Motif ID: bHLH_family.p2

Z-value: 2.035


Transcription factors associated with bHLH_family.p2:

Gene SymbolEntrez IDGene Name
ARNTL 406 aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 56938 aryl hydrocarbon receptor nuclear translocator-like 2
CLOCK 9575 clock homolog (mouse)
HES6 55502 hairy and enhancer of split 6 (Drosophila)
HEY1 23462 hairy/enhancer-of-split related with YRPW motif 1
HEY2 23493 hairy/enhancer-of-split related with YRPW motif 2
HEYL 26508 hairy/enhancer-of-split related with YRPW motif-like
ID1 3397 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MITF 4286 microphthalmia-associated transcription factor
MLXIPL 51085 MLX interacting protein-like
MNT 4335 MAX binding protein
MXD3 83463 MAX dimerization protein 3
MXD4 10608 MAX dimerization protein 4
MXI1 4601 MAX interactor 1
NPAS2 4862 neuronal PAS domain protein 2
OLIG1 116448 oligodendrocyte transcription factor 1
OLIG2 10215 oligodendrocyte lineage transcription factor 2
TFE3 7030 transcription factor binding to IGHM enhancer 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
OLIG1chr21_+_333643160.871.3e-05Click!
HEY2chr6_+_1261125880.731.4e-03Click!
ARNTL2chr12_+_27377034-0.721.6e-03Click!
MLXIPLchr7_-_726767500.711.9e-03Click!
MXD3chr5_-_1766718970.638.2e-03Click!
MXI1chr10_+_1119572920.591.7e-02Click!
HES6chr2_-_2388132840.458.2e-02Click!
HEYLchr1_-_39871226-0.391.4e-01Click!
TFE3chrX_-_48787876-0.371.5e-01Click!
ARNTLchr11_+_132559520.371.5e-01Click!
HEY1chr8_-_808424520.332.1e-01Click!
MNTchr17_-_22509670.253.5e-01Click!
OLIG2chr21_+_333200800.233.8e-01Click!
MITFchr3_+_70068440-0.204.6e-01Click!
MXD4chr4_-_22335040.136.4e-01Click!
CLOCKchr4_-_561077250.126.5e-01Click!
ID1chr20_+_296567440.116.9e-01Click!
NPAS2chr2_+_1008029230.077.9e-01Click!


Activity profile for motif bHLH_family.p2.

activity profile for motif bHLH_family.p2


Sorted Z-values histogram for motif bHLH_family.p2

Sorted Z-values for motif bHLH_family.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of bHLH_family.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_+_38720881 6.242 NM_138435
 FAM83F
family with sequence similarity 83, member F
chr1_+_148521852 3.365 NM_144697
 C1orf51
chromosome 1 open reading frame 51
chr8_+_120289735 3.328 NM_052886
 MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr15_-_81113676 3.275 NM_030594
 CPEB1
cytoplasmic polyadenylation element binding protein 1
chr2_+_176680251 2.656 NM_021192
 HOXD11
homeobox D11
chr13_+_32488477 2.606 NM_004795
 KL
klotho
chrX_-_107866262 2.532 NM_003604
 IRS4
insulin receptor substrate 4
chr2_+_74594093 2.520 TLX2
T-cell leukemia homeobox 2
chr5_+_132176921 2.501 NM_175873
 ANKRD43
ankyrin repeat domain 43
chr1_+_237616457 2.447 CHRM3
cholinergic receptor, muscarinic 3
chr2_-_172675480 2.446 NM_004405
 DLX2
distal-less homeobox 2
chr5_-_132976121 2.405 NM_015082
 FSTL4
follistatin-like 4
chr17_-_37586716 2.321 NM_012285
 KCNH4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr8_+_85258257 2.234 RALYL
RALY RNA binding protein-like
chr17_-_29930431 2.163 NM_207454
 C17orf102
chromosome 17 open reading frame 102
chr1_-_92721633 2.117 GFI1
growth factor independent 1 transcription repressor
chrX_-_131919896 2.066 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr11_+_45900731 2.023 GYLTL1B
glycosyltransferase-like 1B
chr11_-_61441536 2.017 NM_013401
 RAB3IL1
RAB3A interacting protein (rabin3)-like 1
chr8_+_85258056 1.973 NM_173848
 RALYL
RALY RNA binding protein-like

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 41 entries
enrichment   p-value GO term description
1.60 1.55e-04 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.59 1.22e-04 GO:0007417 central nervous system development
1.59 8.65e-03 GO:0007420 brain development
1.56 2.38e-02 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.55 6.90e-06 GO:0010628 positive regulation of gene expression
1.53 9.56e-03 GO:0032583 regulation of gene-specific transcription
1.52 2.07e-04 GO:0045893 positive regulation of transcription, DNA-dependent
1.48 5.29e-04 GO:0051254 positive regulation of RNA metabolic process
1.45 1.19e-04 GO:0031328 positive regulation of cellular biosynthetic process
1.45 5.32e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.44 6.42e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
1.44 1.12e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.43 3.02e-09 GO:0007399 nervous system development
1.43 1.50e-02 GO:0048878 chemical homeostasis
1.42 4.49e-04 GO:0009891 positive regulation of biosynthetic process
1.41 1.63e-04 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.38 2.21e-03 GO:0022008 neurogenesis
1.38 6.45e-03 GO:0048699 generation of neurons
1.38 1.04e-02 GO:0055085 transmembrane transport
1.36 7.48e-03 GO:0048468 cell development

Gene overrepresentation in compartment category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
1.37 4.80e-03 GO:0031988 membrane-bounded vesicle
1.35 1.95e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.34 1.05e-02 GO:0031982 vesicle
1.33 2.48e-02 GO:0031410 cytoplasmic vesicle
1.20 7.15e-03 GO:0044459 plasma membrane part
1.11 1.49e-03 GO:0044444 cytoplasmic part
1.11 5.99e-03 GO:0044422 organelle part
1.11 9.83e-03 GO:0044446 intracellular organelle part
1.10 6.61e-05 GO:0005737 cytoplasm
1.07 4.22e-03 GO:0043226 organelle
1.07 7.65e-03 GO:0043229 intracellular organelle
1.06 4.93e-04 GO:0044424 intracellular part
1.06 6.61e-04 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
1.68 2.43e-04 GO:0016563 transcription activator activity
1.62 4.17e-09 GO:0043565 sequence-specific DNA binding
1.42 5.82e-06 GO:0030528 transcription regulator activity
1.40 7.44e-03 GO:0046983 protein dimerization activity
1.38 1.65e-04 GO:0001071 nucleic acid binding transcription factor activity
1.38 1.65e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.35 2.36e-03 GO:0022857 transmembrane transporter activity
1.34 7.79e-03 GO:0022891 substrate-specific transmembrane transporter activity
1.28 1.38e-02 GO:0005215 transporter activity
1.28 4.76e-02 GO:0022892 substrate-specific transporter activity
1.11 1.88e-04 GO:0005515 protein binding
1.05 8.95e-03 GO:0005488 binding