875 BEND4
BEN domain containing 4
chr4_+_3737872 4.823 ADRA2C
adrenergic, alpha-2C-, receptor
chr20_-_61933012 4.803 ZBTB46
zinc finger and BTB domain containing 46
chr19_+_540849 4.749 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr3_-_130807865 4.731 NM_015103
PLXND1
plexin D1
chr9_+_17568952 4.688 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr4_-_174687104 4.673 HAND2
heart and neural crest derivatives expressed 2
chr10_+_23521464 4.669 NM_178161
PTF1A
pancreas specific transcription factor, 1a
chr14_+_104402626 4.665 NM_001112726
NM_015005
KIAA0284

KIAA0284

chr6_+_159510416 4.660 NM_032532
FNDC1
fibronectin type III domain containing 1
chr10_-_132999798 4.645 TCERG1L
transcription elongation regulator 1-like
chr4_+_2031036 4.536 NM_178557
NAT8L
N-acetyltransferase 8-like (GCN5-related, putative)
chr14_+_103621768 4.511 NM_001080464
ASPG
asparaginase homolog (S. cerevisiae)
chr12_+_127317900 4.506 NM_001136103
TMEM132C
transmembrane protein 132C
chr16_+_82559600 4.422 NM_019065
NECAB2
N-terminal EF-hand calcium binding protein 2
chr1_-_6162669 4.415 NM_015557
CHD5
chromodomain helicase DNA binding protein 5
chr6_+_137285071 4.386 NM_001008783
SLC35D3
solute carrier family 35, member D3
chr10_-_132999973 4.371 NM_174937
TCERG1L
transcription elongation regulator 1-like
chr16_-_2186465 4.276 NM_020764
CASKIN1
CASK interacting protein 1
chr9_+_123501186 4.184 DAB2IP
DAB2 interacting protein
chr17_-_10042579 4.168 NM_201433
GAS7
growth arrest-specific 7
chr14_+_91859904 4.081 NM_153646
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr18_+_65219114 4.065 NM_152721
DOK6
docking protein 6
chr12_+_131705438 4.041 NM_012226
NM_016318
NM_170682
NM_170683
NM_174872
NM_174873
P2RX2





purinergic receptor P2X, ligand-gated ion channel, 2





chrX_+_72140076 4.017 NM_001042506
PABPC1L2B
poly(A) binding protein, cytoplasmic 1-like 2B
chr22_-_45037882 4.011 NM_006071
PKDREJ
polycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin)
chr22_-_43784093 3.996 NM_138415
PHF21B
PHD finger protein 21B
chr3_+_53504070 3.984 NM_000720
NM_001128839
NM_001128840
CACNA1D


calcium channel, voltage-dependent, L type, alpha 1D subunit


chr1_-_111019148 3.921 NM_002232
KCNA3
potassium voltage-gated channel, shaker-related subfamily, member 3
chr2_-_238813284 3.880 HES6
hairy and enhancer of split 6 (Drosophila)
chr1_+_226261374 3.825 NM_033131
WNT3A
wingless-type MMTV integration site family, member 3A
chr4_-_110443247 3.786 NM_032518
NM_198721
COL25A1

collagen, type XXV, alpha 1

chr19_-_411995 3.784 NM_012435
SHC2
SHC (Src homology 2 domain containing) transforming protein 2
chr14_+_105012106 3.723 NM_001312
CRIP2
cysteine-rich protein 2
chr11_-_110088330 3.712 NM_020809
ARHGAP20
Rho GTPase activating protein 20
chr1_-_202921103 3.704 NM_006338
NM_201630
LRRN2

leucine rich repeat neuronal 2

chr12_+_107047594 3.684 NM_014653
WSCD2
WSC domain containing 2
chr1_-_62557559 3.652 KANK4
KN motif and ankyrin repeat domains 4
chrX_+_147389825 3.630 NM_001169122
NM_001169123
NM_001169124
NM_001169125
NM_002025
AFF2




