Motif ID: ESRRA.p2

Z-value: 1.499


Transcription factors associated with ESRRA.p2:

Gene SymbolEntrez IDGene Name
ESRRA 2101 estrogen-related receptor alpha

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ESRRAchr11_+_63829616-0.087.8e-01Click!


Activity profile for motif ESRRA.p2.

activity profile for motif ESRRA.p2


Sorted Z-values histogram for motif ESRRA.p2

Sorted Z-values for motif ESRRA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESRRA.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_17923110 2.184 NM_002248
KCNN1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr9_+_17568952 2.131 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr5_-_148014282 2.115 HTR4
5-hydroxytryptamine (serotonin) receptor 4
chr19_+_540849 2.023 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr5_+_149549712 1.948 NM_014228
SLC6A7
solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
chr17_-_70367479 1.898 NM_000835
GRIN2C
glutamate receptor, ionotropic, N-methyl D-aspartate 2C
chr5_-_1647617 1.876 SDHAP3
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 3
chr11_+_65815940 1.875 NM_153266
TMEM151A
transmembrane protein 151A
chr22_-_29290875 1.860 NM_004861
GAL3ST1
galactose-3-O-sulfotransferase 1
chr15_+_41672543 1.833 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr22_-_28041474 1.808 RASL10A
RAS-like, family 10, member A
chr22_-_28041650 1.722 NM_001007279
NM_006477
RASL10A

RAS-like, family 10, member A

chr11_+_65815911 1.714 TMEM151A
transmembrane protein 151A
chr14_-_47213906 1.568 NM_001113498
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr19_-_4486202 1.520 NM_001013706
PLIN5
perilipin 5
chr20_+_36867708 1.482 NM_001172735
NM_015568
PPP1R16B

protein phosphatase 1, regulatory (inhibitor) subunit 16B

chr9_-_21340885 1.474 NM_021002
IFNA6
interferon, alpha 6
chrX_-_1470862 1.464 NM_001636
SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr10_+_44726635 1.458 NM_001123376
TMEM72
transmembrane protein 72
chr14_-_20572783 1.415 NM_001012264
RNASE13
ribonuclease, RNase A family, 13 (non-active)
chr5_-_63293301 1.405 NM_000524
HTR1A
5-hydroxytryptamine (serotonin) receptor 1A
chr11_-_64268841 1.351 NM_001098670
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr12_+_20413445 1.332 NM_000921
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr11_-_64268126 1.321 NM_001098671
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr4_-_21308415 1.234 NM_001035003
KCNIP4
Kv channel interacting protein 4
chr22_-_42589543 1.214 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr17_-_70430839 1.212 NM_173477
USH1G
Usher syndrome 1G (autosomal recessive)
chr14_-_103058865 1.204 NM_001823
CKB
creatine kinase, brain
chr3_-_27738788 1.199 NM_005442
EOMES
eomesodermin
chr22_+_23221114 1.182 NM_016327
UPB1
ureidopropionase, beta
chr3_+_142253432 1.163 NM_080862
SPSB4
splA/ryanodine receptor domain and SOCS box containing 4
chr12_-_116021473 1.155 NM_001168325
NM_017899
TESC

tescalcin

chr11_-_132318080 1.102 NM_002545
OPCML
opioid binding protein/cell adhesion molecule-like
chr14_+_69021149 1.093 NM_001161498
UPF0639
UPF0639 protein
chr1_+_29086206 1.092 EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr10_+_105334704 1.091 NEURL
neuralized homolog (Drosophila)
chr12_+_56299959 1.071 NM_133489
SLC26A10
solute carrier family 26, member 10
chr11_-_132318741 1.063 OPCML
opioid binding protein/cell adhesion molecule-like
chr17_+_7549138 1.045 NM_001406
EFNB3
ephrin-B3
chr5_-_148013908 1.045 NM_000870
HTR4
5-hydroxytryptamine (serotonin) receptor 4
chr3_+_134947788 1.032 TF
transferrin
chr15_+_41772375 1.027 NM_001015001
CKMT1A
creatine kinase, mitochondrial 1A
chr19_-_60360768 1.020 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr22_+_29848923 1.011 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr5_-_35266305 1.008 PRLR
prolactin receptor
chr17_+_71586857 1.003 NM_180990
ZACN
zinc activated ligand-gated ion channel
chr19_-_44518516 1.001 NM_004877
GMFG
glia maturation factor, gamma
chr3_-_180805104 0.933 NM_020409
NM_177988
MRPL47

