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• Mean activities
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• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: HIC1.p2

Z-value: 4.747

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr19_+_1704661	8.107	NM_001080488	ONECUT3	one cut homeobox 3
chr9_+_94987032	7.901	NM_006648	WNK2	WNK lysine deficient protein kinase 2
chr12_-_131415854	7.591	NM_001122636	GALNT9	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
chr5_+_76542461	7.174	NM_001029851 NM_001029852 NM_001029853 NM_001029854 NM_003719	PDE8B	phosphodiesterase 8B
chr18_+_74841262	6.541	NM_171999	SALL3	sal-like 3 (Drosophila)
chr16_+_162845	6.310	NM_000517	HBA1 HBA2	hemoglobin, alpha 1 hemoglobin, alpha 2
chr18_-_68361742	6.125		CBLN2	cerebellin 2 precursor
chr2_-_233501069	5.860	NM_001114090	NGEF	neuronal guanine nucleotide exchange factor
chr7_+_154943466	5.811	NM_001427	EN2	engrailed homeobox 2
chr11_+_359723	5.537	NM_178537	B4GALNT4	beta-1,4-N-acetyl-galactosaminyl transferase 4
chr15_-_27650218	5.340	NM_015307	FAM189A1	family with sequence similarity 189, member A1
chr19_+_659766	5.316	NM_001040134 NM_002579	PALM	paralemmin
chr22_+_47263919	5.312	NM_001082967	FAM19A5	family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr10_-_103525646	5.311	NM_006119 NM_033163 NM_033164 NM_033165	FGF8	fibroblast growth factor 8 (androgen-induced)
chr7_-_44331544	5.255	NM_001220 NM_172078 NM_172079 NM_172080 NM_172081 NM_172082 NM_172083 NM_172084	CAMK2B	calcium/calmodulin-dependent protein kinase II beta
chr15_-_49174107	5.216		TNFAIP8L3	tumor necrosis factor, alpha-induced protein 8-like 3
chr8_+_1937711	4.938		KBTBD11	kelch repeat and BTB (POZ) domain containing 11
chr19_+_1236766	4.895	NM_001405	EFNA2	ephrin-A2
chr4_-_41848874	4.875		BEND4	BEN domain containing 4
chr4_+_3737872	4.823		ADRA2C	adrenergic, alpha-2C-, receptor
chr20_-_61933012	4.803		ZBTB46	zinc finger and BTB domain containing 46
chr19_+_540849	4.749	NM_001194	HCN2	hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr3_-_130807865	4.731	NM_015103	PLXND1	plexin D1
chr9_+_17568952	4.688	NM_003026	SH3GL2	SH3-domain GRB2-like 2
chr4_-_174687104	4.673		HAND2	heart and neural crest derivatives expressed 2
chr10_+_23521464	4.669	NM_178161	PTF1A	pancreas specific transcription factor, 1a
chr14_+_104402626	4.665	NM_001112726 NM_015005	KIAA0284	KIAA0284
chr6_+_159510416	4.660	NM_032532	FNDC1	fibronectin type III domain containing 1
chr10_-_132999798	4.645		TCERG1L	transcription elongation regulator 1-like
chr4_+_2031036	4.536	NM_178557	NAT8L	N-acetyltransferase 8-like (GCN5-related, putative)
chr14_+_103621768	4.511	NM_001080464	ASPG	asparaginase homolog (S. cerevisiae)
chr12_+_127317900	4.506	NM_001136103	TMEM132C	transmembrane protein 132C
chr16_+_82559600	4.422	NM_019065	NECAB2	N-terminal EF-hand calcium binding protein 2
chr1_-_6162669	4.415	NM_015557	CHD5	chromodomain helicase DNA binding protein 5
chr6_+_137285071	4.386	NM_001008783	SLC35D3	solute carrier family 35, member D3
chr10_-_132999973	4.371	NM_174937	TCERG1L	transcription elongation regulator 1-like
chr16_-_2186465	4.276	NM_020764	CASKIN1	CASK interacting protein 1
chr9_+_123501186	4.184		DAB2IP	DAB2 interacting protein
chr17_-_10042579	4.168	NM_201433	GAS7	growth arrest-specific 7
chr14_+_91859904	4.081	NM_153646	SLC24A4	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr18_+_65219114	4.065	NM_152721	DOK6	docking protein 6
chr12_+_131705438	4.041	NM_012226 NM_016318 NM_170682 NM_170683 NM_174872 NM_174873	P2RX2	purinergic receptor P2X, ligand-gated ion channel, 2
chrX_+_72140076	4.017	NM_001042506	PABPC1L2B	poly(A) binding protein, cytoplasmic 1-like 2B
chr22_-_45037882	4.011	NM_006071	PKDREJ	polycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin)
chr22_-_43784093	3.996	NM_138415	PHF21B	PHD finger protein 21B
