Motif ID: ALX1.p2

Z-value: 0.884


Transcription factors associated with ALX1.p2:

Gene SymbolEntrez IDGene Name
ALX1 8092 ALX homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ALX1chr12_+_841980150.332.2e-01Click!


Activity profile for motif ALX1.p2.

activity profile for motif ALX1.p2


Sorted Z-values histogram for motif ALX1.p2

Sorted Z-values for motif ALX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ALX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_21207303 2.015 NM_002173
IFNA16
interferon, alpha 16
chr1_+_115373937 1.389 NM_000549
TSHB
thyroid stimulating hormone, beta
chr11_-_123695302 1.233 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr2_-_162717159 1.082 NM_002054
GCG
glucagon
chr9_-_21192201 0.986 NM_021057
IFNA7
interferon, alpha 7
chr20_+_34019942 0.857 NM_080834
C20orf152
chromosome 20 open reading frame 152
chr5_+_140215778 0.855 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr8_-_111056099 0.837 NM_014379
KCNV1
potassium channel, subfamily V, member 1
chr12_-_10850845 0.836 NM_023918
TAS2R8
taste receptor, type 2, member 8
chr11_-_128242342 0.812 NM_153764
NM_153765
NM_153766
NM_153767
KCNJ1



potassium inwardly-rectifying channel, subfamily J, member 1



chr15_+_36014748 0.797 NM_152453
TMCO5A
transmembrane and coiled-coil domains 5A
chr4_-_120462705 0.778 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr9_-_21340885 0.774 NM_021002
IFNA6
interferon, alpha 6
chr2_-_199922047 0.721 SATB2
SATB homeobox 2
chr5_+_140537554 0.714 NM_019120
PCDHB8
protocadherin beta 8
chr9_-_21358005 0.696 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr3_+_35658852 0.670 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr19_+_59158101 0.651 NM_031895
CACNG8
calcium channel, voltage-dependent, gamma subunit 8
chr4_-_123761615 0.626 NM_021803
IL21
interleukin 21
chr5_+_140594121 0.617 PCDHB18
protocadherin beta 18 pseudogene
chr8_-_15140162 0.601 NM_139167
SGCZ
sarcoglycan, zeta
chr12_+_100512877 0.541 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr8_-_110730183 0.537 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chrX_-_131089552 0.530 NM_194277
FRMD7
FERM domain containing 7
chr2_+_130995136 0.529 NM_032545
NM_001079530
CFC1
CFC1B
cripto, FRL-1, cryptic family 1
cripto, FRL-1, cryptic family 1B
chr5_+_36644187 0.518 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr8_+_38704860 0.509 NM_001146216
TACC1
transforming, acidic coiled-coil containing protein 1
chr9_+_5221401 0.499 NM_002195
INSL4
insulin-like 4 (placenta)
chrX_-_21686079 0.494 NM_014332
SMPX
small muscle protein, X-linked
chr4_-_107508040 0.490 NM_001195138
LOC100507096
GTPase IMAP family member-like
chr5_+_140762551 0.483 NM_018921
NM_032089
PCDHGA9

protocadherin gamma subfamily A, 9

chr19_-_4486202 0.481 NM_001013706
PLIN5
perilipin 5
chr12_-_4358968 0.476 NM_020638
FGF23
fibroblast growth factor 23
chr4_+_70950747 0.473 NM_002159
HTN1
histatin 1
chr9_-_21218132 0.462 NM_021268
IFNA17
interferon, alpha 17
chr5_+_57823017 0.453 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr19_-_14030970 0.451 NM_001145028
PALM3
paralemmin 3
chr8_+_7821268 0.448 NM_001193630
LOC100132396
zinc finger protein 705D-like
chr2_+_102456193 0.445 NM_001011552
SLC9A4
solute carrier family 9 (sodium/hydrogen exchanger), member 4
chr16_-_70763849 0.445 NM_001160213
PMFBP1
polyamine modulated factor 1 binding protein 1
chr4_+_158361185 0.434 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr5_+_140573692 0.428 NM_018933
PCDHB13
protocadherin beta 13
chr3_+_150065732 0.425 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr12_-_11354620 0.424 NM_002723
PRB4
proline-rich protein BstNI subfamily 4
chr6_-_128281434 0.422 NM_001164687
THEMIS
thymocyte selection associated
chr15_-_88023576 0.420 NM_001145311
NM_002666
PLIN1

