Motif ID: TFAP2B.p2

Z-value: 3.311


Transcription factors associated with TFAP2B.p2:

Gene SymbolEntrez IDGene Name
TFAP2B 7021 transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Bchr6_+_508943970.282.8e-01Click!


Activity profile for motif TFAP2B.p2.

activity profile for motif TFAP2B.p2


Sorted Z-values histogram for motif TFAP2B.p2

Sorted Z-values for motif TFAP2B.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2B.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_55922623 7.265 ZNF713
zinc finger protein 713
chr19_+_39664706 6.126 NM_001080436
WTIP
Wilms tumor 1 interacting protein
chr22_+_48951286 5.862 NM_001160300
NM_052839
PANX2

pannexin 2

chr11_+_359723 5.746 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr20_-_60074237 5.715 NM_003185
TAF4
TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
chr17_+_77582774 5.460 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr20_-_61933012 4.886 ZBTB46
zinc finger and BTB domain containing 46
chr3_-_130807865 4.885 NM_015103
PLXND1
plexin D1
chr8_+_1699418 4.805 CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr2_+_101680594 4.655 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr16_+_88169612 4.217 NM_014427
NM_153636
CPNE7

copine VII

chr8_+_1699276 4.072 NM_018941
CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr4_-_809879 3.965 NM_006651
CPLX1
complexin 1
chr9_+_123501186 3.435 DAB2IP
DAB2 interacting protein
chr7_-_525556 3.378 PDGFA
platelet-derived growth factor alpha polypeptide
chr20_-_60375695 3.329 NM_005560
LAMA5
laminin, alpha 5
chr4_+_3264509 3.278 RGS12
regulator of G-protein signaling 12
chr20_+_8060762 3.207 NM_015192
NM_182734
PLCB1

phospholipase C, beta 1 (phosphoinositide-specific)

chr4_+_2031036 3.183 NM_178557
NAT8L
N-acetyltransferase 8-like (GCN5-related, putative)
chr2_-_110769670 3.165 NM_001164463
NM_005054
RGPD8
RGPD5
RANBP2-like and GRIP domain containing 8
RANBP2-like and GRIP domain containing 5
chr19_-_1518875 3.080 NM_001174118
NM_203304
MEX3D

mex-3 homolog D (C. elegans)

chr7_-_525336 3.070 PDGFA
platelet-derived growth factor alpha polypeptide
chr2_+_42128521 3.054 NM_138370
PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr10_-_134449467 2.986 NM_177400
NKX6-2
NK6 homeobox 2
chr9_+_128128913 2.958 NM_001011703
NM_033446
FAM125B

family with sequence similarity 125, member B

chr19_+_12966970 2.828 NM_002501
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr15_-_27650218 2.820 NM_015307
FAM189A1
family with sequence similarity 189, member A1
chr12_+_127317900 2.791 NM_001136103
TMEM132C
transmembrane protein 132C
chr12_-_103055924 2.775 NM_006166
NFYB
nuclear transcription factor Y, beta
chr15_-_62854749 2.728 NM_194272
RBPMS2
RNA binding protein with multiple splicing 2
chr1_+_41022066 2.667 NM_004700
NM_172163
KCNQ4

potassium voltage-gated channel, KQT-like subfamily, member 4

chr11_+_1367665 2.658 NM_003957
BRSK2
BR serine/threonine kinase 2
chr3_+_12304332 2.592 NM_005037
NM_138712
PPARG

peroxisome proliferator-activated receptor gamma

chr2_-_204108151 2.592 NM_203365
NM_213589
RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

chr9_+_137511448 2.579 NM_014811
KIAA0649
KIAA0649
chr10_-_100017933 2.574 NM_032211
LOXL4
lysyl oxidase-like 4
chr9_+_131974506 2.507 NM_014286
NCS1
neuronal calcium sensor 1
chr7_-_5427367 2.507


chr12_+_120944174 2.505 NM_001024808
NM_020993
BCL7A

B-cell CLL/lymphoma 7A

chr6_+_167970334 2.446 NM_001040000
MLLT4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
chr1_-_1465602 2.435 NM_001114748
C1orf70
chromosome 1 open reading frame 70
chr22_+_38720881 2.418 NM_138435
FAM83F
family with sequence similarity 83, member F
chr8_-_144583718 2.359 NM_201589
MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr19_+_540849 2.348 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr1_-_29321599 2.339 NM_001171868
TMEM200B
transmembrane protein 200B
chrX_+_9943793 2.322 NM_015691
WWC3
WWC family member 3
chr17_+_15789147 2.297 ADORA2B
adenosine A2b receptor
chr10_+_134060681 2.289 NM_001098637
NM_138499
PWWP2B