mitochondrial ribosomal protein L47

chr12_-_642786 0.927 NM_016533
NINJ2
ninjurin 2
chr1_+_29086156 0.914 NM_001166005
NM_001166007
NM_004437
NM_203342
NM_203343
EPB41




erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)




chr20_-_61600834 0.907 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr3_+_134947940 0.905 TF
transferrin
chr5_-_35266550 0.884 NM_000949
PRLR
prolactin receptor
chr3_+_134947894 0.883 TF
transferrin
chr12_-_52980914 0.872 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr12_-_52980984 0.869 NM_001136023
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr11_-_84311867 0.867 DLG2
discs, large homolog 2 (Drosophila)
chr3_-_10724715 0.863 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr5_+_149550003 0.863 SLC6A7
solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
chr1_-_152431175 0.858 NM_152263
TPM3
tropomyosin 3
chr18_-_55136673 0.845 NM_181654
CPLX4
complexin 4
chr18_-_5533967 0.827 NM_012307
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chrX_-_132377087 0.813 GPC4
glypican 4
chr7_-_100630912 0.811 NM_178176
MOGAT3
monoacylglycerol O-acyltransferase 3
chr17_-_34014390 0.806 SRCIN1
SRC kinase signaling inhibitor 1
chr11_+_268569 0.796 NM_138329
NLRP6
NLR family, pyrin domain containing 6
chr11_-_45264193 0.796 NM_020826
SYT13
synaptotagmin XIII
chr10_-_103525646 0.795 NM_006119
NM_033163
NM_033164
NM_033165
FGF8



fibroblast growth factor 8 (androgen-induced)



chrX_+_48505097 0.793 NM_001080489
GLOD5
glyoxalase domain containing 5
chr15_-_76210611 0.791 NM_006383
CIB2
calcium and integrin binding family member 2
chr3_+_9720509 0.787 NM_153635
CPNE9
copine family member IX
chr4_-_44145266 0.765 KCTD8
potassium channel tetramerisation domain containing 8
chr20_-_43767069 0.765 NM_172006
NM_172131
WFDC10B

WAP four-disulfide core domain 10B

chr12_+_76749199 0.765 NM_014903
NAV3
neuron navigator 3
chr22_+_35586950 0.758 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr12_-_107257205 0.752 NM_001142343
NM_001142344
NM_004072
CMKLR1


chemokine-like receptor 1


chr3_+_134947573 0.750 NM_001063
TF
transferrin
chr8_-_61356436 0.732 NM_004056
CA8
carbonic anhydrase VIII
chr8_+_120289735 0.725 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr5_+_176717553 0.723


chr20_-_24987615 0.719 NM_032501
ACSS1
acyl-CoA synthetase short-chain family member 1
chr20_+_41621119 0.701 SGK2
serum/glucocorticoid regulated kinase 2
chr18_+_42751510 0.700 KATNAL2
katanin p60 subunit A-like 2
chr1_+_234916376 0.700 NM_001103
ACTN2
actinin, alpha 2
chr20_-_44713466 0.699 NM_001193339
NM_001193342
NM_022829
SLC13A3