perilipin 1

chr5_+_132433979 0.418 HSPA4
heat shock 70kDa protein 4
chr11_+_123625632 0.418 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr3_+_108578877 0.414 NM_032600
CCDC54
coiled-coil domain containing 54
chr11_-_76800525 0.413 PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr2_-_131073329 0.412 NM_032545
NM_001079530
CFC1
CFC1B
cripto, FRL-1, cryptic family 1
cripto, FRL-1, cryptic family 1B
chr5_+_61910318 0.409 NM_181506
LRRC70
leucine rich repeat containing 70
chr18_-_68362702 0.408 NM_182511
CBLN2
cerebellin 2 precursor
chr8_-_33576907 0.406 NM_024025
DUSP26
dual specificity phosphatase 26 (putative)
chr12_+_9871343 0.405 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr7_+_20653490 0.405 NM_001163942
NM_001163993
NM_178559
ABCB5


ATP-binding cassette, sub-family B (MDR/TAP), member 5


chr8_-_12220195 0.402 NM_001195257
NM_001037804
LOC100133267
DEFB130
defensin, beta 130-like
defensin, beta 130
chr17_+_29707583 0.392 NM_005408
CCL13
chemokine (C-C motif) ligand 13
chr14_-_20098929 0.391 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chr3_-_152541129 0.389 NM_176876
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr1_+_180685878 0.389 NM_001137669
RGSL1
regulator of G-protein signaling like 1
chr5_-_176258920 0.384 NM_002115
HK3
hexokinase 3 (white cell)
chr2_-_207291364 0.383 NM_001093730
DYTN
dystrotelin
chr18_+_28023984 0.383 NM_005925
MEP1B
meprin A, beta
chr7_-_87068106 0.378 ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr7_+_115650240 0.373 NM_152829
TES
testis derived transcript (3 LIM domains)
chr6_-_76259976 0.372 NM_015687
FILIP1
filamin A interacting protein 1
chr14_+_61532293 0.370 NM_031914
SYT16
synaptotagmin XVI
chr7_+_101810018 0.366


chr8_-_33577033 0.365 DUSP26
dual specificity phosphatase 26 (putative)
chr3_-_38810504 0.362 NM_006514
SCN10A
sodium channel, voltage-gated, type X, alpha subunit
chr9_-_21156609 0.362 NM_002175
IFNA21
interferon, alpha 21
chr5_+_140723939 0.360 NM_018918
NM_032054
PCDHGA5

protocadherin gamma subfamily A, 5

chr6_+_105511615 0.359 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr4_+_141484046 0.356 NM_001153446
NM_001153635
NM_001153585
NM_001153690
SCOC



short coiled-coil protein



chrX_+_51562894 0.354 NM_001005332
MAGED1
melanoma antigen family D, 1
chr1_+_67404756 0.353 NM_144701
IL23R
interleukin 23 receptor
chr11_-_7906784 0.344 NM_001004461
OR10A6
olfactory receptor, family 10, subfamily A, member 6
chr5_-_149446319 0.343 CSF1R
colony stimulating factor 1 receptor
chr11_+_7574992 0.341 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr1_-_180908639 0.337 NM_001102450
NM_033345
RGS8

