Motif ID: TFAP4.p2

Z-value: 2.031


Transcription factors associated with TFAP4.p2:

Gene SymbolEntrez IDGene Name
TFAP4 7023 transcription factor AP-4 (activating enhancer binding protein 4)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP4chr16_-_42626960.391.3e-01Click!


Activity profile for motif TFAP4.p2.

activity profile for motif TFAP4.p2


Sorted Z-values histogram for motif TFAP4.p2

Sorted Z-values for motif TFAP4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_20068039 3.080 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr2_+_128119908 2.656 NM_001161415
NM_001161416
NM_001161417
NM_005291
GPR17



G protein-coupled receptor 17



chr21_+_36429079 2.390 NM_001236
CBR3
carbonyl reductase 3
chr22_-_20235372 2.320 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr5_+_129268352 2.039 NM_175856
CHSY3
chondroitin sulfate synthase 3
chr7_-_27136876 1.908 NM_002141
HOXA4
homeobox A4
chr1_+_43769065 1.835 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr17_-_36528113 1.799 NM_033059
KRTAP4-11
keratin associated protein 4-11
chr1_-_93919789 1.758 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chr2_+_159533329 1.747 NM_001145909
NM_033394
TANC1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr19_-_56841819 1.743 NM_001098612
SIGLEC14
sialic acid binding Ig-like lectin 14
chr6_-_167491305 1.699 NM_005299
GPR31
G protein-coupled receptor 31
chr2_+_187266899 1.557 NM_177454
FAM171B
family with sequence similarity 171, member B
chr1_+_208472817 1.429 NM_019605
SERTAD4
SERTA domain containing 4
chr6_-_160599779 1.321 NM_003058
SLC22A2
solute carrier family 22 (organic cation transporter), member 2
chr19_-_55156118 1.278 NM_001135163
NM_052884
SIGLEC11

sialic acid binding Ig-like lectin 11

chr5_-_112658200 1.274 MCC
mutated in colorectal cancers
chr18_-_53621277 1.240 NM_005603
ATP8B1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr19_-_56825400 1.214 NM_003830
SIGLEC5
sialic acid binding Ig-like lectin 5
chr7_+_153633127 1.170 NM_001936
DPP6
dipeptidyl-peptidase 6
chr17_-_36346240 1.162 KRT23
keratin 23 (histone deacetylase inducible)
chr5_+_94981735 1.135 NM_199243
GPR150
G protein-coupled receptor 150
chr6_+_21701942 1.132 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr2_+_132890616 1.122 NM_001508
GPR39
G protein-coupled receptor 39
chr12_-_50871953 1.119 NM_001081492
NM_182507
KRT80

keratin 80

chr9_-_128924706 1.114 ANGPTL2
angiopoietin-like 2
chr9_-_132804243 1.110 NM_001145106
FIBCD1
fibrinogen C domain containing 1
chr6_+_37245860 1.084 NM_002648
PIM1
pim-1 oncogene
chr22_+_17539198 1.082


chr10_-_30388439 1.066 NM_020848
KIAA1462
KIAA1462
chr20_+_31783426 1.058 NM_032819
ZNF341
zinc finger protein 341
chr19_-_59438411 1.049 NM_024318
LILRB3
LILRA6
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chr3_+_32408346 1.034 CMTM7
CKLF-like MARVEL transmembrane domain containing 7
chr1_+_181259317 1.030


chr9_-_128924782 1.017 ANGPTL2
angiopoietin-like 2
chr22_-_19122047 1.016 SCARF2
scavenger receptor class F, member 2
chrX_-_46503415 1.015 NM_032591
SLC9A7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr4_-_191143017 1.006 NM_020040
TUBB4Q
tubulin, beta polypeptide 4, member Q
chr16_-_1215254 1.004 NM_012467
TPSG1
tryptase gamma 1
chr17_-_36507900 1.001 NM_031960
KRTAP4-8
keratin associated protein 4-8
chr17_+_46067114 0.999 NM_001144070
NM_003786
ABCC3

