Motif ID: CDX1,2,4.p2

Z-value: 1.748


Transcription factors associated with CDX1,2,4.p2:

Gene SymbolEntrez IDGene Name
CDX1 1044 caudal type homeobox 1
CDX2 1045 caudal type homeobox 2
CDX4 1046 caudal type homeobox 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
CDX4chrX_+_72583814-0.243.7e-01Click!
CDX2chr13_-_27441143-0.194.8e-01Click!
CDX1chr5_+_149526533-0.087.8e-01Click!


Activity profile for motif CDX1,2,4.p2.

activity profile for motif CDX1,2,4.p2


Sorted Z-values histogram for motif CDX1,2,4.p2

Sorted Z-values for motif CDX1,2,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CDX1,2,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_47678187 4.624 NM_001142564
CNGA1
cyclic nucleotide gated channel alpha 1
chr7_+_151284396 4.015 NM_145292
GALNTL5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5
chr3_-_150533948 3.241 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr22_+_21384862 3.046 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr7_+_116238309 2.325 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr8_-_7207899 2.296 NM_001164457
ZNF705G
zinc finger protein 705G
chr4_+_154397975 2.235 TRIM2
tripartite motif containing 2
chr22_-_23500682 2.083 NM_001008496
PIWIL3
piwi-like 3 (Drosophila)
chr20_+_19818209 1.975 NM_018993
RIN2
Ras and Rab interactor 2
chr3_-_152403636 1.954 NM_013308
GPR171
G protein-coupled receptor 171
chr3_+_108578877 1.930 NM_032600
CCDC54
coiled-coil domain containing 54
chr19_-_10558906 1.927 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr6_+_30238961 1.924 NM_033229
TRIM15
tripartite motif containing 15
chr16_-_70168449 1.923 NM_000353
TAT
tyrosine aminotransferase
chr8_-_27997306 1.830 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr4_-_38460983 1.809 NM_001017388
NM_001195106
NM_001195107
NM_001195108
NM_030956
TLR10




toll-like receptor 10




chr22_+_43527101 1.806 NM_001017526
NM_001198726
NM_181335
ARHGAP8


Rho GTPase activating protein 8


chr1_+_32777358 1.790 NM_001040441
ZBTB8A
zinc finger and BTB domain containing 8A
chr16_+_65558878 1.694 NM_001185176
CES3
carboxylesterase 3
chr6_+_29963328 1.627 HLA-H
major histocompatibility complex, class I, H (pseudogene)
chr6_-_117256890 1.613 NM_148963
GPRC6A
G protein-coupled receptor, family C, group 6, member A
chr16_+_79829794 1.592 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr5_+_36644187 1.567 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_+_161701711 1.498 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr1_+_245647973 1.474 NM_001127462
NM_004895
NM_183395
NLRP3


NLR family, pyrin domain containing 3


chr5_-_156705250 1.420 NM_001001343
FNDC9
fibronectin type III domain containing 9
chr7_-_112513379 1.415 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr1_+_43386180 1.413 NM_001101376
FAM183A
family with sequence similarity 183, member A
chr11_-_102250876 1.403 NM_002426
MMP12
matrix metallopeptidase 12 (macrophage elastase)
chr6_-_25679197 1.378


chr10_-_98021144 1.351 NM_001114094
NM_013314
BLNK

B-cell linker

chr19_-_59258846 1.346 NM_198481
VSTM1
V-set and transmembrane domain containing 1
chr2_+_38009405 1.321 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chr2_-_224574860 1.295 SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr7_+_147918589 1.285 NM_145304
C7orf33
chromosome 7 open reading frame 33
chr2_-_218739891 1.269 NM_000634
CXCR1
chemokine (C-X-C motif) receptor 1
chr4_-_77176163 1.266 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr18_-_26935883 1.216 NM_004949
NM_024422
DSC2

