Motif ID: MSX1,2.p2

Z-value: 0.625


Transcription factors associated with MSX1,2.p2:

Gene SymbolEntrez IDGene Name
MSX1 4487 msh homeobox 1
MSX2 4488 msh homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MSX1chr4_+_49122720.648.0e-03Click!
MSX2chr5_+_1740841370.097.4e-01Click!


Activity profile for motif MSX1,2.p2.

activity profile for motif MSX1,2.p2


Sorted Z-values histogram for motif MSX1,2.p2

Sorted Z-values for motif MSX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MSX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_151456683 0.729 NM_001195571
PRR9
proline rich 9
chr1_-_188713324 0.704 NM_199051
FAM5C
family with sequence similarity 5, member C
chr7_-_96471544 0.599 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr11_-_83071084 0.542 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr6_-_52060327 0.524 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chrX_+_115481774 0.451 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr4_-_41579325 0.448


chr17_+_65582981 0.423 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr2_-_68952006 0.419 NM_014482
BMP10
bone morphogenetic protein 10
chr17_-_30909219 0.406 NM_001129820
SLFN14
schlafen family member 14
chr7_+_94377145 0.392 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr3_-_127810087 0.386 NM_001039783
TXNRD3IT1
thioredoxin reductase 3 intronic transcript 1
chr12_+_70119785 0.380 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr4_-_159311959 0.373 FAM198B
family with sequence similarity 198, member B
chrX_-_11194015 0.373 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr9_+_119506428 0.358 TLR4
toll-like receptor 4
chr7_+_80069439 0.354 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr3_+_129690735 0.345


chr19_-_14030970 0.334 NM_001145028
PALM3
paralemmin 3
chr4_-_66218777 0.326 EPHA5
EPH receptor A5
chrX_-_15530112 0.323 NM_021804
ACE2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr8_-_30826074 0.303 NM_031271
TEX15
testis expressed 15
chr5_+_169713458 0.301 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr9_+_119506446 0.299 TLR4
toll-like receptor 4
chrX_+_115481848 0.293 SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr11_-_100505667 0.288 NM_000926
PGR
progesterone receptor
chr10_-_51678318 0.283 NM_001143974
NM_019893
ASAH2

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2

chr9_+_1040367 0.277 DMRT2
doublesex and mab-3 related transcription factor 2
chr3_-_139315011 0.270 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr3_+_69895310 0.270 NM_001184967
MITF
microphthalmia-associated transcription factor
chr2_+_114916368 0.268 NM_020868
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr9_-_21472311 0.268 NM_176891
IFNE
interferon, epsilon
chr6_-_46155937 0.265 NM_001114086
CLIC5
chloride intracellular channel 5
chr3_-_115380539 0.255 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr4_+_77575276 0.246 NM_020859
SHROOM3
shroom family member 3
chr12_+_84792203 0.244 NM_006183
NTS
neurotensin
chr1_-_150328153 0.234 NM_001008536
TCHHL1
trichohyalin-like 1
chr10_+_124020810 0.230 NM_144587
BTBD16
BTB (POZ) domain containing 16
chr9_+_18464138 0.222 ADAMTSL1
ADAMTS-like 1
chrX_+_99726445 0.221 NM_022144
TNMD
tenomodulin
chr6_+_127940011 0.214 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr9_+_1040333 0.212 NM_006557
NM_001130865
DMRT2

doublesex and mab-3 related transcription factor 2

chr9_+_134843918 0.209 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chrX_-_133620103 0.207 NM_021796
PLAC1
placenta-specific 1
chr8_-_27171814 0.199 NM_030795
STMN4
stathmin-like 4
chr6_+_154373323 0.196 NM_001145279
NM_001145280
NM_001145281
OPRM1


opioid receptor, mu 1


chr5_+_140757787 0.195 NM_018925
NM_032099
PCDHGB5

protocadherin gamma subfamily B, 5

chr10_-_50269912 0.194 NM_001080520
DRGX
dorsal root ganglia homeobox
chr3_+_99484421 0.190 NM_001005482
OR5H2
olfactory receptor, family 5, subfamily H, member 2
chrX_-_19598912 0.190 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chrX_-_110542040 0.186 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr3_+_189425886 0.184 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr8_+_24354387 0.184 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr16_-_29817841 0.183 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr10_+_94823636 0.180 NM_000783
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr12_+_7039453 0.179


chr8_-_27171852 0.178 STMN4
stathmin-like 4
chr1_-_229071957 0.177 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr4_+_71096830 0.174 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr2_-_192420168 0.174 NM_004657
SDPR
serum deprivation response
chr5_-_22248630 0.170 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr1_+_205344200 0.168 NM_000715
C4BPA
complement component 4 binding protein, alpha
chrX_+_28515479 0.161 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr5_+_34723420 0.159 NM_001145523
RAI14
retinoic acid induced 14
chr12_-_112058403 0.157 NM_001193520
NM_004658
RASAL1