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3


chr2_+_219453487 0.697 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr7_+_45580704 0.693 ADCY1
adenylate cyclase 1 (brain)
chr3_-_152449591 0.692 NM_001081455
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr1_+_157824239 0.681 NM_001639
APCS
amyloid P component, serum
chr19_+_50693570 0.677 NM_001080401
PPM1N
protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
chr15_+_76644882 0.676 NM_000745
CHRNA5
cholinergic receptor, nicotinic, alpha 5
chr2_+_74594093 0.652 TLX2
T-cell leukemia homeobox 2
chr4_+_44375165 0.645 NM_021927
GUF1
GUF1 GTPase homolog (S. cerevisiae)
chr10_-_97190885 0.645 NM_001034954
NM_001034955
NM_001034956
NM_001034957
NM_006434
SORBS1




sorbin and SH3 domain containing 1




chr8_+_36760999 0.638 NM_001031836
KCNU1
potassium channel, subfamily U, member 1
chr14_+_87560646 0.636 LOC283587
hypothetical protein LOC283587
chr19_+_19183763 0.632 NM_004386
NCAN
neurocan
chr19_-_44518465 0.625 GMFG
glia maturation factor, gamma
chr5_+_176807931 0.619 NM_001174102
PRR7
proline rich 7 (synaptic)
chr20_+_41621079 0.617 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr2_-_31293882 0.617 NM_001145122
CAPN14
calpain 14
chr7_+_45580606 0.612 NM_021116
ADCY1
adenylate cyclase 1 (brain)
chr14_+_99220349 0.611 NM_006668
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr13_+_32488477 0.596 NM_004795
KL
klotho
chr12_-_16652202 0.596 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr14_+_41146513 0.588 NM_152447
LRFN5
leucine rich repeat and fibronectin type III domain containing 5
chr14_-_74400288 0.587 NM_001080408
PROX2
prospero homeobox 2
chr10_+_68355797 0.585 NM_178011
LRRTM3
leucine rich repeat transmembrane neuronal 3
chrX_+_147389825 0.585 NM_001169122
NM_001169123
NM_001169124
NM_001169125
NM_002025
AFF2




AF4/FMR2 family, member 2




chr11_-_64582568 0.579 NM_005468
NAALADL1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr8_+_100025806 0.573 NM_001142462
NM_053001
OSR2

odd-skipped related 2 (Drosophila)

chr14_+_36200867 0.571 PAX9
paired box 9
chr13_-_51483473 0.566 NM_000053
NM_001005918
ATP7B

ATPase, Cu++ transporting, beta polypeptide

chr1_+_32489426 0.549 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr3_+_51716120 0.547 NM_000839
NM_001130063
GRM2

glutamate receptor, metabotropic 2

chr14_-_69616616 0.546 NM_182936
NM_001130417
SLC8A3

solute carrier family 8 (sodium/calcium exchanger), member 3

chr14_-_73296643 0.539 NM_194278
C14orf43
chromosome 14 open reading frame 43
chr8_-_100975417 0.533 NM_004374
COX6C
cytochrome c oxidase subunit VIc
chr14_+_36200815 0.529 PAX9
paired box 9
chr14_+_92459244 0.527 CHGA
chromogranin A (parathyroid secretory protein 1)
chr1_-_172153024 0.526 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr12_-_3732478 0.524 EFCAB4B
EF-hand calcium binding domain 4B
chr1_-_19089971 0.520 NM_001161504
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr17_+_37247568 0.518 NM_152467
KLHL10
kelch-like 10 (Drosophila)
chr2_-_154043403 0.510 NM_019845
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chr8_-_100975086 0.503 COX6C
cytochrome c oxidase subunit VIc
chr14_-_103058568 0.503 CKB
creatine kinase, brain
chr22_+_40702709 0.503 NM_019106
NM_145733
SEPT3

