Motif ID: SP1.p2

Z-value: 2.575


Transcription factors associated with SP1.p2:

Gene SymbolEntrez IDGene Name
SP1 6667 Sp1 transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SP1chr12_+_52060689-0.486.0e-02Click!


Activity profile for motif SP1.p2.

activity profile for motif SP1.p2


Sorted Z-values histogram for motif SP1.p2

Sorted Z-values for motif SP1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SP1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_57492236 3.769 NM_144684
ZNF480
zinc finger protein 480
chr8_-_99906944 3.694 NM_006281
STK3
serine/threonine kinase 3
chr16_-_3225360 3.222 NM_001145448
NM_198088
NM_001145446
NM_198087
ZNF200



zinc finger protein 200



chr19_+_54786723 3.058 NM_020719
PRR12
proline rich 12
chr16_+_80036275 3.049 NM_198390
CMIP
c-Maf-inducing protein
chr20_+_17498507 2.891 NM_001011546
NM_006870
DSTN

destrin (actin depolymerizing factor)

chr12_+_47498778 2.876 NM_000725
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr19_-_1966628 2.701 NM_017797
BTBD2
BTB (POZ) domain containing 2
chr17_+_77582774 2.641 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr17_-_46298671 2.573 TOB1
transducer of ERBB2, 1
chr8_+_22513043 2.542 NM_001013842
NM_001198827
NM_173686
C8orf58


chromosome 8 open reading frame 58


chr22_-_41913075 2.442 TTLL12
tubulin tyrosine ligase-like family, member 12
chr6_+_37895570 2.388 ZFAND3
zinc finger, AN1-type domain 3
chr22_-_41913002 2.368 TTLL12
tubulin tyrosine ligase-like family, member 12
chr16_+_48744310 2.363 NM_001040284
NM_001040285
PAPD5

PAP associated domain containing 5

chr8_+_1699276 2.342 NM_018941
CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr22_-_41913076 2.330 NM_015140
TTLL12
tubulin tyrosine ligase-like family, member 12
chr17_-_39265965 2.275 NM_001932
MPP3
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
chr6_-_30818198 2.238 NM_005803
FLOT1
flotillin 1
chr2_-_61551403 2.219 USP34
ubiquitin specific peptidase 34
chr6_+_44203335 2.198 NM_018426
TMEM63B
transmembrane protein 63B
chr14_+_23937766 2.139 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr6_-_4080700 2.138 NM_001166010
NM_006117
NM_206836
PECI


peroxisomal D3,D2-enoyl-CoA isomerase


chr6_+_44346457 2.135 NM_001137560
TMEM151B
transmembrane protein 151B
chr6_+_167970334 2.134 NM_001040000
MLLT4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
chr8_-_96350575 2.129 NM_177965
C8orf37
chromosome 8 open reading frame 37
chr4_-_809879 2.125 NM_006651
CPLX1
complexin 1
chr7_+_73506333 2.090 NM_005685
GTF2IRD1
GTF2I repeat domain containing 1
chrX_-_152853402 2.089 NM_003491
NAA10
N(alpha)-acetyltransferase 10, NatA catalytic subunit
chr10_-_15250616 2.054 NM_004808
NMT2
N-myristoyltransferase 2
chr16_-_18845223 2.029 NM_015092
SMG1
SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
chr9_-_111300350 1.963 NM_001145368
NM_002829
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr20_+_1154763 1.956 NM_001136566
RAD21L1
RAD21-like 1 (S. pombe)
chr17_+_34114924 1.932 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr2_-_47986160 1.929 NM_001190274
FBXO11
F-box protein 11
chr4_+_85723080 1.901 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr1_+_945331 1.872 NM_198576
AGRN
agrin
chr4_-_125853166 1.839 NM_001167882
NM_020337
ANKRD50

ankyrin repeat domain 50

chr17_-_78199384 1.814 NM_019613
WDR45L
WDR45-like
chr12_-_56200547 1.787 NM_001195053
NM_001195054
NM_001195055
NM_001195056
NM_001195057
NM_004083
DDIT3





DNA-damage-inducible transcript 3





chr12_-_48508411 1.766 NM_001037806
NCKAP5L
NCK-associated protein 5-like
chrX_-_1291526 1.733 NM_001012288
NM_022148
CRLF2

cytokine receptor-like factor 2

chr20_+_254205 1.729 NM_006943
SOX12
SRY (sex determining region Y)-box 12
chr20_-_39379533 1.725 ZHX3
zinc fingers and homeoboxes 3
chr4_+_3046034 1.723 NM_002111
HTT
huntingtin
chr19_-_51168396 1.722 NM_002516
NOVA2
neuro-oncological ventral antigen 2
chr7_-_127833231 1.717 NM_001142573
NM_001142574
NM_001142575
IMPDH1