ATP-binding cassette, sub-family C (CFTR/MRP), member 3

chr16_-_71650034 0.988 NM_001164766
ZFHX3
zinc finger homeobox 3
chr1_+_143920424 0.988 NM_203458
NOTCH2NL
notch 2 N-terminal like
chr18_-_42804291 0.985 NM_001100817
TCEB3C
TCEB3CL
transcription elongation factor B polypeptide 3C (elongin A3)
transcription elongation factor B polypeptide 3C-like
chr6_-_154873344 0.963 CNKSR3
CNKSR family member 3
chr6_+_31815703 0.962 NM_002441
NM_025259
NM_172165
NM_172166
MSH5-C6ORF26
MSH5



MSH5-C6orf26 read-through transcript
mutS homolog 5 (E. coli)



chr12_-_4425040 0.945 NM_020996
FGF6
fibroblast growth factor 6
chr6_+_36773605 0.939 RAB44
RAB44, member RAS oncogene family
chr22_-_19122107 0.939 NM_153334
NM_182895
SCARF2

scavenger receptor class F, member 2

chr16_+_68765428 0.938 NM_173619
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chr18_-_42810206 0.936 NM_001100817
TCEB3C
TCEB3CL
transcription elongation factor B polypeptide 3C (elongin A3)
transcription elongation factor B polypeptide 3C-like
chr5_-_139402909 0.935 NRG2
neuregulin 2
chr16_+_79829794 0.931 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr16_-_15742883 0.930 MYH11
myosin, heavy chain 11, smooth muscle
chr22_-_17303654 0.929 PRODH
proline dehydrogenase (oxidase) 1
chr18_-_42798364 0.922 NM_001100817
TCEB3C
TCEB3CL
transcription elongation factor B polypeptide 3C (elongin A3)
transcription elongation factor B polypeptide 3C-like
chr21_-_42247007 0.915 NM_015500
C2CD2
C2 calcium-dependent domain containing 2
chr17_+_36515166 0.905 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr3_-_12983959 0.905 NM_014869
IQSEC1
IQ motif and Sec7 domain 1
chr9_-_128924819 0.904 NM_012098
ANGPTL2
angiopoietin-like 2
chr6_-_168222645 0.903 NM_024919
FRMD1
FERM domain containing 1
chr19_+_21056792 0.900 NM_182515
ZNF714
zinc finger protein 714
chr7_+_100515439 0.890 NM_030961
TRIM56
tripartite motif containing 56
chr1_-_226202210 0.886 NM_003395
WNT9A
wingless-type MMTV integration site family, member 9A
chr12_+_62523648 0.883


chr22_+_21559959 0.880 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr9_-_103397023 0.880 NM_147180
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr14_+_92049396 0.879 NM_024832
RIN3
Ras and Rab interactor 3
chr1_-_8008979 0.877 NM_018948
ERRFI1
ERBB receptor feedback inhibitor 1
chr6_-_35804337 0.877 NM_001145775
FKBP5
FK506 binding protein 5
chr1_-_8008934 0.875 ERRFI1
ERBB receptor feedback inhibitor 1
chr17_-_36444626 0.865 NM_030966
KRTAP1-3
keratin associated protein 1-3
chr9_+_128128913 0.862 NM_001011703
NM_033446
FAM125B

family with sequence similarity 125, member B

chr1_+_203503214 0.860 TMCC2
transmembrane and coiled-coil domain family 2
chr6_+_138524717 0.860 NM_020340
KIAA1244
KIAA1244
chr1_+_199975563 0.856 NM_001167738
NAV1
neuron navigator 1
chr1_+_17817397 0.852 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr14_-_22354457 0.852 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr14_+_23937766 0.850 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr1_+_181258952 0.846 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chrX_-_19815586 0.843 NM_031892
SH3KBP1
SH3-domain kinase binding protein 1
chr1_-_6585268 0.841 KLHL21
kelch-like 21 (Drosophila)
chr6_+_36754433 0.836 NM_000389
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr19_-_8118367 0.831 NM_032447
FBN3
fibrillin 3
chr1_-_199704773 0.831 NM_012396
PHLDA3
pleckstrin homology-like domain, family A, member 3
chr6_+_31799099 0.829 NM_025260
NM_138272
NM_138273
NM_138274
NM_138275
NM_138277
C6orf25





