Motif ID: RXRG_dimer.p3

Z-value: 0.991


Transcription factors associated with RXRG_dimer.p3:

Gene SymbolEntrez IDGene Name
NR1H2 7376 nuclear receptor subfamily 1, group H, member 2
PPARA 5465 peroxisome proliferator-activated receptor alpha
PPARG 5468 peroxisome proliferator-activated receptor gamma
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
RXRBchr6_-_332761410.582.0e-02Click!
PPARAchr22_+_44925162-0.504.7e-02Click!
PPARGchr3_+_12367993-0.361.7e-01Click!
RXRGchr1_-_163680941-0.351.8e-01Click!
RXRAchr9_+_1363581340.233.9e-01Click!
NR1H2chr19_+_555714930.165.4e-01Click!


Activity profile for motif RXRG_dimer.p3.

activity profile for motif RXRG_dimer.p3


Sorted Z-values histogram for motif RXRG_dimer.p3

Sorted Z-values for motif RXRG_dimer.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRG_dimer.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_175754366 1.641 NM_001002258
NM_001190329
NM_001689
ATP5G3


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)


chr20_+_37024383 1.591 NM_001190809
NM_021931
DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr2_+_219141761 1.383 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr2_+_161725172 1.201 TANK
TRAF family member-associated NFKB activator
chr5_+_1854493 1.176 NM_004553
NDUFS6
NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
chr10_-_21854616 1.157 NM_207371
C10orf140
chromosome 10 open reading frame 140
chr19_+_44308224 1.142 NM_001014831
NM_001014832
NM_001014834
NM_001014835
NM_005884
PAK4




p21 protein (Cdc42/Rac)-activated kinase 4




chr4_+_109761170 1.122 NM_000995
NM_033625
RPL34

ribosomal protein L34

chr6_+_30702586 1.114 NM_024909
NM_001031722
NM_001190724
ATAT1


alpha tubulin acetyltransferase 1


chr6_+_144040751 1.106 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr2_+_108432097 1.081 GCC2
GRIP and coiled-coil domain containing 2
chr2_+_108432008 1.069 NM_181453
GCC2
GRIP and coiled-coil domain containing 2
chr18_+_52469559 1.051 NM_015285
NM_052834
WDR7

WD repeat domain 7

chr20_-_19981005 1.042 CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr14_-_20642214 0.987


chr6_+_143813472 0.941 NM_003630
PEX3
peroxisomal biogenesis factor 3
chr12_+_14429499 0.924 ATF7IP
activating transcription factor 7 interacting protein
chr2_-_219141199 0.910 NM_020935
USP37
ubiquitin specific peptidase 37
chr5_-_42847716 0.892 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr20_+_19981157 0.865 NM_015585
C20orf26
chromosome 20 open reading frame 26
chr1_+_61320213 0.852 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr1_-_32632601 0.790 NM_001143888
NM_001143889
NM_001143890
NM_018045
BSDC1



BSD domain containing 1



chr20_+_36095263 0.788 NM_021215
RPRD1B
regulation of nuclear pre-mRNA domain containing 1B
chr6_+_31731667 0.780 APOM
apolipoprotein M
chr6_+_31731647 0.772 NM_019101
APOM
apolipoprotein M
chr16_+_79829794 0.741 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr10_-_103805858 0.719 NM_024541
C10orf76
chromosome 10 open reading frame 76
chr20_+_43943254 0.699 NM_080603
ZSWIM1
zinc finger, SWIM-type containing 1
chr9_-_138277467 0.698 NM_181701
QSOX2
quiescin Q6 sulfhydryl oxidase 2
chr8_-_81104938 0.690 NM_014018
MRPS28
mitochondrial ribosomal protein S28
chr3_+_37259684 0.687 NM_001172713
NM_002078
GOLGA4

golgin A4

chr11_+_86426518 0.685 NM_001168724
NM_022918
TMEM135

transmembrane protein 135

chr2_+_138438277 0.683 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr20_-_32363268 0.647 NM_001161766
AHCY
adenosylhomocysteinase
chr7_+_100450080 0.620 NM_001040105
MUC17
mucin 17, cell surface associated
chr2_+_177965734 0.619 AGPS
alkylglycerone phosphate synthase
chr11_+_85690900 0.619 NM_016401
C11orf73
chromosome 11 open reading frame 73
chr14_+_23937766 0.616 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr2_+_219141546 0.615 RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr20_+_36095621 0.601


chr17_+_35532994 0.595 MSL1
male-specific lethal 1 homolog (Drosophila)
chr19_+_16169664 0.595 NM_001130524
NM_032493
AP1M1

adaptor-related protein complex 1, mu 1 subunit

chr13_+_99539269 0.584 NM_000282
NM_001127692
NM_001178004
PCCA


propionyl CoA carboxylase, alpha polypeptide


chr12_-_6995988 0.577 NM_005768
LPCAT3
lysophosphatidylcholine acyltransferase 3
chr1_-_149404954 0.568 NM_212551
NM_001136543
LYSMD1

LysM, putative peptidoglycan-binding, domain containing 1

chr12_-_52407470 0.565 NM_001143682
NM_020898
CALCOCO1

calcium binding and coiled-coil domain 1

chr4_-_7120656 0.555 NM_025196
GRPEL1
GrpE-like 1, mitochondrial (E. coli)
chr20_+_36095552 0.555 RPRD1B
regulation of nuclear pre-mRNA domain containing 1B
chr11_+_118374071 0.552 CCDC84
coiled-coil domain containing 84
chr11_+_117948350 0.542 ARCN1
archain 1
chr12_+_65949631 0.537 CAND1
cullin-associated and neddylation-dissociated 1
chr22_+_28493351 0.527 NM_001003684
NM_013387
UQCR10

ubiquinol-cytochrome c reductase, complex III subunit X

chr11_+_118374051 0.520 NM_198489
CCDC84
coiled-coil domain containing 84
chr1_-_95311031 0.510 NM_144988
ALG14
asparagine-linked glycosylation 14 homolog (S. cerevisiae)
chr2_+_201691664 0.497 CFLAR
CASP8 and FADD-like apoptosis regulator
chr18_-_44730706 0.481 SMAD7
SMAD family member 7
chr2_+_119841611 0.479 NM_001079863
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr17_-_2561676 0.470 NM_015229
KIAA0664
KIAA0664
chr6_-_39801088 0.453 NM_145027
KIF6
kinesin family member 6
chr20_+_42593849 0.436 NM_007066
NM_181804
NM_181805
PKIG


protein kinase (cAMP-dependent, catalytic) inhibitor gamma


chr20_+_55569542 0.431 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr12_+_67489063 0.428 MDM2
Mdm2 p53 binding protein homolog (mouse)
chr2_+_206732859 0.426 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr6_-_146326918 0.422 NM_001042683
NM_173082
SHPRH

SNF2 histone linker PHD RING helicase

chr2_-_206732348 0.422 NM_005006
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr11_+_117948301 0.402 NM_001142281
NM_001655
ARCN1

archain 1

chr2_+_206732575 0.398 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr2_+_201691513 0.394 NM_001127183
CFLAR
CASP8 and FADD-like apoptosis regulator
chr2_+_198073358 0.383 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr11_-_116213511 0.382 NM_000039
APOA1
apolipoprotein A-I
chr6_+_142510094 0.381 NM_016485
VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr22_+_40195058 0.381 NM_001098
ACO2
aconitase 2, mitochondrial
chr6_-_32034607 0.373 NM_002904
RDBP
RD RNA binding protein
chr20_-_36095236 0.368 NM_014657
TTI1
Tel2 interacting protein 1 homolog (S. pombe)
chr2_+_206732562 0.362 NM_001037663
NM_001959
NM_021121
EEF1B2


eukaryotic translation elongation factor 1 beta 2


chr2_-_27966715 0.362 NM_022128
RBKS
ribokinase
chr8_+_96106362 0.354 NM_152416
C8orf38
chromosome 8 open reading frame 38
chr22_-_40194602 0.335 NM_032758
PHF5A
PHD finger protein 5A
chr6_+_142510108 0.326 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr6_-_146327238 0.325 SHPRH
SNF2 histone linker PHD RING helicase
chr2_+_27966985 0.322 NM_199193
NM_199194
NM_004899
NM_199191
NM_199192
BRE




brain and reproductive organ-expressed (TNFRSF1A modulator)




chr12_-_49708279 0.317 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr6_+_142510075 0.317 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr20_+_30409649 0.312 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr14_-_94693359 0.310 DICER1
dicer 1, ribonuclease type III
chr6_+_142510034 0.310 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr1_+_78126787 0.304 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr6_-_146326863 0.301 SHPRH
SNF2 histone linker PHD RING helicase
chr18_-_50004458 0.301 MBD2
methyl-CpG binding domain protein 2
chr2_+_73294852 0.301 NM_006062
SMYD5
SMYD family member 5
chr3_-_114947330 0.300 NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr12_+_65949414 0.295 CAND1
cullin-associated and neddylation-dissociated 1
chr2_+_27967102 0.294 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr22_-_49413326 0.294 NM_000487
NM_001085425
NM_001085426
NM_001085427
NM_001085428
ARSA




arylsulfatase A




chr20_-_7869068 0.289 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr2_-_177965626 0.289 LOC100130691
hypothetical LOC100130691
chr17_-_8138849 0.288 NM_201520
SLC25A35
solute carrier family 25, member 35
chr6_-_33879734 0.287 NM_001040109
NM_001184698
NM_002418
MLN


motilin


chr18_-_44731078 0.279 NM_001190821
NM_005904
SMAD7

SMAD family member 7

chr12_+_94776836 0.277 NM_003095
SNRPF
small nuclear ribonucleoprotein polypeptide F
chr7_-_106991941 0.272 NM_001161520
NM_006348
NM_181733
COG5


component of oligomeric golgi complex 5


chr16_+_4415805 0.270 NM_001135110
NM_005147
DNAJA3

DnaJ (Hsp40) homolog, subfamily A, member 3

chr16_-_86527608 0.266 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr11_-_123261549 0.261 NM_001013743
TMEM225
transmembrane protein 225
chr4_+_30330963 0.257 NM_001173523
NM_002589
NM_032456
NM_032457
PCDH7



protocadherin 7



chr18_-_50004770 0.254 MBD2
methyl-CpG binding domain protein 2
chr6_-_146327155 0.251 SHPRH
SNF2 histone linker PHD RING helicase
chr6_-_2696152 0.248 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr2_+_27967116 0.243 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr7_-_72574383 0.243 BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr2_+_220007943 0.238 NM_005876
SPEG
SPEG complex locus
chr2_+_177965617 0.234 NM_003659
AGPS
alkylglycerone phosphate synthase
chr4_-_141294682 0.234 NM_018717
MAML3
mastermind-like 3 (Drosophila)
chr20_+_43919662 0.232 NM_080752
ZSWIM3
zinc finger, SWIM-type containing 3
chr17_-_8139330 0.229 SLC25A35
solute carrier family 25, member 35
chr6_+_32034767 0.220 SKIV2L
superkiller viralicidic activity 2-like (S. cerevisiae)
chr2_+_27967159 0.219 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr17_+_43328514 0.218 NM_003110
SP2
Sp2 transcription factor
chr12_+_54910767 0.212 NM_001135195
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr6_-_2785682 0.212 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr5_+_132237253 0.212 NM_052971
LEAP2
liver expressed antimicrobial peptide 2
chr7_+_120415958 0.211 NM_024913
C7orf58
chromosome 7 open reading frame 58
chr14_+_49157150 0.210 NM_002408
MGAT2
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr15_+_94674849 0.210 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr17_-_40344322 0.209


chr1_-_101263867 0.207 NM_001077394
NM_001077395
NM_015958
DPH5


DPH5 homolog (S. cerevisiae)


chr17_+_38403991 0.204 RPL27
ribosomal protein L27
chr12_+_94776901 0.203 SNRPF
small nuclear ribonucleoprotein polypeptide F
chr11_-_65962836 0.200 NM_016050
NM_170738
NM_170739
MRPL11


mitochondrial ribosomal protein L11


chr4_+_140806536 0.195 MGST2
microsomal glutathione S-transferase 2
chr2_-_24160683 0.187 TP53I3
tumor protein p53 inducible protein 3
chr2_-_64099935 0.185 VPS54
vacuolar protein sorting 54 homolog (S. cerevisiae)
chr4_+_30331289 0.182 PCDH7
protocadherin 7
chr1_-_209915443 0.181 NM_002497
NEK2
NIMA (never in mitosis gene a)-related kinase 2
chr16_+_3102556 0.178 NM_001042428
NM_003456
ZNF205

zinc finger protein 205

chr12_+_48003237 0.178 NM_001100620
NM_005480
TROAP

trophinin associated protein (tastin)

chr2_-_219742950 0.176 NM_001144889
NM_001144890
NM_144712
SLC23A3


solute carrier family 23 (nucleobase transporters), member 3


chr2_-_191107660 0.172 TMEM194B
transmembrane protein 194B
chr16_+_31446703 0.171 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr17_+_7474128 0.170 SHBG
sex hormone-binding globulin
chr1_-_120112989 0.169 NM_001166107
NM_005518
HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)

chr21_+_44256630 0.166 NM_003274
TRAPPC10
trafficking protein particle complex 10
chr20_-_54400628 0.164 NM_003600
NM_198433
NM_198434
NM_198435
NM_198436
NM_198437
AURKA





aurora kinase A





chr2_+_119841298 0.159 NM_001178017
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr2_-_159021201 0.155 NM_001171637
NM_138803
CCDC148

coiled-coil domain containing 148

chr1_+_101263989 0.154


chr2_+_26422495 0.152 EPT1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr20_-_43919360 0.152 NM_005469
ACOT8
acyl-CoA thioesterase 8
chr17_+_7474177 0.147 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr20_-_34005619 0.144 SCAND1
SCAN domain containing 1
chr19_+_60691733 0.143 SSC5D
scavenger receptor cysteine rich domain containing (5 domains)
chr14_+_94693744 0.140 FLJ45244
hypothetical locus FLJ45244
chr7_-_25131427 0.137 NM_018947
CYCS
cytochrome c, somatic
chr12_+_105692466 0.135 NM_018157
RIC8B
resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
chr17_-_40344203 0.133 GFAP
glial fibrillary acidic protein
chr2_-_19421852 0.133 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr5_+_172416959 0.132 C5orf41
chromosome 5 open reading frame 41
chr1_-_224441024 0.130 NM_022735
ACBD3
acyl-CoA binding domain containing 3
chr9_+_108726257 0.126 ZNF462
zinc finger protein 462
chr2_+_159021653 0.125 PKP4
plakophilin 4
chr17_+_71508581 0.123 NM_001258
CDK3
cyclin-dependent kinase 3
chr2_+_198073257 0.120 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr20_+_54400979 0.117 NM_001324
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr2_+_218843358 0.117 NM_001077399
NM_015488
PNKD

paroxysmal nonkinesigenic dyskinesia

chr1_-_6684465 0.114 DNAJC11
DnaJ (Hsp40) homolog, subfamily C, member 11
chr14_-_94693418 0.108 NM_177438
DICER1
dicer 1, ribonuclease type III
chr8_-_42817604 0.107 NM_018105
NM_199003
THAP1

THAP domain containing, apoptosis associated protein 1

chr17_+_7063970 0.106 ACADVL
acyl-CoA dehydrogenase, very long chain
chr17_-_7064092 0.105 NM_001365
DLG4
discs, large homolog 4 (Drosophila)
chr6_+_32034559 0.104 NM_006929
SKIV2L
superkiller viralicidic activity 2-like (S. cerevisiae)
chr1_+_144439069 0.104 NM_002614
PDZK1
PDZ domain containing 1
chr12_-_49706190 0.103 NM_001174129
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr1_+_149405128 0.102 NM_024041
SCNM1
sodium channel modifier 1
chr7_-_72574474 0.099 BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr8_-_82769761 0.099 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr20_-_34005799 0.098 NM_016558
NM_033630
SCAND1

SCAN domain containing 1

chr12_-_49706364 0.098 NM_000617
NM_001174126
NM_001174127
NM_001174128
SLC11A2



solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2



chr17_+_3324096 0.097 NM_001128085
ASPA
aspartoacylase
chr19_+_6323443 0.093 NM_032306
ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr2_+_219354692 0.092 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr2_+_218992053 0.092 NM_007127
VIL1
villin 1
chr7_-_25131386 0.092 CYCS
cytochrome c, somatic
chr16_-_45564984 0.091 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr9_+_91123204 0.088 NM_024077
SECISBP2
SECIS binding protein 2
chr17_+_38403935 0.083 NM_000988
RPL27
ribosomal protein L27
chr1_-_6684426 0.082 DNAJC11
DnaJ (Hsp40) homolog, subfamily C, member 11
chr1_+_45046740 0.080 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr2_-_198073242 0.077 NM_199440
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr8_-_71478560 0.077 NM_006540
NCOA2
nuclear receptor coactivator 2
chr15_-_100009860 0.071 NM_025141
NM_078474
TM2D3

TM2 domain containing 3

chr12_+_65949327 0.070 NM_018448
CAND1
cullin-associated and neddylation-dissociated 1
chr4_-_102487356 0.070 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr4_-_4594620 0.070 STX18
syntaxin 18
chr16_-_45565068 0.069 NM_005880
DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr20_+_41621079 0.067 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr19_-_43498220 0.066 NM_001039671
NM_001145461
NM_001145462
YIF1B


Yip1 interacting factor homolog B (S. cerevisiae)


chr3_-_50580066 0.065 NM_001171740
NM_001171743
NM_016210
C3orf18


chromosome 3 open reading frame 18


chr3_-_151746821 0.065 SERP1
stress-associated endoplasmic reticulum protein 1
chr4_+_4594619 0.063 LOC100507266
hypothetical LOC100507266
chr13_+_20612709 0.062 SAP18
Sin3A-associated protein, 18kDa

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.46 3.28e-03 GO:0044237 cellular metabolic process
1.39 1.08e-02 GO:0008152 metabolic process
8.95 1.11e-02 GO:0031647 regulation of protein stability

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.31 2.23e-03 GO:0005759 mitochondrial matrix
2.70 7.10e-03 GO:0044429 mitochondrial part
2.11 9.25e-03 GO:0005739 mitochondrion
3.54 1.68e-02 GO:0005743 mitochondrial inner membrane
3.26 3.90e-02 GO:0019866 organelle inner membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
8.60 1.45e-02 GO:0033293 monocarboxylic acid binding
5.78 1.61e-02 GO:0051082 unfolded protein binding