desmocollin 2

chr11_+_59038961 1.209 NM_001004711
OR4D9
olfactory receptor, family 4, subfamily D, member 9
chr21_+_41719847 1.193 NM_002462
NM_001178046
MX1

myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)

chr11_+_113351006 1.160 NM_000869
NM_213621
HTR3A

5-hydroxytryptamine (serotonin) receptor 3A

chr10_-_7699192 1.151 ITIH5
inter-alpha (globulin) inhibitor H5
chr11_-_32772731 1.150 NM_001008391
CCDC73
coiled-coil domain containing 73
chr8_-_124818754 1.142 NM_001003954
NM_004306
ANXA13

annexin A13

chr2_-_178495768 1.141 NM_001077358
PDE11A
phosphodiesterase 11A
chr7_+_142978994 1.132 NM_001008747
CTAGE6P
CTAGE15P
CTAGE family, member 6, pseudogene
CTAGE family, member 15, pseudogene
chr5_-_135318420 1.098 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr1_-_229627412 1.093 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr1_-_178100204 1.092


chr19_+_6415259 1.088 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr3_-_171070314 1.084 NM_024727
LRRC31
leucine rich repeat containing 31
chr2_+_95621492 1.078 NM_138800
TRIM43
tripartite motif containing 43
chr12_+_26096757 1.075 NM_001164746
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr1_-_142536082 1.073


chr1_+_181421796 1.042 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr12_+_100512877 1.042 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr1_+_158975662 0.995 NM_021181
SLAMF7
SLAM family member 7
chr21_+_29439768 0.992 C21orf7
chromosome 21 open reading frame 7
chr3_+_153074118 0.983 NM_033050
SUCNR1
succinate receptor 1
chr1_-_159191184 0.982 NM_080878
ITLN2
intelectin 2
chr7_-_97457286 0.978 NM_006188
OCM2
oncomodulin 2
chr1_-_120155581 0.969 NM_001159352
NM_001159353
NM_032044
REG4


regenerating islet-derived family, member 4


chr8_-_17787342 0.955 FGL1
fibrinogen-like 1
chr19_+_60077360 0.950 NM_002000
NM_133269
NM_133271
NM_133272
NM_133273
NM_133274
NM_133277
NM_133278
NM_133279
FCAR








Fc fragment of IgA, receptor for








chr15_-_49418027 0.944 NM_000103
NM_031226
CYP19A1

cytochrome P450, family 19, subfamily A, polypeptide 1

chr3_+_153014550 0.939 NM_001086
AADAC
arylacetamide deacetylase (esterase)
chr7_-_138014329 0.939 NM_001139456
SVOPL
SVOP-like
chr15_-_48192804 0.936 ATP8B4
ATPase, class I, type 8B, member 4
chr12_+_105602606 0.924 NM_032491
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr1_-_165326148 0.922 NM_005814
GPA33
glycoprotein A33 (transmembrane)
chr11_+_5714253 0.913 NM_001005180
OR56B1
olfactory receptor, family 56, subfamily B, member 1
chr8_+_12914143 0.906 NM_001099677
KIAA1456
KIAA1456
chr9_-_111253484 0.901 NM_001145369
NM_001145370
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr5_+_53787187 0.897 NM_006308
HSPB3
heat shock 27kDa protein 3
chr3_+_46628928 0.894 NM_001195442
LOC100132146
hypothetical LOC100132146
chr11_-_102001259 0.892 NM_004771
MMP20
matrix metallopeptidase 20
chr2_+_39000007 0.891 NM_001145451
ARHGEF33
Rho guanine nucleotide exchange factor (GEF) 33
chr6_-_138935359 0.876 NM_020464
NHSL1
NHS-like 1
chr19_-_9087438 0.870 NM_001005192
OR7G1
olfactory receptor, family 7, subfamily G, member 1
chr9_+_78305368 0.848 NM_001097636
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr1_-_143232526 0.848 FAM91A2
family with sequence similarity 91, member A2
chr8_-_41286088 0.840 NM_003012
SFRP1
secreted frizzled-related protein 1
chr4_-_77163609 0.833 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr1_-_146543102 0.832