regulator of G-protein signaling 8

chr5_-_149446366 0.337 CSF1R
colony stimulating factor 1 receptor
chr12_-_11030777 0.336 NM_176890
TAS2R50
taste receptor, type 2, member 50
chr5_-_177140071 0.335 NM_173663
FAM153A
FAM153C
family with sequence similarity 153, member A
family with sequence similarity 153, member C
chr7_+_99263571 0.334 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr1_+_54132447 0.333 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr12_-_54150188 0.332 NM_001005499
OR6C70
olfactory receptor, family 6, subfamily C, member 70
chr3_+_129124591 0.328 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr11_+_88550687 0.325 NM_000372
TYR
tyrosinase (oculocutaneous albinism IA)
chr4_-_21308415 0.324 NM_001035003
KCNIP4
Kv channel interacting protein 4
chr19_-_63138551 0.320 NM_133460
ZNF418
zinc finger protein 418
chr5_-_149446303 0.320 CSF1R
colony stimulating factor 1 receptor
chr12_-_61832856 0.316 NM_000706
AVPR1A
arginine vasopressin receptor 1A
chr18_+_19826734 0.316 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr9_-_106401514 0.314 NM_001004482
OR13C5
olfactory receptor, family 13, subfamily C, member 5
chr21_+_30895276 0.312 NM_181620
KRTAP22-1
keratin associated protein 22-1
chr12_+_4569504 0.306 NM_003845
DYRK4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr14_+_20306425 0.305 NM_022360
EDDM3B
epididymal protein 3B
chr2_+_86998248 0.304 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr1_+_156991133 0.302 NM_001005184
OR6K6
olfactory receptor, family 6, subfamily K, member 6
chr19_+_54128750 0.299 NM_014475
DHDH
dihydrodiol dehydrogenase (dimeric)
chr14_-_74400288 0.297 NM_001080408
PROX2
prospero homeobox 2
chr5_+_140200995 0.297 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr5_-_149446287 0.297 CSF1R
colony stimulating factor 1 receptor
chr9_-_28709302 0.295 NM_152570
LINGO2
leucine rich repeat and Ig domain containing 2
chr17_+_18566060 0.294 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr5_+_140605330 0.291 NM_018935
PCDHB15
protocadherin beta 15
chr2_+_98329049 0.291 NM_001079878
NM_001298
CNGA3

cyclic nucleotide gated channel alpha 3

chr10_-_21226536 0.291 NM_006393
NEBL
nebulette
chr11_+_113351006 0.290 NM_000869
NM_213621
HTR3A

5-hydroxytryptamine (serotonin) receptor 3A

chr2_+_207512522 0.288 NM_173077
CPO
carboxypeptidase O
chr9_-_21295311 0.287 NM_002169
IFNA5
interferon, alpha 5
chr17_-_16497882 0.285 NM_020787
ZNF624
zinc finger protein 624
chr11_-_57947358 0.284 NM_001005566
OR5B2
olfactory receptor, family 5, subfamily B, member 2
chr19_-_10558906 0.284 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr11_-_13474101 0.283 NM_000315
PTH
parathyroid hormone
chr7_+_156677777 0.280


chrX_+_77889861 0.280 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr1_-_155788775 0.280 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr7_+_27248688 0.279 NM_001989
EVX1
even-skipped homeobox 1
chr4_-_77547481 0.275 NM_001042784
CCDC158
coiled-coil domain containing 158
chr2_-_88946767 0.270


chr5_+_140227951 0.270 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr5_+_140532385 0.269 NM_018940
PCDHB7
protocadherin beta 7
chr10_-_23673777 0.269 NM_153714
C10orf67
chromosome 10 open reading frame 67
chr19_-_5821546 0.265 NM_002034
FUT5
fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
chr11_-_59707074 0.263 NM_022349
NM_152851
NM_152852
MS4A6A