chr3_+_53504070	3.984	NM_000720 NM_001128839 NM_001128840	CACNA1D	calcium channel, voltage-dependent, L type, alpha 1D subunit
chr1_-_111019148	3.921	NM_002232	KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3
chr2_-_238813284	3.880		HES6	hairy and enhancer of split 6 (Drosophila)
chr1_+_226261374	3.825	NM_033131	WNT3A	wingless-type MMTV integration site family, member 3A
chr4_-_110443247	3.786	NM_032518 NM_198721	COL25A1	collagen, type XXV, alpha 1
chr19_-_411995	3.784	NM_012435	SHC2	SHC (Src homology 2 domain containing) transforming protein 2
chr14_+_105012106	3.723	NM_001312	CRIP2	cysteine-rich protein 2
chr11_-_110088330	3.712	NM_020809	ARHGAP20	Rho GTPase activating protein 20
chr1_-_202921103	3.704	NM_006338 NM_201630	LRRN2	leucine rich repeat neuronal 2
chr12_+_107047594	3.684	NM_014653	WSCD2	WSC domain containing 2
chr1_-_62557559	3.652		KANK4	KN motif and ankyrin repeat domains 4
chrX_+_147389825	3.630	NM_001169122 NM_001169123 NM_001169124 NM_001169125 NM_002025	AFF2	AF4/FMR2 family, member 2
chr22_+_48951286	3.624	NM_001160300 NM_052839	PANX2	pannexin 2
chr10_-_99521701	3.593	NM_003015	SFRP5	secreted frizzled-related protein 5
chr11_-_110088097	3.568		ARHGAP20	Rho GTPase activating protein 20
chr15_-_20666684	3.543		LOC283683	hypothetical LOC283683
chr1_-_111019051	3.513
chr4_-_174686918	3.511		HAND2	heart and neural crest derivatives expressed 2
chr14_+_101097440	3.505	NM_001362	DIO3	deiodinase, iodothyronine, type III
chr18_-_55091596	3.494	NM_013435	RAX	retina and anterior neural fold homeobox
chr1_+_237616457	3.481		CHRM3	cholinergic receptor, muscarinic 3
chr16_+_88169612	3.466	NM_014427 NM_153636	CPNE7	copine VII
chr19_-_15204194	3.457	NM_024794	EPHX3	epoxide hydrolase 3
chr11_+_119887630	3.437		LOC100293636 GRIK4	hypothetical protein LOC100293636 glutamate receptor, ionotropic, kainate 4
chr4_+_48180033	3.412	NM_152679	SLC10A4	solute carrier family 10 (sodium/bile acid cotransporter family), member 4
chr17_+_8865547	3.400	NM_004822	NTN1	netrin 1
chr18_-_42590989	3.388	NM_013305	ST8SIA5	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr13_+_95541093	3.377	NM_153456	HS6ST3	heparan sulfate 6-O-sulfotransferase 3
chr22_+_38183480	3.362		MGAT3	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr13_+_32488477	3.300	NM_004795	KL	klotho
chr14_+_89597860	3.261	NM_022054	KCNK13	potassium channel, subfamily K, member 13
chr7_+_128257698	3.250	NM_001127487 NM_001458	FLNC	filamin C, gamma
chr16_+_86194075	3.244		JPH3	junctophilin 3
chr5_-_11956964	3.225	NM_001332	CTNND2	catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr12_+_108636569	3.217	NM_032829	C12orf34	chromosome 12 open reading frame 34
chr3_+_2115449	3.189		CNTN4	contactin 4
chrX_-_19443299	3.114	NM_001001671	MAP3K15	mitogen-activated protein kinase kinase kinase 15
chr12_+_129212955	3.111	NM_007197	FZD10	frizzled homolog 10 (Drosophila)
chr21_+_44594375	3.088		TRPM2	transient receptor potential cation channel, subfamily M, member 2
chr2_-_70848621	3.083	NM_001185055 NM_001617 NM_017482 NM_017488	ADD2	adducin 2 (beta)
chr11_+_1367665	3.061	NM_003957	BRSK2	BR serine/threonine kinase 2
chr22_-_37180958	3.054	NM_152868	KCNJ4	potassium inwardly-rectifying channel, subfamily J, member 4
chr7_-_131911808	3.045	NM_001105543 NM_020911	PLXNA4	plexin A4
chr18_+_53253775	3.044	NM_004852	ONECUT2	one cut homeobox 2
chr1_+_226937732	3.035		RHOU	ras homolog gene family, member U
chr11_-_6633427	3.030	NM_003737	DCHS1	dachsous 1 (Drosophila)
chr2_-_238813365	2.992	NM_001142853 NM_018645	HES6	hairy and enhancer of split 6 (Drosophila)
chr18_-_5620629	2.989		EPB41L3	erythrocyte membrane protein band 4.1-like 3
chr14_+_91859289	2.976	NM_153647	SLC24A4	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr4_+_3738093	2.967	NM_000683	ADRA2C	adrenergic, alpha-2C-, receptor
chr13_-_94162249	2.949	NM_007084	SOX21	SRY (sex determining region Y)-box 21
