Motif ID: AIRE.p2

Z-value: 0.959


Transcription factors associated with AIRE.p2:

Gene SymbolEntrez IDGene Name
AIRE 326 autoimmune regulator

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
AIREchr21_+_445345750.116.9e-01Click!


Activity profile for motif AIRE.p2.

activity profile for motif AIRE.p2


Sorted Z-values histogram for motif AIRE.p2

Sorted Z-values for motif AIRE.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AIRE.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_32772731 2.303 NM_001008391
CCDC73
coiled-coil domain containing 73
chr7_+_116238309 1.639 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr10_-_48010879 1.234 NM_002900
RBP3
retinol binding protein 3, interstitial
chr1_-_199732323 1.000 NM_001193572
CSRP1
cysteine and glycine-rich protein 1
chr6_-_150253729 0.912 NM_139165
RAET1E
retinoic acid early transcript 1E
chr7_+_111908143 0.902 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr1_+_559129 0.857


chr7_+_75892187 0.793 NM_001110354
ZP3
zona pellucida glycoprotein 3 (sperm receptor)
chr4_-_75066533 0.786 NM_002619
PF4
platelet factor 4
chr4_+_159662349 0.781 NM_021634
RXFP1
relaxin/insulin-like family peptide receptor 1
chr2_+_28892366 0.770 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr12_+_100512877 0.747 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr15_-_97607108 0.728 NM_001040655
NM_001040656
NM_001040657
NM_001040658
NM_001040659
NM_001040660
NM_022905
TTC23






tetratricopeptide repeat domain 23






chr5_+_176744037 0.716 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chr7_-_64104441 0.697 NM_001007253
ERV3
ZNF117
endogenous retroviral sequence 3
zinc finger protein 117
chr15_-_19007127 0.695 NM_001145004
GOLGA6L6
golgin A6 family-like 6
chr12_+_53534565 0.640 NM_058173
MUCL1
mucin-like 1
chr16_+_20328355 0.630 NM_017888
ACSM5
acyl-CoA synthetase medium-chain family member 5
chr7_-_38279757 0.629 NM_001003799
NM_001003806
TARP

TRGV9
TCR gamma alternate reading frame protein

T cell receptor gamma variable 9
chr1_-_20318578 0.606 NM_012400
PLA2G2D
phospholipase A2, group IID
chr13_-_35327798 0.599 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr6_-_133120587 0.595 NM_004665
VNN2
vanin 2
chr1_-_89437098 0.578 NM_052941
GBP4
guanylate binding protein 4
chr9_+_6710862 0.571 NM_001146696
KDM4C
lysine (K)-specific demethylase 4C
chr1_+_20353284 0.567


chr1_+_43837096 0.565 PTPRF
protein tyrosine phosphatase, receptor type, F
chr12_+_27511009 0.553 NM_001145010
C12orf70
chromosome 12 open reading frame 70
chr6_-_38671741 0.552 NM_001172418
NM_152733
BTBD9

BTB (POZ) domain containing 9

chr2_+_231829021 0.547


chrX_-_2892288 0.543 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr7_-_91632525 0.536 NM_001161528
LOC401387
leucine-rich repeat and death domain-containing protein
chr1_-_32157845 0.536 NM_001195100
NM_001195101
PTP4A2

protein tyrosine phosphatase type IVA, member 2

chr9_-_124329392 0.513 NM_012363
OR1N1
olfactory receptor, family 1, subfamily N, member 1
chr16_-_11588257 0.507 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr6_+_36752244 0.494 NM_078467
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr8_-_13178327 0.493


chr13_-_97627491 0.483 NM_178861
RNF113B
ring finger protein 113B
chr1_-_17180659 0.462 NM_001135247
NM_017459
MFAP2

microfibrillar-associated protein 2

chr1_-_180624494 0.454 GLUL
glutamate-ammonia ligase
chr8_-_13178399 0.451 DLC1
deleted in liver cancer 1
chr19_-_14646626 0.442 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr6_-_159386007 0.441 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr10_+_49279647 0.429 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr17_+_55098280 0.426 CLTC
clathrin, heavy chain (Hc)
chr6_+_36318922 0.420 NM_173676
NM_001145716
PNPLA1