RAS protein activator like 1 (GAP1 like)

chr21_-_31049566 0.153 NM_181619
KRTAP21-1
keratin associated protein 21-1
chrX_+_16578201 0.152 NM_004057
S100G
S100 calcium binding protein G
chr12_+_887272 0.151 WNK1
WNK lysine deficient protein kinase 1
chr5_-_160211623 0.149 NM_025153
ATP10B
ATPase, class V, type 10B
chrX_+_128966844 0.144 NM_021946
BCORL1
BCL6 corepressor-like 1
chr16_+_55042936 0.144 OGFOD1
2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr3_-_71262426 0.143 FOXP1
forkhead box P1
chrX_+_38096679 0.140 NM_000531
OTC
ornithine carbamoyltransferase
chr9_-_115880281 0.140 AMBP
alpha-1-microglobulin/bikunin precursor
chr3_+_52803823 0.137 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chr3_+_12367993 0.136 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr4_-_77176163 0.136 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr2_-_162808123 0.131 NM_004460
FAP
fibroblast activation protein, alpha
chr17_-_25685175 0.131 NM_206832
TMIGD1
transmembrane and immunoglobulin domain containing 1
chr2_-_165133239 0.129 GRB14
growth factor receptor-bound protein 14
chr17_+_72380323 0.127 NM_198955
MGAT5B
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr7_+_136203938 0.126 NM_001006627
NM_001006630
CHRM2

cholinergic receptor, muscarinic 2

chr2_-_144994349 0.123 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr12_-_89922888 0.122 NM_004950
EPYC
epiphycan
chr17_-_15109315 0.121 NM_000304
PMP22
peripheral myelin protein 22
chr3_+_69895651 0.119 NM_006722
MITF
microphthalmia-associated transcription factor
chr4_+_89115825 0.118 NM_000582
NM_001040058
NM_001040060
SPP1


secreted phosphoprotein 1


chr2_+_102169864 0.117 NM_003854
IL1RL2
interleukin 1 receptor-like 2
chrX_+_66705407 0.113 NM_001011645
AR
androgen receptor
chr4_+_89115892 0.112 SPP1
secreted phosphoprotein 1
chr19_-_6621078 0.110 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr9_-_115880372 0.108 AMBP
alpha-1-microglobulin/bikunin precursor
chr4_-_157006827 0.108 NM_017419
ACCN5
amiloride-sensitive cation channel 5, intestinal
chr4_+_89115862 0.107 SPP1
secreted phosphoprotein 1
chr3_+_68136056 0.105 NM_213609
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr6_+_132901119 0.105 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr20_+_71230 0.104 NM_030931
DEFB126
defensin, beta 126
chr21_-_18697829 0.104 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr11_-_114593838 0.104 CADM1
cell adhesion molecule 1
chr2_+_137464931 0.103 NM_001080427
THSD7B
thrombospondin, type I, domain containing 7B
chr9_+_110664366 0.101 NM_006687
ACTL7A
actin-like 7A
chr4_+_15038726 0.100 NM_031911
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr21_+_30724442 0.100 NM_181600
KRTAP13-4
keratin associated protein 13-4
chr2_-_21087435 0.100 APOB
apolipoprotein B (including Ag(x) antigen)
chr12_-_9252227 0.099 NM_002864
PZP
pregnancy-zone protein
chr2_-_192419896 0.099 SDPR
serum deprivation response
chr3_-_139333813 0.098 NM_016161
A4GNT
alpha-1,4-N-acetylglucosaminyltransferase
chr12_-_89922875 0.097 EPYC
epiphycan
chr1_+_203106600 0.097 NFASC
neurofascin
chr20_+_43283423 0.097 NM_003008
SEMG2
semenogelin II
chr22_+_38296703 0.096 NM_001003406
NM_021096
CACNA1I

calcium channel, voltage-dependent, T type, alpha 1I subunit

chr17_-_15495534 0.096 TRIM16
tripartite motif containing 16
chr9_-_115880425 0.095 AMBP
alpha-1-microglobulin/bikunin precursor
chr8_-_114518194 0.095 NM_052900
NM_198123
CSMD3