chromosome 6 open reading frame 25





chr1_-_6474346 0.825 NM_020631
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr2_-_216944911 0.822 NM_020814
MARCH4
membrane-associated ring finger (C3HC4) 4
chr14_-_22354389 0.817 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr5_+_61637701 0.816 NM_001098511
NM_004520
KIF2A

kinesin heavy chain member 2A

chr10_-_76831430 0.814 NM_032772
ZNF503
zinc finger protein 503
chr11_-_118693021 0.813 NM_006500
MCAM
melanoma cell adhesion molecule
chr6_-_154873480 0.809 CNKSR3
CNKSR family member 3
chr2_+_152900076 0.808 FMNL2
formin-like 2
chr17_-_74432671 0.807 TIMP2
TIMP metallopeptidase inhibitor 2
chr17_-_36587965 0.807 NM_033062
KRTAP4-2
keratin associated protein 4-2
chrX_-_19815370 0.804 SH3KBP1
SH3-domain kinase binding protein 1
chr1_+_26310854 0.803 NM_152835
PDIK1L
PDLIM1 interacting kinase 1 like
chr1_+_113734997 0.793 NM_001142782
NM_152900
MAGI3

membrane associated guanylate kinase, WW and PDZ domain containing 3

chr19_+_18543613 0.782 NM_001033930
NM_003333
UBA52

ubiquitin A-52 residue ribosomal protein fusion product 1

chr6_-_132764257 0.781 NM_015529
MOXD1
monooxygenase, DBH-like 1
chr10_+_129735796 0.777 NM_130435
PTPRE
protein tyrosine phosphatase, receptor type, E
chr16_-_83703496 0.776 NM_198491
FAM92B
family with sequence similarity 92, member B
chrX_-_19815526 0.773 SH3KBP1
SH3-domain kinase binding protein 1
chr6_-_143307976 0.772 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr1_+_225124864 0.768 NM_000447
NM_012486
PSEN2

presenilin 2 (Alzheimer disease 4)

chr16_-_87405817 0.768 NM_000485
NM_001030018
APRT

adenine phosphoribosyltransferase

chr6_+_43151922 0.762 NM_002821
NM_152880
NM_152881
NM_152882
PTK7



PTK7 protein tyrosine kinase 7



chr9_+_123544884 0.760 NM_138709
DAB2IP
DAB2 interacting protein
chr5_+_61637822 0.757 KIF2A
kinesin heavy chain member 2A
chr4_-_24523605 0.756 NM_001130726
CCDC149
coiled-coil domain containing 149
chr1_-_20122638 0.755 NM_014589
PLA2G2E
phospholipase A2, group IIE
chr2_-_219404755 0.755 NM_017431
PRKAG3
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
chr5_-_73972055 0.754 ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr17_+_36636404 0.754 NM_031961
KRTAP9-2
keratin associated protein 9-2
chr6_+_36754467 0.751 CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr16_+_15435825 0.745 NM_033201
C16orf45
chromosome 16 open reading frame 45
chr17_+_36665161 0.739 NM_030975
KRTAP9-9
keratin associated protein 9-9
chr7_-_16427471 0.735 NM_001101417
NM_001101426
ISPD

isoprenoid synthase domain containing

chr16_+_87021379 0.729 NM_001127464
ZNF469
zinc finger protein 469
chr11_-_6397207 0.727 NM_145689
APBB1
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
chr1_+_1104939 0.720 NM_153254
TTLL10
tubulin tyrosine ligase-like family, member 10
chr1_-_16843764 0.714 CROCCP2
ciliary rootlet coiled-coil, rootletin pseudogene 2
chr6_+_11646472 0.713 NM_001100829
TMEM170B
transmembrane protein 170B
chr6_+_32230172 0.708 PPT2
palmitoyl-protein thioesterase 2
chr19_-_50355247 0.704 NM_198478
NKPD1
NTPase, KAP family P-loop domain containing 1
chr14_+_99273751 0.701 EML1
echinoderm microtubule associated protein like 1
chr15_-_68933481 0.695 NM_018357
NM_197958
LARP6

