Motif ID: MTF1.p2

Z-value: 3.294


Transcription factors associated with MTF1.p2:

Gene SymbolEntrez IDGene Name
MTF1 4520 metal-regulatory transcription factor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MTF1chr1_-_38097811-0.391.4e-01Click!


Activity profile for motif MTF1.p2.

activity profile for motif MTF1.p2


Sorted Z-values histogram for motif MTF1.p2

Sorted Z-values for motif MTF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MTF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_121893468 5.971 NM_021021
SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr15_-_27650218 5.599 NM_015307
FAM189A1
family with sequence similarity 189, member A1
chr14_+_101097440 5.076 NM_001362
DIO3
deiodinase, iodothyronine, type III
chr8_-_121893449 4.823 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr5_-_11957127 4.797 CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr9_+_90339835 4.555 NM_001161625
NM_145283
NXNL2

nucleoredoxin-like 2

chr8_+_56177567 4.499 NM_052898
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr18_+_74841262 4.367 NM_171999
SALL3
sal-like 3 (Drosophila)
chr10_-_103525646 4.206 NM_006119
NM_033163
NM_033164
NM_033165
FGF8



fibroblast growth factor 8 (androgen-induced)



chr5_-_11956964 4.174 NM_001332
CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr19_+_1704661 4.026 NM_001080488
ONECUT3
one cut homeobox 3
chr16_-_87535106 3.930 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr8_-_121892877 3.807 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr8_-_121893196 3.789


chr8_-_140784416 3.765 NM_016601
KCNK9
potassium channel, subfamily K, member 9
chr10_+_83625049 3.607 NM_001010848
NM_001165972
NRG3

neuregulin 3

chr16_-_51138306 3.601 NM_001080430
TOX3
TOX high mobility group box family member 3
chr9_+_139892049 3.598 NM_000718
CACNA1B
calcium channel, voltage-dependent, N type, alpha 1B subunit
chr11_-_2863536 3.576 NM_000076
NM_001122630
NM_001122631
CDKN1C


cyclin-dependent kinase inhibitor 1C (p57, Kip2)


chr2_+_74595073 3.465 NM_016170
TLX2
T-cell leukemia homeobox 2
chrX_+_68641802 3.211 NM_015686
FAM155B
family with sequence similarity 155, member B
chr16_+_1143738 3.208 CACNA1H
calcium channel, voltage-dependent, T type, alpha 1H subunit
chr9_-_93751900 3.199 NM_004560
ROR2
receptor tyrosine kinase-like orphan receptor 2
chr3_-_62835601 3.051


chr16_+_55180767 3.042 NM_005954
MT3
metallothionein 3
chr2_+_238060602 2.948 NM_001042467
NM_024101
MLPH

melanophilin

chr11_+_125279481 2.930 NM_013264
DDX25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr19_-_14177980 2.913 NM_001008701
NM_014921
LPHN1

latrophilin 1

chr13_+_111769913 2.894 NM_005986
SOX1
SRY (sex determining region Y)-box 1
chr2_+_120820140 2.842 NM_002193
INHBB
inhibin, beta B
chr8_+_121892719 2.819


chr10_-_131652364 2.709 EBF3
early B-cell factor 3
chr9_-_95757365 2.699 NM_021570
BARX1
BARX homeobox 1
chr7_+_86111887 2.674 GRM3
glutamate receptor, metabotropic 3
chr10_-_44200458 2.657 NM_000609
NM_001033886
NM_001178134
NM_199168
CXCL12



chemokine (C-X-C motif) ligand 12



chr1_-_92721633 2.656 GFI1
growth factor independent 1 transcription repressor
chr10_-_28074752 2.645 NM_173576
MKX
mohawk homeobox
chr2_-_233501069 2.622 NM_001114090
NGEF
neuronal guanine nucleotide exchange factor
chr15_+_77511912 2.619 NM_015206
KIAA1024
KIAA1024
chr9_+_125813849 2.602 LHX2
LIM homeobox 2
chr12_+_2032649 2.600 NM_000719
NM_001129827
NM_001129829
NM_001129830
NM_001129831
NM_001129832
NM_001129833
NM_001129834
NM_001129835
NM_001129836
NM_001129837
NM_001129838
NM_001129839
NM_001129840
NM_001129841
NM_001129842
NM_001129843
NM_001129844
NM_001129846
NM_001167623
NM_001167624
NM_001167625
NM_199460
CACNA1C






