AF4/FMR2 family, member 2




chr22_+_48951286 3.624 NM_001160300
NM_052839
PANX2

pannexin 2

chr10_-_99521701 3.593 NM_003015
SFRP5
secreted frizzled-related protein 5
chr11_-_110088097 3.568 ARHGAP20
Rho GTPase activating protein 20
chr15_-_20666684 3.543 LOC283683
hypothetical LOC283683
chr1_-_111019051 3.513


chr4_-_174686918 3.511 HAND2
heart and neural crest derivatives expressed 2
chr14_+_101097440 3.505 NM_001362
DIO3
deiodinase, iodothyronine, type III
chr18_-_55091596 3.494 NM_013435
RAX
retina and anterior neural fold homeobox
chr1_+_237616457 3.481 CHRM3
cholinergic receptor, muscarinic 3
chr16_+_88169612 3.466 NM_014427
NM_153636
CPNE7

copine VII

chr19_-_15204194 3.457 NM_024794
EPHX3
epoxide hydrolase 3
chr11_+_119887630 3.437 LOC100293636
GRIK4
hypothetical protein LOC100293636
glutamate receptor, ionotropic, kainate 4
chr4_+_48180033 3.412 NM_152679
SLC10A4
solute carrier family 10 (sodium/bile acid cotransporter family), member 4
chr17_+_8865547 3.400 NM_004822
NTN1
netrin 1
chr18_-_42590989 3.388 NM_013305
ST8SIA5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr13_+_95541093 3.377 NM_153456
HS6ST3
heparan sulfate 6-O-sulfotransferase 3
chr22_+_38183480 3.362 MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr13_+_32488477 3.300 NM_004795
KL
klotho
chr14_+_89597860 3.261 NM_022054
KCNK13
potassium channel, subfamily K, member 13
chr7_+_128257698 3.250 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr16_+_86194075 3.244 JPH3
junctophilin 3
chr5_-_11956964 3.225 NM_001332
CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr12_+_108636569 3.217 NM_032829
C12orf34
chromosome 12 open reading frame 34
chr3_+_2115449 3.189 CNTN4
contactin 4
chrX_-_19443299 3.114 NM_001001671
MAP3K15
mitogen-activated protein kinase kinase kinase 15
chr12_+_129212955 3.111 NM_007197
FZD10
frizzled homolog 10 (Drosophila)
chr21_+_44594375 3.088 TRPM2
transient receptor potential cation channel, subfamily M, member 2
chr2_-_70848621 3.083 NM_001185055
NM_001617
NM_017482
NM_017488
ADD2



adducin 2 (beta)



chr11_+_1367665 3.061 NM_003957
BRSK2
BR serine/threonine kinase 2
chr22_-_37180958 3.054 NM_152868
KCNJ4
potassium inwardly-rectifying channel, subfamily J, member 4
chr7_-_131911808 3.045 NM_001105543
NM_020911
PLXNA4

plexin A4

chr18_+_53253775 3.044 NM_004852
ONECUT2
one cut homeobox 2
chr1_+_226937732 3.035 RHOU
ras homolog gene family, member U
chr11_-_6633427 3.030 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr2_-_238813365 2.992 NM_001142853
NM_018645
HES6

hairy and enhancer of split 6 (Drosophila)

chr18_-_5620629 2.989 EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr14_+_91859289 2.976 NM_153647
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr4_+_3738093 2.967 NM_000683
ADRA2C
adrenergic, alpha-2C-, receptor
chr13_-_94162249 2.949 NM_007084
SOX21
SRY (sex determining region Y)-box 21
chr15_+_31390454 2.932 NM_001036
RYR3
ryanodine receptor 3
chr11_-_1549719 2.923 NM_004420
DUSP8
dual specificity phosphatase 8
chr18_-_6404900 2.917 NM_173464
L3MBTL4
l(3)mbt-like 4 (Drosophila)
chr20_-_62151216 2.908 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr13_-_20193739 2.907


chr9_+_138726737 2.906 NM_152421
FAM69B
family with sequence similarity 69, member B
chr3_-_50515857 2.886 NM_001005505
NM_001174051
NM_006030
CACNA2D2


calcium channel, voltage-dependent, alpha 2/delta subunit 2


chr1_-_182273114 2.881 GLT25D2
glycosyltransferase 25 domain containing 2
chr17_+_19377732 2.876 NM_018242
SLC47A1
solute carrier family 47, member 1
chr20_-_54013418 2.876 NM_080617
CBLN4
cerebellin 4 precursor
chr1_-_62557655 2.829 NM_181712
KANK4
KN motif and ankyrin repeat domains 4
chr7_-_4889772 2.825 NM_018059
RADIL
Ras association and DIL domains
chr22_+_28446288 2.821 NM_182527
CABP7
calcium binding protein 7
chr19_+_10402334 2.817 NM_001111308
PDE4A
phosphodiesterase 4A, cAMP-specific
chr14_-_100104014 2.802 NM_001159531
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr22_-_37569679 2.796