chr1_+_242283129 0.830 NM_006352
ZNF238
zinc finger protein 238
chr1_+_218768170 0.828 NM_018650
MARK1
MAP/microtubule affinity-regulating kinase 1
chr1_-_181889070 0.820 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr6_+_158990982 0.820 NM_001009991
SYTL3
synaptotagmin-like 3
chr19_-_5797465 0.809 FUT3
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
chr12_-_51065629 0.804 NM_033045
KRT84
keratin 84
chr10_-_23673777 0.798 NM_153714
C10orf67
chromosome 10 open reading frame 67
chr5_-_172016174 0.796


chr19_-_49725387 0.796 NM_001102597
NM_001102598
NM_001102599
NM_001102600
CEACAM20



carcinoembryonic antigen-related cell adhesion molecule 20



chr6_+_150304813 0.795 NM_025217
ULBP2
UL16 binding protein 2
chr19_+_55488632 0.783 MYH14
myosin, heavy chain 14, non-muscle
chr15_+_57696200 0.780 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr11_-_102081654 0.780 NM_022122
MMP27
matrix metallopeptidase 27
chr12_-_10983072 0.779 NM_023922
TAS2R14
taste receptor, type 2, member 14
chr12_+_53901075 0.777 NM_001005280
OR10A7
olfactory receptor, family 10, subfamily A, member 7
chr22_-_20667131 0.776 NM_003935
TOP3B
topoisomerase (DNA) III beta
chr10_-_62002672 0.772 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr19_+_40895669 0.769 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr4_+_71418886 0.769 NM_212557
AMTN
amelotin
chr18_+_606671 0.769 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr8_-_17797127 0.767 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr1_-_23393808 0.767 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr1_+_207944807 0.761 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr9_+_102380156 0.758 NM_001018116
MURC
muscle-related coiled-coil protein
chr10_-_62163083 0.757 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr11_+_110890719 0.755 NM_001100388
NM_207430
C11orf88

chromosome 11 open reading frame 88

chr13_+_77007809 0.755 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr7_+_134114912 0.745 CALD1
caldesmon 1
chr3_-_17716515 0.741 NM_001134381
TBC1D5
TBC1 domain family, member 5
chr20_+_57966865 0.741 NM_177980
CDH26
cadherin 26
chr1_+_61697209 0.737 NFIA
nuclear factor I/A
chr13_+_97856148 0.736


chr4_+_41678469 0.732 NM_001029955
DCAF4L1
DDB1 and CUL4 associated factor 4-like 1
chr22_-_20667165 0.731 TOP3B
topoisomerase (DNA) III beta
chr7_+_134114957 0.727 CALD1
caldesmon 1
chr10_-_48010879 0.725 NM_002900
RBP3
retinol binding protein 3, interstitial
chr12_-_121753795 0.721 NM_177551
GPR109A
G protein-coupled receptor 109A
chr22_-_20667211 0.721 TOP3B
topoisomerase (DNA) III beta
chr20_-_49747397 0.719 ATP9A
ATPase, class II, type 9A
chr17_-_36409632 0.718 NM_031959
KRTAP3-2
keratin associated protein 3-2
chr2_+_98070026 0.718 NM_144992
VWA3B
von Willebrand factor A domain containing 3B
chr1_-_67366807 0.716 NM_001013674
C1orf141
chromosome 1 open reading frame 141
chr11_+_60016826 0.715 NM_001164470
NM_017716
MS4A12