calcium channel, voltage-dependent, L type, alpha 1C subunit






















chr7_-_35260213 2.591 NM_001077653
NM_001166220
TBX20

T-box 20

chr9_-_95757448 2.577 BARX1
BARX homeobox 1
chr10_-_135088065 2.569 NM_001012508
SPRN
shadow of prion protein homolog (zebrafish)
chr7_+_86111803 2.517 GRM3
glutamate receptor, metabotropic 3
chr7_+_86112012 2.499 GRM3
glutamate receptor, metabotropic 3
chr11_-_2248757 2.480 NM_005170
ASCL2
achaete-scute complex homolog 2 (Drosophila)
chr16_+_82559600 2.466 NM_019065
NECAB2
N-terminal EF-hand calcium binding protein 2
chr13_-_50315832 2.450 NM_198989
DLEU7
deleted in lymphocytic leukemia, 7
chr10_+_133850325 2.439 NM_006426
DPYSL4
dihydropyrimidinase-like 4
chr14_+_105012106 2.391 NM_001312
CRIP2
cysteine-rich protein 2
chr7_-_158630223 2.343 NM_003382
VIPR2
vasoactive intestinal peptide receptor 2
chr4_-_46690197 2.324 NM_000809
GABRA4
gamma-aminobutyric acid (GABA) A receptor, alpha 4
chr20_+_20296744 2.312 NM_002196
INSM1
insulinoma-associated 1
chr19_+_1397268 2.308 APC2
adenomatosis polyposis coli 2
chr14_+_73775927 2.281 NM_182894
VSX2
visual system homeobox 2
chr14_+_99181232 2.232 NM_001127258
NM_032425
HHIPL1

HHIP-like 1

chr2_-_278181 2.229 NM_001002919
FAM150B
family with sequence similarity 150, member B
chr5_+_170668892 2.221 NM_021025
TLX3
T-cell leukemia homeobox 3
chr1_-_50661716 2.170 NM_032110
DMRTA2
DMRT-like family A2
chr2_-_230287442 2.159 NM_139072
DNER
delta/notch-like EGF repeat containing
chr11_+_627268 2.148 NM_000797
DRD4
dopamine receptor D4
chr6_+_69401660 2.135 NM_001704
BAI3
brain-specific angiogenesis inhibitor 3
chr20_-_538909 2.125 NM_004609
TCF15
transcription factor 15 (basic helix-loop-helix)
chr19_-_19233370 2.086 HAPLN4
hyaluronan and proteoglycan link protein 4
chr22_+_24895623 2.083 SEZ6L
seizure related 6 homolog (mouse)-like
chr9_+_94987032 2.076 NM_006648
WNK2
WNK lysine deficient protein kinase 2
chr10_-_128884411 2.051 NM_001039762
FAM196A
family with sequence similarity 196, member A
chr5_+_133478252 2.028 NM_003202
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr11_-_64268841 2.019 NM_001098670
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr3_-_48607596 2.016 NM_000094
COL7A1
collagen, type VII, alpha 1
chr22_+_42138034 2.000 MPPED1
metallophosphoesterase domain containing 1
chr4_+_3737872 1.993 ADRA2C
adrenergic, alpha-2C-, receptor
chr1_-_1525309 1.990 LOC643988
hypothetical LOC643988
chr3_-_10724715 1.988 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr18_-_4445247 1.984 DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr11_+_110675175 1.983 NM_001136105
C11orf93
chromosome 11 open reading frame 93
chr12_+_130878870 1.956 NM_016155
MMP17
matrix metallopeptidase 17 (membrane-inserted)
chr2_+_202607554 1.949 NM_003507
FZD7
frizzled homolog 7 (Drosophila)
chr1_+_177979037 1.947 FAM163A
family with sequence similarity 163, member A
chr10_+_69990050 1.946 NM_030625
TET1
tet oncogene 1
chr12_+_111980044 1.921 NM_004416
DTX1
deltex homolog 1 (Drosophila)
chr22_+_42137955 1.902 NM_001044370
MPPED1
metallophosphoesterase domain containing 1
chr2_+_231610438 1.888 NM_001144994
C2orf72
chromosome 2 open reading frame 72
chr4_-_13158391 1.882 LOC285548
hypothetical LOC285548
chr4_+_3738093 1.878 NM_000683
ADRA2C
adrenergic, alpha-2C-, receptor
chr22_-_28041474 1.871 RASL10A
RAS-like, family 10, member A
chr11_-_64269501 1.870 NM_153819
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr22_-_45311730 1.870 NM_014246
CELSR1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
chr12_-_56418295 1.852 NM_001122772
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr16_+_54782802 1.843 GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr2_+_100087812 1.836


chr3_+_71885890 1.811 NM_018971
GPR27
G protein-coupled receptor 27
chr1_-_925332 1.799 NM_001142467
NM_021170
HES4

