Motif ID: HIC1.p2

Z-value: 4.747


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIC1chr17_+_19062620.523.9e-02Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_1704661 8.107 NM_001080488
 ONECUT3
one cut homeobox 3
chr9_+_94987032 7.901 NM_006648
 WNK2
WNK lysine deficient protein kinase 2
chr12_-_131415854 7.591 NM_001122636
 GALNT9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
chr5_+_76542461 7.174 NM_001029851
NM_001029852
NM_001029853
NM_001029854
NM_003719
 PDE8B




phosphodiesterase 8B




chr18_+_74841262 6.541 NM_171999
 SALL3
sal-like 3 (Drosophila)
chr16_+_162845 6.310 NM_000517
 HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr18_-_68361742 6.125 CBLN2
cerebellin 2 precursor
chr2_-_233501069 5.860 NM_001114090
 NGEF
neuronal guanine nucleotide exchange factor
chr7_+_154943466 5.811 NM_001427
 EN2
engrailed homeobox 2
chr11_+_359723 5.537 NM_178537
 B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr15_-_27650218 5.340 NM_015307
 FAM189A1
family with sequence similarity 189, member A1
chr19_+_659766 5.316 NM_001040134
NM_002579
 PALM

paralemmin

chr22_+_47263919 5.312 NM_001082967
 FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr10_-_103525646 5.311 NM_006119
NM_033163
NM_033164
NM_033165
 FGF8



fibroblast growth factor 8 (androgen-induced)



chr7_-_44331544 5.255 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
 CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr15_-_49174107 5.216 TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr8_+_1937711 4.938 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr19_+_1236766 4.895 NM_001405
 EFNA2
ephrin-A2
chr4_-_41848874 4.875 BEND4
BEN domain containing 4
chr4_+_3737872 4.823 ADRA2C
adrenergic, alpha-2C-, receptor

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 199 entries
enrichment   p-value GO term description
2.32 2.75e-02 GO:0007189 activation of adenylate cyclase activity by G-protein signaling pathway
2.32 2.75e-02 GO:0010578 regulation of adenylate cyclase activity involved in G-protein signaling pathway
2.32 2.75e-02 GO:0010579 positive regulation of adenylate cyclase activity by G-protein signaling pathway
2.19 4.50e-04 GO:0009953 dorsal/ventral pattern formation
2.19 1.38e-02 GO:0090090 negative regulation of canonical Wnt receptor signaling pathway
2.17 2.68e-04 GO:0010721 negative regulation of cell development
2.16 1.22e-04 GO:0021953 central nervous system neuron differentiation
2.15 2.34e-02 GO:0007190 activation of adenylate cyclase activity
2.11 9.21e-05 GO:0060828 regulation of canonical Wnt receptor signaling pathway
2.11 3.89e-02 GO:0031281 positive regulation of cyclase activity
2.11 3.89e-02 GO:0045762 positive regulation of adenylate cyclase activity
2.09 1.32e-02 GO:0043279 response to alkaloid
2.07 4.80e-02 GO:0021543 pallium development
2.06 3.65e-02 GO:0050768 negative regulation of neurogenesis
2.03 1.80e-03 GO:0021915 neural tube development
2.03 1.80e-03 GO:0060485 mesenchyme development
2.02 2.53e-02 GO:0014031 mesenchymal cell development
1.99 2.25e-02 GO:0048762 mesenchymal cell differentiation
1.98 7.47e-03 GO:0030178 negative regulation of Wnt receptor signaling pathway
1.96 3.43e-02 GO:0007498 mesoderm development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 25 entries
enrichment   p-value GO term description
1.99 7.07e-03 GO:0031256 leading edge membrane
1.77 2.90e-02 GO:0008076 voltage-gated potassium channel complex
1.77 2.90e-02 GO:0034705 potassium channel complex
1.74 2.62e-04 GO:0005912 adherens junction
1.70 6.66e-05 GO:0031252 cell leading edge
1.68 4.09e-04 GO:0070161 anchoring junction
1.67 9.44e-08 GO:0044456 synapse part
1.64 5.35e-03 GO:0045211 postsynaptic membrane
1.63 1.88e-02 GO:0034703 cation channel complex
1.61 7.04e-09 GO:0045202 synapse
1.55 4.29e-11 GO:0030054 cell junction
1.51 3.09e-02 GO:0030425 dendrite
1.50 4.68e-03 GO:0005667 transcription factor complex
1.47 7.54e-05 GO:0043005 neuron projection
1.37 2.47e-02 GO:0031012 extracellular matrix
1.29 3.93e-04 GO:0042995 cell projection
1.26 2.34e-10 GO:0044459 plasma membrane part
1.10 2.45e-02 GO:0005886 plasma membrane
1.10 2.93e-02 GO:0071944 cell periphery
1.08 6.70e-06 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 20 of 41 entries
enrichment   p-value GO term description
2.76 2.12e-02 GO:0017147 Wnt-protein binding
2.57 4.25e-02 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
2.23 7.90e-03 GO:0008013 beta-catenin binding
2.02 5.07e-03 GO:0030165 PDZ domain binding
1.88 7.41e-03 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
1.87 3.57e-03 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
1.85 2.97e-03 GO:0005249 voltage-gated potassium channel activity
1.84 1.75e-04 GO:0005267 potassium channel activity
1.82 5.24e-05 GO:0022843 voltage-gated cation channel activity
1.79 8.01e-07 GO:0010843 promoter binding
1.78 6.89e-07 GO:0000975 regulatory region DNA binding
1.78 6.89e-07 GO:0001067 regulatory region nucleic acid binding
1.78 6.89e-07 GO:0044212 transcription regulatory region DNA binding
1.67 2.37e-04 GO:0005244 voltage-gated ion channel activity
1.67 2.37e-04 GO:0022832 voltage-gated channel activity
1.58 9.48e-05 GO:0005261 cation channel activity
1.57 1.39e-13 GO:0043565 sequence-specific DNA binding
1.56 2.53e-05 GO:0016563 transcription activator activity
1.51 1.41e-06 GO:0019904 protein domain specific binding
1.47 9.76e-04 GO:0042578 phosphoric ester hydrolase activity