patatin-like phospholipase domain containing 1

chr19_+_21056792 0.419 NM_182515
ZNF714
zinc finger protein 714
chr2_-_188021117 0.418 NM_005795
CALCRL
calcitonin receptor-like
chr12_-_47031287 0.417 NM_001172682
ZNF641
zinc finger protein 641
chr1_+_559618 0.409


chr12_-_65359019 0.406 GRIP1
glutamate receptor interacting protein 1
chr18_+_19826734 0.406 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr12_-_8706746 0.406 MFAP5
microfibrillar associated protein 5
chr7_-_149960612 0.403 NM_024711
GIMAP6
GTPase, IMAP family member 6
chr16_-_3567354 0.398 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr6_-_32892705 0.397 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr22_+_21359175 0.393 IGLV3-25
immunoglobulin lambda variable 3-25
chr17_+_63367052 0.392 BPTF
bromodomain PHD finger transcription factor
chr3_-_31998241 0.389 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr19_-_17432724 0.389 NM_138454
NXNL1
nucleoredoxin-like 1
chr11_-_64484184 0.387 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr5_+_72504778 0.377 NM_153217
TMEM174
transmembrane protein 174
chr7_-_138014329 0.370 NM_001139456
SVOPL
SVOP-like
chr22_+_21340757 0.367


chr3_-_131948202 0.364 NM_014602
PIK3R4
phosphoinositide-3-kinase, regulatory subunit 4
chr16_+_14201687 0.364 MKL2
MKL/myocardin-like 2
chr17_+_70092651 0.361 NM_152460
C17orf77
chromosome 17 open reading frame 77
chr7_-_38915306 0.357 NM_014396
NM_080631
VPS41

vacuolar protein sorting 41 homolog (S. cerevisiae)

chr1_-_155336223 0.354 NM_001004341
ETV3L
ets variant 3-like
chr17_+_38259620 0.341 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr5_-_64813459 0.341 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr11_+_32808045 0.341 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr6_+_31791063 0.340 NM_021246
LY6G6D
lymphocyte antigen 6 complex, locus G6D
chr1_+_151117421 0.336 NM_030663
SMCP
sperm mitochondria-associated cysteine-rich protein
chr6_+_4835224 0.336 NM_001143971
CDYL
chromodomain protein, Y-like
chr4_-_185376012 0.334 NM_153343
ENPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr1_+_208568218 0.329 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr16_+_28993770 0.322 RRN3P2
RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 2
chr1_+_239762179 0.321 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr3_+_46628928 0.319 NM_001195442
LOC100132146
hypothetical LOC100132146
chr17_-_70220605 0.310 NM_139018
CD300LF
CD300 molecule-like family member f
chr21_-_42608774 0.310 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr19_-_9087438 0.310 NM_001005192
OR7G1
olfactory receptor, family 7, subfamily G, member 1
chr10_-_13316333 0.307 NM_145314
UCMA
upper zone of growth plate and cartilage matrix associated
chr1_-_77457664 0.306 NM_005482
PIGK
phosphatidylinositol glycan anchor biosynthesis, class K
chr10_-_95231933 0.293 NM_013451
NM_133337
MYOF

myoferlin

chr7_+_5904858 0.290 NM_015622
C7orf28B
CCZ1
chromosome 7 open reading frame 28B
CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
chr16_+_2749934 0.290


chrX_+_153310313 0.288 ATP6AP1
ATPase, H+ transporting, lysosomal accessory protein 1
chr11_+_113351006 0.287 NM_000869
NM_213621
HTR3A

5-hydroxytryptamine (serotonin) receptor 3A

chr16_+_80370400 0.278 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr14_+_38804226 0.278 NM_203354
CTAGE5
CTAGE family, member 5
chr17_-_31231421 0.277 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr4_-_87247829 0.272 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr19_-_60320592 0.270 NM_017607
PPP1R12C
protein phosphatase 1, regulatory (inhibitor) subunit 12C
chr12_-_8706533 0.270 MFAP5
microfibrillar associated protein 5
chr8_+_26569709 0.266 DPYSL2
dihydropyrimidinase-like 2
chr1_-_143708467 0.266 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr12_-_65359148 0.264 NM_001178074
NM_021150
GRIP1