hairy and enhancer of split 4 (Drosophila)

chr15_+_90738108 1.786 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr2_-_204108151 1.784 NM_203365
NM_213589
RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

chr19_+_38377329 1.779 NM_002333
LRP3
low density lipoprotein receptor-related protein 3
chr17_-_34015631 1.765 NM_025248
SRCIN1
SRC kinase signaling inhibitor 1
chr11_+_359723 1.758 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr1_-_26245031 1.754 NM_001004434
NM_032513
SLC30A2

solute carrier family 30 (zinc transporter), member 2

chr22_+_24895454 1.748 SEZ6L
seizure related 6 homolog (mouse)-like
chr16_-_695719 1.731 NM_153350
FBXL16
F-box and leucine-rich repeat protein 16
chr22_+_24895424 1.723 NM_001184773
NM_001184774
NM_001184775
NM_001184776
NM_001184777
NM_021115
SEZ6L





seizure related 6 homolog (mouse)-like





chr3_+_3816079 1.721 NM_020873
LRRN1
leucine rich repeat neuronal 1
chr1_+_52871603 1.718 NM_001042693
FAM159A
family with sequence similarity 159, member A
chr22_-_43783449 1.708 PHF21B
PHD finger protein 21B
chr11_+_17697685 1.698 NM_002478
MYOD1
myogenic differentiation 1
chrX_-_71442488 1.688 NM_001144885
NM_001144887
CITED1

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1

chr11_+_14621972 1.685 PDE3B
phosphodiesterase 3B, cGMP-inhibited
chr17_-_29930431 1.683 NM_207454
C17orf102
chromosome 17 open reading frame 102
chr6_+_137285071 1.678 NM_001008783
SLC35D3
solute carrier family 35, member D3
chrX_+_152561086 1.675 NM_001395
DUSP9
dual specificity phosphatase 9
chr4_+_4912272 1.657 NM_002448
MSX1
msh homeobox 1
chr1_+_2975590 1.652 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr10_+_94439658 1.647 NM_002729
HHEX
hematopoietically expressed homeobox
chr12_+_5411534 1.645 NM_001102654
NTF3
neurotrophin 3
chr16_+_1143241 1.638 NM_001005407
NM_021098
CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr14_-_99695684 1.628 NM_206918
DEGS2
degenerative spermatocyte homolog 2, lipid desaturase (Drosophila)
chrX_-_132376660 1.626 NM_001448
GPC4
glypican 4
chr1_+_235272324 1.624 NM_001035
RYR2
ryanodine receptor 2 (cardiac)
chr3_-_69064364 1.621 NM_001005527
NM_182522
FAM19A4

family with sequence similarity 19 (chemokine (C-C motif)-like), member A4

chr8_+_26427378 1.621 NM_001197293
DPYSL2
dihydropyrimidinase-like 2
chr1_-_23623713 1.619 NM_003196
TCEA3
transcription elongation factor A (SII), 3
chr22_+_49386044 1.616 MAPK8IP2
mitogen-activated protein kinase 8 interacting protein 2
chr4_+_2031036 1.609 NM_178557
NAT8L
N-acetyltransferase 8-like (GCN5-related, putative)
chr14_+_95412481 1.593


chr22_-_43784093 1.582 NM_138415
PHF21B
PHD finger protein 21B
chr12_+_48641545 1.576 NM_001651
AQP5
aquaporin 5
chr13_+_48692472 1.572 NM_001507
MLNR
motilin receptor
chr10_+_134751398 1.570 NM_001083909
GPR123
G protein-coupled receptor 123
chr15_+_78483624 1.561 NM_014862
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr11_-_69343128 1.559 NM_005247
FGF3
fibroblast growth factor 3
chr17_+_11085464 1.559 NM_001173461
NM_001173462
NM_207386
SHISA6


shisa homolog 6 (Xenopus laevis)


chr17_-_5344898 1.559 NM_001162371
LOC728392
hypothetical protein LOC728392
chr22_+_47263919 1.558 NM_001082967
FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr1_+_226937732 1.555 RHOU
ras homolog gene family, member U
chr20_-_22514092 1.539 NM_153675
FOXA2
forkhead box A2
chr9_+_78824390 1.539 NM_001013735
FOXB2
forkhead box B2
chr10_+_23521464 1.534 NM_178161
PTF1A
pancreas specific transcription factor, 1a
chr21_+_42946719 1.533 NM_001001567
NM_001001568
NM_001001569
NM_001001570
NM_001001571
NM_001001572
NM_001001573
NM_001001574
NM_001001575
NM_001001576
NM_001001577
NM_001001578
NM_001001579
NM_001001580
NM_001001581
NM_001001582
NM_001001583
NM_001001584
NM_001001585
NM_002606
PDE9A



















phosphodiesterase 9A



















chr7_+_3307445 1.528 NM_152744
SDK1
sidekick homolog 1, cell adhesion molecule (chicken)
chr12_+_131705438 1.527 NM_012226
NM_016318
NM_170682
NM_170683
NM_174872
NM_174873
P2RX2





purinergic receptor P2X, ligand-gated ion channel, 2





chr16_+_25610847 1.524 NM_006040
HS3ST4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr5_+_38294289 1.520 NM_152403
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr10_+_50488352 1.519 NM_003055
SLC18A3
solute carrier family 18 (vesicular acetylcholine), member 3
chr2_+_5750229 1.514 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr1_-_239587007 1.511 RGS7
regulator of G-protein signaling 7
chr4_+_36923084 1.508 NM_001144990
KIAA1239
KIAA1239
chr1_-_925215 1.488 HES4
hairy and enhancer of split 4 (Drosophila)
chr6_-_165996031 1.484 LOC100132188
LP7097
chr2_-_128792515 1.481 NM_004807
HS6ST1
heparan sulfate 6-O-sulfotransferase 1
chr20_-_60484420 1.468 NM_080473
GATA5
GATA binding protein 5
chr16_-_2186465 1.465 NM_020764
CASKIN1
CASK interacting protein 1
chr16_+_65754788 1.464 NM_001040667
NM_001538
HSF4

heat shock transcription factor 4

chr2_+_936534 1.455 NM_018968
SNTG2
syntrophin, gamma 2
chr8_-_133562185 1.454 NM_004519
KCNQ3
potassium voltage-gated channel, KQT-like subfamily, member 3
chr9_+_70509925 1.445 NM_003558
PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr22_+_28446288 1.442 NM_182527
CABP7
calcium binding protein 7
chr6_+_159510416 1.435 NM_032532
FNDC1
fibronectin type III domain containing 1
chrX_-_138114100 1.435 FGF13
fibroblast growth factor 13
chr17_-_47590975 1.434 CA10
carbonic anhydrase X
chr1_-_38285033 1.430 NM_002699
POU3F1
POU class 3 homeobox 1
chr18_-_4445265 1.428 DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr10_-_88116181 1.426 NM_017551
GRID1
glutamate receptor, ionotropic, delta 1
chr8_-_26427304 1.422 NM_007257
PNMA2
paraneoplastic antigen MA2
chr19_-_16998449 1.418 NM_015692
CPAMD8
C3 and PZP-like, alpha-2-macroglobulin domain containing 8
chr13_+_32488477 1.418 NM_004795
KL
klotho
chr20_-_41251878 1.415 NM_007050
NM_133170
PTPRT

protein tyrosine phosphatase, receptor type, T

chr2_-_106869488 1.414


chr22_+_27931685 1.410 NM_133455
EMID1
EMI domain containing 1
chr5_+_149526533 1.408 NM_001804
CDX1
caudal type homeobox 1
chr16_+_88169612 1.388 NM_014427
NM_153636
CPNE7

copine VII

chr17_-_47591123 1.385 NM_020178
CA10
carbonic anhydrase X
chr12_+_2774362 1.377 NM_002014
FKBP4
FK506 binding protein 4, 59kDa
chr3_-_129694717 1.377 NM_032638
GATA2
GATA binding protein 2
chr1_-_57661373 1.373 DAB1
disabled homolog 1 (Drosophila)
chrX_-_8660132 1.368 KAL1
Kallmann syndrome 1 sequence
chr3_+_13565644 1.365 FBLN2
fibulin 2
chr16_-_49742651 1.358 NM_002968
SALL1
sal-like 1 (Drosophila)
chr3_-_50515857 1.357 NM_001005505
NM_001174051
NM_006030
CACNA2D2


calcium channel, voltage-dependent, alpha 2/delta subunit 2


chr1_-_218168548 1.353 NM_018713
SLC30A10
solute carrier family 30, member 10
chr8_+_136538739 1.353 NM_006558
KHDRBS3
KH domain containing, RNA binding, signal transduction associated 3
chr19_-_18198234 1.352 NM_001098818
PDE4C
phosphodiesterase 4C, cAMP-specific
chr9_+_99656013 1.349


chr22_-_37180958 1.339 NM_152868
KCNJ4
potassium inwardly-rectifying channel, subfamily J, member 4
chr22_-_22511173 1.335 NM_001002862
NM_001135751
NM_198440
DERL3


