Motif ID: ZIC1..3.p2

Z-value: 2.829


Transcription factors associated with ZIC1..3.p2:

Gene SymbolEntrez IDGene Name
ZIC1 7545 Zic family member 1 (odd-paired homolog, Drosophila)
ZIC2 7546 Zic family member 2 (odd-paired homolog, Drosophila)
ZIC3 7547 Zic family member 3 (odd-paired homolog, Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZIC3chrX_+_1364763530.861.7e-05Click!
ZIC1chr3_+_1486105160.665.6e-03Click!
ZIC2chr13_+_994322580.665.8e-03Click!


Activity profile for motif ZIC1..3.p2.

activity profile for motif ZIC1..3.p2


Sorted Z-values histogram for motif ZIC1..3.p2

Sorted Z-values for motif ZIC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_28306633 5.997 FOXG1
forkhead box G1
chr4_-_174687104 4.636 HAND2
heart and neural crest derivatives expressed 2
chrX_-_107866262 4.462 NM_003604
 IRS4
insulin receptor substrate 4
chr14_-_103058568 4.080 CKB
creatine kinase, brain
chr1_-_38285033 3.406 NM_002699
 POU3F1
POU class 3 homeobox 1
chr4_-_174686918 3.214 HAND2
heart and neural crest derivatives expressed 2
chr11_-_75056761 3.011 MAP6
microtubule-associated protein 6
chr10_-_95350949 2.976 NM_006744
 RBP4
retinol binding protein 4, plasma
chr12_-_42231990 2.870 NM_025003
 ADAMTS20
ADAM metallopeptidase with thrombospondin type 1 motif, 20
chr13_-_52320774 2.750 NM_002590
NM_032949
 PCDH8

protocadherin 8

chr16_-_47872880 2.737


chr9_+_99656013 2.692


chr19_+_10404110 2.589 NM_001111309
 PDE4A
phosphodiesterase 4A, cAMP-specific
chr14_+_100362236 2.507 MEG3
maternally expressed 3 (non-protein coding)
chr8_+_1937711 2.504 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr14_+_100362204 2.482 MEG3
maternally expressed 3 (non-protein coding)
chr14_-_103058865 2.478 NM_001823
 CKB
creatine kinase, brain
chr11_-_75057062 2.475 NM_033063
NM_207577
 MAP6

microtubule-associated protein 6

chr9_+_78824390 2.462 NM_001013735
 FOXB2
forkhead box B2
chr3_-_73756668 2.334 NM_015009
 PDZRN3
PDZ domain containing ring finger 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 68 entries
enrichment   p-value GO term description
6.79 4.45e-03 GO:0042026 protein refolding
2.10 1.72e-03 GO:0045664 regulation of neuron differentiation
1.91 1.45e-02 GO:0003002 regionalization
1.88 5.79e-04 GO:0007411 axon guidance
1.85 1.06e-09 GO:0030182 neuron differentiation
1.84 2.85e-03 GO:0001501 skeletal system development
1.84 4.09e-02 GO:0050767 regulation of neurogenesis
1.83 1.80e-03 GO:0007389 pattern specification process
1.83 1.51e-02 GO:0051960 regulation of nervous system development
1.82 5.39e-03 GO:0060284 regulation of cell development
1.80 1.65e-03 GO:0007420 brain development
1.79 1.36e-10 GO:0048699 generation of neurons
1.79 6.45e-03 GO:0045597 positive regulation of cell differentiation
1.79 1.71e-02 GO:0022603 regulation of anatomical structure morphogenesis
1.77 6.45e-06 GO:0048666 neuron development
1.77 4.92e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.76 1.81e-10 GO:0022008 neurogenesis
1.76 8.63e-04 GO:0007409 axonogenesis
1.74 1.98e-04 GO:0031175 neuron projection development
1.72 1.16e-02 GO:0009792 embryo development ending in birth or egg hatching

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
2.37 1.89e-02 GO:0008021 synaptic vesicle
2.26 8.14e-04 GO:0034703 cation channel complex
1.96 1.62e-03 GO:0034702 ion channel complex
1.75 2.49e-02 GO:0005667 transcription factor complex
1.69 1.23e-03 GO:0045202 synapse
1.69 2.51e-02 GO:0044456 synapse part
1.33 1.15e-05 GO:0044459 plasma membrane part
1.17 4.38e-03 GO:0005886 plasma membrane
1.16 1.14e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
2.42 4.49e-02 GO:0005262 calcium channel activity
2.21 1.82e-03 GO:0022843 voltage-gated cation channel activity
1.93 3.00e-04 GO:0005261 cation channel activity
1.91 2.19e-02 GO:0005244 voltage-gated ion channel activity
1.91 2.19e-02 GO:0022832 voltage-gated channel activity
1.77 1.32e-08 GO:0043565 sequence-specific DNA binding
1.75 6.25e-03 GO:0022836 gated channel activity
1.70 1.63e-02 GO:0016563 transcription activator activity
1.62 1.29e-08 GO:0001071 nucleic acid binding transcription factor activity
1.62 1.29e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
1.62 3.11e-04 GO:0008324 cation transmembrane transporter activity
1.58 1.76e-02 GO:0019904 protein domain specific binding
1.58 4.86e-02 GO:0005216 ion channel activity
1.57 4.03e-02 GO:0015267 channel activity
1.57 4.39e-02 GO:0022803 passive transmembrane transporter activity
1.45 3.67e-04 GO:0030528 transcription regulator activity
1.43 3.05e-02 GO:0015075 ion transmembrane transporter activity
1.14 1.71e-05 GO:0005515 protein binding
1.06 2.26e-02 GO:0005488 binding