membrane-spanning 4-domains, subfamily A, member 12

chr1_+_195123766 0.715 NM_006684
CFHR4
complement factor H-related 4
chr22_-_43987978 0.714 KIAA0930
KIAA0930
chr6_-_130585650 0.713 NM_001017373
SAMD3
sterile alpha motif domain containing 3
chr5_+_127012611 0.707 NM_001048252
CTXN3
cortexin 3
chr12_-_51132129 0.705 NM_005555
KRT6B
keratin 6B
chr6_-_29451042 0.703 NM_030959
OR12D3
olfactory receptor, family 12, subfamily D, member 3
chr17_+_3326045 0.694 NM_000049
ASPA
aspartoacylase
chr11_-_64484184 0.694 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr5_+_140772691 0.693 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr4_+_37638450 0.693 NM_006607
PTTG2
pituitary tumor-transforming 2
chr1_+_43837096 0.688 PTPRF
protein tyrosine phosphatase, receptor type, F
chr16_+_67235651 0.687 NM_001793
CDH3
cadherin 3, type 1, P-cadherin (placental)
chr11_+_73339011 0.687 NM_153614
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr6_+_29663661 0.679 NM_007160
OR2H2
olfactory receptor, family 2, subfamily H, member 2
chr3_+_133801670 0.674 NM_178445
CCRL1
chemokine (C-C motif) receptor-like 1
chr10_-_27097782 0.673 ABI1
abl-interactor 1
chr10_-_30958631 0.672 NM_183058
LYZL2
lysozyme-like 2
chr12_+_8557402 0.672 NM_080387
CLEC4D
C-type lectin domain family 4, member D
chr9_+_140164359 0.671 TUBBP5
tubulin, beta pseudogene 5
chr5_-_180099663 0.667 NM_001001657
OR2Y1
olfactory receptor, family 2, subfamily Y, member 1
chr2_+_201182187 0.655 AOX1
aldehyde oxidase 1
chr12_+_8216416 0.643 NM_001004328
ZNF705A
zinc finger protein 705A
chr11_-_16953135 0.640 RPL36A
ribosomal protein L36a
chr10_+_74323344 0.640 NM_152635
OIT3
oncoprotein induced transcript 3
chr7_-_38279757 0.627 NM_001003799
NM_001003806
TARP

TRGV9
TCR gamma alternate reading frame protein

T cell receptor gamma variable 9
chr1_+_218768146 0.627 MARK1
MAP/microtubule affinity-regulating kinase 1
chr7_-_111216180 0.623 DOCK4
dedicator of cytokinesis 4
chr2_+_88605283 0.623 NM_152670
C2orf51
chromosome 2 open reading frame 51
chr5_+_68823874 0.620 NM_002538
OCLN
occludin
chr3_+_12367993 0.619 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr7_+_101810018 0.618


chrX_-_62487693 0.616 NM_001012968
SPIN4
spindlin family, member 4
chr12_-_25692754 0.615 NM_001145727
IFLTD1
intermediate filament tail domain containing 1
chr1_-_145163779 0.612 NM_001144829
NM_001144830
NM_001461
FMO5


flavin containing monooxygenase 5


chr8_+_92330691 0.610 NM_052832
NM_134266
SLC26A7

solute carrier family 26, member 7

chr12_+_10222823 0.609 NM_153022
C12orf59
chromosome 12 open reading frame 59
chr3_+_38282301 0.609 NM_004256
SLC22A13
solute carrier family 22 (organic anion transporter), member 13
chr7_+_142629251 0.609 NM_176882
TAS2R40
taste receptor, type 2, member 40
chr4_+_89519004 0.602 HERC6
hect domain and RLD 6
chr6_-_38671741 0.598 NM_001172418
NM_152733
BTBD9

BTB (POZ) domain containing 9

chr1_-_54256390 0.597 NM_001010978
LDLRAD1
low density lipoprotein receptor class A domain containing 1
chr12_-_27815475 0.592 NM_001146221
LOC100287284
MANSC domain-containing protein ENSP00000370673
chr15_-_70385709 0.590 NM_001172685
CELF6
CUGBP, Elav-like family member 6
chr11_+_113165134 0.590 LOC390251
SH3-domain GRB2-like 1 pseudogene
chr1_-_177106702 0.588 NM_004673
ANGPTL1
angiopoietin-like 1
chr15_-_68781662 0.587 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr6_+_151688327 0.585 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr4_+_89518898 0.581 NM_001165136
NM_017912
HERC6

hect domain and RLD 6

chr15_+_19869841 0.580 NM_001004719
OR4M2
olfactory receptor, family 4, subfamily M, member 2
chr10_+_71482542 0.579 H2AFY2
H2A histone family, member Y2
chr2_+_113532685 0.573 NM_173170
IL1F5
interleukin 1 family, member 5 (delta)
chr12_-_121767272 0.569 NM_006018
GPR109B
G protein-coupled receptor 109B
chr2_-_26395420 0.566 NM_001145168
NM_001145169
GPR113

G protein-coupled receptor 113

chr4_+_155707089 0.565 FGB
fibrinogen beta chain
chr7_+_137411717 0.564 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr20_-_33783409 0.559 RBM39
RNA binding motif protein 39
chr6_+_29732736 0.559 NM_001008228
NM_001008229
NM_001170418
NM_002433
NM_206809
NM_206810
NM_206811
NM_206812
NM_206814
MOG








myelin oligodendrocyte glycoprotein








chr3_-_140879463 0.555 NM_178177
NMNAT3
nicotinamide nucleotide adenylyltransferase 3
chr4_-_5881271 0.547 CRMP1
collapsin response mediator protein 1
chr3_-_152449591 0.546 NM_001081455
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr12_+_55443358 0.545 NM_003725
HSD17B6
hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)
chr12_-_11106159 0.544 NM_176887
TAS2R46
taste receptor, type 2, member 46
chr6_-_136889302 0.540 MAP7
microtubule-associated protein 7
chr1_+_195503956 0.536 NM_001193640
NM_201253
CRB1

crumbs homolog 1 (Drosophila)

chr7_+_75928907 0.535 NM_001102594
NM_001102595
NM_020892
DTX2


deltex homolog 2 (Drosophila)


chr9_-_103397023 0.532 NM_147180
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr19_-_56946911 0.531 NM_001193306
NM_002029
FPR1

formyl peptide receptor 1

chr3_+_46591048 0.531 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chr11_-_129268113 0.530 NM_006165
NFRKB
nuclear factor related to kappaB binding protein
chr11_-_111636792 0.525 NM_001145024
C11orf34
chromosome 11 open reading frame 34
chr19_+_50144267 0.520 APOC2
apolipoprotein C-II
chr9_+_124463665 0.519 NM_001005236
OR1L1
olfactory receptor, family 1, subfamily L, member 1
chr12_+_74014685 0.517 NM_152779
GLIPR1L1
GLI pathogenesis-related 1 like 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.50 3.02e-17 GO:0007606 sensory perception of chemical stimulus
2.49 4.47e-15 GO:0007608 sensory perception of smell
1.84 5.07e-10 GO:0007600 sensory perception
1.49 1.80e-05 GO:0050877 neurological system process
1.40 1.45e-04 GO:0003008 system process
1.17 2.59e-03 GO:0032501 multicellular organismal process
1.14 2.38e-02 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.24 1.62e-06 GO:0005886 plasma membrane
1.24 1.73e-06 GO:0071944 cell periphery
1.31 5.26e-04 GO:0005576 extracellular region
1.12 2.46e-02 GO:0044425 membrane part
1.10 3.25e-02 GO:0016020 membrane
1.13 4.32e-02 GO:0016021 integral to membrane
1.13 4.68e-02 GO:0031224 intrinsic to membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.53 1.11e-15 GO:0004984 olfactory receptor activity
1.88 2.40e-12 GO:0004930 G-protein coupled receptor activity
1.62 8.93e-10 GO:0004888 transmembrane receptor activity
1.50 7.39e-09 GO:0004872 receptor activity
1.39 8.52e-07 GO:0004871 signal transducer activity
1.39 8.52e-07 GO:0060089 molecular transducer activity