Der1-like domain family, member 3


chr14_-_59113301 1.331 NM_001164399
C14orf38
chromosome 14 open reading frame 38
chr17_+_40089270 1.328 NM_001145080
C17orf104
chromosome 17 open reading frame 104
chr2_+_208979800 1.327 NM_005048
PTH2R
parathyroid hormone 2 receptor
chr22_+_47350781 1.316 NM_015381
FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr5_+_3649167 1.314 NM_024337
IRX1
iroquois homeobox 1
chr1_-_37272295 1.314 NM_000831
GRIK3
glutamate receptor, ionotropic, kainate 3
chr4_+_77391876 1.313 NM_001136570
FAM47E
family with sequence similarity 47, member E
chr10_+_50487146 1.313 NM_020984
CHAT
choline O-acetyltransferase
chr19_+_659766 1.310 NM_001040134
NM_002579
PALM

paralemmin

chr16_-_30288988 1.302 NM_015527
TBC1D10B
TBC1 domain family, member 10B
chr2_+_42128521 1.302 NM_138370
PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr17_+_56831951 1.300 NM_005994
TBX2
T-box 2
chr7_+_100156358 1.300 NM_000799
EPO
erythropoietin
chr20_+_60918836 1.299 NM_001853
COL9A3
collagen, type IX, alpha 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.70 9.41e-35 GO:0007399 nervous system development
1.86 9.84e-31 GO:0022008 neurogenesis
1.86 4.65e-29 GO:0048699 generation of neurons
1.43 5.29e-28 GO:0048731 system development
1.37 2.47e-27 GO:0007275 multicellular organismal development
1.89 2.58e-24 GO:0030182 neuron differentiation
1.33 5.33e-24 GO:0032502 developmental process
1.37 1.66e-23 GO:0048856 anatomical structure development
1.47 2.06e-22 GO:0030154 cell differentiation
1.44 7.71e-21 GO:0048869 cellular developmental process
1.48 2.07e-18 GO:0023051 regulation of signaling
1.66 2.36e-18 GO:0048468 cell development
1.83 7.83e-17 GO:0048666 neuron development
1.28 8.13e-17 GO:0023052 signaling
1.87 2.82e-16 GO:0000904 cell morphogenesis involved in differentiation
1.52 3.42e-16 GO:0051239 regulation of multicellular organismal process
1.86 1.14e-15 GO:0031175 neuron projection development
1.92 1.44e-15 GO:0048667 cell morphogenesis involved in neuron differentiation
1.10 1.56e-15 GO:0009987 cellular process
1.61 2.97e-15 GO:0050793 regulation of developmental process
1.84 3.30e-15 GO:0007417 central nervous system development
1.72 3.32e-15 GO:0045595 regulation of cell differentiation
1.47 3.51e-15 GO:0009653 anatomical structure morphogenesis
1.56 7.98e-15 GO:0010646 regulation of cell communication
1.15 9.11e-15 GO:0065007 biological regulation
1.88 1.09e-14 GO:0048812 neuron projection morphogenesis
1.90 2.05e-14 GO:0007409 axonogenesis
1.16 1.07e-13 GO:0050794 regulation of cellular process
1.20 1.52e-13 GO:0032501 multicellular organismal process
1.62 1.23e-12 GO:2000026 regulation of multicellular organismal development
1.15 2.50e-12 GO:0050789 regulation of biological process
1.69 4.00e-12 GO:0000902 cell morphogenesis
1.76 5.26e-12 GO:0048858 cell projection morphogenesis
1.75 5.97e-12 GO:0032990 cell part morphogenesis
1.66 6.58e-12 GO:0030030 cell projection organization
1.36 9.39e-12 GO:0048513 organ development
1.66 1.16e-11 GO:0032989 cellular component morphogenesis
1.42 1.53e-11 GO:0009966 regulation of signal transduction
1.73 6.72e-11 GO:0019226 transmission of nerve impulse
1.73 6.72e-11 GO:0035637 multicellular organismal signaling
1.32 1.30e-10 GO:0048523 negative regulation of cellular process
1.88 1.57e-10 GO:0007411 axon guidance
1.90 1.68e-10 GO:0060284 regulation of cell development
1.96 2.22e-10 GO:0051960 regulation of nervous system development
1.24 5.23e-10 GO:0007165 signal transduction
1.58 1.23e-09 GO:0009790 embryo development
2.39 1.50e-09 GO:0022604 regulation of cell morphogenesis
1.74 1.63e-09 GO:0007268 synaptic transmission
1.29 1.80e-09 GO:0048519 negative regulation of biological process
1.23 2.05e-09 GO:0051179 localization
2.37 3.63e-09 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.66 5.15e-09 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.33 5.65e-09 GO:0007166 cell surface receptor linked signaling pathway
1.82 7.72e-09 GO:0045597 positive regulation of cell differentiation
1.85 9.08e-09 GO:0022603 regulation of anatomical structure morphogenesis
1.95 1.27e-08 GO:0050767 regulation of neurogenesis
1.57 1.90e-08 GO:0007167 enzyme linked receptor protein signaling pathway
1.45 2.79e-08 GO:0032879 regulation of localization
1.24 3.24e-08 GO:0006810 transport
1.24 3.98e-08 GO:0051234 establishment of localization
1.77 5.72e-08 GO:0007389 pattern specification process
1.67 6.23e-08 GO:0023057 negative regulation of signaling
1.75 6.77e-08 GO:0007420 brain development
1.67 8.39e-08 GO:0051094 positive regulation of developmental process
1.43 9.00e-08 GO:0007154 cell communication
1.50 1.13e-07 GO:0007267 cell-cell signaling
1.57 1.21e-07 GO:0009887 organ morphogenesis
1.66 1.61e-07 GO:0010648 negative regulation of cell communication
1.29 8.91e-07 GO:0048583 regulation of response to stimulus
1.49 1.01e-06 GO:0051049 regulation of transport
1.94 1.32e-06 GO:0045664 regulation of neuron differentiation
1.72 1.82e-06 GO:0044057 regulation of system process
2.31 1.93e-06 GO:0010720 positive regulation of cell development
1.18 2.03e-06 GO:0051716 cellular response to stimulus
1.64 2.25e-06 GO:0009968 negative regulation of signal transduction
1.25 2.73e-06 GO:0042221 response to chemical stimulus
1.24 4.70e-06 GO:0048522 positive regulation of cellular process
2.21 4.74e-06 GO:0050804 regulation of synaptic transmission
1.22 7.11e-06 GO:0048518 positive regulation of biological process
1.60 1.06e-05 GO:0060341 regulation of cellular localization
1.40 1.54e-05 GO:0006811 ion transport
1.80 2.10e-05 GO:0048568 embryonic organ development
1.62 3.05e-05 GO:0009792 embryo development ending in birth or egg hatching
2.00 3.10e-05 GO:0045165 cell fate commitment
2.10 3.14e-05 GO:0010975 regulation of neuron projection development
2.07 4.30e-05 GO:0051969 regulation of transmission of nerve impulse
1.61 5.68e-05 GO:0043009 chordate embryonic development
2.36 6.96e-05 GO:0021953 central nervous system neuron differentiation
1.39 7.93e-05 GO:0040011 locomotion
2.17 7.99e-05 GO:0006836 neurotransmitter transport
1.45 8.33e-05 GO:0009719 response to endogenous stimulus
2.43 9.04e-05 GO:0050770 regulation of axonogenesis
1.56 9.57e-05 GO:0032583 regulation of gene-specific transcription
2.33 1.10e-04 GO:0050769 positive regulation of neurogenesis
1.60 1.12e-04 GO:0048598 embryonic morphogenesis
1.50 1.20e-04 GO:0023056 positive regulation of signaling
1.50 1.35e-04 GO:0010647 positive regulation of cell communication
1.52 1.36e-04 GO:0030001 metal ion transport
1.98 1.36e-04 GO:0031644 regulation of neurological system process
1.94 1.60e-04 GO:0031344 regulation of cell projection organization
2.11 1.66e-04 GO:0003001 generation of a signal involved in cell-cell signaling
2.11 1.66e-04 GO:0023061 signal release
1.74 1.81e-04 GO:0003002 regionalization
1.23 1.84e-04 GO:0065008 regulation of biological quality
1.35 2.49e-04 GO:0009605 response to external stimulus
1.70 2.84e-04 GO:0045596 negative regulation of cell differentiation
1.51 3.58e-04 GO:0048646 anatomical structure formation involved in morphogenesis
2.20 4.12e-04 GO:0001505 regulation of neurotransmitter levels
1.49 4.13e-04 GO:0048585 negative regulation of response to stimulus
1.63 4.35e-04 GO:0007610 behavior
1.84 5.66e-04 GO:0030900 forebrain development
1.66 5.72e-04 GO:0035295 tube development
1.37 6.93e-04 GO:0051128 regulation of cellular component organization
1.60 7.30e-04 GO:0051093 negative regulation of developmental process
1.48 8.42e-04 GO:0009967 positive regulation of signal transduction
2.30 8.92e-04 GO:0010721 negative regulation of cell development
1.44 1.05e-03 GO:0006812 cation transport
1.63 1.27e-03 GO:0007423 sensory organ development
1.42 1.49e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.70 1.54e-03 GO:0002009 morphogenesis of an epithelium
1.76 1.69e-03 GO:0032582 negative regulation of gene-specific transcription
1.69 1.92e-03 GO:0032868 response to insulin stimulus
1.37 2.34e-03 GO:0007155 cell adhesion
1.37 2.34e-03 GO:0022610 biological adhesion
1.44 2.60e-03 GO:0051253 negative regulation of RNA metabolic process
1.54 2.69e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.56 2.71e-03 GO:0043434 response to peptide hormone stimulus
1.51 3.04e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.28 3.04e-03 GO:0010033 response to organic substance
1.44 3.23e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.15 3.42e-03 GO:0080090 regulation of primary metabolic process
1.45 3.45e-03 GO:0006935 chemotaxis
1.45 3.45e-03 GO:0042330 taxis
1.40 3.60e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.84 3.93e-03 GO:0034762 regulation of transmembrane transport
1.82 4.19e-03 GO:0048562 embryonic organ morphogenesis
1.16 4.39e-03 GO:0016043 cellular component organization
1.89 4.75e-03 GO:0030111 regulation of Wnt receptor signaling pathway
1.74 5.32e-03 GO:0035239 tube morphogenesis
1.33 5.32e-03 GO:0009888 tissue development
1.80 5.41e-03 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.31 5.65e-03 GO:0042127 regulation of cell proliferation
1.47 6.25e-03 GO:0046903 secretion
1.45 7.30e-03 GO:0072358 cardiovascular system development
1.45 7.30e-03 GO:0072359 circulatory system development
1.39 7.54e-03 GO:0001932 regulation of protein phosphorylation
1.17 7.78e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.39 8.26e-03 GO:0009725 response to hormone stimulus
1.15 8.48e-03 GO:0031323 regulation of cellular metabolic process
1.78 8.93e-03 GO:0006813 potassium ion transport
1.37 9.80e-03 GO:0010628 positive regulation of gene expression
1.37 9.80e-03 GO:0042325 regulation of phosphorylation
1.36 9.85e-03 GO:0009890 negative regulation of biosynthetic process
1.56 1.02e-02 GO:0048729 tissue morphogenesis
1.15 1.03e-02 GO:0071840 cellular component organization or biogenesis
2.26 1.07e-02 GO:0007269 neurotransmitter secretion
1.17 1.20e-02 GO:0051171 regulation of nitrogen compound metabolic process
1.36 1.23e-02 GO:0019220 regulation of phosphate metabolic process
1.36 1.23e-02 GO:0051174 regulation of phosphorus metabolic process
1.33 1.26e-02 GO:0055085 transmembrane transport
1.80 1.36e-02 GO:0001655 urogenital system development
1.36 1.37e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.38 1.49e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.92 1.55e-02 GO:0007611 learning or memory
1.87 1.59e-02 GO:0050890 cognition
1.17 1.66e-02 GO:0071842 cellular component organization at cellular level
1.52 1.66e-02 GO:0071495 cellular response to endogenous stimulus
1.53 1.73e-02 GO:0051046 regulation of secretion
1.45 1.77e-02 GO:0006873 cellular ion homeostasis
1.24 1.81e-02 GO:0065009 regulation of molecular function
1.37 1.90e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
2.67 2.05e-02 GO:0050772 positive regulation of axonogenesis
2.25 2.45e-02 GO:0050768 negative regulation of neurogenesis
1.52 2.58e-02 GO:0032940 secretion by cell
1.24 2.61e-02 GO:0035556 intracellular signal transduction
2.04 2.94e-02 GO:0008016 regulation of heart contraction
1.29 3.00e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.89 3.02e-02 GO:0072001 renal system development
1.61 3.23e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.13 3.32e-02 GO:0019222 regulation of metabolic process
1.97 3.36e-02 GO:0021537 telencephalon development
1.14 3.46e-02 GO:0060255 regulation of macromolecule metabolic process
3.67 3.77e-02 GO:0032228 regulation of synaptic transmission, GABAergic
1.88 4.00e-02 GO:0050796 regulation of insulin secretion
1.81 4.19e-02 GO:0043010 camera-type eye development