membrane-spanning 4-domains, subfamily A, member 6A


chr12_-_21818881 0.260 NM_004982
KCNJ8
potassium inwardly-rectifying channel, subfamily J, member 8
chr19_+_7468444 0.258 NM_198534
C19orf45
chromosome 19 open reading frame 45
chr12_-_9987277 0.258 LOC100506159
hypothetical LOC100506159
chr19_-_61431470 0.257 NM_024303
ZSCAN5A
zinc finger and SCAN domain containing 5A
chr10_-_13316333 0.255 NM_145314
UCMA
upper zone of growth plate and cartilage matrix associated
chr3_+_28406990 0.253 NM_001040432
ZCWPW2
zinc finger, CW type with PWWP domain 2
chr22_-_15682555 0.253 NM_175878
XKR3
XK, Kell blood group complex subunit-related family, member 3
chr19_+_9984861 0.253 NM_015725
RDH8
retinol dehydrogenase 8 (all-trans)
chr1_-_76170563 0.252 NM_080868
ASB17
ankyrin repeat and SOCS box containing 17
chr3_+_35697432 0.251 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr5_+_140583098 0.248 NM_018934
PCDHB14
protocadherin beta 14
chr9_-_27287106 0.248 NM_001161585
NM_020641
C9orf11

chromosome 9 open reading frame 11

chr9_+_6231677 0.247 NM_033439
IL33
interleukin 33
chr3_+_122769467 0.245 NM_001012659
ARGFX
arginine-fifty homeobox
chr3_-_12561962 0.243 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr14_+_73153300 0.243 NM_001037162
ACOT6
acyl-CoA thioesterase 6
chr5_-_132228375 0.243 NM_005260
GDF9
growth differentiation factor 9
chr7_+_37689903 0.241


chr9_+_106496480 0.241 NM_001004484
OR13D1
olfactory receptor, family 13, subfamily D, member 1
chr6_-_10939095 0.240 NM_005906
MAK
male germ cell-associated kinase
chr19_-_23225001 0.238 ZNF724P
zinc finger protein 724, pseudogene
chr19_+_21480229 0.237 NM_001001415
ZNF429
zinc finger protein 429
chr14_+_100365390 0.236 MEG3
maternally expressed 3 (non-protein coding)
chr5_-_149446182 0.236 CSF1R
colony stimulating factor 1 receptor
chr9_-_106407728 0.235 NM_001004481
OR13C2
olfactory receptor, family 13, subfamily C, member 2
chr17_-_77498399 0.233 NM_001145113
MYADML2
myeloid-associated differentiation marker-like 2
chr1_+_195010552 0.228 NM_001166624
NM_021023
CFHR3

complement factor H-related 3

chr10_+_29617995 0.226 NM_032517
LYZL1
lysozyme-like 1
chr1_-_180840016 0.224 NM_002928
RGS16
regulator of G-protein signaling 16
chr5_+_140742585 0.223 NM_018920
NM_032087
PCDHGA7

protocadherin gamma subfamily A, 7

chr11_+_59920062 0.222 NM_001079692
NM_032597
MS4A14

membrane-spanning 4-domains, subfamily A, member 14

chr17_+_44564820 0.219 NM_001159388
B4GALNT2
beta-1,4-N-acetyl-galactosaminyl transferase 2
chr1_+_150005754 0.217 NM_016178
OAZ3
ornithine decarboxylase antizyme 3
chr12_+_108452117 0.215 UBE3B
ubiquitin protein ligase E3B
chr15_+_92700167 0.214 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr12_-_10853940 0.214 NM_023917
TAS2R9
taste receptor, type 2, member 9
chr4_-_15549047 0.212 NM_005130
FGFBP1
fibroblast growth factor binding protein 1
chr9_-_21177529 0.210 NM_021068
IFNA4
interferon, alpha 4
chr8_-_7710547 0.210 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr1_-_197173159 0.210 LOC100131234
familial acute myelogenous leukemia related factor
chr1_+_51340487 0.210 NM_001136508
C1orf185
chromosome 1 open reading frame 185
chr9_+_101628829 0.209 NM_173200
NR4A3
nuclear receptor subfamily 4, group A, member 3
chrX_-_6156655 0.209 NM_181332
NLGN4X
neuroligin 4, X-linked
chr6_+_70633168 0.208 NM_001858
COL19A1
collagen, type XIX, alpha 1
chr3_-_17716515 0.208 NM_001134381
TBC1D5
TBC1 domain family, member 5
chr11_+_73339011 0.208 NM_153614
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr19_-_21438525 0.208