IMP (inosine 5'-monophosphate) dehydrogenase 1


chr20_+_55359706 1.705 RAE1
RAE1 RNA export 1 homolog (S. pombe)
chr17_-_77129802 1.691 NM_025161
C17orf70
chromosome 17 open reading frame 70
chr19_-_15421761 1.690 NM_021241
WIZ
widely interspaced zinc finger motifs
chr20_-_51644187 1.685 ZNF217
zinc finger protein 217
chr1_-_223907283 1.685 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr20_+_55359551 1.680 NM_003610
RAE1
RAE1 RNA export 1 homolog (S. pombe)
chr19_-_15351523 1.673 NM_005858
AKAP8
A kinase (PRKA) anchor protein 8
chr2_+_42249896 1.668 NM_001145076
NM_019063
EML4

echinoderm microtubule associated protein like 4

chr3_+_37878647 1.667 NM_001008392
NM_005808
CTDSPL

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like

chr20_-_32877029 1.666 NM_014071
NCOA6
nuclear receptor coactivator 6
chr7_+_73506172 1.659 GTF2IRD1
GTF2I repeat domain containing 1
chr19_+_4423149 1.653 NM_001001520
NM_032631
HDGFRP2

hepatoma-derived growth factor-related protein 2

chr16_-_65287967 1.651 NM_178818
NM_181521
CMTM4

CKLF-like MARVEL transmembrane domain containing 4

chr14_-_94855848 1.644 NM_024734
CLMN
calmin (calponin-like, transmembrane)
chr20_-_39680405 1.623 NM_032221
CHD6
chromodomain helicase DNA binding protein 6
chr21_+_17807167 1.596 NM_001338
CXADR
coxsackie virus and adenovirus receptor
chr9_-_5997891 1.585 NM_001017969
KIAA2026
KIAA2026
chr1_+_231530136 1.580 NM_032435
KIAA1804
mixed lineage kinase 4
chr9_-_73573121 1.541 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr17_-_40484329 1.535 NM_001128631
DCAKD
dephospho-CoA kinase domain containing
chr18_+_58341637 1.530 NM_017742
ZCCHC2
zinc finger, CCHC domain containing 2
chr20_+_36810510 1.530 NM_024855
ACTR5
ARP5 actin-related protein 5 homolog (yeast)
chr19_+_40451842 1.529 USF2
upstream transcription factor 2, c-fos interacting
chr11_+_117812282 1.527 NM_001197104
NM_005933
MLL

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)

chr20_+_30410447 1.523 ASXL1
additional sex combs like 1 (Drosophila)
chr6_+_41714171 1.507 NM_005586
MDFI
MyoD family inhibitor
chr1_+_945472 1.494 AGRN
agrin
chr1_+_149750485 1.485 NM_020770
CGN
cingulin
chr2_-_36678657 1.480 NM_001042548
NM_005102
FEZ2

fasciculation and elongation protein zeta 2 (zygin II)

chr3_+_160964574 1.472 SCHIP1
schwannomin interacting protein 1
chr14_+_23908141 1.467 NM_001198966
NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
chr14_+_34585098 1.466 NM_173607
FAM177A1
family with sequence similarity 177, member A1
chr20_-_62071584 1.461 NM_020713
ZNF512B
zinc finger protein 512B
chr6_-_160034176 1.456 SOD2
superoxide dismutase 2, mitochondrial
chr1_-_201202956 1.446 NM_016243
CYB5R1
cytochrome b5 reductase 1
chr4_+_3264509 1.436 RGS12
regulator of G-protein signaling 12
chr20_+_48781457 1.435 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr12_+_110328126 1.434 NM_005475
SH2B3
SH2B adaptor protein 3
chr8_+_30133354 1.410 NM_006571
DCTN6
dynactin 6
chr2_-_9061193 1.400 NM_138799
MBOAT2
membrane bound O-acyltransferase domain containing 2
chr10_+_86078136 1.393 NM_018999
FAM190B
family with sequence similarity 190, member B
chr2_-_61551350 1.391 NM_014709
USP34
ubiquitin specific peptidase 34
chr5_+_172193826 1.383 NM_001031711
ERGIC1
endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
chr17_+_582406 1.378 NM_024792
FAM57A
family with sequence similarity 57, member A
chr2_+_85051942 1.366 KCMF1
potassium channel modulatory factor 1
chr12_+_92295738 1.361 NM_019094
NM_199040
NUDT4

NUDT4P1
nudix (nucleoside diphosphate linked moiety X)-type motif 4

nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1
chr2_+_241944333 1.345 NM_014808
FARP2
FERM, RhoGEF and pleckstrin domain protein 2
chr16_+_29724926 1.344 MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr16_+_29725311 1.340 NM_001042539
NM_002383
MAZ

MYC-associated zinc finger protein (purine-binding transcription factor)

chr3_-_12983959 1.339 NM_014869
IQSEC1
IQ motif and Sec7 domain 1
chr2_-_235070431 1.338 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr9_-_137938778 1.334 NM_015447
CAMSAP1
calmodulin regulated spectrin-associated protein 1
chr16_-_29513787 1.332 LOC440354
PI-3-kinase-related kinase SMG-1 pseudogene
chr14_+_23675233 1.310 PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr7_-_525556 1.308 PDGFA
platelet-derived growth factor alpha polypeptide
chr5_+_150612805 1.307 NM_000405
NM_001167607
GM2A