septin 3

chr7_+_37926687 0.496 NM_017549
EPDR1
ependymin related protein 1 (zebrafish)
chr19_+_55614006 0.493 NM_003121
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr11_+_43920385 0.490 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr3_-_134863316 0.490 NM_007027
TOPBP1
topoisomerase (DNA) II binding protein 1
chr2_+_104838177 0.488 NM_006236
POU3F3
POU class 3 homeobox 3
chr5_+_271428 0.484 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr22_-_29197944 0.483 NM_174975
SEC14L3
SEC14-like 3 (S. cerevisiae)
chr2_+_222997456 0.481 SGPP2
sphingosine-1-phosphate phosphatase 2
chr1_-_172153087 0.481 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr20_-_1922393 0.480 NM_001190900
PDYN
prodynorphin
chr2_+_222997529 0.478 NM_152386
SGPP2
sphingosine-1-phosphate phosphatase 2
chr17_+_45778381 0.477 NM_022167
XYLT2
xylosyltransferase II
chr22_-_22440054 0.473 NM_213720
CHCHD10
coiled-coil-helix-coiled-coil-helix domain containing 10
chr15_+_38520594 0.473 NM_014952
BAHD1
bromo adjacent homology domain containing 1
chr5_-_45731976 0.470 NM_021072
HCN1
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chr20_+_1132097 0.467 NM_001009612
C20orf202
chromosome 20 open reading frame 202
chr6_+_31662454 0.457 NM_205837
LST1
leukocyte specific transcript 1
chr2_+_119905812 0.456 NM_183240
TMEM37
transmembrane protein 37
chr2_-_30883775 0.455 NM_144575
CAPN13
calpain 13
chr19_-_12773591 0.454 NM_005809
NM_181738
PRDX2

peroxiredoxin 2

chr17_-_4747147 0.445 NM_000080
CHRNE
cholinergic receptor, nicotinic, epsilon
chr22_-_48866484 0.443 NM_015166
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr5_+_271441 0.441 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr8_+_11599119 0.441 NM_002052
GATA4
GATA binding protein 4
chr22_+_30480848 0.438 NM_001136029
DEPDC5
DEP domain containing 5
chr3_-_148605996 0.434 NM_001168379
ZIC4
Zic family member 4
chr20_+_3000265 0.422 NM_000915
OXT
oxytocin, prepropeptide
chr9_-_99994704 0.417 NM_052820
CORO2A
coronin, actin binding protein, 2A
chr12_+_119647953 0.415 NM_000017
ACADS
acyl-CoA dehydrogenase, C-2 to C-3 short chain
chr22_-_48865907 0.406 NM_139202
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr5_-_150517528 0.403 NM_001155
ANXA6
annexin A6
chr18_-_42590989 0.398 NM_013305
ST8SIA5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr5_+_271447 0.392 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr3_+_130451160 0.392 COPG
coatomer protein complex, subunit gamma
chr4_+_7245218 0.392 NM_020777
SORCS2
sortilin-related VPS10 domain containing receptor 2
chr6_+_44418374 0.391 NM_145026
SPATS1
spermatogenesis associated, serine-rich 1
chrX_-_53002900 0.390 NM_014138
FAM156A
family with sequence similarity 156, member A
chr9_-_88064338 0.386 NM_001010907
C9orf153
chromosome 9 open reading frame 153
chr22_-_48865980 0.383 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr2_-_86871459 0.381 CD8A
CD8a molecule
chr4_-_40212670 0.379 NM_019027
RBM47
RNA binding motif protein 47
chr22_-_22646602 0.375 NM_001084392
DDT
D-dopachrome tautomerase
chr8_+_55533047 0.374 NM_022454
SOX17
SRY (sex determining region Y)-box 17
chr11_+_22652957 0.373 GAS2
growth arrest-specific 2
chr2_+_218843358 0.370 NM_001077399
NM_015488
PNKD