chr15_-_81113676 2.788 NM_030594
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr12_+_109956210 2.770 NM_015267
CUX2
cut-like homeobox 2
chr1_-_50661716 2.767 NM_032110
DMRTA2
DMRT-like family A2
chr7_+_98084531 2.767 NM_002523
NPTX2
neuronal pentraxin II
chr6_-_105691235 2.765 NM_007073
BVES
blood vessel epicardial substance
chr10_+_116843108 2.763 NM_207303
ATRNL1
attractin-like 1
chr1_+_22909916 2.746 NM_004442
NM_017449
EPHB2

EPH receptor B2

chr3_+_12304332 2.741 NM_005037
NM_138712
PPARG

peroxisome proliferator-activated receptor gamma

chr1_+_63561632 2.726 FOXD3
forkhead box D3
chr1_-_115682374 2.720 NM_002506
NGF
nerve growth factor (beta polypeptide)
chr15_-_38362078 2.709 NM_001190479
LOC100131244
hypothetical protein LOC100131244
chr16_+_2009741 2.698 NPW
neuropeptide W
chr15_+_39573363 2.695 NM_002220
ITPKA
inositol 1,4,5-trisphosphate 3-kinase A
chr4_+_156349230 2.681 NM_000910
NPY2R
neuropeptide Y receptor Y2
chr19_-_5291700 2.677 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr8_-_144583718 2.670 NM_201589
MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr4_-_5940893 2.669 CRMP1
collapsin response mediator protein 1
chr3_+_71885890 2.651 NM_018971
GPR27
G protein-coupled receptor 27
chr2_+_120820140 2.650 NM_002193
INHBB
inhibin, beta B
chr10_+_83625049 2.618 NM_001010848
NM_001165972
NRG3

neuregulin 3

chr14_+_72773957 2.595 NM_173462
NDRG2
PAPLN
NDRG family member 2
papilin, proteoglycan-like sulfated glycoprotein
chr9_-_135140450 2.593 NM_020469
ABO
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
chr14_+_51804180 2.581 NM_000953
PTGDR
prostaglandin D2 receptor (DP)
chr18_-_68685789 2.572 NM_138966
NETO1
neuropilin (NRP) and tolloid (TLL)-like 1
chr17_-_77512346 2.565 NM_178493
NOTUM
notum pectinacetylesterase homolog (Drosophila)
chr3_-_129689394 2.545 NM_001145662
GATA2
GATA binding protein 2
chr9_+_140037863 2.540 CACNA1B
calcium channel, voltage-dependent, N type, alpha 1B subunit
chr15_-_91433165 2.533 NM_020211
RGMA
RGM domain family, member A
chr1_+_41022066 2.530 NM_004700
NM_172163
KCNQ4

potassium voltage-gated channel, KQT-like subfamily, member 4

chr5_+_92946348 2.525 NR2F1
nuclear receptor subfamily 2, group F, member 1
chr17_-_42411587 2.525 NM_203400
RPRML
reprimo-like
chr22_-_43783449 2.520 PHF21B
PHD finger protein 21B
chr3_+_141136691 2.518 NM_022131
CLSTN2
calsyntenin 2
chr12_+_4788602 2.517 NM_002235
KCNA6
potassium voltage-gated channel, shaker-related subfamily, member 6
chr22_-_37569962 2.505 NM_014293
NPTXR
neuronal pentraxin receptor
chr3_-_199291938 2.503 LOC348840
hypothetical LOC348840
chr12_-_128954164 2.488 NM_133448
TMEM132D
transmembrane protein 132D
chr11_-_27678551 2.485 NM_001143813
NM_001143814
NM_001709
BDNF


brain-derived neurotrophic factor


chr14_-_77034853 2.480 NM_182509
NM_199296
ISM2

isthmin 2 homolog (zebrafish)

chr16_+_166678 2.469 NM_000558
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr11_+_627268 2.465 NM_000797
DRD4
dopamine receptor D4
chr17_+_11085464 2.464 NM_001173461
NM_001173462
NM_207386
SHISA6


shisa homolog 6 (Xenopus laevis)


chr20_-_4177519 2.462 NM_000678
ADRA1D
adrenergic, alpha-1D-, receptor
chr17_+_5914364 2.461 NM_015253
WSCD1
WSC domain containing 1
chr9_-_135140425 2.454 ABO
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
chr19_-_18867868 2.450 NM_021267
NM_198207
NM_001492
LASS1