1.16 4.22e-02 GO:0071841 cellular component organization or biogenesis at cellular level
1.28 4.32e-02 GO:0006793 phosphorus metabolic process
1.28 4.32e-02 GO:0006796 phosphate metabolic process
1.49 4.59e-02 GO:0015672 monovalent inorganic cation transport
1.50 4.85e-02 GO:0001501 skeletal system development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.35 2.77e-14 GO:0044459 plasma membrane part
1.76 8.69e-11 GO:0045202 synapse
1.82 5.19e-09 GO:0044456 synapse part
1.49 1.34e-06 GO:0030054 cell junction
1.31 1.06e-05 GO:0031226 intrinsic to plasma membrane
1.56 4.02e-05 GO:0031012 extracellular matrix
1.30 4.34e-05 GO:0005887 integral to plasma membrane
1.14 1.09e-04 GO:0005886 plasma membrane
1.14 1.97e-04 GO:0071944 cell periphery
1.09 5.60e-04 GO:0016020 membrane
1.55 8.95e-04 GO:0005578 proteinaceous extracellular matrix
2.06 1.23e-03 GO:0008021 synaptic vesicle
1.80 2.97e-03 GO:0034703 cation channel complex
1.05 4.73e-03 GO:0044424 intracellular part
1.03 6.54e-03 GO:0044464 cell part
1.03 6.88e-03 GO:0005623 cell
1.07 1.60e-02 GO:0005737 cytoplasm
1.57 1.93e-02 GO:0034702 ion channel complex
1.41 2.07e-02 GO:0043005 neuron projection
1.95 2.34e-02 GO:0014069 postsynaptic density
1.42 2.51e-02 GO:0009986 cell surface
2.33 2.57e-02 GO:0044306 neuron projection terminus
1.04 2.65e-02 GO:0005622 intracellular
1.67 2.66e-02 GO:0045211 postsynaptic membrane
1.23 3.21e-02 GO:0000267 cell fraction
1.88 3.55e-02 GO:0008076 voltage-gated potassium channel complex
1.88 3.55e-02 GO:0034705 potassium channel complex
1.50 3.81e-02 GO:0005667 transcription factor complex
2.33 3.90e-02 GO:0043679 axon terminus
1.28 4.92e-02 GO:0031988 membrane-bounded vesicle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.61 4.49e-12 GO:0043565 sequence-specific DNA binding
1.44 3.50e-09 GO:0001071 nucleic acid binding transcription factor activity
1.44 3.50e-09 GO:0003700 sequence-specific DNA binding transcription factor activity
1.61 1.10e-06 GO:0022803 passive transmembrane transporter activity
1.60 1.80e-06 GO:0015267 channel activity
1.62 1.87e-06 GO:0005216 ion channel activity
1.41 1.99e-06 GO:0022891 substrate-specific transmembrane transporter activity
1.75 2.00e-06 GO:0005261 cation channel activity
2.42 2.02e-06 GO:0019199 transmembrane receptor protein kinase activity
1.11 2.06e-06 GO:0005515 protein binding
1.51 2.28e-06 GO:0008324 cation transmembrane transporter activity
1.39 2.46e-06 GO:0022857 transmembrane transporter activity
1.44 2.70e-06 GO:0015075 ion transmembrane transporter activity
1.60 2.92e-06 GO:0022838 substrate-specific channel activity
1.66 1.38e-05 GO:0022836 gated channel activity
1.35 2.08e-05 GO:0022892 substrate-specific transporter activity
1.32 2.41e-05 GO:0005215 transporter activity
1.06 3.06e-05 GO:0005488 binding
1.76 1.28e-04 GO:0000975 regulatory region DNA binding
1.76 1.28e-04 GO:0001067 regulatory region nucleic acid binding
1.76 1.28e-04 GO:0044212 transcription regulatory region DNA binding
1.33 1.39e-04 GO:0030528 transcription regulator activity
1.77 2.19e-04 GO:0005244 voltage-gated ion channel activity
1.77 2.19e-04 GO:0022832 voltage-gated channel activity
1.76 2.24e-04 GO:0010843 promoter binding
2.37 3.19e-04 GO:0004714 transmembrane receptor protein tyrosine kinase activity
1.87 4.09e-04 GO:0022843 voltage-gated cation channel activity
1.89 1.23e-03 GO:0005267 potassium channel activity
2.16 6.22e-03 GO:0030165 PDZ domain binding
1.51 6.88e-03 GO:0016563 transcription activator activity
1.31 1.08e-02 GO:0016301 kinase activity
1.32 1.14e-02 GO:0019899 enzyme binding
2.38 1.31e-02 GO:0008013 beta-catenin binding
1.90 1.36e-02 GO:0005249 voltage-gated potassium channel activity
1.40 2.32e-02 GO:0019904 protein domain specific binding
2.00 2.34e-02 GO:0005262 calcium channel activity
1.75 3.24e-02 GO:0015276 ligand-gated ion channel activity
1.75 3.24e-02 GO:0022834 ligand-gated channel activity