CUB and Sushi multiple domains 3

chr2_-_210726539 0.095 C2orf67
chromosome 2 open reading frame 67
chr21_-_30836051 0.094 NM_181612
KRTAP19-6
keratin associated protein 19-6
chr4_-_44348414 0.094 NM_182592
YIPF7
Yip1 domain family, member 7
chr5_+_139856688 0.094 ANKHD1
ankyrin repeat and KH domain containing 1
chr14_-_104330982 0.093 NM_005163
AKT1
v-akt murine thymoma viral oncogene homolog 1
chr11_+_130745580 0.093 NM_001048209
NTM
neurotrimin
chr1_-_19058741 0.091 NM_152232
TAS1R2
taste receptor, type 1, member 2
chr11_-_40272239 0.090 NM_020929
LRRC4C
leucine rich repeat containing 4C
chrX_+_22927998 0.088 NM_182699
DDX53
DEAD (Asp-Glu-Ala-Asp) box polypeptide 53
chr11_-_10671608 0.088 NM_001100167
MRVI1
murine retrovirus integration site 1 homolog
chr13_-_34948758 0.086 NM_005584
MAB21L1
mab-21-like 1 (C. elegans)
chr3_-_99236520 0.085 NM_001105580
GABRR3
gamma-aminobutyric acid (GABA) receptor, rho 3
chrX_-_19898302 0.085 NM_198279
CXorf23
chromosome X open reading frame 23
chr7_+_5609416 0.084 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr11_+_114054409 0.084 NM_182495
FAM55B
family with sequence similarity 55, member B
chr1_+_195179533 0.082 NM_005666
CFHR2
complement factor H-related 2
chr17_-_10217046 0.082 NM_003802
MYH13
myosin, heavy chain 13, skeletal muscle
chrX_-_131181141 0.081 RAP2C
RAP2C, member of RAS oncogene family
chr4_+_89115923 0.081 SPP1
secreted phosphoprotein 1
chr1_+_195123766 0.081 NM_006684
CFHR4
complement factor H-related 4
chr12_-_69837831 0.081 TSPAN8
tetraspanin 8
chr12_+_49634048 0.081 NM_001109619
HIGD1C
HIG1 hypoxia inducible domain family, member 1C
chr12_+_52105131 0.080 AMHR2
anti-Mullerian hormone receptor, type II
chr6_+_50894397 0.080 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr5_+_140698537 0.080 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr1_-_104040594 0.078 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr13_+_57103789 0.078 NM_001040429
PCDH17
protocadherin 17
chr12_+_53178834 0.078 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr3_-_71262405 0.078 FOXP1
forkhead box P1
chr12_+_56114724 0.077 NM_005538
INHBC
inhibin, beta C
chr12_-_44877769 0.076 SLC38A1
solute carrier family 38, member 1
chrX_-_24600661 0.075 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr11_-_59140192 0.075 NM_002556
OSBP
oxysterol binding protein
chr1_+_150029798 0.074


chr3_+_185377341 0.074 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr6_-_130578110 0.074 NM_152552
SAMD3
sterile alpha motif domain containing 3
chr15_-_68128924 0.073 TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr6_-_123999640 0.073 NM_006073
TRDN
triadin
chr10_+_68355797 0.073 NM_178011
LRRTM3
leucine rich repeat transmembrane neuronal 3
chr4_+_71330797 0.073 NM_001145006
MUC7
mucin 7, secreted
chr14_-_93324518 0.072 NM_178013
PRIMA1
proline rich membrane anchor 1
chr16_-_3025542 0.072 NM_001103175
CCDC64B
coiled-coil domain containing 64B
chr21_-_30720100 0.071 NM_181622
KRTAP13-3
keratin associated protein 13-3
chr16_-_55042614 0.071 NM_007006
NUDT21
nudix (nucleoside diphosphate linked moiety X)-type motif 21
chr12_+_54172413 0.070 NM_001005519
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr7_+_120415958 0.070 NM_024913
C7orf58
chromosome 7 open reading frame 58
chr11_-_102100833 0.069 NM_002424
MMP8
matrix metallopeptidase 8 (neutrophil collagenase)
chr17_-_19592178 0.069 NM_000691
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr9_+_18464090 0.069 NM_001040272
NM_052866
ADAMTSL1

