Motif ID: PAX5.p2

Z-value: 2.958


Transcription factors associated with PAX5.p2:

Gene SymbolEntrez IDGene Name
PAX5 5079 paired box 5

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
PAX5chr9_-_37024358-0.611.3e-02Click!


Activity profile for motif PAX5.p2.

activity profile for motif PAX5.p2


Sorted Z-values histogram for motif PAX5.p2

Sorted Z-values for motif PAX5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_22513043 3.555 NM_001013842
NM_001198827
NM_173686
 C8orf58


chromosome 8 open reading frame 58


chr8_-_99906944 3.309 NM_006281
 STK3
serine/threonine kinase 3
chr5_+_76047536 2.914 NM_001992
 F2R
coagulation factor II (thrombin) receptor
chr2_+_235525355 2.611 NM_014521
 SH3BP4
SH3-domain binding protein 4
chr1_-_22136263 2.429 NM_005529
 HSPG2
heparan sulfate proteoglycan 2
chr4_+_3264509 2.400 RGS12
regulator of G-protein signaling 12
chr11_-_2907169 2.391 NM_003311
 PHLDA2
pleckstrin homology-like domain, family A, member 2
chr20_-_43410437 2.342 NM_002999
 SDC4
syndecan 4
chr1_+_25999245 2.226 NM_020451
NM_206926
 SEPN1

selenoprotein N, 1

chr4_-_809879 2.215 NM_006651
 CPLX1
complexin 1
chr7_-_525556 2.189 PDGFA
platelet-derived growth factor alpha polypeptide
chr7_+_5289079 2.104 NM_001040661
NM_153247
 SLC29A4

solute carrier family 29 (nucleoside transporters), member 4

chr14_+_99329198 2.087 NM_001008707
NM_004434
 EML1

echinoderm microtubule associated protein like 1

chr2_+_10101081 1.996 NM_003597
NM_001177716
 KLF11

Kruppel-like factor 11

chr3_-_71857097 1.948 NM_001134651
 EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr17_+_77582774 1.935 NM_005052
 RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr18_-_802268 1.907 NM_005433
 YES1
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr8_+_1699418 1.851 CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr3_-_125085834 1.823 NM_053025
NM_053026
NM_053027
NM_053028
 MYLK



myosin light chain kinase



chr19_-_1518875 1.814 NM_001174118
NM_203304
 MEX3D

mex-3 homolog D (C. elegans)


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 124 entries
enrichment   p-value GO term description
2.00 6.46e-03 GO:0090090 negative regulation of canonical Wnt receptor signaling pathway
1.92 2.40e-02 GO:0046519 sphingoid metabolic process
1.87 4.13e-02 GO:0042058 regulation of epidermal growth factor receptor signaling pathway
1.86 4.39e-04 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.77 1.69e-02 GO:0030178 negative regulation of Wnt receptor signaling pathway
1.67 1.38e-03 GO:0030111 regulation of Wnt receptor signaling pathway
1.61 5.90e-03 GO:0016055 Wnt receptor signaling pathway
1.53 3.69e-04 GO:0048011 nerve growth factor receptor signaling pathway
1.50 1.51e-03 GO:0051129 negative regulation of cellular component organization
1.46 2.08e-06 GO:0009968 negative regulation of signal transduction
1.45 4.16e-04 GO:0060284 regulation of cell development
1.44 9.93e-03 GO:0030334 regulation of cell migration
1.43 3.83e-03 GO:0001944 vasculature development
1.43 1.13e-02 GO:2000145 regulation of cell motility
1.42 9.05e-03 GO:0051270 regulation of cellular component movement
1.41 5.05e-05 GO:0010648 negative regulation of cell communication
1.41 1.30e-02 GO:0040012 regulation of locomotion
1.39 1.29e-04 GO:0023057 negative regulation of signaling
1.39 2.03e-03 GO:0051056 regulation of small GTPase mediated signal transduction
1.36 2.99e-03 GO:0008285 negative regulation of cell proliferation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 39 entries
enrichment   p-value GO term description
2.05 3.98e-03 GO:0008287 protein serine/threonine phosphatase complex
1.79 6.24e-05 GO:0005925 focal adhesion
1.75 2.55e-07 GO:0005912 adherens junction
1.73 2.42e-04 GO:0005924 cell-substrate adherens junction
1.69 5.32e-04 GO:0030055 cell-substrate junction
1.67 2.20e-06 GO:0070161 anchoring junction
1.62 4.02e-02 GO:0016327 apicolateral plasma membrane
1.51 1.69e-03 GO:0031252 cell leading edge
1.50 2.12e-02 GO:0005769 early endosome
1.48 3.16e-04 GO:0016323 basolateral plasma membrane
1.31 3.05e-02 GO:0048471 perinuclear region of cytoplasm
1.26 2.08e-14 GO:0005829 cytosol
1.26 4.79e-03 GO:0030054 cell junction
1.22 6.16e-04 GO:0005794 Golgi apparatus
1.22 2.73e-02 GO:0015630 microtubule cytoskeleton
1.19 9.83e-04 GO:0005654 nucleoplasm
1.16 4.32e-05 GO:0070013 intracellular organelle lumen
1.16 9.31e-05 GO:0044428 nuclear part
1.16 5.38e-04 GO:0031981 nuclear lumen
1.16 2.46e-03 GO:0012505 endomembrane system

Gene overrepresentation in function category:

Showing 1 to 20 of 35 entries
enrichment   p-value GO term description
2.02 7.67e-03 GO:0019888 protein phosphatase regulator activity
1.92 1.36e-02 GO:0019208 phosphatase regulator activity
1.63 5.94e-03 GO:0017124 SH3 domain binding
1.47 3.58e-02 GO:0000287 magnesium ion binding
1.47 4.58e-02 GO:0004721 phosphoprotein phosphatase activity
1.47 4.58e-02 GO:0005085 guanyl-nucleotide exchange factor activity
1.44 8.13e-08 GO:0030695 GTPase regulator activity
1.43 1.39e-07 GO:0060589 nucleoside-triphosphatase regulator activity
1.41 4.75e-06 GO:0019904 protein domain specific binding
1.40 2.48e-03 GO:0008134 transcription factor binding
1.39 5.59e-03 GO:0005083 small GTPase regulator activity
1.38 2.66e-02 GO:0005096 GTPase activator activity
1.35 7.97e-04 GO:0004674 protein serine/threonine kinase activity
1.34 3.02e-03 GO:0008047 enzyme activator activity
1.33 4.89e-02 GO:0003779 actin binding
1.31 7.86e-04 GO:0008092 cytoskeletal protein binding
1.29 5.71e-05 GO:0019899 enzyme binding
1.28 9.17e-05 GO:0016301 kinase activity
1.27 1.47e-05 GO:0030234 enzyme regulator activity
1.26 1.47e-03 GO:0042802 identical protein binding