chr15_+_31390454	2.932	NM_001036	RYR3	ryanodine receptor 3
chr11_-_1549719	2.923	NM_004420	DUSP8	dual specificity phosphatase 8
chr18_-_6404900	2.917	NM_173464	L3MBTL4	l(3)mbt-like 4 (Drosophila)
chr20_-_62151216	2.908	NM_018419	SOX18	SRY (sex determining region Y)-box 18
chr13_-_20193739	2.907
chr9_+_138726737	2.906	NM_152421	FAM69B	family with sequence similarity 69, member B
chr3_-_50515857	2.886	NM_001005505 NM_001174051 NM_006030	CACNA2D2	calcium channel, voltage-dependent, alpha 2/delta subunit 2
chr1_-_182273114	2.881		GLT25D2	glycosyltransferase 25 domain containing 2
chr17_+_19377732	2.876	NM_018242	SLC47A1	solute carrier family 47, member 1
chr20_-_54013418	2.876	NM_080617	CBLN4	cerebellin 4 precursor
chr1_-_62557655	2.829	NM_181712	KANK4	KN motif and ankyrin repeat domains 4
chr7_-_4889772	2.825	NM_018059	RADIL	Ras association and DIL domains
chr22_+_28446288	2.821	NM_182527	CABP7	calcium binding protein 7
chr19_+_10402334	2.817	NM_001111308	PDE4A	phosphodiesterase 4A, cAMP-specific
chr14_-_100104014	2.802	NM_001159531	BEGAIN	brain-enriched guanylate kinase-associated homolog (rat)
chr22_-_37569679	2.796
chr15_-_81113676	2.788	NM_030594	CPEB1	cytoplasmic polyadenylation element binding protein 1
chr12_+_109956210	2.770	NM_015267	CUX2	cut-like homeobox 2
chr1_-_50661716	2.767	NM_032110	DMRTA2	DMRT-like family A2
chr7_+_98084531	2.767	NM_002523	NPTX2	neuronal pentraxin II
chr6_-_105691235	2.765	NM_007073	BVES	blood vessel epicardial substance
chr10_+_116843108	2.763	NM_207303	ATRNL1	attractin-like 1
chr1_+_22909916	2.746	NM_004442 NM_017449	EPHB2	EPH receptor B2
chr3_+_12304332	2.741	NM_005037 NM_138712	PPARG	peroxisome proliferator-activated receptor gamma
chr1_+_63561632	2.726		FOXD3	forkhead box D3
chr1_-_115682374	2.720	NM_002506	NGF	nerve growth factor (beta polypeptide)
chr15_-_38362078	2.709	NM_001190479	LOC100131244	hypothetical protein LOC100131244
chr16_+_2009741	2.698		NPW	neuropeptide W
chr15_+_39573363	2.695	NM_002220	ITPKA	inositol 1,4,5-trisphosphate 3-kinase A
chr4_+_156349230	2.681	NM_000910	NPY2R	neuropeptide Y receptor Y2
chr19_-_5291700	2.677	NM_002850 NM_130853 NM_130854 NM_130855	PTPRS	protein tyrosine phosphatase, receptor type, S
chr8_-_144583718	2.670	NM_201589	MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr4_-_5940893	2.669		CRMP1	collapsin response mediator protein 1
chr3_+_71885890	2.651	NM_018971	GPR27	G protein-coupled receptor 27
chr2_+_120820140	2.650	NM_002193	INHBB	inhibin, beta B
chr10_+_83625049	2.618	NM_001010848 NM_001165972	NRG3	neuregulin 3
chr14_+_72773957	2.595	NM_173462	NDRG2 PAPLN	NDRG family member 2 papilin, proteoglycan-like sulfated glycoprotein
chr9_-_135140450	2.593	NM_020469	ABO	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
chr14_+_51804180	2.581	NM_000953	PTGDR	prostaglandin D2 receptor (DP)
chr18_-_68685789	2.572	NM_138966	NETO1	neuropilin (NRP) and tolloid (TLL)-like 1
chr17_-_77512346	2.565	NM_178493	NOTUM	notum pectinacetylesterase homolog (Drosophila)
chr3_-_129689394	2.545	NM_001145662	GATA2	GATA binding protein 2
chr9_+_140037863	2.540		CACNA1B	calcium channel, voltage-dependent, N type, alpha 1B subunit
chr15_-_91433165	2.533	NM_020211	RGMA	RGM domain family, member A
chr1_+_41022066	2.530	NM_004700 NM_172163	KCNQ4	potassium voltage-gated channel, KQT-like subfamily, member 4
chr5_+_92946348	2.525		NR2F1	nuclear receptor subfamily 2, group F, member 1
chr17_-_42411587	2.525	NM_203400	RPRML	reprimo-like
chr22_-_43783449	2.520		PHF21B	PHD finger protein 21B
chr3_+_141136691	2.518	NM_022131	CLSTN2	calsyntenin 2
chr12_+_4788602	2.517	NM_002235	KCNA6	potassium voltage-gated channel, shaker-related subfamily, member 6
chr22_-_37569962	2.505	NM_014293	NPTXR	neuronal pentraxin receptor
chr3_-_199291938	2.503		LOC348840	hypothetical LOC348840
chr12_-_128954164	2.488	NM_133448	TMEM132D	transmembrane protein 132D
chr11_-_27678551	2.485	NM_001143813 NM_001143814 NM_001709	BDNF	brain-derived neurotrophic factor
chr14_-_77034853	2.480	NM_182509 NM_199296	ISM2	isthmin 2 homolog (zebrafish)
chr16_+_166678	2.469	NM_000558	HBA1 HBA2	hemoglobin, alpha 1 hemoglobin, alpha 2
chr11_+_627268	2.465	NM_000797	DRD4	dopamine receptor D4
chr17_+_11085464	2.464	NM_001173461 NM_001173462 NM_207386	SHISA6	shisa homolog 6 (Xenopus laevis)
chr20_-_4177519	2.462	NM_000678	ADRA1D	adrenergic, alpha-1D-, receptor
chr17_+_5914364	2.461	NM_015253	WSCD1	WSC domain containing 1
chr9_-_135140425	2.454		ABO	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
chr19_-_18867868	2.450	NM_021267 NM_198207 NM_001492	LASS1 GDF1	LAG1 homolog, ceramide synthase 1 growth differentiation factor 1
chr12_+_20413445	2.444	NM_000921	PDE3A	phosphodiesterase 3A, cGMP-inhibited
chr4_-_1156362	2.440		SPON2	spondin 2, extracellular matrix protein
chr6_+_69401660	2.433	NM_001704	BAI3	brain-specific angiogenesis inhibitor 3
chr16_+_86194170	2.421		JPH3	junctophilin 3
chr17_-_1874927	2.403	NM_178568	RTN4RL1	reticulon 4 receptor-like 1
chr11_-_64268841	2.400	NM_001098670	RASGRP2	RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr18_-_4445247	2.396		DLGAP1	discs, large (Drosophila) homolog-associated protein 1
chr4_+_156807311	2.395	NM_000856 NM_001130682 NM_001130686 NM_001130687 NM_001130683 NM_001130685	GUCY1A3	guanylate cyclase 1, soluble, alpha 3
chr5_+_80292213	2.382		RASGRF2	Ras protein-specific guanine nucleotide-releasing factor 2
chr11_-_61104866	2.373	NM_004200	SYT7	synaptotagmin VII
chr19_-_1188840	2.368	NM_152769	C19orf26	chromosome 19 open reading frame 26
chr16_-_1908231	2.367	NM_001009606	HS3ST6	heparan sulfate (glucosamine) 3-O-sulfotransferase 6
chr1_-_111018798	2.353		KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3
chr15_+_39638445	2.347	NM_006293	TYRO3	TYRO3 protein tyrosine kinase
chr3_-_62835601	2.345
chr15_-_71448194	2.331		HCN4	hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr19_-_54267690	2.325		KCNA7	potassium voltage-gated channel, shaker-related subfamily, member 7
chr4_+_156899575	2.325	NM_000857	GUCY1B3	guanylate cyclase 1, soluble, beta 3
chr7_+_3307445	2.324	NM_152744	SDK1	sidekick homolog 1, cell adhesion molecule (chicken)
chrX_+_9392980	2.315	NM_005647	TBL1X	transducin (beta)-like 1X-linked
chr19_-_52614550	2.315	NM_001009813 NM_020160	MEIS3	Meis homeobox 3
chr4_-_1156378	2.305		SPON2	spondin 2, extracellular matrix protein
chr14_-_76677711	2.304		ZDHHC22	zinc finger, DHHC-type containing 22
chr22_-_31784328	2.303	NM_001135774	SYN3	synapsin III
chr6_-_84475211	2.302		SNAP91	synaptosomal-associated protein, 91kDa homolog (mouse)
chr6_-_110786167	2.298	NM_001123364	C6orf186	chromosome 6 open reading frame 186
chr12_-_129212720	2.295		FLJ31485	hypothetical LOC440119
chr10_-_134449467	2.288	NM_177400	NKX6-2	NK6 homeobox 2
chr10_-_118022707	2.284	NM_001145453	GFRA1	GDNF family receptor alpha 1
chr9_-_21549696	2.279		LOC554202	hypothetical LOC554202
chr15_-_50869379	2.270	NM_004498	ONECUT1	one cut homeobox 1
chr1_+_159495140	2.267	NM_001102566	PCP4L1	Purkinje cell protein 4 like 1
chr17_-_60986905	2.263		AXIN2	axin 2
chr19_-_52614280	2.262		MEIS3	Meis homeobox 3
chr18_-_23019176	2.261	NM_031422	CHST9	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr3_+_128830656	2.246	NM_015720	PODXL2	podocalyxin-like 2
chr18_+_73090913	2.244	NM_001480	GALR1	galanin receptor 1
chr20_-_21326046	2.240	NM_033176	NKX2-4	NK2 homeobox 4
chr4_+_184257337	2.239	NM_024949	WWC2	WW and C2 domain containing 2
chr8_-_41873401	2.237	NM_001142446	ANK1	ankyrin 1, erythrocytic
chr11_+_65815940	2.236	NM_153266	TMEM151A	transmembrane protein 151A
chr11_-_74818858	2.232		KLHL35	kelch-like 35 (Drosophila)

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.58	2.68e-31	GO:0007399	nervous system development
1.34	2.75e-30	GO:0007275	multicellular organismal development
1.32	1.77e-28	GO:0032502	developmental process
1.36	2.86e-25	GO:0048731	system development
1.33	3.19e-24	GO:0048856	anatomical structure development
1.66	4.06e-24	GO:0022008	neurogenesis
1.42	4.49e-24	GO:0030154	cell differentiation
1.66	9.39e-24	GO:0048468	cell development
1.50	9.81e-24	GO:0009653	anatomical structure morphogenesis
1.41	4.06e-23	GO:0048869	cellular developmental process
1.67	5.33e-23	GO:0048699	generation of neurons
1.85	1.50e-20	GO:0000904	cell morphogenesis involved in differentiation
1.71	2.39e-20	GO:0030182	neuron differentiation
1.76	1.00e-18	GO:0048666	neuron development
1.87	1.31e-18	GO:0048667	cell morphogenesis involved in neuron differentiation
1.85	2.26e-18	GO:0048812	neuron projection morphogenesis
1.87	3.29e-18	GO:0007409	axonogenesis
1.42	9.39e-18	GO:0023051	regulation of signaling
1.79	1.62e-17	GO:0031175	neuron projection development
1.71	4.28e-17	GO:0000902	cell morphogenesis
1.75	4.26e-16	GO:0032990	cell part morphogenesis
1.75	5.81e-16	GO:0007417	central nervous system development
1.75	7.30e-16	GO:0048858	cell projection morphogenesis
1.66	1.40e-15	GO:0032989	cellular component morphogenesis
1.62	5.45e-14	GO:0030030	cell projection organization
1.09	5.90e-14	GO:0009987	cellular process
1.15	1.67e-13	GO:0050794	regulation of cellular process
1.45	1.38e-12	GO:0010646	regulation of cell communication
1.33	1.84e-12	GO:0048513	organ development
1.13	1.99e-12	GO:0065007	biological regulation
1.82	2.93e-12	GO:0007411	axon guidance
1.13	4.69e-12	GO:0050789	regulation of biological process
1.36	7.24e-11	GO:0009966	regulation of signal transduction
1.75	7.78e-11	GO:0007420	brain development
1.55	7.19e-10	GO:0009887	organ morphogenesis
1.44	7.19e-10	GO:0050793	regulation of developmental process
1.20	1.15e-09	GO:0023052	signaling
1.48	2.05e-09	GO:2000026	regulation of multicellular organismal development
1.15	2.42e-09	GO:0032501	multicellular organismal process
1.50	3.06e-09	GO:0045595	regulation of cell differentiation
1.27	3.29e-09	GO:0048523	negative regulation of cellular process
1.48	1.15e-08	GO:0009790	embryo development
1.50	1.36e-08	GO:0007167	enzyme linked receptor protein signaling pathway
1.71	3.59e-08	GO:0060284	regulation of cell development
1.24	4.19e-08	GO:0048519	negative regulation of biological process
1.33	6.46e-08	GO:0051239	regulation of multicellular organismal process
1.41	1.42e-07	GO:0040011	locomotion
1.27	1.96e-07	GO:0007166	cell surface receptor linked signaling pathway
1.65	2.75e-07	GO:0007389	pattern specification process
1.54	3.37e-07	GO:0019226	transmission of nerve impulse
1.54	3.37e-07	GO:0035637	multicellular organismal signaling
1.18	5.13e-07	GO:0007165	signal transduction
1.51	8.65e-07	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
1.67	8.92e-07	GO:0022603	regulation of anatomical structure morphogenesis
1.36	1.77e-06	GO:0006357	regulation of transcription from RNA polymerase II promoter
1.22	1.83e-06	GO:0048522	positive regulation of cellular process
1.52	2.15e-06	GO:0072358	cardiovascular system development
1.52	2.15e-06	GO:0072359	circulatory system development
1.68	2.22e-06	GO:0035295	tube development
1.54	2.65e-06	GO:0007268	synaptic transmission
1.58	3.34e-06	GO:0048598	embryonic morphogenesis
1.58	4.19e-06	GO:0009792	embryo development ending in birth or egg hatching
1.53	4.94e-06	GO:0023057	negative regulation of signaling
1.35	5.17e-06	GO:0032879	regulation of localization
1.62	5.61e-06	GO:0001501	skeletal system development
1.53	6.09e-06	GO:0010648	negative regulation of cell communication
1.24	6.31e-06	GO:0048583	regulation of response to stimulus
1.64	7.01e-06	GO:0048729	tissue morphogenesis
1.20	7.31e-06	GO:0048518	positive regulation of biological process
1.19	9.12e-06	GO:0051171	regulation of nitrogen compound metabolic process
1.20	1.08e-05	GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.65	1.10e-05	GO:0051960	regulation of nervous system development
1.56	1.36e-05	GO:0043009	chordate embryonic development
1.16	1.47e-05	GO:0051179	localization
1.36	2.46e-05	GO:0009888	tissue development
1.52	2.73e-05	GO:0009968	negative regulation of signal transduction
1.58	3.04e-05	GO:0045597	positive regulation of cell differentiation
1.93	3.06e-05	GO:0030111	regulation of Wnt receptor signaling pathway
1.48	3.20e-05	GO:0045944	positive regulation of transcription from RNA polymerase II promoter
1.21	3.24e-05	GO:0042221	response to chemical stimulus
1.69	3.38e-05	GO:0003002	regionalization
1.19	3.52e-05	GO:0071842	cellular component organization at cellular level
1.53	3.65e-05	GO:0000122	negative regulation of transcription from RNA polymerase II promoter
1.34	5.91e-05	GO:0006351	transcription, DNA-dependent
1.66	6.09e-05	GO:0050767	regulation of neurogenesis
1.58	6.46e-05	GO:0007610	behavior
1.16	6.60e-05	GO:0080090	regulation of primary metabolic process
1.45	7.14e-05	GO:0006935	chemotaxis
1.45	7.14e-05	GO:0042330	taxis
1.20	7.35e-05	GO:0051252	regulation of RNA metabolic process
1.49	7.94e-05	GO:0032583	regulation of gene-specific transcription
1.53	8.34e-05	GO:0010551	regulation of gene-specific transcription from RNA polymerase II promoter
1.14	8.56e-05	GO:0051716	cellular response to stimulus
2.11	9.21e-05	GO:0060828	regulation of canonical Wnt receptor signaling pathway
1.68	9.46e-05	GO:0002009	morphogenesis of an epithelium
1.47	9.54e-05	GO:0048646	anatomical structure formation involved in morphogenesis
1.41	9.58e-05	GO:0045893	positive regulation of transcription, DNA-dependent
1.44	1.06e-04	GO:0045892	negative regulation of transcription, DNA-dependent
1.15	1.11e-04	GO:0031323	regulation of cellular metabolic process
1.43	1.13e-04	GO:0051253	negative regulation of RNA metabolic process
2.16	1.22e-04	GO:0021953	central nervous system neuron differentiation
1.39	1.29e-04	GO:0051254	positive regulation of RNA metabolic process
1.31	1.38e-04	GO:0007154	cell communication
1.56	1.58e-04	GO:0051093	negative regulation of developmental process
1.47	1.61e-04	GO:0051094	positive regulation of developmental process
1.18	1.81e-04	GO:0031326	regulation of cellular biosynthetic process
1.38	1.84e-04	GO:0009890	negative regulation of biosynthetic process
1.40	1.88e-04	GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.40	2.03e-04	GO:0051172	negative regulation of nitrogen compound metabolic process
1.35	2.04e-04	GO:0051173	positive regulation of nitrogen compound metabolic process
1.20	2.13e-04	GO:0006355	regulation of transcription, DNA-dependent
1.75	2.30e-04	GO:0030900	forebrain development
1.34	2.36e-04	GO:0031328	positive regulation of cellular biosynthetic process
1.73	2.61e-04	GO:0035239	tube morphogenesis
2.17	2.68e-04	GO:0010721	negative regulation of cell development
1.18	2.72e-04	GO:0009889	regulation of biosynthetic process
1.37	3.04e-04	GO:0031327	negative regulation of cellular biosynthetic process
1.78	3.37e-04	GO:0006813	potassium ion transport
1.87	4.23e-04	GO:0010769	regulation of cell morphogenesis involved in differentiation
2.19	4.50e-04	GO:0009953	dorsal/ventral pattern formation
1.88	5.05e-04	GO:0050890	cognition
1.37	5.12e-04	GO:0010628	positive regulation of gene expression
1.43	5.17e-04	GO:0048585	negative regulation of response to stimulus
1.90	5.99e-04	GO:0050804	regulation of synaptic transmission
1.59	6.01e-04	GO:0045596	negative regulation of cell differentiation
1.85	6.08e-04	GO:0022604	regulation of cell morphogenesis
1.19	6.93e-04	GO:0065008	regulation of biological quality
1.17	7.42e-04	GO:0071841	cellular component organization or biogenesis at cellular level
1.38	7.91e-04	GO:0010629	negative regulation of gene expression
1.32	8.19e-04	GO:0009891	positive regulation of biosynthetic process
1.84	8.68e-04	GO:0051969	regulation of transmission of nerve impulse
