Motif ID: FOSL2.p2

Z-value: 1.007


Transcription factors associated with FOSL2.p2:

Gene SymbolEntrez IDGene Name
FOSL2 2355 FOS-like antigen 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOSL2chr2_+_284691720.312.4e-01Click!


Activity profile for motif FOSL2.p2.

activity profile for motif FOSL2.p2


Sorted Z-values histogram for motif FOSL2.p2

Sorted Z-values for motif FOSL2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOSL2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_17719405 1.135 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr10_-_31328426 1.135 NM_001143769
ZNF438
zinc finger protein 438
chr13_+_112746908 1.098 MCF2L
MCF.2 cell line derived transforming sequence-like
chr22_+_20899155 1.016


chr12_-_56445653 0.993 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr11_-_116199145 0.894 NM_000482
APOA4
apolipoprotein A-IV
chr1_-_117554999 0.884 NM_024626
VTCN1
V-set domain containing T cell activation inhibitor 1
chr11_-_118571793 0.802 NM_001145018
CCDC153
coiled-coil domain containing 153
chr15_-_40089736 0.776 NM_001080490
PLA2G4E
phospholipase A2, group IVE
chr18_+_19706979 0.775 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr6_+_37360144 0.772 TBC1D22B
TBC1 domain family, member 22B
chr1_+_17507276 0.763 NM_012387
PADI4
peptidyl arginine deiminase, type IV
chr16_+_56219802 0.745 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr19_+_43971689 0.739 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr1_+_207995999 0.737 NM_025228
TRAF3IP3
TRAF3 interacting protein 3
chr19_+_40895669 0.712 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr7_+_30927439 0.677 NM_001185060
NM_001185061
NM_001185062
AQP1


aquaporin 1 (Colton blood group)


chr19_-_40684638 0.677 NM_001035516
DMKN
dermokine
chr3_-_58175437 0.668 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr19_-_40673185 0.635 NM_207392
KRTDAP
keratinocyte differentiation-associated protein
chr10_-_128199986 0.621 NM_001004298
C10orf90
chromosome 10 open reading frame 90
chr15_+_65245546 0.604 NM_001145104
SMAD3
SMAD family member 3
chr1_-_43523825 0.596 NM_182517
NM_001164829
C1orf210

chromosome 1 open reading frame 210

chr7_+_128367961 0.580 NM_001098627
IRF5
interferon regulatory factor 5
chr19_+_4180494 0.579 NM_005755
EBI3
Epstein-Barr virus induced 3
chr1_-_202432165 0.566 NM_002256
KISS1
KiSS-1 metastasis-suppressor
chr3_+_190147633 0.560 TPRG1
tumor protein p63 regulated 1
chr17_+_41424665 0.556 MAPT
microtubule-associated protein tau
chr22_+_21393107 0.552 IGLJ3
immunoglobulin lambda joining 3
chr12_+_6292077 0.522 NM_001144857
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr1_+_205105776 0.513 NM_018724
IL20
interleukin 20
chr6_-_30236667 0.510 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr22_+_23921072 0.505 KIAA1671
KIAA1671
chr5_+_177473071 0.504 NM_015111
N4BP3
NEDD4 binding protein 3
chr17_+_65582981 0.494 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr22_+_21407066 0.491


chr17_+_77910411 0.487 NM_207459
TEX19
testis expressed 19
chr22_+_20316968 0.486 NM_152612
CCDC116
coiled-coil domain containing 116
chr11_+_48194937 0.484 NM_001005470
OR4B1
olfactory receptor, family 4, subfamily B, member 1
chr16_+_2023279 0.480 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr2_+_74595073 0.476 NM_016170
TLX2
T-cell leukemia homeobox 2
chr1_-_221919982 0.475 CAPN8
calpain 8
chr12_+_102505180 0.471 NM_017564
STAB2
stabilin 2
chrX_-_15593074 0.468 NM_020665
TMEM27
transmembrane protein 27
chr22_+_36549334 0.466 NM_003614
GALR3
galanin receptor 3
chr1_+_40508336 0.464 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr17_+_22823151 0.461 NM_014238
KSR1
kinase suppressor of ras 1
chr6_-_41781655 0.458 TFEB
transcription factor EB
chr1_-_108032645 0.456 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr8_+_87180248 0.452 NM_152565
ATP6V0D2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
chr22_+_21053972 0.446