PWWP domain containing 2B

chr17_+_15788955 2.280 NM_000676
ADORA2B
adenosine A2b receptor
chr16_+_88517187 2.271 NM_006086
TUBB3
tubulin, beta 3
chr9_+_137119339 2.176 OLFM1
olfactomedin 1
chr16_+_1143241 2.160 NM_001005407
NM_021098
CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr7_+_94374862 2.159 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr11_-_2863536 2.148 NM_000076
NM_001122630
NM_001122631
CDKN1C


cyclin-dependent kinase inhibitor 1C (p57, Kip2)


chr1_-_232811846 2.137 NM_001077397
NM_182972
IRF2BP2

interferon regulatory factor 2 binding protein 2

chr16_+_86193993 2.137 NM_020655
JPH3
junctophilin 3
chr8_-_99906944 2.130 NM_006281
STK3
serine/threonine kinase 3
chr6_+_158164294 2.120 SNX9
sorting nexin 9
chr7_-_526005 2.116 NM_002607
NM_033023
PDGFA

platelet-derived growth factor alpha polypeptide

chr22_-_37569962 2.102 NM_014293
NPTXR
neuronal pentraxin receptor
chr9_+_137119334 2.083 OLFM1
olfactomedin 1
chr11_-_110087982 2.063 ARHGAP20
Rho GTPase activating protein 20
chr18_-_5533967 2.055 NM_012307
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr2_-_235070431 2.045 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr2_-_160972606 2.043 RBMS1
RNA binding motif, single stranded interacting protein 1
chr14_+_99329198 2.021 NM_001008707
NM_004434
EML1

echinoderm microtubule associated protein like 1

chr22_-_41913002 2.005 TTLL12
tubulin tyrosine ligase-like family, member 12
chr22_-_27405708 1.986 NM_001145418
TTC28
tetratricopeptide repeat domain 28
chrX_+_152606945 1.969 NM_001142805
NM_005629
SLC6A8

solute carrier family 6 (neurotransmitter transporter, creatine), member 8

chr11_-_110088330 1.954 NM_020809
ARHGAP20
Rho GTPase activating protein 20
chr14_+_105012106 1.948 NM_001312
CRIP2
cysteine-rich protein 2
chr9_+_77695334 1.948 NM_001190482
NM_006200
PCSK5

proprotein convertase subtilisin/kexin type 5

chr6_-_119441045 1.946 FAM184A
family with sequence similarity 184, member A
chr2_+_154436670 1.940 NM_052917
GALNT13
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)
chr17_+_8865547 1.940 NM_004822
NTN1
netrin 1
chr1_+_2149993 1.921 NM_003036
SKI
v-ski sarcoma viral oncogene homolog (avian)
chr3_-_71857097 1.899 NM_001134651
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr6_+_158164269 1.887 NM_016224
SNX9
sorting nexin 9
chr1_+_22909916 1.868 NM_004442
NM_017449
EPHB2

EPH receptor B2

chr4_-_41848874 1.867 BEND4
BEN domain containing 4
chr22_-_49041786 1.865 MAPK12
mitogen-activated protein kinase 12
chr20_-_538909 1.853 NM_004609
TCF15
transcription factor 15 (basic helix-loop-helix)
chr19_-_17217022 1.850 NM_005234
NR2F6
nuclear receptor subfamily 2, group F, member 6
chr6_-_117193505 1.839 NM_001085480
FAM162B
family with sequence similarity 162, member B
chr2_+_104838177 1.820 NM_006236
POU3F3
POU class 3 homeobox 3
chr16_-_79395379 1.815 NM_152342
CDYL2
chromodomain protein, Y-like 2
chr1_-_31154023 1.811 NM_014654
SDC3
syndecan 3
chr6_-_18095831 1.802 KIF13A
kinesin family member 13A
chr22_+_36286350 1.784 NM_152243
CDC42EP1
CDC42 effector protein (Rho GTPase binding) 1
chr1_-_33669190 1.770 PHC2
polyhomeotic homolog 2 (Drosophila)
chr17_+_14145051 1.770 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr1_+_179148935 1.760 NM_020950
KIAA1614
KIAA1614
chr17_+_56831951 1.744 NM_005994
TBX2
T-box 2
chr9_-_38059082 1.723 SHB
Src homology 2 domain containing adaptor protein B
chr2_-_133144094 1.711 LYPD1
LY6/PLAUR domain containing 1
chr12_+_121885930 1.703 NM_003959
HIP1R
huntingtin interacting protein 1 related
chr10_+_59942874 1.693 NM_001080512
BICC1
bicaudal C homolog 1 (Drosophila)
chr7_+_44110470 1.691 NM_001129
AEBP1
AE binding protein 1
chr2_+_5750229 1.690 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr4_+_36923084 1.689 NM_001144990
KIAA1239
KIAA1239
chr8_+_136538739 1.676 NM_006558
KHDRBS3
KH domain containing, RNA binding, signal transduction associated 3
chr1_+_39319675 1.667 NM_012090
MACF1
microtubule-actin crosslinking factor 1
chr22_-_41913075 1.666 TTLL12
tubulin tyrosine ligase-like family, member 12
chr5_-_38592439 1.665 NM_001127671
LIFR
leukemia inhibitory factor receptor alpha
chr16_+_88422354 1.662 NM_032451
SPIRE2
spire homolog 2 (Drosophila)
chr1_+_52871603 1.659 NM_001042693
FAM159A
family with sequence similarity 159, member A
chr4_+_151218862 1.659 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr8_+_30361485 1.653 NM_001008710
NM_001008711
NM_001008712
NM_006867
RBPMS



RNA binding protein with multiple splicing



chr17_+_75366524 1.639 NM_005189
NM_032647
CBX2

chromobox homolog 2

chr19_+_7486987 1.638 NM_018083
ZNF358
zinc finger protein 358
chr6_-_119441458 1.636 NM_024581
FAM184A
family with sequence similarity 184, member A
chr4_-_86106567 1.630 NM_014991
WDFY3
WD repeat and FYVE domain containing 3
chr12_+_107047594 1.620 NM_014653
WSCD2
WSC domain containing 2
chr11_+_12652427 1.601 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr2_+_202607554 1.578 NM_003507
FZD7
frizzled homolog 7 (Drosophila)
chr16_-_27982277 1.571 NM_001109763
GSG1L
GSG1-like
chr11_+_76171780 1.565 NM_015516
TSKU
tsukushi small leucine rich proteoglycan homolog (Xenopus laevis)
chr12_-_45759691 1.560 NM_001143668
NM_181847
AMIGO2

adhesion molecule with Ig-like domain 2

chr11_-_16992524 1.557 NM_175058
PLEKHA7
pleckstrin homology domain containing, family A member 7
chr12_+_50271283 1.553 NM_014191
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr16_-_56393871 1.550 KIFC3
kinesin family member C3
chr19_-_54557450 1.537 NM_003598
TEAD2
TEA domain family member 2
chr18_-_9604555 1.535 NM_001042388
NM_005134
PPP4R1

protein phosphatase 4, regulatory subunit 1

chr7_+_101245812 1.529 NM_001913
NM_181500
CUX1

cut-like homeobox 1

chr5_-_158459006 1.527 EBF1
early B-cell factor 1
chr22_-_49042065 1.526 NM_002969
MAPK12
mitogen-activated protein kinase 12
chr19_+_4423149 1.525 NM_001001520
NM_032631
HDGFRP2

hepatoma-derived growth factor-related protein 2

chr22_+_27798887 1.519 NM_001039570
NM_032045
KREMEN1

kringle containing transmembrane protein 1

chr19_-_411995 1.514 NM_012435
SHC2
SHC (Src homology 2 domain containing) transforming protein 2
chr22_+_49459935 1.495 NM_001080420
SHANK3
SH3 and multiple ankyrin repeat domains 3
chr7_-_100262971 1.493 NM_004444
EPHB4
EPH receptor B4
chr3_-_127558747 1.484 NM_014079
KLF15
Kruppel-like factor 15
chr9_+_136358145 1.484 RXRA
retinoid X receptor, alpha
chr12_+_45759634 1.482 FAM113B
family with sequence similarity 113, member B
chr19_-_1188840 1.480 NM_152769
C19orf26
chromosome 19 open reading frame 26
chr14_+_105063975 1.474 NM_025268
TMEM121
transmembrane protein 121
chr8_-_18915443 1.474 NM_015310
PSD3
pleckstrin and Sec7 domain containing 3
chr6_+_124166767 1.473 NM_001040214
NM_153355
NKAIN2

Na+/K+ transporting ATPase interacting 2

chr1_+_66990692 1.473 NM_152665
TCTEX1D1
Tctex1 domain containing 1
chr12_+_26003218 1.470 NM_001164748
NM_007211
RASSF8

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

chr15_+_97010219 1.468 NM_000875
IGF1R
insulin-like growth factor 1 receptor
chr7_+_18093068 1.457 HDAC9
histone deacetylase 9
chr5_+_98132898 1.445 NM_001012761
RGMB
RGM domain family, member B
chr16_+_86194075 1.440 JPH3
junctophilin 3
chr9_+_136358134 1.438 NM_002957
RXRA
retinoid X receptor, alpha
chr22_+_47350781 1.436 NM_015381
FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr20_-_38751289 1.435 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr7_-_5429702 1.433 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr22_+_27609889 1.427 NM_032173
ZNRF3
zinc and ring finger 3
chr1_-_182273114 1.424 GLT25D2
glycosyltransferase 25 domain containing 2
chr15_-_53667800 1.423 PYGO1
pygopus homolog 1 (Drosophila)
chr1_+_66990736 1.402 TCTEX1D1
Tctex1 domain containing 1
chr17_+_35472566 1.399 NM_001190918
NM_003250
NM_199334
THRA


thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)


chr2_+_241586927 1.391 NM_001080437
SNED1
sushi, nidogen and EGF-like domains 1
chr2_+_9264360 1.381 ASAP2
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
chr11_-_27678551 1.380 NM_001143813
NM_001143814
NM_001709
BDNF


brain-derived neurotrophic factor


chr2_+_242289983 1.379 NM_032329
ING5
inhibitor of growth family, member 5
chr19_-_2672337 1.375 NM_145173
DIRAS1
DIRAS family, GTP-binding RAS-like 1
chr20_+_20296744 1.374 NM_002196
INSM1
insulinoma-associated 1
chr22_+_36531059 1.369 NM_005318
H1F0
H1 histone family, member 0
chr21_+_32167175 1.362 NM_014586
HUNK
hormonally up-regulated Neu-associated kinase
chr2_+_176702667 1.361 NM_019558
HOXD8
homeobox D8
chr7_-_139123906 1.359 NM_001113239
NM_022740
HIPK2

homeodomain interacting protein kinase 2

chr4_+_48187012 1.354 NM_175619
ZAR1
zygote arrest 1
chrX_-_19443299 1.354 NM_001001671
MAP3K15
mitogen-activated protein kinase kinase kinase 15
chr4_-_140420789 1.353 NM_032623
C4orf49
chromosome 4 open reading frame 49
chr15_-_27901628 1.353 TJP1
tight junction protein 1 (zona occludens 1)
chr22_-_41913076 1.351 NM_015140
TTLL12
tubulin tyrosine ligase-like family, member 12
chr7_+_44110527 1.342 AEBP1
AE binding protein 1
chr1_-_3437834 1.336 MEGF6
multiple EGF-like-domains 6
chr9_-_98421894 1.334 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr20_-_61108831 1.328 NM_080606
BHLHE23
basic helix-loop-helix family, member e23
chr2_-_73193566 1.321 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr10_+_63803921 1.319 NM_014951
NM_199450
NM_199451
ZNF365


zinc finger protein 365


chr6_-_18095672 1.312 NM_001105566
NM_001105567
NM_001105568
NM_022113
KIF13A



kinesin family member 13A



chr6_+_118335381 1.312 NM_001029858
SLC35F1
solute carrier family 35, member F1
chr8_+_136539290 1.310 KHDRBS3
KH domain containing, RNA binding, signal transduction associated 3
chr19_+_56506907 1.306 NM_001101372
IGLON5
IgLON family member 5
chr18_+_46340400 1.305 NM_002747
MAPK4
mitogen-activated protein kinase 4
chr4_-_41849333 1.304 BEND4
BEN domain containing 4
chr16_+_2016807 1.303 NM_001130012
NM_004785
SLC9A3R2

solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2

chr9_-_139214962 1.302 NM_001128228
TPRN
taperin
chr8_+_37672427 1.299 NM_025069
ZNF703
zinc finger protein 703
chr22_+_36531178 1.299 H1F0
H1 histone family, member 0
chr5_-_57791544 1.295 NM_006622
PLK2
polo-like kinase 2
chr6_-_72187168 1.292 C6orf155
chromosome 6 open reading frame 155
chr21_+_45649719 1.290


chr16_+_28741861 1.288 ATXN2L
ataxin 2-like
chr7_-_50828608 1.288 NM_001001555
GRB10
growth factor receptor-bound protein 10
chr7_-_50828159 1.287 GRB10
growth factor receptor-bound protein 10
chr19_-_55914837 1.287


chr10_+_83625049 1.282 NM_001010848
NM_001165972
NRG3

neuregulin 3

chr6_+_12120709 1.278 NM_002114
HIVEP1
human immunodeficiency virus type I enhancer binding protein 1
chr12_+_51777684 1.277 NM_002178
IGFBP6
insulin-like growth factor binding protein 6
chr19_-_44158130 1.270 NM_024907
FBXO17
F-box protein 17
chr2_-_73193419 1.247 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr12_+_51777715 1.247 IGFBP6
insulin-like growth factor binding protein 6
chr1_-_226661089 1.245 NM_145214
TRIM11
tripartite motif containing 11
chr16_-_65287967 1.238 NM_178818
NM_181521
CMTM4

CKLF-like MARVEL transmembrane domain containing 4

chr19_-_15421761 1.236 NM_021241
WIZ
widely interspaced zinc finger motifs

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.09 4.26e-24 GO:0009987 cellular process
1.37 5.83e-19 GO:0007399 nervous system development
1.14 6.46e-19 GO:0050794 regulation of cellular process
1.13 7.66e-18 GO:0050789 regulation of biological process
1.15 2.49e-17 GO:0044237 cellular metabolic process
1.36 2.75e-17 GO:0009653 anatomical structure morphogenesis
1.12 6.81e-17 GO:0065007 biological regulation
1.19 7.14e-17 GO:0044260 cellular macromolecule metabolic process
1.28 3.87e-16 GO:0048523 negative regulation of cellular process
1.20 4.76e-16 GO:0032502 developmental process
1.22 1.40e-15 GO:0048856 anatomical structure development
1.25 1.62e-14 GO:0048519 negative regulation of biological process
1.23 4.07e-14 GO:0048731 system development
1.19 7.22e-14 GO:0031323 regulation of cellular metabolic process
1.20 9.27e-14 GO:0007275 multicellular organismal development
1.40 2.00e-12 GO:0022008 neurogenesis
1.41 2.21e-12 GO:0048699 generation of neurons
1.11 2.80e-12 GO:0008152 metabolic process
1.25 6.68e-12 GO:0048869 cellular developmental process
1.17 6.93e-12 GO:0019222 regulation of metabolic process
1.18 1.17e-11 GO:0080090 regulation of primary metabolic process
1.12 1.62e-11 GO:0044238 primary metabolic process
1.14 1.70e-11 GO:0043170 macromolecule metabolic process
1.25 2.83e-11 GO:0030154 cell differentiation
1.52 4.27e-11 GO:0000904 cell morphogenesis involved in differentiation
1.46 1.95e-10 GO:0000902 cell morphogenesis
1.46 3.38e-10 GO:0009887 organ morphogenesis
1.18 6.49e-10 GO:0060255 regulation of macromolecule metabolic process
1.27 7.04e-10 GO:0023051 regulation of signaling
1.44 8.61e-10 GO:0032989 cellular component morphogenesis
1.21 1.41e-09 GO:0048522 positive regulation of cellular process
1.41 3.02e-09 GO:0009790 embryo development
1.24 4.38e-09 GO:0006464 protein modification process
1.35 6.54e-09 GO:0048468 cell development
1.40 6.94e-09 GO:0030182 neuron differentiation
1.20 8.33e-09 GO:0044267 cellular protein metabolic process
1.19 9.19e-09 GO:0048518 positive regulation of biological process
1.41 9.59e-09 GO:0007167 enzyme linked receptor protein signaling pathway
1.23 9.59e-09 GO:0043412 macromolecule modification
1.50 9.76e-09 GO:0048667 cell morphogenesis involved in neuron differentiation
1.27 1.47e-08 GO:0009966 regulation of signal transduction
1.46 1.58e-08 GO:0032990 cell part morphogenesis
1.16 2.46e-08 GO:0016043 cellular component organization
1.19 2.87e-08 GO:0071842 cellular component organization at cellular level
1.46 3.89e-08 GO:0048858 cell projection morphogenesis
1.16 4.12e-08 GO:0071840 cellular component organization or biogenesis
1.32 4.51e-08 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.50 4.61e-08 GO:0007409 axonogenesis
1.18 4.71e-08 GO:0071841 cellular component organization or biogenesis at cellular level
1.52 6.96e-08 GO:0048598 embryonic morphogenesis
1.44 1.47e-07 GO:0007417 central nervous system development
1.47 1.52e-07 GO:0048812 neuron projection morphogenesis
1.18 2.20e-07 GO:0051171 regulation of nitrogen compound metabolic process
1.43 2.83e-07 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.18 2.98e-07 GO:0010468 regulation of gene expression
1.32 3.35e-07 GO:0050793 regulation of developmental process
1.38 4.01e-07 GO:0030030 cell projection organization
1.34 8.80e-07 GO:2000026 regulation of multicellular organismal development
1.52 1.09e-06 GO:0007411 axon guidance
1.17 1.16e-06 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.17 1.16e-06 GO:0031326 regulation of cellular biosynthetic process
1.43 1.18e-06 GO:0031175 neuron projection development
1.18 1.49e-06 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.38 2.81e-06 GO:0010629 negative regulation of gene expression
1.38 2.91e-06 GO:0048666 neuron development
1.17 3.40e-06 GO:0009889 regulation of biosynthetic process
1.35 3.94e-06 GO:0045595 regulation of cell differentiation
1.49 3.95e-06 GO:0007389 pattern specification process
1.30 4.13e-06 GO:0031324 negative regulation of cellular metabolic process
1.26 4.16e-06 GO:0010604 positive regulation of macromolecule metabolic process
1.18 4.83e-06 GO:0051252 regulation of RNA metabolic process
1.29 5.16e-06 GO:0009892 negative regulation of metabolic process
1.26 5.52e-06 GO:0031325 positive regulation of cellular metabolic process
1.30 6.04e-06 GO:0010605 negative regulation of macromolecule metabolic process
1.25 7.24e-06 GO:0009893 positive regulation of metabolic process
1.39 7.34e-06 GO:0051253 negative regulation of RNA metabolic process
1.39 7.38e-06 GO:0045892 negative regulation of transcription, DNA-dependent
1.28 8.59e-06 GO:0032268 regulation of cellular protein metabolic process
1.36 8.87e-06 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.34 1.37e-05 GO:0010628 positive regulation of gene expression
1.56 2.28e-05 GO:0003002 regionalization
1.33 4.02e-05 GO:0031327 negative regulation of cellular biosynthetic process
1.32 4.12e-05 GO:0009890 negative regulation of biosynthetic process
1.33 5.12e-05 GO:0051254 positive regulation of RNA metabolic process
1.17 5.76e-05 GO:0006355 regulation of transcription, DNA-dependent
1.29 5.83e-05 GO:0051128 regulation of cellular component organization
1.16 8.00e-05 GO:0010556 regulation of macromolecule biosynthetic process
1.14 8.04e-05 GO:0019538 protein metabolic process
1.12 1.02e-04 GO:0023052 signaling
1.18 1.03e-04 GO:0048513 organ development
1.28 1.04e-04 GO:0006351 transcription, DNA-dependent
1.23 1.05e-04 GO:0051239 regulation of multicellular organismal process
1.32 1.21e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
1.33 1.39e-04 GO:0045893 positive regulation of transcription, DNA-dependent
1.46 1.52e-04 GO:0001501 skeletal system development
1.29 1.53e-04 GO:0031399 regulation of protein modification process
1.33 1.63e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.46 1.85e-04 GO:0032870 cellular response to hormone stimulus
1.13 1.86e-04 GO:0006807 nitrogen compound metabolic process
1.24 2.00e-04 GO:0051246 regulation of protein metabolic process
1.33 2.32e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
1.53 2.65e-04 GO:0048568 embryonic organ development
1.42 2.72e-04 GO:0007420 brain development
1.44 2.76e-04 GO:0071495 cellular response to endogenous stimulus
1.41 3.57e-04 GO:0009792 embryo development ending in birth or egg hatching
1.44 4.30e-04 GO:0060284 regulation of cell development
1.41 4.51e-04 GO:0043009 chordate embryonic development
1.69 5.37e-04 GO:0048705 skeletal system morphogenesis
1.13 5.78e-04 GO:0034641 cellular nitrogen compound metabolic process
1.52 6.54e-04 GO:0071375 cellular response to peptide hormone stimulus
1.20 6.99e-04 GO:0065009 regulation of molecular function
1.25 8.11e-04 GO:0042127 regulation of cell proliferation
1.39 9.22e-04 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.61 9.43e-04 GO:0048562 embryonic organ morphogenesis
1.20 1.01e-03 GO:0035556 intracellular signal transduction
1.14 1.23e-03 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.15 1.54e-03 GO:0044249 cellular biosynthetic process
1.15 1.56e-03 GO:0090304 nucleic acid metabolic process
1.12 2.01e-03 GO:0007165 signal transduction
1.10 2.25e-03 GO:0051716 cellular response to stimulus
1.34 2.52e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.23 2.54e-03 GO:0006793 phosphorus metabolic process
1.23 2.54e-03 GO:0006796 phosphate metabolic process
1.11 2.64e-03 GO:0051179 localization
1.13 2.82e-03 GO:0051234 establishment of localization
1.22 3.03e-03 GO:0010646 regulation of cell communication
1.42 3.49e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.26 4.31e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.26 4.41e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.12 4.85e-03 GO:0006810 transport
1.21 4.94e-03 GO:0051649 establishment of localization in cell
1.54 4.98e-03 GO:0032869 cellular response to insulin stimulus
1.63 5.21e-03 GO:0030111 regulation of Wnt receptor signaling pathway
1.14 5.95e-03 GO:0009058 biosynthetic process
1.24 6.86e-03 GO:0031328 positive regulation of cellular biosynthetic process
1.20 8.82e-03 GO:0044248 cellular catabolic process
1.16 8.90e-03 GO:0016070 RNA metabolic process
1.19 1.03e-02 GO:0051641 cellular localization
1.46 1.11e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.22 1.15e-02 GO:0032774 RNA biosynthetic process
1.28 1.25e-02 GO:0051726 regulation of cell cycle
1.38 1.27e-02 GO:0044257 cellular protein catabolic process
1.16 1.31e-02 GO:0034645 cellular macromolecule biosynthetic process
1.33 1.40e-02 GO:0010648 negative regulation of cell communication
1.38 1.43e-02 GO:0043632 modification-dependent macromolecule catabolic process
1.38 1.61e-02 GO:0019941 modification-dependent protein catabolic process
1.25 1.69e-02 GO:0006468 protein phosphorylation
1.25 1.70e-02 GO:0010557 positive regulation of macromolecule biosynthetic process
1.73 1.75e-02 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.37 1.78e-02 GO:0051603 proteolysis involved in cellular protein catabolic process
1.32 1.88e-02 GO:0023057 negative regulation of signaling
1.23 1.95e-02 GO:0009891 positive regulation of biosynthetic process
1.35 2.01e-02 GO:0051056 regulation of small GTPase mediated signal transduction
1.74 2.10e-02 GO:0021915 neural tube development
1.39 2.28e-02 GO:0048729 tissue morphogenesis
1.44 2.50e-02 GO:0002009 morphogenesis of an epithelium
1.16 2.54e-02 GO:0009059 macromolecule biosynthetic process
1.29 2.63e-02 GO:0044265 cellular macromolecule catabolic process
1.52 2.73e-02 GO:0009952 anterior/posterior pattern formation
1.35 2.80e-02 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.32 3.11e-02 GO:0032583 regulation of gene-specific transcription
1.23 3.20e-02 GO:0016310 phosphorylation
1.96 3.38e-02 GO:0001649 osteoblast differentiation
1.68 3.55e-02 GO:0021537 telencephalon development
1.20 3.56e-02 GO:0043067 regulation of programmed cell death
1.37 3.92e-02 GO:0006511 ubiquitin-dependent protein catabolic process
1.20 4.19e-02 GO:0010941 regulation of cell death
1.49 4.27e-02 GO:0030900 forebrain development
1.26 4.61e-02 GO:0009057 macromolecule catabolic process
1.84 4.98e-02 GO:0001889 liver development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.10 3.51e-34 GO:0005622 intracellular
1.10 3.91e-32 GO:0044424 intracellular part
1.12 7.22e-22 GO:0005737 cytoplasm
1.10 3.69e-21 GO:0043226 organelle
1.10 4.59e-21 GO:0043229 intracellular organelle
1.11 4.94e-20 GO:0043231 intracellular membrane-bounded organelle
1.11 5.01e-20 GO:0043227 membrane-bounded organelle
1.13 2.50e-12 GO:0005634 nucleus
1.11 6.31e-10 GO:0044444 cytoplasmic part
1.12 9.31e-10 GO:0044446 intracellular organelle part
1.12 9.60e-10 GO:0044422 organelle part
1.03 3.88e-08 GO:0044464 cell part
1.03 4.29e-08 GO:0005623 cell
1.19 2.17e-07 GO:0044428 nuclear part
1.18 1.31e-05 GO:0031981 nuclear lumen
1.21 4.55e-05 GO:0005654 nucleoplasm
1.16 5.92e-05 GO:0070013 intracellular organelle lumen
1.15 1.02e-04 GO:0043233 organelle lumen
1.15 1.18e-04 GO:0031974 membrane-enclosed lumen
1.56 1.32e-04 GO:0031252 cell leading edge
1.16 2.27e-04 GO:0005829 cytosol
1.59 3.24e-04 GO:0005912 adherens junction
1.90 5.28e-04 GO:0031256 leading edge membrane
1.55 6.57e-04 GO:0070161 anchoring junction
1.14 1.30e-03 GO:0031090 organelle membrane
1.26 7.14e-03 GO:0030054 cell junction
1.40 8.26e-03 GO:0005667 transcription factor complex
1.15 1.93e-02 GO:0012505 endomembrane system
1.30 1.98e-02 GO:0043005 neuron projection
1.10 2.15e-02 GO:0043234 protein complex
1.22 2.77e-02 GO:0044451 nucleoplasm part
1.18 3.05e-02 GO:0005794 Golgi apparatus
1.65 3.83e-02 GO:0031461 cullin-RING ubiquitin ligase complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 1.74e-25 GO:0005515 protein binding
1.08 1.54e-21 GO:0005488 binding
1.31 1.19e-08 GO:0001071 nucleic acid binding transcription factor activity
1.31 1.19e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
1.27 1.54e-06 GO:0030528 transcription regulator activity
1.48 6.41e-06 GO:0016563 transcription activator activity
1.17 1.20e-05 GO:0000166 nucleotide binding
1.29 1.39e-05 GO:0016301 kinase activity
1.30 2.19e-05 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.30 6.00e-05 GO:0043565 sequence-specific DNA binding
1.31 1.26e-04 GO:0004672 protein kinase activity
1.16 7.84e-04 GO:0017076 purine nucleotide binding
1.15 1.89e-03 GO:0032553 ribonucleotide binding
1.15 1.89e-03 GO:0032555 purine ribonucleotide binding
1.11 2.18e-03 GO:0003676 nucleic acid binding
1.14 2.29e-03 GO:0003677 DNA binding
1.08 3.32e-03 GO:0003824 catalytic activity
1.15 3.61e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.47 3.81e-03 GO:0000975 regulatory region DNA binding
1.47 3.81e-03 GO:0001067 regulatory region nucleic acid binding
1.47 3.81e-03 GO:0044212 transcription regulatory region DNA binding
1.24 4.03e-03 GO:0019899 enzyme binding
1.22 4.10e-03 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.32 4.51e-03 GO:0004674 protein serine/threonine kinase activity
1.17 4.58e-03 GO:0030554 adenyl nucleotide binding
1.16 1.04e-02 GO:0032559 adenyl ribonucleotide binding
1.45 1.20e-02 GO:0010843 promoter binding
1.15 1.20e-02 GO:0016740 transferase activity
1.66 1.38e-02 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
1.15 2.27e-02 GO:0005524 ATP binding
1.66 3.56e-02 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity