Motif ID: TFAP2B.p2

Z-value: 3.311


Transcription factors associated with TFAP2B.p2:

Gene SymbolEntrez IDGene Name
TFAP2B 7021 transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Bchr6_+_508943970.282.8e-01Click!


Activity profile for motif TFAP2B.p2.

activity profile for motif TFAP2B.p2


Sorted Z-values histogram for motif TFAP2B.p2

Sorted Z-values for motif TFAP2B.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2B.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_55922623 7.265 ZNF713
zinc finger protein 713
chr19_+_39664706 6.126 NM_001080436
 WTIP
Wilms tumor 1 interacting protein
chr22_+_48951286 5.862 NM_001160300
NM_052839
 PANX2

pannexin 2

chr11_+_359723 5.746 NM_178537
 B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr20_-_60074237 5.715 NM_003185
 TAF4
TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
chr17_+_77582774 5.460 NM_005052
 RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr20_-_61933012 4.886 ZBTB46
zinc finger and BTB domain containing 46
chr3_-_130807865 4.885 NM_015103
 PLXND1
plexin D1
chr8_+_1699418 4.805 CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr2_+_101680594 4.655 NM_004834
NM_145686
NM_145687
 MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr16_+_88169612 4.217 NM_014427
NM_153636
 CPNE7

copine VII

chr8_+_1699276 4.072 NM_018941
 CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr4_-_809879 3.965 NM_006651
 CPLX1
complexin 1
chr9_+_123501186 3.435 DAB2IP
DAB2 interacting protein
chr7_-_525556 3.378 PDGFA
platelet-derived growth factor alpha polypeptide
chr20_-_60375695 3.329 NM_005560
 LAMA5
laminin, alpha 5
chr4_+_3264509 3.278 RGS12
regulator of G-protein signaling 12
chr20_+_8060762 3.207 NM_015192
NM_182734
 PLCB1

phospholipase C, beta 1 (phosphoinositide-specific)

chr4_+_2031036 3.183 NM_178557
 NAT8L
N-acetyltransferase 8-like (GCN5-related, putative)
chr2_-_110769670 3.165 NM_001164463
NM_005054
 RGPD8
RGPD5
RANBP2-like and GRIP domain containing 8
RANBP2-like and GRIP domain containing 5

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 170 entries
enrichment   p-value GO term description
1.96 3.38e-02 GO:0001649 osteoblast differentiation
1.84 4.98e-02 GO:0001889 liver development
1.74 2.10e-02 GO:0021915 neural tube development
1.73 1.75e-02 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.69 5.37e-04 GO:0048705 skeletal system morphogenesis
1.68 3.55e-02 GO:0021537 telencephalon development
1.63 5.21e-03 GO:0030111 regulation of Wnt receptor signaling pathway
1.61 9.43e-04 GO:0048562 embryonic organ morphogenesis
1.56 2.28e-05 GO:0003002 regionalization
1.54 4.98e-03 GO:0032869 cellular response to insulin stimulus
1.53 2.65e-04 GO:0048568 embryonic organ development
1.52 4.27e-11 GO:0000904 cell morphogenesis involved in differentiation
1.52 6.96e-08 GO:0048598 embryonic morphogenesis
1.52 1.09e-06 GO:0007411 axon guidance
1.52 6.54e-04 GO:0071375 cellular response to peptide hormone stimulus
1.52 2.73e-02 GO:0009952 anterior/posterior pattern formation
1.50 9.76e-09 GO:0048667 cell morphogenesis involved in neuron differentiation
1.50 4.61e-08 GO:0007409 axonogenesis
1.49 3.95e-06 GO:0007389 pattern specification process
1.49 4.27e-02 GO:0030900 forebrain development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
1.90 5.28e-04 GO:0031256 leading edge membrane
1.65 3.83e-02 GO:0031461 cullin-RING ubiquitin ligase complex
1.59 3.24e-04 GO:0005912 adherens junction
1.56 1.32e-04 GO:0031252 cell leading edge
1.55 6.57e-04 GO:0070161 anchoring junction
1.40 8.26e-03 GO:0005667 transcription factor complex
1.30 1.98e-02 GO:0043005 neuron projection
1.26 7.14e-03 GO:0030054 cell junction
1.22 2.77e-02 GO:0044451 nucleoplasm part
1.21 4.55e-05 GO:0005654 nucleoplasm
1.19 2.17e-07 GO:0044428 nuclear part
1.18 1.31e-05 GO:0031981 nuclear lumen
1.18 3.05e-02 GO:0005794 Golgi apparatus
1.16 5.92e-05 GO:0070013 intracellular organelle lumen
1.16 2.27e-04 GO:0005829 cytosol
1.15 1.02e-04 GO:0043233 organelle lumen
1.15 1.18e-04 GO:0031974 membrane-enclosed lumen
1.15 1.93e-02 GO:0012505 endomembrane system
1.14 1.30e-03 GO:0031090 organelle membrane
1.13 2.50e-12 GO:0005634 nucleus

Gene overrepresentation in function category:

Showing 1 to 20 of 31 entries
enrichment   p-value GO term description
1.66 1.38e-02 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
1.66 3.56e-02 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
1.48 6.41e-06 GO:0016563 transcription activator activity
1.47 3.81e-03 GO:0000975 regulatory region DNA binding
1.47 3.81e-03 GO:0001067 regulatory region nucleic acid binding
1.47 3.81e-03 GO:0044212 transcription regulatory region DNA binding
1.45 1.20e-02 GO:0010843 promoter binding
1.32 4.51e-03 GO:0004674 protein serine/threonine kinase activity
1.31 1.19e-08 GO:0001071 nucleic acid binding transcription factor activity
1.31 1.19e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
1.31 1.26e-04 GO:0004672 protein kinase activity
1.30 2.19e-05 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.30 6.00e-05 GO:0043565 sequence-specific DNA binding
1.29 1.39e-05 GO:0016301 kinase activity
1.27 1.54e-06 GO:0030528 transcription regulator activity
1.24 4.03e-03 GO:0019899 enzyme binding
1.22 4.10e-03 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.17 1.20e-05 GO:0000166 nucleotide binding
1.17 4.58e-03 GO:0030554 adenyl nucleotide binding
1.16 7.84e-04 GO:0017076 purine nucleotide binding