chr10_-_91092410 0.208 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr4_-_87247829 0.207 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr4_+_71283383 0.207 NM_006685
SMR3B
submaxillary gland androgen regulated protein 3B
chr12_+_52696908 0.205 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr13_-_47916803 0.200 NM_005767
LPAR6
lysophosphatidic acid receptor 6
chr1_-_67039518 0.199 NM_005478
INSL5
insulin-like 5
chr22_+_31526801 0.198 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr6_-_26216299 0.198 NM_005323
HIST1H1T
histone cluster 1, H1t
chr6_-_50097606 0.197 NM_001037497
NM_001037728
DEFB110

defensin, beta 110 locus

chr12_-_119249938 0.197 NM_000928
PLA2G1B
phospholipase A2, group IB (pancreas)
chr4_-_160175782 0.196 NM_152543
C4orf45
chromosome 4 open reading frame 45
chr1_+_171871283 0.195 NM_001195190
LOC730159
hypothetical protein LOC730159
chr1_-_42738535 0.194 TMSB4XP1
thymosin beta 4, X-linked pseudogene 1
chr3_+_160473784 0.193 SCHIP1
schwannomin interacting protein 1
chr5_+_76470829 0.192


chr11_+_63282639 0.191 RTN3
reticulon 3
chr11_-_113971607 0.191 FAM55D
family with sequence similarity 55, member D
chr19_+_7639971 0.189 NM_001193374
NM_020415
RETN

resistin

chr11_-_18214891 0.189 NM_006512
SAA4
serum amyloid A4, constitutive
chr5_-_22889487 0.187 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr3_+_150028130 0.186 NM_001871
CPB1
carboxypeptidase B1 (tissue)
chrX_-_2896285 0.186 ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr12_+_10222823 0.186 NM_153022
C12orf59
chromosome 12 open reading frame 59
chrX_+_82649924 0.186 NM_000307
POU3F4
POU class 3 homeobox 4
chr19_+_9347991 0.183 NM_001172651
ZNF177
zinc finger protein 177
chr10_+_13668944 0.183 NM_003675
PRPF18
PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.27 1.20e-12 GO:0007606 sensory perception of chemical stimulus
2.59 4.51e-12 GO:0007600 sensory perception
3.28 3.23e-11 GO:0007608 sensory perception of smell
1.97 4.11e-08 GO:0050877 neurological system process
1.83 1.05e-07 GO:0003008 system process
8.88 2.37e-05 GO:0060338 regulation of type I interferon-mediated signaling pathway
1.30 7.36e-04 GO:0032501 multicellular organismal process
5.08 1.88e-03 GO:0060337 type I interferon-mediated signaling pathway
5.08 1.88e-03 GO:0071357 cellular response to type I interferon
5.00 2.28e-03 GO:0034340 response to type I interferon

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.71 4.83e-08 GO:0005576 extracellular region
1.35 1.31e-04 GO:0005886 plasma membrane
1.29 2.11e-04 GO:0016021 integral to membrane
1.28 2.41e-04 GO:0031224 intrinsic to membrane
1.34 2.57e-04 GO:0071944 cell periphery
1.87 9.55e-04 GO:0005615 extracellular space
1.69 4.14e-03 GO:0044421 extracellular region part
1.22 4.68e-03 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.44 1.13e-12 GO:0004984 olfactory receptor activity
2.52 2.96e-12 GO:0004930 G-protein coupled receptor activity
2.11 7.25e-11 GO:0004888 transmembrane receptor activity
1.89 6.22e-10 GO:0004872 receptor activity
1.68 3.74e-07 GO:0004871 signal transducer activity
1.68 3.74e-07 GO:0060089 molecular transducer activity
21.19 6.28e-07 GO:0005132 interferon-alpha/beta receptor binding
3.58 2.57e-02 GO:0004867 serine-type endopeptidase inhibitor activity
4.96 2.63e-02 GO:0043498 cell surface binding
2.56 3.24e-02 GO:0005125 cytokine activity
2.62 3.41e-02 GO:0005126 cytokine receptor binding
1.78 4.91e-02 GO:0005509 calcium ion binding