GM2 ganglioside activator

chr1_+_945399 1.303


chr1_-_154290112 1.300 NM_020131
UBQLN4
ubiquilin 4
chr3_-_116348780 1.295 NM_015642
ZBTB20
zinc finger and BTB domain containing 20
chr1_-_109386112 1.287 NM_001142550
NM_001142551
NM_014969
WDR47


WD repeat domain 47


chr1_-_152162074 1.287 NM_020699
GATAD2B
GATA zinc finger domain containing 2B
chr9_-_122679387 1.282 NM_001009936
NM_015651
PHF19

PHD finger protein 19

chr19_+_47480445 1.280 NM_015125
CIC
capicua homolog (Drosophila)
chr17_-_63965156 1.274 NM_017983
WIPI1
WD repeat domain, phosphoinositide interacting 1
chr3_-_187025438 1.270 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr6_+_143423723 1.269 AIG1
androgen-induced 1
chr15_-_100082134 1.262 NM_152334
TARSL2
threonyl-tRNA synthetase-like 2
chr22_+_49459935 1.259 NM_001080420
SHANK3
SH3 and multiple ankyrin repeat domains 3
chr14_+_31616196 1.255 NM_001030055
NM_001173
ARHGAP5

Rho GTPase activating protein 5

chr19_+_6690697 1.249 NM_004240
TRIP10
thyroid hormone receptor interactor 10
chr2_+_242289983 1.248 NM_032329
ING5
inhibitor of growth family, member 5
chr7_+_43589163 1.248 NM_004760
STK17A
serine/threonine kinase 17a
chr6_+_17501589 1.243 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr8_+_1699418 1.240 CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr17_-_39632845 1.239 ATXN7L3
ataxin 7-like 3
chr3_-_15875932 1.234 NM_015199
ANKRD28
ankyrin repeat domain 28
chr2_+_8739563 1.233 NM_002166
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr6_+_37895244 1.225 NM_021943
ZFAND3
zinc finger, AN1-type domain 3
chr3_-_17759100 1.224 NM_001134380
TBC1D5
TBC1 domain family, member 5
chr15_+_83092854 1.215 ZNF592
zinc finger protein 592
chr20_+_44083667 1.211 NM_001134771
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr20_+_56397695 1.211 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr8_+_146023706 1.210 NM_003416
ZNF7
zinc finger protein 7
chr4_+_52403922 1.210 NM_001040402
NM_015115
DCUN1D4

DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)

chr14_+_23675206 1.210 NM_006263
NM_176783
PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

chr16_-_8870343 1.203 NM_014316
CARHSP1
calcium regulated heat stable protein 1, 24kDa
chr6_-_160034308 1.202 NM_000636
NM_001024465
NM_001024466
SOD2


superoxide dismutase 2, mitochondrial


chr22_+_27609889 1.201 NM_032173
ZNRF3
zinc and ring finger 3
chr2_+_26768894 1.199 NM_002246
KCNK3
potassium channel, subfamily K, member 3
chr12_-_123617962 1.188 NM_001077261
NM_006312
NCOR2

nuclear receptor corepressor 2

chr20_-_60074237 1.187 NM_003185
TAF4
TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
chr1_-_113059396 1.182 NM_005167
PPM1J
protein phosphatase, Mg2+/Mn2+ dependent, 1J
chr4_-_110870414 1.178 NM_030821
PLA2G12A
phospholipase A2, group XIIA
chr9_+_129962292 1.175 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr9_-_129573330 1.174 NM_005489
SH2D3C
SH2 domain containing 3C
chr11_-_2907169 1.172 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr12_+_970613 1.171 NM_178039
NM_178040
ERC1

ELKS/RAB6-interacting/CAST family member 1

chr2_+_192251105 1.171 NM_001031716
OBFC2A
oligonucleotide/oligosaccharide-binding fold containing 2A
chr7_-_100325209 1.168 NM_001015072
UFSP1
UFM1-specific peptidase 1 (non-functional)
chr17_-_46553083 1.163 NM_001130528
NM_003971
SPAG9

sperm associated antigen 9

chr2_+_218972963 1.160 NM_182642
CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr1_+_181259317 1.160


chr7_+_5289079 1.159 NM_001040661
NM_153247
SLC29A4

solute carrier family 29 (nucleoside transporters), member 4

chr8_-_103737058 1.159 NM_005655
KLF10
Kruppel-like factor 10
chr4_+_152549776 1.154 NM_001109977
FAM160A1
family with sequence similarity 160, member A1
chr17_+_24742068 1.149 NM_020791
TAOK1
TAO kinase 1
chr20_+_25176698 1.149 NM_002862
PYGB
phosphorylase, glycogen; brain
chr6_+_155096494 1.145 SCAF8
SR-related CTD-associated factor 8
chr1_-_22136263 1.142 NM_005529
HSPG2
heparan sulfate proteoglycan 2
chr14_-_50367513 1.141 NM_016350
NM_020921
NM_182944
NM_182946
NIN



ninein (GSK3B interacting protein)



chr22_-_34754343 1.137 NM_001082578
NM_001082579
RBFOX2

RNA binding protein, fox-1 homolog (C. elegans) 2

chr2_-_68332985 1.136 NM_000945
PPP3R1
protein phosphatase 3, regulatory subunit B, alpha
chr20_+_35407872 1.136 NM_198291
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr1_-_52791309 1.135 NM_001009881
NM_015269
ZCCHC11

zinc finger, CCHC domain containing 11

chr17_-_17667580 1.134 SREBF1
sterol regulatory element binding transcription factor 1
chr21_+_36614347 1.127 NM_015358
MORC3
MORC family CW-type zinc finger 3
chr19_-_4016467 1.119 ZBTB7A
zinc finger and BTB domain containing 7A
chrX_-_1531733 1.119 NM_001173474
NM_004192
ASMTL

acetylserotonin O-methyltransferase-like

chr13_-_76499270 1.114 FBXL3
F-box and leucine-rich repeat protein 3
chr9_+_19398924 1.114 NM_001010887
ACER2
alkaline ceramidase 2
chr1_-_32632601 1.114 NM_001143888
NM_001143889
NM_001143890
NM_018045
BSDC1



BSD domain containing 1



chr1_+_153366928 1.111 NM_004428
NM_182685
EFNA1

ephrin-A1

chr17_-_34157962 1.111 NM_007144
PCGF2
polycomb group ring finger 2
chr2_+_54536780 1.106 NM_003128
SPTBN1
spectrin, beta, non-erythrocytic 1
chr3_-_13896618 1.102 NM_004625
WNT7A
wingless-type MMTV integration site family, member 7A
chr7_-_143230096 1.102 NM_014719
FAM115A
family with sequence similarity 115, member A
chr16_+_86193993 1.101 NM_020655
JPH3
junctophilin 3
chr6_+_83130673 1.098 NM_001166392
TPBG
trophoblast glycoprotein
chr21_-_39607415 1.096 NM_001007246
NM_018963
NM_033656
BRWD1


bromodomain and WD repeat domain containing 1


chr19_-_60557875 1.093 NM_144613
COX6B2
cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr14_-_38971370 1.089 NM_203301
FBXO33
F-box protein 33
chr20_-_3336586 1.084 C20orf194
chromosome 20 open reading frame 194
chr16_-_11744103 1.078 NM_015914
TXNDC11
thioredoxin domain containing 11
chr6_+_138767151 1.070 HEBP2
heme binding protein 2
chr7_+_64136078 1.064 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr2_-_70634129 1.062 NM_001099691
NM_003236
TGFA

transforming growth factor, alpha

chr1_-_9892852 1.057 NM_001012329
NM_020248
CTNNBIP1

catenin, beta interacting protein 1

chr10_-_35143900 1.055 NM_001184785
NM_001184786
NM_001184787
NM_001184788
NM_001184789
NM_001184790
NM_001184791
NM_001184792
NM_001184793
NM_001184794
NM_019619
PARD3










par-3 partitioning defective 3 homolog (C. elegans)










chr14_-_38971049 1.051 FBXO33
F-box protein 33
chr16_+_4948318 1.050 NM_014692
SEC14L5
SEC14-like 5 (S. cerevisiae)
chr1_+_153366559 1.050 EFNA1
ephrin-A1
chr9_+_138805581 1.047 NM_032928
TMEM141
transmembrane protein 141
chr5_-_16989371 1.044 NM_012334
MYO10
myosin X
chr4_-_84152985 1.043 NM_001115007
LIN54
lin-54 homolog (C. elegans)
chr1_-_11663762 1.043 NM_006341
MAD2L2
MAD2 mitotic arrest deficient-like 2 (yeast)
chr3_-_48569213 1.037 NM_004567
PFKFB4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chr19_-_52426055 1.036 NM_014417
BBC3
BCL2 binding component 3
chr17_-_71362971 1.034 NM_012478
WBP2
WW domain binding protein 2
chr9_-_122679283 1.033 PHF19
PHD finger protein 19
chr17_-_46140015 1.031 NM_052855
ANKRD40
ankyrin repeat domain 40
chr3_-_184180985 1.031 NM_020640
DCUN1D1
DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
chr7_-_127837195 1.030 IMPDH1
IMP (inosine 5'-monophosphate) dehydrogenase 1
chr9_+_130354490 1.030 NM_001130438
NM_001195532
NM_003127
SPTAN1


spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.07 2.83e-26 GO:0009987 cellular process
1.12 1.30e-24 GO:0050794 regulation of cellular process
1.12 4.07e-23 GO:0044237 cellular metabolic process
1.10 7.11e-23 GO:0065007 biological regulation
1.11 1.14e-22 GO:0050789 regulation of biological process
1.15 2.84e-20 GO:0044260 cellular macromolecule metabolic process
1.25 3.03e-20 GO:0006464 protein modification process
1.17 2.21e-19 GO:0031323 regulation of cellular metabolic process
1.15 1.09e-18 GO:0019222 regulation of metabolic process
1.23 1.15e-18 GO:0043412 macromolecule modification
1.16 1.90e-17 GO:0080090 regulation of primary metabolic process
1.17 2.47e-17 GO:0060255 regulation of macromolecule metabolic process
1.10 4.23e-16 GO:0008152 metabolic process
1.10 8.03e-16 GO:0044238 primary metabolic process
1.19 1.41e-15 GO:0044267 cellular protein metabolic process
1.20 1.11e-14 GO:0048523 negative regulation of cellular process
1.12 1.99e-14 GO:0043170 macromolecule metabolic process
1.19 2.87e-14 GO:0048519 negative regulation of biological process
1.14 9.39e-12 GO:0016043 cellular component organization
1.16 9.73e-12 GO:0048518 positive regulation of biological process
1.16 1.45e-10 GO:0010468 regulation of gene expression
1.16 2.01e-10 GO:0048522 positive regulation of cellular process
1.16 2.67e-10 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.20 5.44e-10 GO:0006996 organelle organization
1.13 5.65e-10 GO:0071840 cellular component organization or biogenesis
1.25 7.17e-10 GO:0032268 regulation of cellular protein metabolic process
1.15 9.35e-10 GO:0071842 cellular component organization at cellular level
1.15 1.21e-09 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.21 2.23e-09 GO:0009966 regulation of signal transduction
1.19 2.24e-09 GO:0023051 regulation of signaling
1.14 2.37e-09 GO:0019538 protein metabolic process
1.24 2.99e-09 GO:0051246 regulation of protein metabolic process
1.14 3.15e-09 GO:0051171 regulation of nitrogen compound metabolic process
1.15 4.80e-09 GO:0010556 regulation of macromolecule biosynthetic process
1.14 6.03e-09 GO:0031326 regulation of cellular biosynthetic process
1.24 7.74e-09 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.12 3.54e-08 GO:0007165 signal transduction
1.14 4.18e-08 GO:0071841 cellular component organization or biogenesis at cellular level
1.14 4.71e-08 GO:0009889 regulation of biosynthetic process
1.15 1.39e-07 GO:0051252 regulation of RNA metabolic process
1.21 1.63e-07 GO:0010604 positive regulation of macromolecule metabolic process
1.19 2.45e-07 GO:0035556 intracellular signal transduction
1.18 3.26e-07 GO:0065009 regulation of molecular function
1.11 3.46e-07 GO:0023052 signaling
1.20 6.00e-07 GO:0009893 positive regulation of metabolic process
1.24 6.32e-07 GO:0051128 regulation of cellular component organization
1.23 7.84e-07 GO:0010605 negative regulation of macromolecule metabolic process
1.32 9.09e-07 GO:0072358 cardiovascular system development
1.32 9.09e-07 GO:0072359 circulatory system development
1.10 1.19e-06 GO:0051716 cellular response to stimulus
1.14 1.41e-06 GO:0006355 regulation of transcription, DNA-dependent
1.15 1.44e-06 GO:0048583 regulation of response to stimulus
1.37 1.89e-06 GO:0070647 protein modification by small protein conjugation or removal
1.41 2.28e-06 GO:0016567 protein ubiquitination
1.39 2.99e-06 GO:0001944 vasculature development
1.10 3.08e-06 GO:0032502 developmental process
1.21 3.53e-06 GO:0009892 negative regulation of metabolic process
1.13 3.57e-06 GO:0009058 biosynthetic process
1.14 3.90e-06 GO:0065008 regulation of biological quality
1.24 3.90e-06 GO:0031399 regulation of protein modification process
1.14 4.16e-06 GO:0030154 cell differentiation
1.11 5.67e-06 GO:0007275 multicellular organismal development
1.22 6.13e-06 GO:0022008 neurogenesis
1.13 6.50e-06 GO:0044249 cellular biosynthetic process
1.39 6.62e-06 GO:0032446 protein modification by small protein conjugation
1.25 8.06e-06 GO:0019220 regulation of phosphate metabolic process
1.25 8.06e-06 GO:0051174 regulation of phosphorus metabolic process
1.19 1.03e-05 GO:0031325 positive regulation of cellular metabolic process
1.25 1.60e-05 GO:0042325 regulation of phosphorylation
1.21 1.61e-05 GO:0031324 negative regulation of cellular metabolic process
1.22 1.64e-05 GO:0048699 generation of neurons
1.39 1.65e-05 GO:0001568 blood vessel development
1.42 1.94e-05 GO:0048011 nerve growth factor receptor signaling pathway
1.21 2.01e-05 GO:0048468 cell development
1.28 2.75e-05 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.13 2.77e-05 GO:0048869 cellular developmental process
1.20 2.91e-05 GO:0006793 phosphorus metabolic process
1.20 2.91e-05 GO:0006796 phosphate metabolic process
1.25 2.97e-05 GO:0010558 negative regulation of macromolecule biosynthetic process
1.16 3.11e-05 GO:0007399 nervous system development
1.33 3.55e-05 GO:0016568 chromatin modification
1.23 3.97e-05 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.25 5.12e-05 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.23 8.79e-05 GO:0009890 negative regulation of biosynthetic process
1.23 9.19e-05 GO:0031327 negative regulation of cellular biosynthetic process
1.24 9.96e-05 GO:0001932 regulation of protein phosphorylation
1.24 1.02e-04 GO:0051254 positive regulation of RNA metabolic process
1.10 1.09e-04 GO:0006807 nitrogen compound metabolic process
1.20 1.48e-04 GO:0050793 regulation of developmental process
1.19 1.62e-04 GO:0007049 cell cycle
1.24 1.67e-04 GO:0010629 negative regulation of gene expression
1.24 1.78e-04 GO:0045893 positive regulation of transcription, DNA-dependent
1.35 1.88e-04 GO:0051270 regulation of cellular component movement
1.11 1.95e-04 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.27 2.11e-04 GO:0031175 neuron projection development
1.27 2.30e-04 GO:0007010 cytoskeleton organization
1.21 2.43e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
1.10 2.61e-04 GO:0034641 cellular nitrogen compound metabolic process
1.23 2.81e-04 GO:0010628 positive regulation of gene expression
1.14 3.15e-04 GO:0034645 cellular macromolecule biosynthetic process
1.14 3.29e-04 GO:0009059 macromolecule biosynthetic process
1.33 3.52e-04 GO:0060284 regulation of cell development
1.21 4.18e-04 GO:2000026 regulation of multicellular organismal development
1.26 4.75e-04 GO:0051338 regulation of transferase activity
1.16 4.97e-04 GO:0051239 regulation of multicellular organismal process
1.20 5.22e-04 GO:0008219 cell death
1.23 5.42e-04 GO:0009057 macromolecule catabolic process
1.26 5.84e-04 GO:0043549 regulation of kinase activity
1.24 6.25e-04 GO:0042060 wound healing
1.23 6.44e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.15 6.95e-04 GO:0009653 anatomical structure morphogenesis
1.34 7.34e-04 GO:0010608 posttranscriptional regulation of gene expression
1.27 7.35e-04 GO:0048812 neuron projection morphogenesis
1.21 7.49e-04 GO:0010557 positive regulation of macromolecule biosynthetic process
1.19 8.01e-04 GO:0016265 death
1.25 8.64e-04 GO:0044265 cellular macromolecule catabolic process
1.16 8.93e-04 GO:0050790 regulation of catalytic activity
1.20 9.49e-04 GO:0044093 positive regulation of molecular function
1.24 9.54e-04 GO:0050878 regulation of body fluid levels
1.21 1.05e-03 GO:0006468 protein phosphorylation
1.16 1.07e-03 GO:0051641 cellular localization
1.19 1.11e-03 GO:0031328 positive regulation of cellular biosynthetic process
1.26 1.16e-03 GO:0045859 regulation of protein kinase activity
1.19 1.20e-03 GO:0006351 transcription, DNA-dependent
1.26 1.26e-03 GO:0006066 alcohol metabolic process
1.16 1.34e-03 GO:0044248 cellular catabolic process
1.22 1.76e-03 GO:0030030 cell projection organization
1.27 1.80e-03 GO:0007409 axonogenesis
1.19 2.20e-03 GO:0009891 positive regulation of biosynthetic process
1.17 2.23e-03 GO:0043067 regulation of programmed cell death
1.17 3.02e-03 GO:0042981 regulation of apoptosis
1.21 3.04e-03 GO:0009719 response to endogenous stimulus
1.19 3.37e-03 GO:0033554 cellular response to stress
1.20 3.42e-03 GO:0016192 vesicle-mediated transport
1.23 3.78e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.24 3.83e-03 GO:0000904 cell morphogenesis involved in differentiation
1.22 3.88e-03 GO:0009725 response to hormone stimulus
1.22 3.94e-03 GO:0048666 neuron development
1.20 4.11e-03 GO:0012501 programmed cell death
1.14 4.23e-03 GO:0009056 catabolic process
1.12 4.23e-03 GO:0044281 small molecule metabolic process
1.33 4.33e-03 GO:2000145 regulation of cell motility
1.09 4.40e-03 GO:0048856 anatomical structure development
1.10 4.63e-03 GO:0048731 system development
1.36 4.73e-03 GO:0048514 blood vessel morphogenesis
1.18 5.05e-03 GO:0016310 phosphorylation
1.33 5.40e-03 GO:0030334 regulation of cell migration
1.20 5.59e-03 GO:0006915 apoptosis
1.16 5.60e-03 GO:0010941 regulation of cell death
1.25 6.70e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.31 6.72e-03 GO:0040012 regulation of locomotion
1.22 6.88e-03 GO:0051253 negative regulation of RNA metabolic process
1.58 8.76e-03 GO:0007173 epidermal growth factor receptor signaling pathway
1.28 8.94e-03 GO:0009894 regulation of catabolic process
1.27 8.97e-03 GO:0030163 protein catabolic process
1.20 9.12e-03 GO:0045595 regulation of cell differentiation
1.20 1.04e-02 GO:0030182 neuron differentiation
1.23 1.05e-02 GO:0048858 cell projection morphogenesis
1.28 1.17e-02 GO:0019941 modification-dependent protein catabolic process
1.21 1.36e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.18 1.38e-02 GO:0046907 intracellular transport
1.29 1.46e-02 GO:0022603 regulation of anatomical structure morphogenesis
1.15 1.48e-02 GO:0010646 regulation of cell communication
1.27 1.73e-02 GO:0051301 cell division
1.22 1.74e-02 GO:0032990 cell part morphogenesis
1.28 1.78e-02 GO:0006511 ubiquitin-dependent protein catabolic process
1.20 1.80e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
1.30 1.86e-02 GO:0051101 regulation of DNA binding
1.37 2.01e-02 GO:0016570 histone modification
1.15 2.05e-02 GO:0051649 establishment of localization in cell
1.27 2.15e-02 GO:0043632 modification-dependent macromolecule catabolic process
1.24 2.18e-02 GO:0043066 negative regulation of apoptosis
1.26 2.21e-02 GO:0018193 peptidyl-amino acid modification
1.20 2.27e-02 GO:0000902 cell morphogenesis
1.24 2.32e-02 GO:0043069 negative regulation of programmed cell death
1.27 2.46e-02 GO:0007411 axon guidance
1.27 2.46e-02 GO:0051603 proteolysis involved in cellular protein catabolic process
1.31 2.46e-02 GO:0050767 regulation of neurogenesis
1.13 2.48e-02 GO:0033036 macromolecule localization
1.23 2.62e-02 GO:0044262 cellular carbohydrate metabolic process
1.23 2.78e-02 GO:0060548 negative regulation of cell death
1.27 2.80e-02 GO:0044257 cellular protein catabolic process
1.23 2.89e-02 GO:0032583 regulation of gene-specific transcription
1.20 2.96e-02 GO:0051726 regulation of cell cycle
1.14 2.97e-02 GO:0010033 response to organic substance
1.25 3.01e-02 GO:0090066 regulation of anatomical structure size
1.35 3.31e-02 GO:0016569 covalent chromatin modification
1.48 3.55e-02 GO:0006643 membrane lipid metabolic process
1.22 3.66e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.22 3.82e-02 GO:0007599 hemostasis
1.25 3.87e-02 GO:0007264 small GTPase mediated signal transduction
1.32 3.97e-02 GO:0005996 monosaccharide metabolic process
1.43 4.02e-02 GO:0007265 Ras protein signal transduction
1.26 4.20e-02 GO:0071495 cellular response to endogenous stimulus
1.49 4.57e-02 GO:0006665 sphingolipid metabolic process
1.15 4.60e-02 GO:0032879 regulation of localization
1.22 4.63e-02 GO:0006325 chromatin organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.10 1.38e-63 GO:0005622 intracellular
1.10 3.80e-61 GO:0044424 intracellular part
1.11 2.17e-44 GO:0043226 organelle
1.12 2.44e-44 GO:0043227 membrane-bounded organelle
1.11 4.14e-44 GO:0043229 intracellular organelle
1.12 1.26e-43 GO:0043231 intracellular membrane-bounded organelle
1.11 2.08e-35 GO:0005737 cytoplasm
1.15 1.20e-29 GO:0005634 nucleus
1.12 1.39e-21 GO:0044444 cytoplasmic part
1.11 1.46e-16 GO:0044422 organelle part
1.11 1.48e-16 GO:0044446 intracellular organelle part
1.20 4.29e-16 GO:0005829 cytosol
1.21 1.38e-15 GO:0031981 nuclear lumen
1.19 2.96e-15 GO:0044428 nuclear part
1.03 3.48e-14 GO:0044464 cell part
1.03 4.12e-14 GO:0005623 cell
1.17 3.24e-13 GO:0031974 membrane-enclosed lumen
1.18 3.86e-13 GO:0070013 intracellular organelle lumen
1.17 6.99e-13 GO:0043233 organelle lumen
1.23 1.12e-12 GO:0005654 nucleoplasm