chr9_+_102231616 0.444 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr1_-_221920023 0.431 NM_001143962
CAPN8
calpain 8
chr5_-_75954807 0.428 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr3_-_49812257 0.425 NM_001007540
CDHR4
cadherin-related family member 4
chr7_-_76667045 0.424 NM_006682
FGL2
fibrinogen-like 2
chr3_+_187840842 0.420 NM_014375
FETUB
fetuin B
chr20_+_35266581 0.417 RPN2
ribophorin II
chr6_-_24985432 0.416 NM_015864
FAM65B
family with sequence similarity 65, member B
chr1_+_148747208 0.415 ECM1
extracellular matrix protein 1
chr9_-_86173232 0.405 NM_022127
SLC28A3
solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
chr7_-_128330615 0.404 KCP
kielin/chordin-like protein
chr11_+_72660894 0.399 NM_004154
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr11_+_44026106 0.394 NM_001031854
ACCSL
1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like
chr22_-_37214480 0.394 NM_001098505
NM_030881
DDX17

DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

chr22_+_21116283 0.393


chr12_+_55018925 0.392 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr11_+_120966280 0.391 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr11_-_47502115 0.390 NM_001172639
CELF1
CUGBP, Elav-like family member 1
chr22_+_21484240 0.390


chr1_-_110414756 0.384 NM_006492
ALX3
ALX homeobox 3
chr4_+_76700281 0.377 NM_178497
C4orf26
chromosome 4 open reading frame 26
chr11_+_57123927 0.376 SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr5_+_145297490 0.375 SH3RF2
SH3 domain containing ring finger 2
chr5_+_147562531 0.375 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr1_+_153232685 0.373 NM_018655
LENEP
lens epithelial protein
chr1_-_178100204 0.373


chr15_-_88023576 0.369 NM_001145311
NM_002666
PLIN1

perilipin 1

chr11_-_65186790 0.369 RELA
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
chr12_-_10173947 0.367 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr1_+_203740306 0.365 NM_002596
NM_212502
NM_212503
CDK18


cyclin-dependent kinase 18


chr12_-_65359019 0.363 GRIP1
glutamate receptor interacting protein 1
chr19_-_11549441 0.358 ACP5
acid phosphatase 5, tartrate resistant
chr19_-_11549484 0.356 ACP5
acid phosphatase 5, tartrate resistant
chr3_-_197549588 0.353 TM4SF19
transmembrane 4 L six family member 19
chr3_+_192529567 0.349 NM_174908
NM_178335
CCDC50

coiled-coil domain containing 50

chr3_-_197549640 0.349 NM_138461
TM4SF19
transmembrane 4 L six family member 19
chr1_+_54780515 0.345 ACOT11
acyl-CoA thioesterase 11
chr9_+_4829763 0.340 RCL1
RNA terminal phosphate cyclase-like 1
chr3_+_134976965 0.338 TF
transferrin
chr3_-_156876798 0.338 NM_001130960
NM_001130961
PLCH1

phospholipase C, eta 1

chr2_-_85494639 0.337 CAPG
capping protein (actin filament), gelsolin-like
chr3_+_185377341 0.337 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr9_+_5500544 0.336 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr1_+_160618143 0.335 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr22_+_21359175 0.335 IGLV3-25
immunoglobulin lambda variable 3-25
chr15_+_38923914 0.333 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr21_+_29439768 0.331 C21orf7
chromosome 21 open reading frame 7
chr12_-_68291208 0.331 NM_201550
LRRC10
leucine rich repeat containing 10
chr1_+_151223180 0.330 NM_005987
SPRR1A
small proline-rich protein 1A
chr19_+_40242634 0.328 HPN
hepsin
chr12_+_32546243 0.327 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr6_+_41712907 0.327 MDFI
MyoD family inhibitor
chr1_+_152644668 0.325 IL6R
interleukin 6 receptor
chr10_+_47867667 0.324 NM_001137556
NM_001137549
NM_001137548
FAM25B
FAM25G
FAM25C
family with sequence similarity 25, member B
family with sequence similarity 25, member G
family with sequence similarity 25, member C
chr8_+_10567556 0.322 NM_001040032
C8orf74
chromosome 8 open reading frame 74
chr7_+_101978777 0.321 NM_001166339
NM_001031618
SPDYE2L
SPDYE2
WBSCR19-like protein 3
speedy homolog E2 (Xenopus laevis)
chr4_-_151990061 0.320 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr4_+_78172966 0.319 SEPT11
septin 11
chr1_+_148747110 0.318 NM_004425
NM_022664
ECM1

extracellular matrix protein 1

chr17_-_70480385 0.317 NM_030630
C17orf28
chromosome 17 open reading frame 28
chr8_+_22900863 0.316 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr9_-_139068269 0.316 NM_001246
NM_203468
ENTPD2

ectonucleoside triphosphate diphosphohydrolase 2

chr1_-_36589744 0.315


chr7_-_98305599 0.313 NM_001134450
NM_001134451
NM_152913
TMEM130


transmembrane protein 130


chr1_-_26070330 0.312 NM_178422
PAQR7
progestin and adipoQ receptor family member VII
chr1_+_203740391 0.310 CDK18
cyclin-dependent kinase 18
chr1_-_151804929 0.308 NM_005978
S100A2
S100 calcium binding protein A2
chr12_+_50981915 0.307 NM_002284
KRT86
keratin 86
chr4_-_171161486 0.307 NM_001009554
MFAP3L
microfibrillar-associated protein 3-like
chr10_+_82268433 0.306 TSPAN14
tetraspanin 14
chr15_-_68781662 0.305 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr3_+_52325374 0.304 NM_015512
DNAH1
dynein, axonemal, heavy chain 1
chr7_+_26298136 0.303 SNX10
sorting nexin 10
chr1_+_110494654 0.301 NM_001010898
SLC6A17
solute carrier family 6, member 17
chr19_-_43955984 0.297 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr8_+_22266256 0.297 PIWIL2
piwi-like 2 (Drosophila)
chr16_-_30032330 0.295 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr7_-_98305551 0.295 TMEM130
transmembrane protein 130
chr3_+_125586241 0.291 KALRN
kalirin, RhoGEF kinase
chr21_-_42659671 0.290 NM_003225
TFF1
trefoil factor 1
chrX_-_10761729 0.290 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr13_-_59223074 0.289


chr12_+_6903886 0.288 NM_001007026
ATN1
atrophin 1
chr19_+_55123770 0.287 NM_012068
ATF5
activating transcription factor 5
chr11_-_62213946 0.286 NM_203422
LRRN4CL
LRRN4 C-terminal like
chr5_+_176170041 0.285 NM_133369
UNC5A
unc-5 homolog A (C. elegans)
chr14_-_93919305 0.283 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr20_+_42777419 0.283 WISP2
WNT1 inducible signaling pathway protein 2
chr15_+_39918302 0.279 NM_001114633
PLA2G4B
phospholipase A2, group IVB (cytosolic)
chr11_-_64133908 0.276


chr13_-_99983945 0.274 NM_033110
A2LD1
AIG2-like domain 1
chr3_-_11585264 0.272 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr3_+_185377430 0.268 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr4_-_5879488 0.267 CRMP1
collapsin response mediator protein 1
chr15_+_38923470 0.266 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr19_-_11549508 0.264 NM_001611
ACP5
acid phosphatase 5, tartrate resistant
chr19_-_40939756 0.262 NM_144617
HSPB6
heat shock protein, alpha-crystallin-related, B6
chr8_-_125649926 0.262 MTSS1
metastasis suppressor 1
chr6_+_41118214 0.261 NM_001010873
NM_001159726
TSPO2

translocator protein 2

chr5_-_149446182 0.259 CSF1R
colony stimulating factor 1 receptor
chr19_-_43926953 0.259 NM_144691
CAPN12
calpain 12
chr11_+_117903357 0.259 NM_001080441
TTC36
tetratricopeptide repeat domain 36
chr17_-_24069299 0.258 NM_001142624
NM_001142625
NM_001144943
RAB34


RAB34, member RAS oncogene family


chr8_-_25338472 0.257 NM_000825
NM_001083111
GNRH1

gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)

chr8_+_11599119 0.257 NM_002052
GATA4
GATA binding protein 4
chr19_-_19599973 0.256 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr14_+_54291255 0.255 NM_001161577
SAMD4A
sterile alpha motif domain containing 4A
chr5_+_150000394 0.255 NM_001109974
NM_007286
SYNPO

synaptopodin

chr20_+_30480848 0.255 ASXL1
additional sex combs like 1 (Drosophila)
chrX_+_24393264 0.254 NM_001142386
NM_005391
PDK3

pyruvate dehydrogenase kinase, isozyme 3

chr1_-_6474346 0.254 NM_020631
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr8_-_11748330 0.254


chr10_-_49152918 0.253 NM_001018071
FRMPD2
FERM and PDZ domain containing 2
chr17_-_38421363 0.252 VAT1
vesicle amine transport protein 1 homolog (T. californica)
chr21_-_34908614 0.252 NM_203417
RCAN1
regulator of calcineurin 1
chr1_-_7998265 0.251 ERRFI1
ERBB receptor feedback inhibitor 1
chr2_+_218833982 0.250 NM_001077191
NM_001077194
NM_170699
GPBAR1