paroxysmal nonkinesigenic dyskinesia

chr1_-_199259447 0.370 NM_017596
KIF21B
kinesin family member 21B
chr3_-_50624085 0.368 CISH
cytokine inducible SH2-containing protein
chr7_+_138859213 0.368 NM_001080511
CLEC2L
C-type lectin domain family 2, member L
chr4_+_36923084 0.367 NM_001144990
KIAA1239
KIAA1239
chr8_-_93176819 0.367 RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr9_-_32540818 0.367 TOPORS
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
chr20_+_3724905 0.365 CDC25B
cell division cycle 25 homolog B (S. pombe)
chr3_-_132704339 0.364 NM_007208
MRPL3
mitochondrial ribosomal protein L3
chrX_-_21686079 0.363 NM_014332
SMPX
small muscle protein, X-linked
chr5_-_150707281 0.361 NM_181776
SLC36A2
solute carrier family 36 (proton/amino acid symporter), member 2
chr8_-_100975041 0.360 COX6C
cytochrome c oxidase subunit VIc
chr5_-_150517499 0.356 ANXA6
annexin A6
chr4_+_24406336 0.355 SOD3
superoxide dismutase 3, extracellular
chr11_+_82545784 0.349 NM_015885
PCF11
PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae)
chr11_+_65140207 0.347 NM_032223
PCNXL3
pecanex-like 3 (Drosophila)
chr1_+_55237193 0.346 NM_057176
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr5_-_137938904 0.343 HSPA9
heat shock 70kDa protein 9 (mortalin)
chr12_-_16650697 0.343 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr2_-_86942504 0.343 NM_001178100
NM_004931
NM_172101
NM_172102
NM_172213
CD8B




CD8b molecule




chr22_-_48865864 0.342 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr19_+_54621499 0.341 NM_001195256
LOC645971
hypothetical protein LOC645971
chrX_-_132376660 0.339 NM_001448
GPC4
glypican 4
chr1_+_119759076 0.338 NM_001166120
HSD3B2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr9_-_116190038 0.337 AKNA
AT-hook transcription factor
chr2_+_6935246 0.336 NM_080657
RSAD2
radical S-adenosyl methionine domain containing 2
chr19_+_50863341 0.334 NM_000164
GIPR
gastric inhibitory polypeptide receptor
chr3_+_182900081 0.334 SOX2OT
SOX2 overlapping transcript (non-protein coding)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.90 1.85e-06 GO:0045333 cellular respiration
4.21 1.47e-05 GO:0022904 respiratory electron transport chain
2.38 3.21e-05 GO:0006091 generation of precursor metabolites and energy
2.69 3.48e-05 GO:0015980 energy derivation by oxidation of organic compounds
1.84 6.55e-05 GO:0055114 oxidation-reduction process
3.30 4.61e-04 GO:0022900 electron transport chain
1.39 5.51e-04 GO:0006810 transport
1.37 1.13e-03 GO:0051234 establishment of localization
4.31 3.13e-02 GO:0006119 oxidative phosphorylation
1.29 3.55e-02 GO:0051179 localization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.62 5.22e-10 GO:0031966 mitochondrial membrane
2.94 1.19e-09 GO:0005743 mitochondrial inner membrane
2.54 1.23e-09 GO:0005740 mitochondrial envelope
4.19 1.15e-08 GO:0044455 mitochondrial membrane part
2.71 2.99e-08 GO:0019866 organelle inner membrane
2.15 3.04e-08 GO:0044429 mitochondrial part
1.76 7.90e-08 GO:0005739 mitochondrion
1.95 5.14e-06 GO:0031975 envelope
1.93 1.16e-05 GO:0031967 organelle envelope
1.18 4.01e-04 GO:0016020 membrane
4.00 1.23e-03 GO:0070469 respiratory chain
1.20 2.20e-03 GO:0044444 cytoplasmic part
4.04 2.29e-03 GO:0005746 mitochondrial respiratory chain
1.16 4.13e-02 GO:0044425 membrane part
1.13 4.72e-02 GO:0005737 cytoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.32 6.36e-03 GO:0022890 inorganic cation transmembrane transporter activity
1.72 6.97e-03 GO:0016491 oxidoreductase activity