GDF1
LAG1 homolog, ceramide synthase 1

growth differentiation factor 1
chr12_+_20413445 2.444 NM_000921
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr4_-_1156362 2.440 SPON2
spondin 2, extracellular matrix protein
chr6_+_69401660 2.433 NM_001704
BAI3
brain-specific angiogenesis inhibitor 3
chr16_+_86194170 2.421 JPH3
junctophilin 3
chr17_-_1874927 2.403 NM_178568
RTN4RL1
reticulon 4 receptor-like 1
chr11_-_64268841 2.400 NM_001098670
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr18_-_4445247 2.396 DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr4_+_156807311 2.395 NM_000856
NM_001130682
NM_001130686
NM_001130687
NM_001130683
NM_001130685
GUCY1A3





guanylate cyclase 1, soluble, alpha 3





chr5_+_80292213 2.382 RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr11_-_61104866 2.373 NM_004200
SYT7
synaptotagmin VII
chr19_-_1188840 2.368 NM_152769
C19orf26
chromosome 19 open reading frame 26
chr16_-_1908231 2.367 NM_001009606
HS3ST6
heparan sulfate (glucosamine) 3-O-sulfotransferase 6
chr1_-_111018798 2.353 KCNA3
potassium voltage-gated channel, shaker-related subfamily, member 3
chr15_+_39638445 2.347 NM_006293
TYRO3
TYRO3 protein tyrosine kinase
chr3_-_62835601 2.345


chr15_-_71448194 2.331 HCN4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr19_-_54267690 2.325 KCNA7
potassium voltage-gated channel, shaker-related subfamily, member 7
chr4_+_156899575 2.325 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr7_+_3307445 2.324 NM_152744
SDK1
sidekick homolog 1, cell adhesion molecule (chicken)
chrX_+_9392980 2.315 NM_005647
TBL1X
transducin (beta)-like 1X-linked
chr19_-_52614550 2.315 NM_001009813
NM_020160
MEIS3

Meis homeobox 3

chr4_-_1156378 2.305 SPON2
spondin 2, extracellular matrix protein
chr14_-_76677711 2.304 ZDHHC22
zinc finger, DHHC-type containing 22
chr22_-_31784328 2.303 NM_001135774
SYN3
synapsin III
chr6_-_84475211 2.302 SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr6_-_110786167 2.298 NM_001123364
C6orf186
chromosome 6 open reading frame 186
chr12_-_129212720 2.295 FLJ31485
hypothetical LOC440119
chr10_-_134449467 2.288 NM_177400
NKX6-2
NK6 homeobox 2
chr10_-_118022707 2.284 NM_001145453
GFRA1
GDNF family receptor alpha 1
chr9_-_21549696 2.279 LOC554202
hypothetical LOC554202
chr15_-_50869379 2.270 NM_004498
ONECUT1
one cut homeobox 1
chr1_+_159495140 2.267 NM_001102566
PCP4L1
Purkinje cell protein 4 like 1
chr17_-_60986905 2.263 AXIN2
axin 2
chr19_-_52614280 2.262 MEIS3
Meis homeobox 3
chr18_-_23019176 2.261 NM_031422
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr3_+_128830656 2.246 NM_015720
PODXL2
podocalyxin-like 2
chr18_+_73090913 2.244 NM_001480
GALR1
galanin receptor 1
chr20_-_21326046 2.240 NM_033176
NKX2-4
NK2 homeobox 4
chr4_+_184257337 2.239 NM_024949
WWC2
WW and C2 domain containing 2
chr8_-_41873401 2.237 NM_001142446
ANK1
ankyrin 1, erythrocytic
chr11_+_65815940 2.236 NM_153266
TMEM151A
transmembrane protein 151A
chr11_-_74818858 2.232 KLHL35
kelch-like 35 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.58 2.68e-31 GO:0007399 nervous system development
1.34 2.75e-30 GO:0007275 multicellular organismal development
1.32 1.77e-28 GO:0032502 developmental process
1.36 2.86e-25 GO:0048731 system development
1.33 3.19e-24 GO:0048856 anatomical structure development
1.66 4.06e-24 GO:0022008 neurogenesis
1.42 4.49e-24 GO:0030154 cell differentiation
1.66 9.39e-24 GO:0048468 cell development
1.50 9.81e-24 GO:0009653 anatomical structure morphogenesis
1.41 4.06e-23 GO:0048869 cellular developmental process
1.67 5.33e-23 GO:0048699 generation of neurons
1.85 1.50e-20 GO:0000904 cell morphogenesis involved in differentiation
1.71 2.39e-20 GO:0030182 neuron differentiation
1.76 1.00e-18 GO:0048666 neuron development
1.87 1.31e-18 GO:0048667 cell morphogenesis involved in neuron differentiation
1.85 2.26e-18 GO:0048812 neuron projection morphogenesis
1.87 3.29e-18 GO:0007409 axonogenesis
1.42 9.39e-18 GO:0023051 regulation of signaling
1.79 1.62e-17 GO:0031175 neuron projection development
1.71 4.28e-17 GO:0000902 cell morphogenesis
1.75 4.26e-16 GO:0032990 cell part morphogenesis
1.75 5.81e-16 GO:0007417 central nervous system development
1.75 7.30e-16 GO:0048858 cell projection morphogenesis
1.66 1.40e-15 GO:0032989 cellular component morphogenesis
1.62 5.45e-14 GO:0030030 cell projection organization
1.09 5.90e-14 GO:0009987 cellular process
1.15 1.67e-13 GO:0050794 regulation of cellular process
1.45 1.38e-12 GO:0010646 regulation of cell communication
1.33 1.84e-12 GO:0048513 organ development
1.13 1.99e-12 GO:0065007 biological regulation
1.82 2.93e-12 GO:0007411 axon guidance
1.13 4.69e-12 GO:0050789 regulation of biological process
1.36 7.24e-11 GO:0009966 regulation of signal transduction
1.75 7.78e-11 GO:0007420 brain development
1.55 7.19e-10 GO:0009887 organ morphogenesis
1.44 7.19e-10 GO:0050793 regulation of developmental process
1.20 1.15e-09 GO:0023052 signaling
1.48 2.05e-09 GO:2000026 regulation of multicellular organismal development
1.15 2.42e-09 GO:0032501 multicellular organismal process
1.50 3.06e-09 GO:0045595 regulation of cell differentiation
1.27 3.29e-09 GO:0048523 negative regulation of cellular process
1.48 1.15e-08 GO:0009790 embryo development
1.50 1.36e-08 GO:0007167 enzyme linked receptor protein signaling pathway
1.71 3.59e-08 GO:0060284 regulation of cell development
1.24 4.19e-08 GO:0048519 negative regulation of biological process
1.33 6.46e-08 GO:0051239 regulation of multicellular organismal process
1.41 1.42e-07 GO:0040011 locomotion
1.27 1.96e-07 GO:0007166 cell surface receptor linked signaling pathway
1.65 2.75e-07 GO:0007389 pattern specification process
1.54 3.37e-07 GO:0019226 transmission of nerve impulse
1.54 3.37e-07 GO:0035637 multicellular organismal signaling
1.18 5.13e-07 GO:0007165 signal transduction
1.51 8.65e-07 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.67 8.92e-07 GO:0022603 regulation of anatomical structure morphogenesis
1.36 1.77e-06 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.22 1.83e-06 GO:0048522 positive regulation of cellular process
1.52 2.15e-06 GO:0072358 cardiovascular system development
1.52 2.15e-06 GO:0072359 circulatory system development
1.68 2.22e-06 GO:0035295 tube development
1.54 2.65e-06 GO:0007268 synaptic transmission
1.58 3.34e-06 GO:0048598 embryonic morphogenesis
1.58 4.19e-06 GO:0009792 embryo development ending in birth or egg hatching
1.53 4.94e-06 GO:0023057 negative regulation of signaling
1.35 5.17e-06 GO:0032879 regulation of localization
1.62 5.61e-06 GO:0001501 skeletal system development
1.53 6.09e-06 GO:0010648 negative regulation of cell communication
1.24 6.31e-06 GO:0048583 regulation of response to stimulus
1.64 7.01e-06 GO:0048729 tissue morphogenesis
1.20 7.31e-06 GO:0048518 positive regulation of biological process
1.19 9.12e-06 GO:0051171 regulation of nitrogen compound metabolic process
1.20 1.08e-05 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.65 1.10e-05 GO:0051960 regulation of nervous system development
1.56 1.36e-05 GO:0043009 chordate embryonic development
1.16 1.47e-05 GO:0051179 localization
1.36 2.46e-05 GO:0009888 tissue development
1.52 2.73e-05 GO:0009968 negative regulation of signal transduction
1.58 3.04e-05 GO:0045597 positive regulation of cell differentiation
1.93 3.06e-05 GO:0030111 regulation of Wnt receptor signaling pathway
1.48 3.20e-05 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.21 3.24e-05 GO:0042221 response to chemical stimulus
1.69 3.38e-05 GO:0003002 regionalization
1.19 3.52e-05 GO:0071842 cellular component organization at cellular level
1.53 3.65e-05 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.34 5.91e-05 GO:0006351 transcription, DNA-dependent
1.66 6.09e-05 GO:0050767 regulation of neurogenesis
1.58 6.46e-05 GO:0007610 behavior
1.16 6.60e-05 GO:0080090 regulation of primary metabolic process
1.45 7.14e-05 GO:0006935 chemotaxis
1.45 7.14e-05 GO:0042330 taxis
1.20 7.35e-05 GO:0051252 regulation of RNA metabolic process
1.49 7.94e-05 GO:0032583 regulation of gene-specific transcription
1.53 8.34e-05 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.14 8.56e-05 GO:0051716 cellular response to stimulus
2.11 9.21e-05 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.68 9.46e-05 GO:0002009 morphogenesis of an epithelium
1.47 9.54e-05 GO:0048646 anatomical structure formation involved in morphogenesis
1.41 9.58e-05 GO:0045893 positive regulation of transcription, DNA-dependent
1.44 1.06e-04 GO:0045892 negative regulation of transcription, DNA-dependent
1.15 1.11e-04 GO:0031323 regulation of cellular metabolic process
1.43 1.13e-04 GO:0051253 negative regulation of RNA metabolic process
2.16 1.22e-04 GO:0021953 central nervous system neuron differentiation
1.39 1.29e-04 GO:0051254 positive regulation of RNA metabolic process
1.31 1.38e-04 GO:0007154 cell communication
1.56 1.58e-04 GO:0051093 negative regulation of developmental process
1.47 1.61e-04 GO:0051094 positive regulation of developmental process
1.18 1.81e-04 GO:0031326 regulation of cellular biosynthetic process
1.38 1.84e-04 GO:0009890 negative regulation of biosynthetic process
1.40 1.88e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.40 2.03e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
1.35 2.04e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
1.20 2.13e-04 GO:0006355 regulation of transcription, DNA-dependent
1.75 2.30e-04 GO:0030900 forebrain development
1.34 2.36e-04 GO:0031328 positive regulation of cellular biosynthetic process
1.73 2.61e-04 GO:0035239 tube morphogenesis
2.17 2.68e-04 GO:0010721 negative regulation of cell development
1.18 2.72e-04 GO:0009889 regulation of biosynthetic process
1.37 3.04e-04 GO:0031327 negative regulation of cellular biosynthetic process
1.78 3.37e-04 GO:0006813 potassium ion transport
1.87 4.23e-04 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.19 4.50e-04 GO:0009953 dorsal/ventral pattern formation
1.88 5.05e-04 GO:0050890 cognition
1.37 5.12e-04 GO:0010628 positive regulation of gene expression
1.43 5.17e-04 GO:0048585 negative regulation of response to stimulus
1.90 5.99e-04 GO:0050804 regulation of synaptic transmission
1.59 6.01e-04 GO:0045596 negative regulation of cell differentiation
1.85 6.08e-04 GO:0022604 regulation of cell morphogenesis
1.19 6.93e-04 GO:0065008 regulation of biological quality
1.17 7.42e-04 GO:0071841 cellular component organization or biogenesis at cellular level
1.38 7.91e-04 GO:0010629 negative regulation of gene expression
1.32 8.19e-04 GO:0009891 positive regulation of biosynthetic process
1.84 8.68e-04 GO:0051969 regulation of transmission of nerve impulse
1.17 8.74e-04 GO:0010468 regulation of gene expression
1.56 8.93e-04 GO:0001944 vasculature development
1.37 1.01e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.34 1.03e-03 GO:0007267 cell-cell signaling
1.82 1.23e-03 GO:0048705 skeletal system morphogenesis
1.78 1.59e-03 GO:0031644 regulation of neurological system process
1.91 1.61e-03 GO:0010720 positive regulation of cell development
