Motif ID: TBX4,5.p2

Z-value: 1.457


Transcription factors associated with TBX4,5.p2:

Gene SymbolEntrez IDGene Name
TBX4 9496 T-box 4
TBX5 6910 T-box 5

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TBX4chr17_+_568885880.401.2e-01Click!
TBX5chr12_-_1133305740.282.9e-01Click!


Activity profile for motif TBX4,5.p2.

activity profile for motif TBX4,5.p2


Sorted Z-values histogram for motif TBX4,5.p2

Sorted Z-values for motif TBX4,5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBX4,5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_26609893 1.667 LIN28A
lin-28 homolog A (C. elegans)
chr1_+_43661383 1.551 NM_015284
 KIAA0467
KIAA0467
chr1_+_26609819 1.312 NM_024674
 LIN28A
lin-28 homolog A (C. elegans)
chr9_-_34387786 0.985 NM_032596
 C9orf24
chromosome 9 open reading frame 24
chr18_+_30810889 0.929 NM_001143826
 MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr4_+_8633116 0.925 NM_080819
 GPR78
G protein-coupled receptor 78
chr4_-_66218777 0.890 EPHA5
EPH receptor A5
chr11_-_72063059 0.882 NM_002599
 PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr3_+_129690735 0.852


chr3_+_26639300 0.843 NM_052953
 LRRC3B
leucine rich repeat containing 3B
chr1_-_47468029 0.838 NM_003189
 TAL1
T-cell acute lymphocytic leukemia 1
chr11_+_61204392 0.799 NM_006133
 DAGLA
diacylglycerol lipase, alpha
chr12_-_56312696 0.798 B4GALNT1
beta-1,4-N-acetyl-galactosaminyl transferase 1
chr2_-_133144094 0.759 LYPD1
LY6/PLAUR domain containing 1
chr2_+_176761552 0.756 NM_024501
 HOXD1
homeobox D1
chr3_+_12020803 0.737 NM_003178
NM_133625
 SYN2

synapsin II

chr19_-_51829778 0.735 NM_033258
 GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr3_-_173648896 0.728 NM_004122
NM_198407
 GHSR

growth hormone secretagogue receptor

chr12_-_3472245 0.725 LOC100129223
hypothetical LOC100129223
chr20_+_8060762 0.712 NM_015192
NM_182734
 PLCB1

phospholipase C, beta 1 (phosphoinositide-specific)


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 27 entries
enrichment   p-value GO term description
4.72 2.24e-02 GO:0050766 positive regulation of phagocytosis
2.22 6.48e-04 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
2.18 2.66e-03 GO:0045165 cell fate commitment
2.11 4.36e-04 GO:0032582 negative regulation of gene-specific transcription
1.87 2.56e-02 GO:0043193 positive regulation of gene-specific transcription
1.72 3.61e-04 GO:0032583 regulation of gene-specific transcription
1.69 1.26e-03 GO:0007268 synaptic transmission
1.68 1.24e-02 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.66 4.29e-07 GO:0007267 cell-cell signaling
1.66 8.73e-04 GO:0019226 transmission of nerve impulse
1.66 8.73e-04 GO:0035637 multicellular organismal signaling
1.56 3.01e-02 GO:0030001 metal ion transport
1.53 3.91e-06 GO:0007154 cell communication
1.40 1.07e-02 GO:0032879 regulation of localization
1.39 8.69e-05 GO:0007399 nervous system development
1.36 5.77e-03 GO:0051239 regulation of multicellular organismal process
1.28 4.97e-03 GO:0030154 cell differentiation
1.27 6.22e-03 GO:0048869 cellular developmental process
1.24 2.35e-02 GO:0048519 negative regulation of biological process
1.22 2.44e-03 GO:0048856 anatomical structure development

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
3.02 3.59e-03 GO:0030672 synaptic vesicle membrane
2.20 4.41e-02 GO:0008021 synaptic vesicle
1.82 2.22e-04 GO:0044456 synapse part
1.62 2.40e-03 GO:0045202 synapse
1.50 2.58e-03 GO:0030054 cell junction
1.37 2.99e-02 GO:0005624 membrane fraction
1.29 6.23e-05 GO:0044459 plasma membrane part
1.16 7.48e-03 GO:0071944 cell periphery
1.16 7.81e-03 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
2.12 8.67e-03 GO:0015276 ligand-gated ion channel activity
2.12 8.67e-03 GO:0022834 ligand-gated channel activity
1.95 1.81e-03 GO:0010843 promoter binding
1.87 6.23e-03 GO:0000975 regulatory region DNA binding
1.87 6.23e-03 GO:0001067 regulatory region nucleic acid binding
1.87 6.23e-03 GO:0044212 transcription regulatory region DNA binding
1.78 5.91e-04 GO:0022836 gated channel activity
1.75 7.08e-03 GO:0005261 cation channel activity
1.70 1.75e-04 GO:0015267 channel activity
1.70 1.97e-04 GO:0022803 passive transmembrane transporter activity
1.70 3.25e-04 GO:0022838 substrate-specific channel activity
1.69 6.20e-04 GO:0005216 ion channel activity
1.57 3.20e-05 GO:0043565 sequence-specific DNA binding
1.52 4.56e-03 GO:0008324 cation transmembrane transporter activity
1.47 1.26e-03 GO:0015075 ion transmembrane transporter activity
1.40 3.32e-03 GO:0022857 transmembrane transporter activity
1.40 7.48e-03 GO:0022891 substrate-specific transmembrane transporter activity
1.33 3.71e-02 GO:0022892 substrate-specific transporter activity
1.31 2.26e-02 GO:0005215 transporter activity