1.23 2.19e-06 GO:0044451 nucleoplasm part
1.13 2.65e-06 GO:0031090 organelle membrane
1.15 2.68e-06 GO:0012505 endomembrane system
1.20 4.89e-06 GO:0005794 Golgi apparatus
1.23 1.53e-04 GO:0044431 Golgi apparatus part
1.09 2.65e-04 GO:0043234 protein complex
1.42 5.39e-04 GO:0005912 adherens junction
1.67 1.34e-03 GO:0034708 methyltransferase complex
1.67 1.34e-03 GO:0035097 histone methyltransferase complex
1.39 1.39e-03 GO:0070161 anchoring junction
1.23 1.50e-03 GO:0000139 Golgi membrane
1.42 1.53e-03 GO:0000151 ubiquitin ligase complex
1.48 2.74e-03 GO:0005925 focal adhesion
1.36 2.77e-03 GO:0031252 cell leading edge
1.31 4.68e-03 GO:0016323 basolateral plasma membrane
1.14 5.76e-03 GO:0005783 endoplasmic reticulum
1.18 7.74e-03 GO:0015630 microtubule cytoskeleton
1.27 8.62e-03 GO:0015629 actin cytoskeleton
1.44 9.10e-03 GO:0030055 cell-substrate junction
1.82 9.24e-03 GO:0032432 actin filament bundle
1.78 9.79e-03 GO:0042641 actomyosin
1.85 1.50e-02 GO:0032154 cleavage furrow
1.43 1.66e-02 GO:0005924 cell-substrate adherens junction
1.08 1.79e-02 GO:0043228 non-membrane-bounded organelle
1.08 1.79e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.48 1.85e-02 GO:0000790 nuclear chromatin
1.13 1.85e-02 GO:0000267 cell fraction
1.21 1.89e-02 GO:0005768 endosome
1.07 2.61e-02 GO:0032991 macromolecular complex
1.80 3.06e-02 GO:0001725 stress fiber
1.80 3.06e-02 GO:0032153 cell division site
1.80 3.06e-02 GO:0032155 cell division site part
1.44 3.58e-02 GO:0016585 chromatin remodeling complex
1.22 4.73e-02 GO:0048471 perinuclear region of cytoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 3.36e-42 GO:0005515 protein binding
1.07 2.47e-29 GO:0005488 binding
1.09 4.78e-09 GO:0003824 catalytic activity
1.16 9.06e-08 GO:0016740 transferase activity
1.30 9.26e-08 GO:0008092 cytoskeletal protein binding
1.24 3.82e-07 GO:0019899 enzyme binding
1.31 1.54e-06 GO:0004674 protein serine/threonine kinase activity
1.38 3.13e-06 GO:0016881 acid-amino acid ligase activity
1.20 4.02e-06 GO:0001071 nucleic acid binding transcription factor activity
1.20 4.02e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
1.36 4.24e-06 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.28 1.37e-05 GO:0016874 ligase activity
1.19 2.28e-05 GO:0030528 transcription regulator activity
1.20 2.29e-05 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.39 2.74e-05 GO:0019787 small conjugating protein ligase activity
1.39 4.36e-05 GO:0004842 ubiquitin-protein ligase activity
1.12 4.45e-05 GO:0003677 DNA binding
1.21 5.68e-05 GO:0016301 kinase activity
1.21 1.16e-04 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.33 1.24e-04 GO:0008134 transcription factor binding
1.26 2.45e-04 GO:0019904 protein domain specific binding
1.12 3.07e-04 GO:0032553 ribonucleotide binding
1.12 3.07e-04 GO:0032555 purine ribonucleotide binding
1.12 3.40e-04 GO:0035639 purine ribonucleoside triphosphate binding
1.21 4.98e-04 GO:0043565 sequence-specific DNA binding
1.12 5.23e-04 GO:0017076 purine nucleotide binding
1.09 5.92e-04 GO:0003676 nucleic acid binding
1.11 6.73e-04 GO:0000166 nucleotide binding
1.25 7.84e-04 GO:0030695 GTPase regulator activity
1.24 1.55e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.26 1.84e-03 GO:0000988 protein binding transcription factor activity
1.26 1.84e-03 GO:0000989 transcription factor binding transcription factor activity
1.26 2.35e-03 GO:0003712 transcription cofactor activity
1.13 3.39e-03 GO:0032559 adenyl ribonucleotide binding
1.20 3.56e-03 GO:0004672 protein kinase activity
1.12 4.46e-03 GO:0030554 adenyl nucleotide binding
1.12 5.59e-03 GO:0005524 ATP binding
1.27 6.93e-03 GO:0003779 actin binding
1.32 9.51e-03 GO:0003713 transcription coactivator activity
1.30 1.12e-02 GO:0019900 kinase binding
1.27 1.36e-02 GO:0005083 small GTPase regulator activity
1.26 1.44e-02 GO:0016564 transcription repressor activity
1.26 1.76e-02 GO:0016563 transcription activator activity
1.07 2.08e-02 GO:0043167 ion binding
1.29 2.53e-02 GO:0016791 phosphatase activity
1.07 2.70e-02 GO:0043169 cation binding
1.42 2.89e-02 GO:0015631 tubulin binding
1.07 3.70e-02 GO:0046872 metal ion binding
1.09 4.90e-02 GO:0008270 zinc ion binding