G protein-coupled bile acid receptor 1


chr8_+_120289735 0.250 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr6_-_112001590 0.250 NM_001164282
TRAF3IP2
TRAF3 interacting protein 2
chr20_+_42777298 0.249 NM_003881
WISP2
WNT1 inducible signaling pathway protein 2
chr14_+_76362467 0.249 NM_194287
C14orf166B
chromosome 14 open reading frame 166B
chr10_+_35575958 0.248 NM_181698
CCNY
cyclin Y
chr22_+_21340757 0.247


chr1_-_151333624 0.246 NM_001024209
SPRR2E
small proline-rich protein 2E
chr5_+_175241449 0.245 CPLX2
complexin 2
chr8_-_143820825 0.244 NM_020427
SLURP1
secreted LY6/PLAUR domain containing 1
chr3_+_153074118 0.243 NM_033050
SUCNR1
succinate receptor 1
chr10_-_46601687 0.243 NM_001137556
NM_001137549
NM_001137548
FAM25B
FAM25G
FAM25C
family with sequence similarity 25, member B
family with sequence similarity 25, member G
family with sequence similarity 25, member C
chr19_-_6621078 0.242 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr21_-_36760594 0.242 NM_012130
CLDN14
claudin 14
chr10_+_88770025 0.242 NM_001146157
FAM25A
family with sequence similarity 25, member A
chr5_-_141041982 0.242 NM_022481
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr15_+_57691382 0.242 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr17_+_23824784 0.241 NM_001145975
NM_001145976
NM_003984
SLC13A2


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2


chr5_-_141041933 0.239 ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr1_-_92725017 0.239 NM_005263
GFI1
growth factor independent 1 transcription repressor
chr15_+_88696480 0.239 NM_001004309
ZNF774
zinc finger protein 774
chr17_+_35718948 0.238 NM_000964
RARA
retinoic acid receptor, alpha
chr4_+_661710 0.238 NM_002477
MYL5
myosin, light chain 5, regulatory
chr5_-_150501393 0.238 NM_001193544
ANXA6
annexin A6
chr5_-_86739683 0.237 CCNH
cyclin H
chr12_-_47545816 0.236 NM_014470
RND1
Rho family GTPase 1
chr4_-_78038025 0.236 NM_001029870
ANKRD56
ankyrin repeat domain 56
chr17_+_7225088 0.235 NM_003985
TNK1
tyrosine kinase, non-receptor, 1
chr19_+_46489987 0.235 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr1_-_202387532 0.234 ETNK2
ethanolamine kinase 2
chr19_-_63177713 0.234 NM_152474
C19orf18
chromosome 19 open reading frame 18
chr5_-_131658838 0.233


chrX_+_47114925 0.233 NM_003446
ZNF157
zinc finger protein 157

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.37 3.21e-03 GO:0065008 regulation of biological quality
5.73 7.59e-03 GO:0048588 developmental cell growth
1.38 1.00e-02 GO:0048583 regulation of response to stimulus
2.78 1.61e-02 GO:0035023 regulation of Rho protein signal transduction
1.76 2.79e-02 GO:0001775 cell activation
2.10 3.58e-02 GO:0046578 regulation of Ras protein signal transduction

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.28 4.04e-04 GO:0001533 cornified envelope
1.23 1.55e-03 GO:0005886 plasma membrane
1.33 3.22e-03 GO:0044459 plasma membrane part
1.22 3.39e-03 GO:0071944 cell periphery
1.67 4.93e-03 GO:0030054 cell junction
1.74 3.21e-02 GO:0045202 synapse

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.07 1.66e-02 GO:0005089 Rho guanyl-nucleotide exchange factor activity
2.75 2.91e-02 GO:0005088 Ras guanyl-nucleotide exchange factor activity
2.13 3.38e-02 GO:0005529 sugar binding