1.17	8.74e-04	GO:0010468	regulation of gene expression
1.56	8.93e-04	GO:0001944	vasculature development
1.37	1.01e-03	GO:2000113	negative regulation of cellular macromolecule biosynthetic process
1.34	1.03e-03	GO:0007267	cell-cell signaling
1.82	1.23e-03	GO:0048705	skeletal system morphogenesis
1.78	1.59e-03	GO:0031644	regulation of neurological system process
1.91	1.61e-03	GO:0010720	positive regulation of cell development
2.03	1.80e-03	GO:0021915	neural tube development
2.03	1.80e-03	GO:0060485	mesenchyme development
1.45	1.80e-03	GO:0016477	cell migration
1.65	2.01e-03	GO:0045664	regulation of neuron differentiation
1.41	2.06e-03	GO:0030001	metal ion transport
1.28	2.07e-03	GO:0009605	response to external stimulus
1.35	2.44e-03	GO:0010558	negative regulation of macromolecule biosynthetic process
1.49	2.46e-03	GO:0044057	regulation of system process
1.32	2.55e-03	GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.14	2.73e-03	GO:0060255	regulation of macromolecule metabolic process
1.13	2.78e-03	GO:0019222	regulation of metabolic process
1.74	3.12e-03	GO:0045165	cell fate commitment
1.15	3.28e-03	GO:0051234	establishment of localization
1.65	3.29e-03	GO:0032582	negative regulation of gene-specific transcription
1.86	3.77e-03	GO:0072001	renal system development
1.14	3.96e-03	GO:0016043	cellular component organization
1.17	4.09e-03	GO:2000112	regulation of cellular macromolecule biosynthetic process
1.73	4.23e-03	GO:0060562	epithelial tube morphogenesis
1.58	4.24e-03	GO:0048568	embryonic organ development
1.93	4.29e-03	GO:0021537	telencephalon development
1.15	4.91e-03	GO:0006810	transport
1.84	5.39e-03	GO:0007611	learning or memory
1.85	6.51e-03	GO:0001822	kidney development
1.29	7.00e-03	GO:0006811	ion transport
1.31	7.10e-03	GO:0010557	positive regulation of macromolecule biosynthetic process
1.98	7.47e-03	GO:0030178	negative regulation of Wnt receptor signaling pathway
1.56	8.41e-03	GO:0007507	heart development
1.36	9.33e-03	GO:0006928	cellular component movement
1.44	1.02e-02	GO:0051056	regulation of small GTPase mediated signal transduction
1.41	1.02e-02	GO:0008285	negative regulation of cell proliferation
1.22	1.08e-02	GO:0035556	intracellular signal transduction
1.52	1.13e-02	GO:0001568	blood vessel development
1.73	1.17e-02	GO:0016055	Wnt receptor signaling pathway
1.46	1.26e-02	GO:0015672	monovalent inorganic cation transport
2.09	1.32e-02	GO:0043279	response to alkaloid
1.26	1.34e-02	GO:0032774	RNA biosynthetic process
1.67	1.37e-02	GO:0010553	negative regulation of gene-specific transcription from RNA polymerase II promoter
2.19	1.38e-02	GO:0090090	negative regulation of canonical Wnt receptor signaling pathway
1.35	1.51e-02	GO:0006812	cation transport
1.24	1.66e-02	GO:0031325	positive regulation of cellular metabolic process
1.93	1.70e-02	GO:0055123	digestive system development
1.56	1.76e-02	GO:0048011	nerve growth factor receptor signaling pathway
1.87	1.78e-02	GO:0051216	cartilage development
1.99	2.25e-02	GO:0048762	mesenchymal cell differentiation
1.15	2.29e-02	GO:0010556	regulation of macromolecule biosynthetic process
1.66	2.33e-02	GO:0048562	embryonic organ morphogenesis
2.15	2.34e-02	GO:0007190	activation of adenylate cyclase activity
1.30	2.48e-02	GO:0051049	regulation of transport
2.02	2.53e-02	GO:0014031	mesenchymal cell development
2.32	2.75e-02	GO:0007189	activation of adenylate cyclase activity by G-protein signaling pathway
2.32	2.75e-02	GO:0010578	regulation of adenylate cyclase activity involved in G-protein signaling pathway
2.32	2.75e-02	GO:0010579	positive regulation of adenylate cyclase activity by G-protein signaling pathway
1.96	3.43e-02	GO:0007498	mesoderm development
2.06	3.65e-02	GO:0050768	negative regulation of neurogenesis
2.11	3.89e-02	GO:0031281	positive regulation of cyclase activity
2.11	3.89e-02	GO:0045762	positive regulation of adenylate cyclase activity
1.37	4.21e-02	GO:0048870	cell motility
1.37	4.21e-02	GO:0051674	localization of cell
2.07	4.80e-02	GO:0021543	pallium development
1.46	4.87e-02	GO:0051270	regulation of cellular component movement
1.65	4.94e-02	GO:0001655	urogenital system development

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.55	4.29e-11	GO:0030054	cell junction
1.26	2.34e-10	GO:0044459	plasma membrane part
1.61	7.04e-09	GO:0045202	synapse
1.67	9.44e-08	GO:0044456	synapse part
1.08	6.70e-06	GO:0005737	cytoplasm
1.05	4.69e-05	GO:0044424	intracellular part
1.05	5.90e-05	GO:0005622	intracellular
1.70	6.66e-05	GO:0031252	cell leading edge
1.47	7.54e-05	GO:0043005	neuron projection
1.74	2.62e-04	GO:0005912	adherens junction
1.29	3.93e-04	GO:0042995	cell projection
1.68	4.09e-04	GO:0070161	anchoring junction
1.08	5.29e-04	GO:0016020	membrane
1.03	1.40e-03	GO:0044464	cell part
1.03	1.49e-03	GO:0005623	cell
1.50	4.68e-03	GO:0005667	transcription factor complex
1.64	5.35e-03	GO:0045211	postsynaptic membrane
1.99	7.07e-03	GO:0031256	leading edge membrane
1.63	1.88e-02	GO:0034703	cation channel complex
1.10	2.45e-02	GO:0005886	plasma membrane
1.37	2.47e-02	GO:0031012	extracellular matrix
1.77	2.90e-02	GO:0008076	voltage-gated potassium channel complex
1.77	2.90e-02	GO:0034705	potassium channel complex
1.10	2.93e-02	GO:0071944	cell periphery
1.51	3.09e-02	GO:0030425	dendrite

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.57	1.39e-13	GO:0043565	sequence-specific DNA binding
1.44	6.96e-12	GO:0001071	nucleic acid binding transcription factor activity
1.44	6.96e-12	GO:0003700	sequence-specific DNA binding transcription factor activity
1.37	1.46e-08	GO:0030528	transcription regulator activity
1.78	6.89e-07	GO:0000975	regulatory region DNA binding
1.78	6.89e-07	GO:0001067	regulatory region nucleic acid binding
1.78	6.89e-07	GO:0044212	transcription regulatory region DNA binding
1.79	8.01e-07	GO:0010843	promoter binding
1.51	1.41e-06	GO:0019904	protein domain specific binding
1.44	3.33e-06	GO:0008324	cation transmembrane transporter activity
1.06	5.90e-06	GO:0005488	binding
1.33	2.52e-05	GO:0022891	substrate-specific transmembrane transporter activity
1.56	2.53e-05	GO:0016563	transcription activator activity
1.31	4.45e-05	GO:0022857	transmembrane transporter activity
1.82	5.24e-05	GO:0022843	voltage-gated cation channel activity
1.58	9.48e-05	GO:0005261	cation channel activity
1.84	1.75e-04	GO:0005267	potassium channel activity
1.67	2.37e-04	GO:0005244	voltage-gated ion channel activity
1.67	2.37e-04	GO:0022832	voltage-gated channel activity
1.33	2.69e-04	GO:0015075	ion transmembrane transporter activity
1.47	9.76e-04	GO:0042578	phosphoric ester hydrolase activity
1.26	1.91e-03	GO:0022892	substrate-specific transporter activity
1.08	2.07e-03	GO:0005515	protein binding
1.47	2.36e-03	GO:0022836	gated channel activity
1.85	2.97e-03	GO:0005249	voltage-gated potassium channel activity
1.87	3.57e-03	GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
1.37	4.93e-03	GO:0030695	GTPase regulator activity
2.02	5.07e-03	GO:0030165	PDZ domain binding
1.36	6.72e-03	GO:0060589	nucleoside-triphosphatase regulator activity
1.88	7.41e-03	GO:0003705	sequence-specific enhancer binding RNA polymerase II transcription factor activity
2.23	7.90e-03	GO:0008013	beta-catenin binding
1.45	1.31e-02	GO:0005083	small GTPase regulator activity
1.37	1.72e-02	GO:0022803	passive transmembrane transporter activity
1.38	1.90e-02	GO:0005216	ion channel activity
1.15	2.11e-02	GO:0003677	DNA binding
2.76	2.12e-02	GO:0017147	Wnt-protein binding
1.36	2.39e-02	GO:0015267	channel activity
1.47	2.51e-02	GO:0016791	phosphatase activity
1.37	2.83e-02	GO:0022838	substrate-specific channel activity
1.20	3.83e-02	GO:0005215	transporter activity
2.57	4.25e-02	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity

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