La ribonucleoprotein domain family, member 6

chr2_+_43919606 0.695 NM_022437
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr1_-_120413542 0.691 NOTCH2
notch 2
chr1_+_22224571 0.691 HSPC157
hypothetical LOC29092
chr15_-_53822468 0.688 NM_173814
PRTG
protogenin
chr1_+_68070573 0.688


chr2_+_56265260 0.687


chr1_-_16843744 0.685 CROCCP2
ciliary rootlet coiled-coil, rootletin pseudogene 2
chr1_-_56817568 0.683 PPAP2B
phosphatidic acid phosphatase type 2B
chr11_-_5494391 0.676 NM_145053
UBQLNL
ubiquilin-like
chr8_-_7427584 0.675 NM_001136572
FAM90A7
family with sequence similarity 90, member A7
chr17_-_27210330 0.674 NM_018405
C17orf79
chromosome 17 open reading frame 79
chr5_-_139402989 0.669 NM_001184935
NM_004883
NM_013981
NM_013982
NM_013983
NRG2




neuregulin 2




chr9_-_71476917 0.665 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr17_+_36493927 0.663 NM_033061
KRTAP4-7
keratin associated protein 4-7
chr6_+_7671267 0.663 BMP6
bone morphogenetic protein 6
chr6_+_31910623 0.662 NM_001040437
NM_001040438
C6orf48

chromosome 6 open reading frame 48

chr1_-_23376860 0.661 LUZP1
leucine zipper protein 1
chr21_-_29286982 0.658 NM_015565
LTN1
listerin E3 ubiquitin protein ligase 1
chr3_-_18441763 0.657 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr2_-_43919392 0.656 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr15_+_72253940 0.655 NM_201526
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr16_-_20323533 0.654 NM_174924
PDILT
protein disulfide isomerase-like, testis expressed
chr10_+_124210980 0.653 NM_002775
HTRA1
HtrA serine peptidase 1
chr13_+_56639331 0.653 NM_198441
NM_001130404
NM_001130405
NM_001130406
NM_001130407
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
proline rich 20A
proline rich 20B
proline rich 20C
proline rich 20D
proline rich 20E
chr4_+_169989680 0.649 NM_001166110
PALLD
palladin, cytoskeletal associated protein
chr2_-_20075929 0.648 NM_002381
MATN3
matrilin 3
chr7_-_127833231 0.646 NM_001142573
NM_001142574
NM_001142575
IMPDH1


IMP (inosine 5'-monophosphate) dehydrogenase 1


chr1_-_32176475 0.646 PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr22_+_21359175 0.636 IGLV3-25
immunoglobulin lambda variable 3-25
chr19_+_61379200 0.634 NM_001145546
NM_033106
GALP

galanin-like peptide

chr16_-_73798539 0.634 NM_001025200
CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr22_-_18687511 0.633 NM_033257
DGCR6L
DiGeorge syndrome critical region gene 6-like
chr11_+_7965442 0.632 NM_003754
EIF3F
eukaryotic translation initiation factor 3, subunit F
chr19_-_10305186 0.629 NM_133452
RAVER1
ribonucleoprotein, PTB-binding 1
chr16_+_68542310 0.623 NM_182619
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chr3_-_196787563 0.623 APOD
apolipoprotein D
chr16_-_23515104 0.621 NM_005003
NDUFAB1
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
chr15_+_39032927 0.620 NM_001142776
NM_024111
CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr9_-_122679387 0.618 NM_001009936
NM_015651
PHF19