glutamate receptor interacting protein 1

chr10_-_7699192 0.264 ITIH5
inter-alpha (globulin) inhibitor H5
chr5_+_65408500 0.264 ERBB2IP
erbb2 interacting protein
chr15_-_75135496 0.264 TSPAN3
tetraspanin 3
chr2_+_218698980 0.264 NM_001557
CXCR2
chemokine (C-X-C motif) receptor 2
chr12_-_10173947 0.264 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr4_-_123761615 0.263 NM_021803
IL21
interleukin 21
chr17_+_63766874 0.259 NM_014960
ARSG
arylsulfatase G
chr6_-_50097606 0.256 NM_001037497
NM_001037728
DEFB110

defensin, beta 110 locus

chr17_+_64922420 0.256 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr11_-_59237893 0.255 NM_001005324
OR10V1
olfactory receptor, family 10, subfamily V, member 1
chr16_-_56886380 0.254 NM_001080492
PRSS54
protease, serine, 54
chr3_-_152478843 0.251 NM_014879
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr16_-_11282595 0.251 NM_002761
PRM1
protamine 1
chr3_-_187744808 0.249 NM_017541
CRYGS
crystallin, gamma S
chr6_+_163904564 0.249 QKI
quaking homolog, KH domain RNA binding (mouse)
chr12_+_28301399 0.248 NM_018318
CCDC91
coiled-coil domain containing 91
chr2_-_198248828 0.244 NM_144629
RFTN2
raftlin family member 2
chr1_+_146843980 0.242 NM_001102663
NBPF15
NBPF8
NBPF16
neuroblastoma breakpoint family, member 15
neuroblastoma breakpoint family, member 8
neuroblastoma breakpoint family, member 16
chr21_+_36458708 0.242 NM_005128
DOPEY2
dopey family member 2
chr19_-_59573869 0.242 LAIR1
leukocyte-associated immunoglobulin-like receptor 1
chr15_+_20287609 0.238 NM_001001413
GOLGA6L1
golgin A6 family-like 1
chr1_-_9052207 0.237 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr12_-_121753795 0.237 NM_177551
GPR109A
G protein-coupled receptor 109A
chr1_+_158975662 0.234 NM_021181
SLAMF7
SLAM family member 7
chr21_-_42219849 0.233 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr6_-_99957253 0.233 SFRS18
splicing factor, arginine/serine-rich 18
chr18_-_46600295 0.233 NM_001127175
NM_001127176
NM_031939
MRO


maestro


chr3_+_108578877 0.231 NM_032600
CCDC54
coiled-coil domain containing 54
chr18_+_8708448 0.230


chr1_+_151897817 0.230 SNAPIN
SNAP-associated protein
chr3_+_173954940 0.229 NM_018098
ECT2
epithelial cell transforming sequence 2 oncogene
chr7_+_75947762 0.227 NM_001102596
DTX2
deltex homolog 2 (Drosophila)
chr7_+_77307382 0.225 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr11_-_2149591 0.220 NM_000360
NM_199292
NM_199293
TH


tyrosine hydroxylase


chr1_-_115070413 0.220 CSDE1
cold shock domain containing E1, RNA-binding
chr19_+_46489987 0.218 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr11_-_67207112 0.216 RPL37
ribosomal protein L37
chr6_+_149763187 0.215 NM_001002255
SUMO4
SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)
chr3_-_15357878 0.215 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr5_-_39430180 0.213 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr16_-_85146181 0.211 NM_001159380
NM_001159377
NM_001159378
NM_001159379
NM_022764
MTHFSD




methenyltetrahydrofolate synthetase domain containing




chr11_+_59001421 0.211 NM_001004705
OR4D10
olfactory receptor, family 4, subfamily D, member 10
chr12_-_8706637 0.211 NM_003480
MFAP5
microfibrillar associated protein 5
chr8_-_7710547 0.209 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr7_-_92615593 0.204 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr3_-_152585226 0.204 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr8_-_42742729 0.202 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr3_-_56810869 0.201 NM_019555
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr3_+_120375053 0.201 NM_006952
UPK1B
uroplakin 1B
chr2_+_135312655 0.198 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr18_+_41560915 0.198 NM_001146037
SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr22_-_20419975 0.194 NM_013313
YPEL1
yippee-like 1 (Drosophila)
chr7_-_87774130 0.191 NM_024636
STEAP4
STEAP family member 4
chr3_+_39399770 0.189 NM_017875
SLC25A38
solute carrier family 25, member 38
chr1_-_17638729 0.188 RCC2
regulator of chromosome condensation 2
chr19_+_59866237 0.187 LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
chr2_-_231498184 0.185 NM_005683
GPR55
G protein-coupled receptor 55
chr17_-_36113502 0.184 NM_019016
KRT24
keratin 24
chr6_+_6533932 0.181 NM_004271
LY86
lymphocyte antigen 86
chr10_+_123738678 0.181 NM_206861
NM_206862
TACC2

transforming, acidic coiled-coil containing protein 2

chr14_-_105796665 0.180 IGHV4-31
IGHV3-23
IGHA1
IGHG1
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-23
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr19_+_50144267 0.180 APOC2
apolipoprotein C-II
chr3_+_153074118 0.179 NM_033050
SUCNR1
succinate receptor 1
chr1_+_43055362 0.178 NM_001017922
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr6_-_46811388 0.177 NM_001168357
PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr5_+_118993152 0.175 NM_001163991
NM_182761
FAM170A

family with sequence similarity 170, member A

chr2_+_113911737 0.173 NM_172003
CBWD2
CBWD1
COBW domain containing 2
COBW domain containing 1
chr1_+_151897768 0.173 NM_012437
SNAPIN
SNAP-associated protein
chr1_-_246857051 0.170 NM_001001964
OR2T11
olfactory receptor, family 2, subfamily T, member 11
chr19_-_53912025 0.169 NM_182574
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr2_-_20390601 0.169 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr4_-_152316105 0.169 NM_001128924
SH3D19
SH3 domain containing 19
chr18_+_27425727 0.169 NM_000371
TTR
transthyretin
chr9_-_111230926 0.168 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr1_+_109057078 0.168 NM_001144937
FNDC7
fibronectin type III domain containing 7
chr1_-_151614681 0.167 NM_005621
S100A12
S100 calcium binding protein A12
chr1_+_147006065 0.167 NM_001102663
NBPF15
NBPF8
NBPF16
neuroblastoma breakpoint family, member 15
neuroblastoma breakpoint family, member 8
neuroblastoma breakpoint family, member 16
chr1_-_246912227 0.165 NM_001004734
OR14I1
olfactory receptor, family 14, subfamily I, member 1
chr4_+_636965 0.164 NM_001145292
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr10_-_13584950 0.164 NM_001100912
NM_152751
BEND7

BEN domain containing 7

chr19_+_18069596 0.163 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr2_+_201182187 0.163 AOX1
aldehyde oxidase 1
chr1_-_172199799 0.162 RC3H1
ring finger and CCCH-type domains 1
chr2_-_24199647 0.162 NM_199346
PFN4
profilin family, member 4
chr13_+_22653059 0.162 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr17_-_10500189 0.161 NM_002470
MYH3
myosin, heavy chain 3, skeletal muscle, embryonic
chr3_-_172227223 0.159 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr20_-_42373151 0.159 NM_001080472
FITM2
fat storage-inducing transmembrane protein 2
chr20_+_35755832 0.158 NM_030877
CTNNBL1
catenin, beta like 1
chr2_+_39000007 0.157 NM_001145451
ARHGEF33
Rho guanine nucleotide exchange factor (GEF) 33
chr20_+_35755857 0.155 CTNNBL1
catenin, beta like 1
chr12_-_54965996 0.154 CS
citrate synthase
chr12_-_121404968 0.154 CLIP1
CAP-GLY domain containing linker protein 1
chr8_-_30704984 0.152 NM_000637
NM_001195102
NM_001195103
NM_001195104
GSR



glutathione reductase



chr2_-_99238001 0.152 NM_175735
LYG2
lysozyme G-like 2
chr1_+_51208499 0.152 CDKN2C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr20_+_35755865 0.152 CTNNBL1
catenin, beta like 1
chr19_+_13999959 0.150 NM_080864
RLN3
relaxin 3
chr3_+_109498082 0.149 HHLA2
HERV-H LTR-associating 2
chr11_-_4782185 0.149 NM_001005177
OR52R1
olfactory receptor, family 52, subfamily R, member 1
chr8_-_102034777 0.149 NM_003406
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr19_-_9186512 0.149 NM_001005191
OR7D4
olfactory receptor, family 7, subfamily D, member 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.68 2.60e-02 GO:0050778 positive regulation of immune response
1.91 3.34e-02 GO:0006952 defense response

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
7.58 3.54e-02 GO:0045028 purinergic nucleotide receptor activity, G-protein coupled