2.03 1.80e-03 GO:0021915 neural tube development
2.03 1.80e-03 GO:0060485 mesenchyme development
1.45 1.80e-03 GO:0016477 cell migration
1.65 2.01e-03 GO:0045664 regulation of neuron differentiation
1.41 2.06e-03 GO:0030001 metal ion transport
1.28 2.07e-03 GO:0009605 response to external stimulus
1.35 2.44e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.49 2.46e-03 GO:0044057 regulation of system process
1.32 2.55e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.14 2.73e-03 GO:0060255 regulation of macromolecule metabolic process
1.13 2.78e-03 GO:0019222 regulation of metabolic process
1.74 3.12e-03 GO:0045165 cell fate commitment
1.15 3.28e-03 GO:0051234 establishment of localization
1.65 3.29e-03 GO:0032582 negative regulation of gene-specific transcription
1.86 3.77e-03 GO:0072001 renal system development
1.14 3.96e-03 GO:0016043 cellular component organization
1.17 4.09e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.73 4.23e-03 GO:0060562 epithelial tube morphogenesis
1.58 4.24e-03 GO:0048568 embryonic organ development
1.93 4.29e-03 GO:0021537 telencephalon development
1.15 4.91e-03 GO:0006810 transport
1.84 5.39e-03 GO:0007611 learning or memory
1.85 6.51e-03 GO:0001822 kidney development
1.29 7.00e-03 GO:0006811 ion transport
1.31 7.10e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.98 7.47e-03 GO:0030178 negative regulation of Wnt receptor signaling pathway
1.56 8.41e-03 GO:0007507 heart development
1.36 9.33e-03 GO:0006928 cellular component movement
1.44 1.02e-02 GO:0051056 regulation of small GTPase mediated signal transduction
1.41 1.02e-02 GO:0008285 negative regulation of cell proliferation
1.22 1.08e-02 GO:0035556 intracellular signal transduction
1.52 1.13e-02 GO:0001568 blood vessel development
1.73 1.17e-02 GO:0016055 Wnt receptor signaling pathway
1.46 1.26e-02 GO:0015672 monovalent inorganic cation transport
2.09 1.32e-02 GO:0043279 response to alkaloid
1.26 1.34e-02 GO:0032774 RNA biosynthetic process
1.67 1.37e-02 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
2.19 1.38e-02 GO:0090090 negative regulation of canonical Wnt receptor signaling pathway
1.35 1.51e-02 GO:0006812 cation transport
1.24 1.66e-02 GO:0031325 positive regulation of cellular metabolic process
1.93 1.70e-02 GO:0055123 digestive system development
1.56 1.76e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.87 1.78e-02 GO:0051216 cartilage development
1.99 2.25e-02 GO:0048762 mesenchymal cell differentiation
1.15 2.29e-02 GO:0010556 regulation of macromolecule biosynthetic process
1.66 2.33e-02 GO:0048562 embryonic organ morphogenesis
2.15 2.34e-02 GO:0007190 activation of adenylate cyclase activity
1.30 2.48e-02 GO:0051049 regulation of transport
2.02 2.53e-02 GO:0014031 mesenchymal cell development
2.32 2.75e-02 GO:0007189 activation of adenylate cyclase activity by G-protein signaling pathway
2.32 2.75e-02 GO:0010578 regulation of adenylate cyclase activity involved in G-protein signaling pathway
2.32 2.75e-02 GO:0010579 positive regulation of adenylate cyclase activity by G-protein signaling pathway
1.96 3.43e-02 GO:0007498 mesoderm development
2.06 3.65e-02 GO:0050768 negative regulation of neurogenesis
2.11 3.89e-02 GO:0031281 positive regulation of cyclase activity
2.11 3.89e-02 GO:0045762 positive regulation of adenylate cyclase activity
1.37 4.21e-02 GO:0048870 cell motility
1.37 4.21e-02 GO:0051674 localization of cell
2.07 4.80e-02 GO:0021543 pallium development
1.46 4.87e-02 GO:0051270 regulation of cellular component movement
1.65 4.94e-02 GO:0001655 urogenital system development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.55 4.29e-11 GO:0030054 cell junction
1.26 2.34e-10 GO:0044459 plasma membrane part
1.61 7.04e-09 GO:0045202 synapse
1.67 9.44e-08 GO:0044456 synapse part
1.08 6.70e-06 GO:0005737 cytoplasm
1.05 4.69e-05 GO:0044424 intracellular part
1.05 5.90e-05 GO:0005622 intracellular
1.70 6.66e-05 GO:0031252 cell leading edge
1.47 7.54e-05 GO:0043005 neuron projection
1.74 2.62e-04 GO:0005912 adherens junction
1.29 3.93e-04 GO:0042995 cell projection
1.68 4.09e-04 GO:0070161 anchoring junction
1.08 5.29e-04 GO:0016020 membrane
1.03 1.40e-03 GO:0044464 cell part
1.03 1.49e-03 GO:0005623 cell
1.50 4.68e-03 GO:0005667 transcription factor complex
1.64 5.35e-03 GO:0045211 postsynaptic membrane
1.99 7.07e-03 GO:0031256 leading edge membrane
1.63 1.88e-02 GO:0034703 cation channel complex
1.10 2.45e-02 GO:0005886 plasma membrane
1.37 2.47e-02 GO:0031012 extracellular matrix
1.77 2.90e-02 GO:0008076 voltage-gated potassium channel complex
1.77 2.90e-02 GO:0034705 potassium channel complex
1.10 2.93e-02 GO:0071944 cell periphery
1.51 3.09e-02 GO:0030425 dendrite