PHD finger protein 19

chr3_-_10027770 0.617 NM_001008737
LOC401052
hypothetical LOC401052
chr12_-_51528983 0.615 NM_173352
KRT78
keratin 78
chr5_+_148186348 0.614 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr9_-_122679283 0.612 PHF19
PHD finger protein 19
chr1_+_20788027 0.611 NM_001785
CDA
cytidine deaminase
chr3_-_38666122 0.611 NM_000335
NM_001099404
NM_001099405
NM_198056
NM_001160160
NM_001160161
SCN5A





sodium channel, voltage-gated, type V, alpha subunit





chr15_-_62854749 0.609 NM_194272
RBPMS2
RNA binding protein with multiple splicing 2
chr16_+_55199978 0.606 NM_005953
MT2A
metallothionein 2A
chr14_+_30161267 0.605 NM_016106
NM_182835
SCFD1

sec1 family domain containing 1

chr22_+_21393107 0.604 IGLJ3
immunoglobulin lambda joining 3
chr7_+_45894480 0.603 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chr15_+_84021271 0.600 NM_144767
AKAP13
A kinase (PRKA) anchor protein 13
chr20_-_42373151 0.600 NM_001080472
FITM2
fat storage-inducing transmembrane protein 2
chr1_+_77520315 0.596 NM_174858
AK5
adenylate kinase 5
chr20_+_21231921 0.596 NM_012255
XRN2
5'-3' exoribonuclease 2
chr1_-_16272523 0.595 NM_182623
FAM131C
family with sequence similarity 131, member C
chr1_-_6402467 0.594 NM_019089
HES2
hairy and enhancer of split 2 (Drosophila)
chr16_+_73810383 0.592 NM_001906
CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr7_-_95063738 0.592 NM_002612
PDK4
pyruvate dehydrogenase kinase, isozyme 4
chr14_+_30161285 0.589 SCFD1
sec1 family domain containing 1
chr10_-_116382089 0.583 ABLIM1
actin binding LIM protein 1
chr16_-_23559978 0.583 NM_024675
PALB2
partner and localizer of BRCA2
chr12_+_50981915 0.583 NM_002284
KRT86
keratin 86
chr7_+_2525922 0.576 NM_001040167
NM_001040168
LFNG

LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr8_+_144711619 0.574 NM_024736
GSDMD
gasdermin D
chr3_-_126257425 0.570 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr18_+_32131628 0.570 NM_025135
FHOD3
formin homology 2 domain containing 3
chr19_+_56337368 0.565 NM_014385
NM_016543
SIGLEC7

sialic acid binding Ig-like lectin 7

chrX_-_70755023 0.564 NM_001142797
NM_001504
CXCR3

chemokine (C-X-C motif) receptor 3

chr1_+_3531410 0.563 NM_182752
TPRG1L
tumor protein p63 regulated 1-like
chr1_+_32251988 0.561 NM_006559
KHDRBS1
KH domain containing, RNA binding, signal transduction associated 1
chr10_+_88404285 0.561 NM_001030015
NM_033282
OPN4

opsin 4

chr6_-_154873396 0.561 NM_173515
CNKSR3
CNKSR family member 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.38 5.86e-03 GO:0016265 death
1.38 6.43e-03 GO:0008219 cell death
1.41 1.61e-02 GO:0006915 apoptosis
1.39 2.51e-02 GO:0012501 programmed cell death

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.13 1.64e-10 GO:0045095 keratin filament
1.94 2.95e-05 GO:0045111 intermediate filament cytoskeleton
2.00 5.75e-05 GO:0005882 intermediate filament
1.10 1.82e-04 GO:0005737 cytoplasm
1.52 3.27e-02 GO:0005773 vacuole
1.57 3.52e-02 GO:0000323 lytic vacuole
1.57 3.52e-02 GO:0005764 lysosome
1.10 3.76e-02 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.10 2.01e-03 GO:0005515 protein binding