ADAMTS-like 1

chr19_-_51109875 0.066 NM_001029861
NANOS2
nanos homolog 2 (Drosophila)
chr19_+_6723801 0.066


chrX_+_119621771 0.066 NM_014060
MCTS1
malignant T cell amplified sequence 1
chr2_+_176695658 0.066 NM_014213
HOXD9
homeobox D9
chr10_+_85944383 0.065 NM_001171971
NM_033100
CDHR1

cadherin-related family member 1

chrX_-_48713194 0.065 NM_004979
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr14_-_105997732 0.065 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_-_188903038 0.065 NM_001004312
RTP2
receptor (chemosensory) transporter protein 2
chr19_+_6723705 0.065 NM_005428
VAV1
vav 1 guanine nucleotide exchange factor
chr5_-_36337756 0.064 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr5_-_138238877 0.064 LRRTM2
leucine rich repeat transmembrane neuronal 2
chrX_+_119621933 0.063 MCTS1
malignant T cell amplified sequence 1
chr12_+_111713931 0.062 NM_001143854
NM_014954
RPH3A

rabphilin 3A homolog (mouse)

chrX_-_131089552 0.061 NM_194277
FRMD7
FERM domain containing 7
chr12_-_121277972 0.061 NM_019887
NM_138929
DIABLO

diablo homolog (Drosophila)

chrX_-_43717864 0.060 NM_000266
NDP
Norrie disease (pseudoglioma)
chr16_+_55042924 0.060 NM_018233
OGFOD1
2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr1_+_31655607 0.059 NM_001199037
SERINC2
serine incorporator 2
chr3_-_150578148 0.059 TM4SF1
transmembrane 4 L six family member 1
chr14_-_106282128 0.058 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_+_185377430 0.058 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr1_+_66772393 0.057 NM_032291
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr1_+_151209751 0.057 NM_173080
SPRR4
small proline-rich protein 4
chr3_-_194579207 0.057 NM_198505
ATP13A5
ATPase type 13A5
chr22_+_34109095 0.057 HMOX1
heme oxygenase (decycling) 1
chrX_+_144716619 0.057 NM_004709
CXorf1
chromosome X open reading frame 1
chr6_+_131613196 0.057 NM_004842
NM_138633
AKAP7

A kinase (PRKA) anchor protein 7

chrX_-_135690699 0.056 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr3_+_46591048 0.056 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chr3_+_101720753 0.055 TMEM45A
transmembrane protein 45A
chr4_+_86918870 0.055 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr10_-_98315090 0.055 TM9SF3
transmembrane 9 superfamily member 3
chr5_+_15553288 0.055 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr1_-_200182090 0.054 LMOD1
leiomodin 1 (smooth muscle)
chr11_+_55700669 0.054 NM_001005492
OR5J2
olfactory receptor, family 5, subfamily J, member 2
chr12_+_111714096 0.054 RPH3A
rabphilin 3A homolog (mouse)
chr8_-_72437020 0.054 NM_000503
EYA1
eyes absent homolog 1 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.49 8.30e-05 GO:0032501 multicellular organismal process
1.87 5.23e-03 GO:0003008 system process
2.08 3.78e-02 GO:0009605 response to external stimulus
1.88 4.92e-02 GO:0050877 neurological system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.69 1.78e-08 GO:0071944 cell periphery
1.67 6.60e-08 GO:0005886 plasma membrane
2.28 1.14e-03 GO:0005626 insoluble fraction
2.29 1.47e-03 GO:0005624 membrane fraction
1.34 2.08e-03 GO:0044425 membrane part
1.28 2.16e-03 GO:0016020 membrane
1.64 8.33e-03 GO:0044459 plasma membrane part
1.94 1.38e-02 GO:0000267 cell fraction
30.96 1.52e-02 GO:0071437 invadopodium
1.61 3.40e-02 GO:0005576 extracellular region

Nothing significant found in function category.