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.57 1.39e-13 GO:0043565 sequence-specific DNA binding
1.44 6.96e-12 GO:0001071 nucleic acid binding transcription factor activity
1.44 6.96e-12 GO:0003700 sequence-specific DNA binding transcription factor activity
1.37 1.46e-08 GO:0030528 transcription regulator activity
1.78 6.89e-07 GO:0000975 regulatory region DNA binding
1.78 6.89e-07 GO:0001067 regulatory region nucleic acid binding
1.78 6.89e-07 GO:0044212 transcription regulatory region DNA binding
1.79 8.01e-07 GO:0010843 promoter binding
1.51 1.41e-06 GO:0019904 protein domain specific binding
1.44 3.33e-06 GO:0008324 cation transmembrane transporter activity
1.06 5.90e-06 GO:0005488 binding
1.33 2.52e-05 GO:0022891 substrate-specific transmembrane transporter activity
1.56 2.53e-05 GO:0016563 transcription activator activity
1.31 4.45e-05 GO:0022857 transmembrane transporter activity
1.82 5.24e-05 GO:0022843 voltage-gated cation channel activity
1.58 9.48e-05 GO:0005261 cation channel activity
1.84 1.75e-04 GO:0005267 potassium channel activity
1.67 2.37e-04 GO:0005244 voltage-gated ion channel activity
1.67 2.37e-04 GO:0022832 voltage-gated channel activity
1.33 2.69e-04 GO:0015075 ion transmembrane transporter activity
1.47 9.76e-04 GO:0042578 phosphoric ester hydrolase activity
1.26 1.91e-03 GO:0022892 substrate-specific transporter activity
1.08 2.07e-03 GO:0005515 protein binding
1.47 2.36e-03 GO:0022836 gated channel activity
1.85 2.97e-03 GO:0005249 voltage-gated potassium channel activity
1.87 3.57e-03 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
1.37 4.93e-03 GO:0030695 GTPase regulator activity
2.02 5.07e-03 GO:0030165 PDZ domain binding
1.36 6.72e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.88 7.41e-03 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
2.23 7.90e-03 GO:0008013 beta-catenin binding
1.45 1.31e-02 GO:0005083 small GTPase regulator activity
1.37 1.72e-02 GO:0022803 passive transmembrane transporter activity
1.38 1.90e-02 GO:0005216 ion channel activity
1.15 2.11e-02 GO:0003677 DNA binding
2.76 2.12e-02 GO:0017147 Wnt-protein binding
1.36 2.39e-02 GO:0015267 channel activity
1.47 2.51e-02 GO:0016791 phosphatase activity
1.37 2.83e-02 GO:0022838 substrate-specific channel activity
1.20 3.83e-02 GO:0005215 transporter activity
2.57 4.25e-02 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity