Motif ID: CUX2.p2

Z-value: 0.535


Transcription factors associated with CUX2.p2:

Gene SymbolEntrez IDGene Name
CUX2 23316 cut-like homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
CUX2chr12_+_1099562100.312.4e-01Click!


Activity profile for motif CUX2.p2.

activity profile for motif CUX2.p2


Sorted Z-values histogram for motif CUX2.p2

Sorted Z-values for motif CUX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CUX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_22646229 1.164 NM_177553
GAS2
growth arrest-specific 2
chr14_+_28311740 0.816 C14orf23
chromosome 14 open reading frame 23
chr18_-_68683913 0.749 NM_138999
NM_153181
NETO1

neuropilin (NRP) and tolloid (TLL)-like 1

chr7_+_80069439 0.635 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr8_-_120720200 0.475 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr14_+_87560646 0.470 LOC283587
hypothetical protein LOC283587
chr5_+_127012611 0.466 NM_001048252
CTXN3
cortexin 3
chr10_+_68355797 0.418 NM_178011
LRRTM3
leucine rich repeat transmembrane neuronal 3
chr7_-_23476497 0.350 NM_006547
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr1_+_57093030 0.316 NM_000562
C8A
complement component 8, alpha polypeptide
chr3_-_114176401 0.290 NM_138806
NM_138939
NM_138940
NM_170780
CD200R1



CD200 receptor 1



chr12_+_109956210 0.289 NM_015267
CUX2
cut-like homeobox 2
chr4_-_72868598 0.287 NM_000583
GC
group-specific component (vitamin D binding protein)
chr22_+_23921072 0.286 KIAA1671
KIAA1671
chr19_-_63556632 0.278 NM_130786
A1BG
alpha-1-B glycoprotein
chr7_+_93373755 0.252 NM_021955
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr3_+_35696119 0.236 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr8_+_77756077 0.230 ZFHX4
zinc finger homeobox 4
chr5_-_160044844 0.227 ATP10B
ATPase, class V, type 10B
chr1_+_246150942 0.224 NM_001005522
OR2T8
olfactory receptor, family 2, subfamily T, member 8
chr3_+_101720753 0.220 TMEM45A
transmembrane protein 45A
chr1_-_144779601 0.219 NM_001101663
NBPF11
NBPF24
neuroblastoma breakpoint family, member 11
neuroblastoma breakpoint family, member 24
chr13_-_45654292 0.215 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr5_+_57823017 0.211 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr21_+_30690165 0.196 NM_181599
KRTAP13-1
keratin associated protein 13-1
chr9_+_27099138 0.195 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr13_-_45654296 0.195 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr12_-_11313907 0.193 NM_006249
PRB3
proline-rich protein BstNI subfamily 3
chr2_-_88946767 0.191


chr9_-_106420305 0.173 NM_001001956
OR13C9
olfactory receptor, family 13, subfamily C, member 9
chr18_-_29273979 0.166 NM_001105528
C18orf34
chromosome 18 open reading frame 34
chr12_+_54011750 0.164 NM_054104
OR6C3
olfactory receptor, family 6, subfamily C, member 3
chr14_-_20098929 0.164 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chr6_-_161614962 0.158 NM_020133
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr6_+_129245978 0.151 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr18_-_68362702 0.148 NM_182511
CBLN2
cerebellin 2 precursor
chr4_+_15038726 0.146 NM_031911
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr12_+_21570457 0.142 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr1_+_144374513 0.136 RNF115
ring finger protein 115
chr5_-_147142249 0.132 JAKMIP2
janus kinase and microtubule interacting protein 2
chr11_-_74478405 0.125 NM_001005285
OR2AT4
olfactory receptor, family 2, subfamily AT, member 4
chr10_-_69125932 0.124 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chrX_-_106248706 0.123 NM_001171080
NM_018301
RBM41

RNA binding motif protein 41

chr18_+_57308754 0.121 NM_031891
CDH20
cadherin 20, type 2
chr6_+_72982865 0.118 NM_001168409
RIMS1
regulating synaptic membrane exocytosis 1
chr4_+_71126376 0.116 NM_152997
C4orf7
chromosome 4 open reading frame 7
chr11_+_116580892 0.115 TAGLN
transgelin
chr15_+_36014748 0.114 NM_152453
TMCO5A
transmembrane and coiled-coil domains 5A
chr9_-_21218132 0.113 NM_021268
IFNA17
interferon, alpha 17
chr12_-_21980894 0.110 NM_005691
NM_020297
NM_020298
ABCC9


ATP-binding cassette, sub-family C (CFTR/MRP), member 9


chr1_+_50344550 0.110 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr3_+_63403792 0.110 NM_144642
SYNPR
synaptoporin
chr2_-_162717159 0.109 NM_002054
GCG
glucagon
chr6_+_46869052 0.108 NM_005588
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr6_-_26216299 0.108 NM_005323
HIST1H1T
histone cluster 1, H1t
chr2_+_108230082 0.107 NM_001008743
SULT1C3
sulfotransferase family, cytosolic, 1C, member 3
chr4_-_68766392 0.107 NM_001129907
TMPRSS11BNL
TMPRSS11B N terminal-like
chr20_-_22514092 0.106 NM_153675
FOXA2
forkhead box A2
chr17_-_30545489 0.105 NM_152462
AMAC1
acyl-malonyl condensing enzyme 1
chr14_-_23117268 0.096 JPH4
junctophilin 4
chr3_-_127760447 0.093 NM_152533
C3orf22
chromosome 3 open reading frame 22
chr8_+_77756061 0.092 NM_024721
ZFHX4
zinc finger homeobox 4
chr14_-_23090606 0.092 NM_033400
ZFHX2
zinc finger homeobox 2
chr3_+_52786642 0.087 NM_002215
ITIH1
inter-alpha (globulin) inhibitor H1
chr6_+_32817140 0.084 NM_020056
HLA-DQA2
major histocompatibility complex, class II, DQ alpha 2
chr9_-_21177529 0.083 NM_021068
IFNA4
interferon, alpha 4
chr12_-_7709734 0.082 NM_001644
APOBEC1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr1_+_117098579 0.080 NM_001767
CD2
CD2 molecule
chr11_-_30562324 0.079 MPPED2
metallophosphoesterase domain containing 2
chr11_-_77411933 0.079 NM_023930
KCTD14
potassium channel tetramerisation domain containing 14
chr12_-_53661888 0.078 NM_001098815
KIAA0748
KIAA0748
chr13_-_45654327 0.076 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr22_-_38619739 0.075 NM_152512
ENTHD1
ENTH domain containing 1
chrX_+_123307812 0.073 NM_001114937
NM_002351
SH2D1A

SH2 domain containing 1A

chr3_-_42427026 0.071 NM_144634
LYZL4
lysozyme-like 4
chr14_-_63076155 0.070 PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr1_-_611896 0.068 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr12_+_6703410 0.068 NM_001164094
NM_016319
NM_001164095
COPS7A


COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)


chr12_-_11354620 0.067 NM_002723
PRB4
proline-rich protein BstNI subfamily 4
chr14_-_19843918 0.066 TTC5
tetratricopeptide repeat domain 5
chr11_+_55407348 0.065 NM_032681
SPRYD5
SPRY domain containing 5
chr11_+_59902530 0.064 NM_021201
NM_206938
NM_206939
NM_206940
MS4A7



membrane-spanning 4-domains, subfamily A, member 7



chr4_+_41395493 0.063 LIMCH1
LIM and calponin homology domains 1
chr7_+_156677777 0.061


chr3_+_159310631 0.061 RSRC1
arginine/serine-rich coiled-coil 1
chr8_-_15140162 0.059 NM_139167
SGCZ
sarcoglycan, zeta
chr1_-_157950898 0.059 NM_000567
CRP
C-reactive protein, pentraxin-related
chr16_+_11966464 0.059 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr17_+_53670785 0.058 NM_001160102
NM_006151
LPO

lactoperoxidase

chr3_-_172227152 0.058 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr10_+_90474280 0.058 NM_001080518
LIPK
lipase, family member K
chr7_+_99263571 0.056 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr1_-_156078115 0.056 NM_005894
CD5L
CD5 molecule-like
chr5_+_180726874 0.053 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr6_+_27400518 0.053 NM_032030
FKSG83
FKSG83
chr11_-_56166490 0.053 NM_001002925
OR5AP2
olfactory receptor, family 5, subfamily AP, member 2
chr15_+_56511466 0.052 NM_000236
LIPC
lipase, hepatic
chr7_-_112515068 0.052 NM_001146265
NM_018970
GPR85

G protein-coupled receptor 85

chr11_+_61794205 0.051 NM_002411
SCGB2A2
secretoglobin, family 2A, member 2
chr7_+_143646150 0.049 NM_001005287
NM_001001802
OR2A1
OR2A42
olfactory receptor, family 2, subfamily A, member 1
olfactory receptor, family 2, subfamily A, member 42
chr3_+_85858321 0.048 NM_153184
CADM2
cell adhesion molecule 2
chr8_+_18293034 0.047 NM_000015
NAT2
N-acetyltransferase 2 (arylamine N-acetyltransferase)
chr7_-_112515035 0.047 GPR85
G protein-coupled receptor 85
chr3_+_51837608 0.046 NM_001085479
IQCF3
IQ motif containing F3
chr12_-_10870134 0.046 NM_023921
TAS2R10
taste receptor, type 2, member 10
chr1_+_357502 0.046 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr20_-_17487480 0.045 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr4_-_70861301 0.045 NM_001891
CSN2
casein beta
chr4_-_82345224 0.044 NM_006259
PRKG2
protein kinase, cGMP-dependent, type II
chr2_-_171999473 0.043 NM_024770
METTL8
methyltransferase like 8
chrX_-_63532057 0.041 NM_017677
MTMR8
myotubularin related protein 8
chr17_-_36209672 0.041 NM_181535
KRT28
keratin 28
chr7_-_143560850 0.040 NM_001005287
NM_001001802
OR2A1
OR2A42
olfactory receptor, family 2, subfamily A, member 1
olfactory receptor, family 2, subfamily A, member 42
chr1_+_160002733 0.040 ATF6
activating transcription factor 6
chr2_+_204509698 0.040 NM_012092
ICOS
inducible T-cell co-stimulator
chr17_-_61655915 0.039 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr11_+_59902598 0.039 MS4A7
membrane-spanning 4-domains, subfamily A, member 7
chr9_-_114814286 0.038 NM_001101338
ZNF883
zinc finger protein 883
chr6_-_154719560 0.036 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chrX_-_11194015 0.035 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr10_-_69095362 0.035 NM_001127384
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr7_-_36730525 0.034 NM_001177506
NM_001177507
NM_001637
AOAH


acyloxyacyl hydrolase (neutrophil)


chrX_-_15312390 0.034 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr12_-_15757114 0.034 EPS8
epidermal growth factor receptor pathway substrate 8
chr4_+_74498042 0.034 ALB
albumin
chr1_-_202595666 0.033 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr5_-_58918031 0.032 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr11_+_60223622 0.031 NM_031457
MS4A8B
membrane-spanning 4-domains, subfamily A, member 8B
chr10_+_104493701 0.029 C10orf26
chromosome 10 open reading frame 26
chr10_+_95507555 0.029 NM_005097
LGI1
leucine-rich, glioma inactivated 1
chr1_-_146076704 0.027 NM_001101663
NBPF11
NBPF24
neuroblastoma breakpoint family, member 11
neuroblastoma breakpoint family, member 24
chr4_-_46421379 0.026 RAC1
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
chr19_-_49725387 0.025 NM_001102597
NM_001102598
NM_001102599
NM_001102600
CEACAM20



carcinoembryonic antigen-related cell adhesion molecule 20



chrX_+_106057984 0.025 CLDN2
claudin 2
chr18_-_29882555 0.025 NM_001198549
NOL4
nucleolar protein 4
chr12_-_52939584 0.025 NM_001127322
CBX5
chromobox homolog 5
chr1_+_160002746 0.025 ATF6
activating transcription factor 6
chr5_+_121493113 0.024 NM_207317
ZNF474
zinc finger protein 474
chr11_-_58368555 0.024 NM_145016
GLYATL2
glycine-N-acyltransferase-like 2
chr14_-_19867372 0.024 NM_182852
NM_182851
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr4_-_47678187 0.024 NM_001142564
CNGA1
cyclic nucleotide gated channel alpha 1
chr8_-_107023 0.024 NM_001005504
OR4F21
olfactory receptor, family 4, subfamily F, member 21
chr10_-_99383841 0.023 NM_001098831
MORN4
MORN repeat containing 4
chr1_-_153915867 0.023


chr11_+_91724909 0.023 NM_001008781
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chr12_+_14429499 0.022 ATF7IP
activating transcription factor 7 interacting protein
chr1_+_110795271 0.022 NM_032414
PROK1
prokineticin 1
chr4_-_46421360 0.022 RAC1
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
chr13_-_40454360 0.021 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr1_+_160002693 0.020 NM_007348
ATF6
activating transcription factor 6
chr11_+_5732498 0.020 NM_001005175
OR52N4
olfactory receptor, family 52, subfamily N, member 4
chr2_+_69055208 0.020 NM_019617
GKN1
gastrokine 1
chrX_+_30169977 0.019 NM_002367
MAGEB4
melanoma antigen family B, 4
chr7_+_113853790 0.018 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr12_-_11230809 0.016 NM_181429
TAS2R42
taste receptor, type 2, member 42
chr18_-_62422195 0.015 NM_021153
CDH19
cadherin 19, type 2
chr11_-_57964221 0.014 NM_001004733
OR5B12
olfactory receptor, family 5, subfamily B, member 12
chrX_-_107569256 0.014 NM_001847
COL4A6
collagen, type IV, alpha 6
chr16_+_29971955 0.014 ALDOA
aldolase A, fructose-bisphosphate
chr7_-_91632525 0.013 NM_001161528
LOC401387
leucine-rich repeat and death domain-containing protein
chr12_+_73217817 0.012 NM_001136262
ATXN7L3B
ataxin 7-like 3B
chr18_+_59767567 0.012 NM_001123366
HMSD
histocompatibility (minor) serpin domain containing
chr7_+_80113570 0.012 NM_001127443
NM_001127444
CD36

CD36 molecule (thrombospondin receptor)

chr10_+_104580420 0.012


chr19_+_49337548 0.011 NM_001144824
NM_006630
ZNF234

zinc finger protein 234

chr4_-_47160476 0.010 COMMD8
COMM domain containing 8
chr10_-_93992982 0.009 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr11_-_123799976 0.009 NM_001005196
OR8B4
olfactory receptor, family 8, subfamily B, member 4
chr16_+_29971971 0.009 NM_000034
ALDOA
aldolase A, fructose-bisphosphate
chr1_+_103961476 0.009 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr5_+_140227951 0.008 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr11_-_5766621 0.008 NM_001001913
OR52N1
olfactory receptor, family 52, subfamily N, member 1
chr5_+_140509803 0.008 NM_018939
PCDHB6
protocadherin beta 6
chr5_-_145503190 0.008 LARS
leucyl-tRNA synthetase
chr13_-_83354425 0.008 SLITRK1
SLIT and NTRK-like family, member 1
chr11_+_60016826 0.007 NM_001164470
NM_017716
MS4A12

membrane-spanning 4-domains, subfamily A, member 12

chr9_+_5646582 0.007 NM_020829
KIAA1432
KIAA1432
chr8_-_17797127 0.007 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr4_+_187424111 0.005 NM_000128
F11
coagulation factor XI
chr4_+_74497998 0.005 ALB
albumin
chr12_+_6703525 0.004 COPS7A
COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)
chr15_-_70838703 0.003


chr13_+_51933228 0.002 CKAP2
cytoskeleton associated protein 2
chr16_-_73708118 0.001 LDHD
lactate dehydrogenase D
chr17_-_44043278 0.001 HOXB7
homeobox B7
chr14_+_55148488 0.001 KTN1
kinectin 1 (kinesin receptor)
chr8_-_82557956 0.001 NM_001442
FABP4
fatty acid binding protein 4, adipocyte

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.35 1.46e-05 GO:0005576 extracellular region
2.78 6.93e-03 GO:0005615 extracellular space
2.50 7.52e-03 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
15.80 2.86e-04 GO:0043498 cell surface binding
3.73 1.27e-02 GO:0004984 olfactory receptor activity
2.05 2.15e-02 GO:0004872 receptor activity
21.72 4.90e-02 GO:0051635 bacterial cell surface binding