Motif ID: POU5F1.p2

Z-value: 1.640


Transcription factors associated with POU5F1.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU5F1chr6_-_312425930.562.4e-02Click!


Activity profile for motif POU5F1.p2.

activity profile for motif POU5F1.p2


Sorted Z-values histogram for motif POU5F1.p2

Sorted Z-values for motif POU5F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_16649211 4.014 LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_-_110443247 3.354 NM_032518
NM_198721
 COL25A1

collagen, type XXV, alpha 1

chr2_+_5750229 2.694 NM_003108
 SOX11
SRY (sex determining region Y)-box 11
chr10_+_68355797 2.676 NM_178011
 LRRTM3
leucine rich repeat transmembrane neuronal 3
chr15_+_26832300 2.540 LOC100289656
Dexi homolog (mouse) pseudogene
chr13_-_101852028 2.476 NM_175929
 FGF14
fibroblast growth factor 14
chr17_-_33178987 2.475 HNF1B
HNF1 homeobox B
chr11_-_3620060 2.444 NM_053017
NM_001079536
 ART5

ADP-ribosyltransferase 5

chr13_-_52320774 2.425 NM_002590
NM_032949
 PCDH8

protocadherin 8

chrX_-_6156655 2.421 NM_181332
 NLGN4X
neuroligin 4, X-linked
chr13_-_60887210 2.301 PCDH20
protocadherin 20
chr17_+_7494964 2.294 NM_001678
 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr17_+_7495140 2.185 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr4_+_158361185 2.078 NM_000826
NM_001083619
NM_001083620
 GRIA2


glutamate receptor, ionotropic, AMPA 2


chrX_-_33267646 2.053 NM_000109
 DMD
dystrophin
chr4_-_41445479 1.999 PHOX2B
paired-like homeobox 2b
chr17_-_33179118 1.955 NM_000458
NM_001165923
 HNF1B

HNF1 homeobox B

chr4_+_41395493 1.949 LIMCH1
LIM and calponin homology domains 1
chr6_+_105511615 1.932 NM_001004317
 LIN28B
lin-28 homolog B (C. elegans)
chr15_-_86600658 1.816 NM_001007156
NM_001012338
NM_002530
 NTRK3


neurotrophic tyrosine kinase, receptor, type 3



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 64 entries
enrichment   p-value GO term description
3.74 5.06e-03 GO:0048663 neuron fate commitment
2.81 2.66e-02 GO:0021953 central nervous system neuron differentiation
2.25 3.71e-02 GO:0045165 cell fate commitment
1.94 2.80e-06 GO:0007417 central nervous system development
1.92 9.10e-03 GO:0016337 cell-cell adhesion
1.90 1.51e-08 GO:0030182 neuron differentiation
1.82 1.21e-02 GO:0007420 brain development
1.81 4.57e-05 GO:0048666 neuron development
1.81 6.14e-04 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.78 9.97e-09 GO:0022008 neurogenesis
1.78 3.96e-08 GO:0048699 generation of neurons
1.77 9.63e-03 GO:0007409 axonogenesis
1.73 1.68e-02 GO:0032583 regulation of gene-specific transcription
1.73 1.68e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
1.71 6.20e-13 GO:0007399 nervous system development
1.70 1.02e-02 GO:0031175 neuron projection development
1.68 1.11e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.67 9.18e-07 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.67 1.97e-02 GO:0001775 cell activation
1.66 3.39e-02 GO:0019226 transmission of nerve impulse

Gene overrepresentation in compartment category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
1.72 4.87e-03 GO:0043005 neuron projection
1.50 4.24e-02 GO:0030054 cell junction
1.38 2.83e-06 GO:0044459 plasma membrane part
1.32 8.01e-11 GO:0005886 plasma membrane
1.31 1.87e-10 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
3.43 1.13e-03 GO:0004879 ligand-dependent nuclear receptor activity
3.43 2.19e-03 GO:0003707 steroid hormone receptor activity
2.00 8.11e-12 GO:0043565 sequence-specific DNA binding
1.85 5.42e-13 GO:0001071 nucleic acid binding transcription factor activity
1.85 5.42e-13 GO:0003700 sequence-specific DNA binding transcription factor activity
1.64 2.01e-07 GO:0030528 transcription regulator activity
1.51 1.78e-04 GO:0005102 receptor binding
1.38 6.88e-03 GO:0004888 transmembrane receptor activity
1.37 4.41e-04 GO:0004872 receptor activity
1.34 1.48e-04 GO:0004871 signal transducer activity
1.34 1.48e-04 GO:0060089 molecular transducer activity
1.31 2.20e-04 GO:0003677 DNA binding