Motif ID: KLF4.p3

Z-value: 2.289


Transcription factors associated with KLF4.p3:

Gene SymbolEntrez IDGene Name
KLF4 9314 Kruppel-like factor 4 (gut)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
KLF4chr9_-_109291130-0.146.0e-01Click!


Activity profile for motif KLF4.p3.

activity profile for motif KLF4.p3


Sorted Z-values histogram for motif KLF4.p3

Sorted Z-values for motif KLF4.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF4.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_63965156 4.626 NM_017983
WIPI1
WD repeat domain, phosphoinositide interacting 1
chr6_-_4080700 4.296 NM_001166010
NM_006117
NM_206836
PECI


peroxisomal D3,D2-enoyl-CoA isomerase


chr20_-_39680405 2.792 NM_032221
CHD6
chromodomain helicase DNA binding protein 6
chr3_-_12983959 2.603 NM_014869
IQSEC1
IQ motif and Sec7 domain 1
chr9_-_129573330 2.576 NM_005489
SH2D3C
SH2 domain containing 3C
chr2_-_37752272 2.556 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr17_+_58954418 2.542 NM_030779
NM_173092
KCNH6

potassium voltage-gated channel, subfamily H (eag-related), member 6

chr17_-_46298671 2.534 TOB1
transducer of ERBB2, 1
chr20_-_51644187 2.514 ZNF217
zinc finger protein 217
chr6_+_44346457 2.351 NM_001137560
TMEM151B
transmembrane protein 151B
chr22_-_37062114 2.307 CSNK1E
casein kinase 1, epsilon
chr2_-_36678657 2.265 NM_001042548
NM_005102
FEZ2

fasciculation and elongation protein zeta 2 (zygin II)

chr8_-_99906944 2.196 NM_006281
STK3
serine/threonine kinase 3
chr2_-_37752731 2.157 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr14_-_104718565 2.122 NM_177533
NUDT14
nudix (nucleoside diphosphate linked moiety X)-type motif 14
chr22_-_49050847 2.104 NM_002751
MAPK11
mitogen-activated protein kinase 11
chr7_-_134845363 2.052 NM_001008225
NM_001190847
NM_001190848
NM_001190849
NM_001190850
NM_013316
CNOT4





CCR4-NOT transcription complex, subunit 4





chr12_+_47498778 2.010 NM_000725
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr20_-_32877029 2.002 NM_014071
NCOA6
nuclear receptor coactivator 6
chr2_-_17563186 1.968 NM_001099218
RAD51AP2
RAD51 associated protein 2
chr20_+_36810510 1.933 NM_024855
ACTR5
ARP5 actin-related protein 5 homolog (yeast)
chr16_-_18845223 1.877 NM_015092
SMG1
SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
chr2_-_148494732 1.868 NM_001190882
NM_001190879
NM_002552
NM_001190881
NM_181741
ORC4




origin recognition complex, subunit 4




chr14_+_34585098 1.848 NM_173607
FAM177A1
family with sequence similarity 177, member A1
chr2_+_219779737 1.814 NM_138802
ZFAND2B
zinc finger, AN1-type domain 2B
chr16_-_8870343 1.797 NM_014316
CARHSP1
calcium regulated heat stable protein 1, 24kDa
chr20_+_1154763 1.795 NM_001136566
RAD21L1
RAD21-like 1 (S. pombe)
chr12_-_6852709 1.786 NM_001146316
NM_032641
SPSB2

splA/ryanodine receptor domain and SOCS box containing 2

chr19_+_59386915 1.755 NM_001077446
TSEN34
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
chr20_-_3336586 1.714 C20orf194
chromosome 20 open reading frame 194
chr6_-_30818198 1.694 NM_005803
FLOT1
flotillin 1
chr16_+_87765661 1.678 NM_004933
CDH15
cadherin 15, type 1, M-cadherin (myotubule)
chr19_+_6690697 1.672 NM_004240
TRIP10
thyroid hormone receptor interactor 10
chr7_-_104440707 1.647 LOC100216545
hypothetical LOC100216545
chr19_+_5855842 1.646 NM_001017921
VMAC
vimentin-type intermediate filament associated coiled-coil protein
chr14_-_22658078 1.641 NM_001805
CEBPE
CCAAT/enhancer binding protein (C/EBP), epsilon
chr20_+_56318415 1.617 RAB22A
RAB22A, member RAS oncogene family
chr14_+_23610582 1.610 NM_006032
CPNE6
copine VI (neuronal)
chr2_-_122210873 1.592 NM_032390
MKI67IP
MKI67 (FHA domain) interacting nucleolar phosphoprotein
chr12_+_56435042 1.584 NM_138396
MARCH9
membrane-associated ring finger (C3HC4) 9
chr6_-_29708647 1.562 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr14_-_38971370 1.549 NM_203301
FBXO33
F-box protein 33
chr4_-_103968104 1.535 NM_003340
NM_181886
NM_181888
NM_181889
UBE2D3



ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)



chr16_-_69030421 1.525 NM_006927
ST3GAL2
ST3 beta-galactoside alpha-2,3-sialyltransferase 2
chr14_-_20975241 1.506 NM_020920
CHD8
chromodomain helicase DNA binding protein 8
chr20_+_17498507 1.505 NM_001011546
NM_006870
DSTN

destrin (actin depolymerizing factor)

chr2_+_202949289 1.478 NM_001204
BMPR2
bone morphogenetic protein receptor, type II (serine/threonine kinase)
chr17_-_73867748 1.454 NM_003955
SOCS3
suppressor of cytokine signaling 3
chr14_-_20636337 1.450 ZNF219
zinc finger protein 219
chr16_+_29725311 1.437 NM_001042539
NM_002383
MAZ

MYC-associated zinc finger protein (purine-binding transcription factor)

chr1_-_9892852 1.434 NM_001012329
NM_020248
CTNNBIP1

catenin, beta interacting protein 1

chr17_-_15407497 1.412 NM_001135036
NM_145301
FAM18B2-CDRT4
FAM18B2

FAM18B2-CDRT4 read-through transcript
family with sequence similarity 18, member B2

chr2_+_220015016 1.399 SPEG
SPEG complex locus
chr2_-_27147995 1.389 NM_001134693
OST4
oligosaccharyltransferase 4 homolog (S. cerevisiae)
chr16_-_21439195 1.342 SLC7A5P2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 pseudogene 2
chr20_-_3336219 1.337 NM_001009984
C20orf194
chromosome 20 open reading frame 194
chr4_+_154606900 1.306 NM_001131007
NM_015196
KIAA0922

KIAA0922

chr20_-_44426407 1.302 NM_015945
NM_173073
NM_173179
SLC35C2


solute carrier family 35, member C2


chrX_-_1532648 1.294 NM_001173473
ASMTL
acetylserotonin O-methyltransferase-like
chr12_-_56200547 1.271 NM_001195053
NM_001195054
NM_001195055
NM_001195056
NM_001195057
NM_004083
DDIT3





DNA-damage-inducible transcript 3





chr2_+_42649348 1.271 MTA3
metastasis associated 1 family, member 3
chr20_-_472335 1.244 NM_001895
NM_177559
NM_177560
CSNK2A1


casein kinase 2, alpha 1 polypeptide


chr14_-_38642165 1.228 NM_006364
SEC23A
Sec23 homolog A (S. cerevisiae)
chr7_-_33068699 1.222 NM_001002010
NT5C3
5'-nucleotidase, cytosolic III
chr6_+_3063860 1.217 NM_004332
BPHL
biphenyl hydrolase-like (serine hydrolase)
chr17_-_70380663 1.214 NM_004110
NM_024417
FDXR

ferredoxin reductase

chr5_-_108773468 1.212 NM_014819
PJA2
praja ring finger 2
chr1_+_172104115 1.210 NM_001122770
NM_032522
ZBTB37

zinc finger and BTB domain containing 37

chr1_-_113059396 1.209 NM_005167
PPM1J
protein phosphatase, Mg2+/Mn2+ dependent, 1J
chr14_+_23937766 1.201 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr2_+_148495043 1.200 NM_018328
MBD5
methyl-CpG binding domain protein 5
chr6_+_37245860 1.198 NM_002648
PIM1
pim-1 oncogene
chr6_-_31658044 1.196 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr14_-_22596522 1.187 NM_022478
NM_144985
CDH24

cadherin 24, type 2

chr22_+_18081968 1.186 NM_002688
SEPT5
septin 5
chr12_+_120635021 1.182 NM_001080825
TMEM120B
transmembrane protein 120B
chr6_+_2945025 1.180 NM_000904
NQO2
NAD(P)H dehydrogenase, quinone 2
chr16_+_29724926 1.180 MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr5_+_150612805 1.170 NM_000405
NM_001167607
GM2A

GM2 ganglioside activator

chr20_+_254205 1.170 NM_006943
SOX12
SRY (sex determining region Y)-box 12
chr6_+_44203335 1.168 NM_018426
TMEM63B
transmembrane protein 63B
chr3_-_48105287 1.167 MAP4
microtubule-associated protein 4
chr20_+_43531806 1.167 NM_006103
WFDC2
WAP four-disulfide core domain 2
chr6_-_7258351 1.163 NM_003144
SSR1
signal sequence receptor, alpha
chr17_+_72789086 1.162 NM_001113491
SEPT9
septin 9
chr22_-_29015452 1.157 NM_001037666
GATSL3
GATS protein-like 3
chr11_+_85017269 1.156 NM_001193537
NM_001193538
NM_018480
TMEM126B


transmembrane protein 126B


chr20_+_37024383 1.154 NM_001190809
NM_021931
DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr20_+_13924263 1.152 MACROD2
MACRO domain containing 2
chr17_-_50854054 1.145 NM_012329
MMD
monocyte to macrophage differentiation-associated
chr12_-_3852655 1.137 NM_020367
PARP11
poly (ADP-ribose) polymerase family, member 11
chr2_+_220200530 1.136 NM_005070
NM_201574
SLC4A3

solute carrier family 4, anion exchanger, member 3

chr19_+_45807909 1.135


chr15_+_61356801 1.135 NM_001145646
NM_031301
APH1B

anterior pharynx defective 1 homolog B (C. elegans)

chr17_-_39265965 1.130 NM_001932
MPP3
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
chr2_+_48521411 1.126 NM_001135629
NM_001193475
NM_152994
KLRAQ1


KLRAQ motif containing 1


chr17_+_39990124 1.124 NM_001466
FZD2
frizzled homolog 2 (Drosophila)
chr16_-_85974810 1.124 NM_024735
FBXO31
F-box protein 31
chr2_+_42249896 1.122 NM_001145076
NM_019063
EML4

echinoderm microtubule associated protein like 4

chr6_-_158985727 1.120 NM_006519
DYNLT1
dynein, light chain, Tctex-type 1
chr17_-_60401967 1.109 AMZ2P1
archaelysin family metallopeptidase 2 pseudogene 1
chr9_-_138277467 1.107 NM_181701
QSOX2
quiescin Q6 sulfhydryl oxidase 2
chr1_-_203985701 1.103 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr8_+_124498145 1.097 NM_018024
WDYHV1
WDYHV motif containing 1
chr6_-_42527760 1.094 NM_033502
TRERF1
transcriptional regulating factor 1
chr10_+_92970487 1.092 PCGF5
polycomb group ring finger 5
chr2_+_96790298 1.086 NM_020184
CNNM4
cyclin M4
chr11_+_64838882 1.083 NM_006779
CDC42EP2
CDC42 effector protein (Rho GTPase binding) 2
chr16_-_2125825 1.083 NM_000296
NM_001009944
PKD1

polycystic kidney disease 1 (autosomal dominant)

chr20_-_39379533 1.081 ZHX3
zinc fingers and homeoboxes 3
chr2_-_201082978 1.078 NM_152387
KCTD18
potassium channel tetramerisation domain containing 18
chr20_+_48781457 1.078 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr20_+_44083667 1.077 NM_001134771
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr12_+_115455579 1.072 NCRNA00173
non-protein coding RNA 173
chr2_+_27504987 1.072 NRBP1
nuclear receptor binding protein 1
chr2_-_175060001 1.069 NM_001033045
NM_152529
GPR155

G protein-coupled receptor 155

chr10_+_49184658 1.068 MAPK8
mitogen-activated protein kinase 8
chr2_-_33677798 1.066 NM_015475
FAM98A
family with sequence similarity 98, member A
chr2_-_175741096 1.065 NM_001880
ATF2
activating transcription factor 2
chr14_-_34168911 1.064 SNX6
sorting nexin 6
chr2_+_219141761 1.059 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr7_+_64136078 1.056 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr13_+_97426713 1.050 IPO5
importin 5
chr11_-_13441294 1.040 NM_032320
BTBD10
BTB (POZ) domain containing 10
chr20_+_56318245 1.035 RAB22A
RAB22A, member RAS oncogene family
chr20_-_3102169 1.035 ProSAPiP1
ProSAPiP1 protein
chr16_-_11257539 1.027 NM_003745
SOCS1
suppressor of cytokine signaling 1
chr10_-_131799051 1.024 LOC387723
hypothetical LOC387723
chr17_-_7323528 1.022 ZBTB4
zinc finger and BTB domain containing 4
chr11_-_85457469 1.021 PICALM
phosphatidylinositol binding clathrin assembly protein
chr1_+_110554836 1.020 NM_001039574
NM_004978
KCNC4

potassium voltage-gated channel, Shaw-related subfamily, member 4

chr2_-_97646758 1.013 ACTR1B
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr17_-_39556535 1.011 NM_001015053
NM_005474
HDAC5

histone deacetylase 5

chr2_+_63922488 1.005 NM_006759
UGP2
UDP-glucose pyrophosphorylase 2
chr1_-_109386112 1.003 NM_001142550
NM_001142551
NM_014969
WDR47


WD repeat domain 47


chr1_-_203985752 0.993 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr17_-_39632845 0.991 ATXN7L3
ataxin 7-like 3
chr17_-_46553083 0.991 NM_001130528
NM_003971
SPAG9

sperm associated antigen 9

chr10_+_75427853 0.988 NM_003373
NM_014000
VCL

vinculin

chr6_-_45453552 0.978 NM_003599
NM_181356
SUPT3H

suppressor of Ty 3 homolog (S. cerevisiae)

chr6_+_114285209 0.978 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr17_-_53946899 0.978 MTMR4
myotubularin related protein 4
chr8_+_26204997 0.976 PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr7_+_21434097 0.976 NM_003112
SP4
Sp4 transcription factor
chr17_+_45488330 0.975 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr14_-_104705753 0.975 JAG2
jagged 2
chr17_+_45488356 0.975 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr12_-_6995988 0.966 NM_005768
LPCAT3
lysophosphatidylcholine acyltransferase 3
chr17_+_52688842 0.965 NM_138962
MSI2
musashi homolog 2 (Drosophila)
chr12_+_69046241 0.964 NM_014505
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr14_+_35365266 0.959 NM_032352
BRMS1L
breast cancer metastasis-suppressor 1-like
chr11_-_85457736 0.952 PICALM
phosphatidylinositol binding clathrin assembly protein
chr1_-_42274160 0.949


chr9_-_87546620 0.948 NM_015239
AGTPBP1
ATP/GTP binding protein 1
chr9_-_5997891 0.946 NM_001017969
KIAA2026
KIAA2026
chr10_+_112247614 0.946 NM_004419
DUSP5
dual specificity phosphatase 5
chr20_+_39402834 0.943 NM_022896
LPIN3
lipin 3
chr21_+_16024241 0.943 NM_013396
USP25
ubiquitin specific peptidase 25
chr16_+_29725597 0.942


chr14_-_37133927 0.940 FOXA1
forkhead box A1
chr16_+_15644624 0.937 NM_001143979
NDE1
nudE nuclear distribution gene E homolog 1 (A. nidulans)
chr18_-_50004770 0.935 MBD2
methyl-CpG binding domain protein 2
chr16_+_76313909 0.935 NM_001105663
NUDT7
nudix (nucleoside diphosphate linked moiety X)-type motif 7
chr20_+_33823318 0.934 NM_016436
PHF20
PHD finger protein 20
chr20_+_36534871 0.934 NM_020336
RALGAPB
Ral GTPase activating protein, beta subunit (non-catalytic)
chr2_+_47863724 0.934 NM_000179
MSH6
mutS homolog 6 (E. coli)
chr20_+_56318155 0.931 NM_020673
RAB22A
RAB22A, member RAS oncogene family
chr14_-_20636568 0.930 NM_016423
ZNF219
zinc finger protein 219
chr17_-_53950191 0.928 NM_004687
MTMR4
myotubularin related protein 4
chr2_+_190981257 0.925 NM_017694
MFSD6
major facilitator superfamily domain containing 6
chr1_-_203985780 0.921 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr15_-_100082134 0.920 NM_152334
TARSL2
threonyl-tRNA synthetase-like 2
chr2_-_196744546 0.901 NM_004226
STK17B
serine/threonine kinase 17b
chr16_-_30254189 0.900 LOC595101
PI-3-kinase-related kinase SMG-1 pseudogene
chr17_-_24302450 0.897 PHF12
PHD finger protein 12
chr3_+_184898234 0.896 NM_018023
YEATS2
YEATS domain containing 2
chr21_-_33935883 0.896 NM_145858
CRYZL1
crystallin, zeta (quinone reductase)-like 1
chr8_-_96350575 0.895 NM_177965
C8orf37
chromosome 8 open reading frame 37
chr4_+_85723080 0.895 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr2_+_178767317 0.892 NM_032523
OSBPL6
oxysterol binding protein-like 6
chr12_+_121803255 0.886 NM_003677
DENR
density-regulated protein
chr1_+_103841155 0.884 NM_017619
RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr16_+_4948318 0.881 NM_014692
SEC14L5
SEC14-like 5 (S. cerevisiae)
chr14_-_29466562 0.881 NM_002742
PRKD1
protein kinase D1
chr17_-_2153561 0.879 NM_001170957
SMG6
Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr1_+_1099145 0.871 NM_001130045
TTLL10
tubulin tyrosine ligase-like family, member 10
chr17_-_39265705 0.871 MPP3
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
chr6_-_34772495 0.869 C6orf106
chromosome 6 open reading frame 106
chr19_-_45663463 0.866 NM_000713
BLVRB
biliverdin reductase B (flavin reductase (NADPH))
chr9_+_138805581 0.866 NM_032928
TMEM141
transmembrane protein 141
chr2_+_84986273 0.862 NM_021103
TMSB10
thymosin beta 10
chr2_+_203901160 0.860 NM_005759
ABI2
abl-interactor 2
chr6_-_41855564 0.860 NM_006653
FRS3
fibroblast growth factor receptor substrate 3
chr7_+_99919485 0.860 NM_173564
C7orf51
chromosome 7 open reading frame 51
chr14_+_22410795 0.859 NM_014045
LRP10
low density lipoprotein receptor-related protein 10
chr20_+_42947754 0.858 NM_003404
NM_139323
YWHAB

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

chr20_+_61841553 0.856 NM_020062
SLC2A4RG
SLC2A4 regulator
chr17_-_17667580 0.854 SREBF1
sterol regulatory element binding transcription factor 1
chr20_+_61841662 0.853 SLC2A4RG
SLC2A4 regulator
chr16_+_31036474 0.852 NM_032188
NM_182958
MYST1

MYST histone acetyltransferase 1


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.07 1.98e-21 GO:0009987 cellular process
1.13 2.23e-21 GO:0044237 cellular metabolic process
1.16 6.12e-18 GO:0044260 cellular macromolecule metabolic process
1.11 8.92e-17 GO:0008152 metabolic process
1.11 2.90e-15 GO:0044238 primary metabolic process
1.13 4.44e-13 GO:0043170 macromolecule metabolic process
1.22 1.63e-11 GO:0006464 protein modification process
1.20 1.05e-09 GO:0043412 macromolecule modification
1.28 1.15e-09 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.14 1.28e-09 GO:0006807 nitrogen compound metabolic process
1.17 2.52e-09 GO:0044267 cellular protein metabolic process
1.09 4.63e-09 GO:0050794 regulation of cellular process
1.14 1.44e-08 GO:0034641 cellular nitrogen compound metabolic process
1.15 5.82e-08 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.08 8.07e-08 GO:0050789 regulation of biological process
1.13 1.19e-07 GO:0031323 regulation of cellular metabolic process
1.12 1.89e-07 GO:0019222 regulation of metabolic process
1.07 4.23e-07 GO:0065007 biological regulation
1.12 1.67e-06 GO:0016043 cellular component organization
1.12 2.16e-06 GO:0080090 regulation of primary metabolic process
1.39 2.74e-06 GO:0016568 chromatin modification
1.18 6.55e-06 GO:0006996 organelle organization
1.12 1.06e-05 GO:0060255 regulation of macromolecule metabolic process
1.15 2.86e-05 GO:0048523 negative regulation of cellular process
1.11 2.99e-05 GO:0071840 cellular component organization or biogenesis
1.13 5.36e-05 GO:0009058 biosynthetic process
1.19 6.64e-05 GO:0009893 positive regulation of metabolic process
1.20 8.26e-05 GO:0031325 positive regulation of cellular metabolic process
1.12 1.03e-04 GO:0048518 positive regulation of biological process
1.13 1.23e-04 GO:0048522 positive regulation of cellular process
1.17 1.26e-04 GO:0009056 catabolic process
1.12 1.48e-04 GO:0071842 cellular component organization at cellular level
1.13 1.58e-04 GO:0044249 cellular biosynthetic process
1.12 1.65e-04 GO:0019538 protein metabolic process
1.23 2.07e-04 GO:0046907 intracellular transport
1.22 2.27e-04 GO:0008219 cell death
1.12 2.48e-04 GO:0010468 regulation of gene expression
1.13 2.57e-04 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.13 2.73e-04 GO:0048519 negative regulation of biological process
1.19 4.75e-04 GO:0044248 cellular catabolic process
1.22 4.83e-04 GO:0016265 death
1.19 5.85e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.13 6.99e-04 GO:0090304 nucleic acid metabolic process
1.15 8.55e-04 GO:0023051 regulation of signaling
1.15 8.59e-04 GO:0034645 cellular macromolecule biosynthetic process
1.15 9.18e-04 GO:0009059 macromolecule biosynthetic process
1.25 1.13e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.25 1.13e-03 GO:0051276 chromosome organization
1.12 1.16e-03 GO:0031326 regulation of cellular biosynthetic process
1.12 1.49e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.19 1.76e-03 GO:0032268 regulation of cellular protein metabolic process
1.18 1.77e-03 GO:0051246 regulation of protein metabolic process
1.22 2.06e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.23 2.13e-03 GO:0010628 positive regulation of gene expression
1.20 2.20e-03 GO:0006351 transcription, DNA-dependent
1.24 2.26e-03 GO:0051254 positive regulation of RNA metabolic process
1.11 2.60e-03 GO:0071841 cellular component organization or biogenesis at cellular level
1.16 2.67e-03 GO:0009966 regulation of signal transduction
1.27 3.37e-03 GO:0006325 chromatin organization
1.21 3.86e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.11 4.61e-03 GO:0009889 regulation of biosynthetic process
1.67 4.92e-03 GO:0006338 chromatin remodeling
1.31 6.39e-03 GO:0018193 peptidyl-amino acid modification
1.11 6.51e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.32 6.80e-03 GO:0070647 protein modification by small protein conjugation or removal
1.20 8.06e-03 GO:0031328 positive regulation of cellular biosynthetic process
1.21 8.66e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.14 9.06e-03 GO:0016070 RNA metabolic process
1.12 9.24e-03 GO:0051252 regulation of RNA metabolic process
1.16 9.88e-03 GO:0033036 macromolecule localization
1.12 1.11e-02 GO:0006355 regulation of transcription, DNA-dependent
1.09 1.15e-02 GO:0032502 developmental process
1.19 1.19e-02 GO:0009891 positive regulation of biosynthetic process
1.23 1.27e-02 GO:0009057 macromolecule catabolic process
1.41 1.37e-02 GO:0016570 histone modification
1.13 1.41e-02 GO:0044281 small molecule metabolic process
1.24 1.44e-02 GO:0044265 cellular macromolecule catabolic process
1.40 2.04e-02 GO:0016569 covalent chromatin modification
1.38 2.29e-02 GO:0044087 regulation of cellular component biogenesis
1.24 2.36e-02 GO:0070727 cellular macromolecule localization
1.25 2.83e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.20 2.98e-02 GO:0012501 programmed cell death
1.10 3.06e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.20 3.34e-02 GO:0006915 apoptosis
1.21 3.37e-02 GO:0045595 regulation of cell differentiation
1.26 3.51e-02 GO:0044262 cellular carbohydrate metabolic process
1.25 3.58e-02 GO:0072358 cardiovascular system development
1.25 3.58e-02 GO:0072359 circulatory system development
1.12 4.32e-02 GO:0030154 cell differentiation
1.32 4.38e-02 GO:0032446 protein modification by small protein conjugation
1.23 4.62e-02 GO:0034613 cellular protein localization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.10 1.02e-50 GO:0044424 intracellular part
1.10 1.42e-50 GO:0005622 intracellular
1.10 6.10e-32 GO:0043229 intracellular organelle
1.10 8.27e-32 GO:0043226 organelle
1.12 9.72e-32 GO:0005737 cytoplasm
1.11 7.62e-31 GO:0043227 membrane-bounded organelle
1.11 8.02e-31 GO:0043231 intracellular membrane-bounded organelle
1.14 6.98e-23 GO:0005634 nucleus
1.13 1.82e-20 GO:0044444 cytoplasmic part
1.13 4.06e-19 GO:0044446 intracellular organelle part
1.13 2.23e-18 GO:0044422 organelle part
1.21 1.01e-14 GO:0044428 nuclear part
1.21 4.52e-14 GO:0005829 cytosol
1.03 5.61e-14 GO:0044464 cell part
1.03 6.53e-14 GO:0005623 cell
1.21 2.38e-12 GO:0031981 nuclear lumen
1.18 1.68e-11 GO:0070013 intracellular organelle lumen
1.18 5.60e-11 GO:0043233 organelle lumen
1.24 6.26e-11 GO:0005654 nucleoplasm
1.17 1.64e-10 GO:0031974 membrane-enclosed lumen
1.14 3.88e-09 GO:0043234 protein complex
1.29 2.57e-08 GO:0044451 nucleoplasm part
1.18 4.95e-07 GO:0012505 endomembrane system
1.10 1.25e-05 GO:0032991 macromolecular complex
1.14 2.33e-05 GO:0031090 organelle membrane
1.20 4.57e-05 GO:0005794 Golgi apparatus
1.11 7.33e-04 GO:0043228 non-membrane-bounded organelle
1.11 7.33e-04 GO:0043232 intracellular non-membrane-bounded organelle
1.59 1.31e-03 GO:0016585 chromatin remodeling complex
1.17 1.62e-03 GO:0005783 endoplasmic reticulum
1.21 2.37e-03 GO:0015630 microtubule cytoskeleton
1.30 7.63e-03 GO:0015629 actin cytoskeleton
1.51 8.41e-03 GO:0005925 focal adhesion
1.41 9.90e-03 GO:0005912 adherens junction
1.37 1.21e-02 GO:0030424 axon
1.26 1.80e-02 GO:0048471 perinuclear region of cytoplasm
1.92 2.01e-02 GO:0032153 cell division site
1.92 2.01e-02 GO:0032155 cell division site part
1.12 2.15e-02 GO:0005856 cytoskeleton
1.37 2.24e-02 GO:0070161 anchoring junction
1.18 2.34e-02 GO:0044432 endoplasmic reticulum part
1.20 2.37e-02 GO:0044431 Golgi apparatus part
1.18 2.55e-02 GO:0042175 nuclear membrane-endoplasmic reticulum network
1.26 2.59e-02 GO:0005815 microtubule organizing center
1.58 2.67e-02 GO:0034399 nuclear periphery
1.15 2.92e-02 GO:0044430 cytoskeletal part
1.32 3.04e-02 GO:0016604 nuclear body
1.22 3.32e-02 GO:0000139 Golgi membrane
1.46 3.53e-02 GO:0005924 cell-substrate adherens junction
1.18 3.58e-02 GO:0005789 endoplasmic reticulum membrane
1.24 3.80e-02 GO:0043005 neuron projection
1.20 3.94e-02 GO:0005694 chromosome
1.16 4.02e-02 GO:0042995 cell projection
1.34 4.39e-02 GO:0005819 spindle
1.51 4.78e-02 GO:0000790 nuclear chromatin

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 2.87e-32 GO:0005515 protein binding
1.07 2.45e-24 GO:0005488 binding
1.30 3.10e-09 GO:0019899 enzyme binding
1.15 1.81e-07 GO:0000166 nucleotide binding
1.08 4.61e-06 GO:0003824 catalytic activity
1.14 6.72e-05 GO:0032553 ribonucleotide binding
1.14 6.72e-05 GO:0032555 purine ribonucleotide binding
1.14 1.03e-04 GO:0017076 purine nucleotide binding
1.36 1.89e-04 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.14 1.91e-04 GO:0035639 purine ribonucleoside triphosphate binding
1.14 2.78e-04 GO:0016740 transferase activity
1.15 8.35e-04 GO:0032559 adenyl ribonucleotide binding
1.27 9.49e-04 GO:0016874 ligase activity
1.15 1.00e-03 GO:0030554 adenyl nucleotide binding
1.38 1.12e-03 GO:0019900 kinase binding
1.18 1.38e-03 GO:0030528 transcription regulator activity
1.14 1.89e-03 GO:0005524 ATP binding
1.34 3.03e-03 GO:0016881 acid-amino acid ligase activity
1.37 9.89e-03 GO:0019901 protein kinase binding
1.25 1.15e-02 GO:0019904 protein domain specific binding
1.16 2.88e-02 GO:0001071 nucleic acid binding transcription factor activity
1.16 2.88e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.29 3.36e-02 GO:0008134 transcription factor binding
1.19 4.15e-02 GO:0043565 sequence-specific DNA binding
1.25 4.72e-02 GO:0000988 protein binding transcription factor activity
1.25 4.72e-02 GO:0000989 transcription factor binding transcription factor activity