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• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: TFAP4.p2

Z-value: 2.031

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr22_+_20068039	3.080	NM_001128635	RIMBP3B	RIMS binding protein 3B
chr2_+_128119908	2.656	NM_001161415 NM_001161416 NM_001161417 NM_005291	GPR17	G protein-coupled receptor 17
chr21_+_36429079	2.390	NM_001236	CBR3	carbonyl reductase 3
chr22_-_20235372	2.320	NM_001128635	RIMBP3B	RIMS binding protein 3B
chr5_+_129268352	2.039	NM_175856	CHSY3	chondroitin sulfate synthase 3
chr7_-_27136876	1.908	NM_002141	HOXA4	homeobox A4
chr1_+_43769065	1.835	NM_002840 NM_130440	PTPRF	protein tyrosine phosphatase, receptor type, F
chr17_-_36528113	1.799	NM_033059	KRTAP4-11	keratin associated protein 4-11
chr1_-_93919789	1.758	NM_003567	BCAR3	breast cancer anti-estrogen resistance 3
chr2_+_159533329	1.747	NM_001145909 NM_033394	TANC1	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
chr19_-_56841819	1.743	NM_001098612	SIGLEC14	sialic acid binding Ig-like lectin 14
chr6_-_167491305	1.699	NM_005299	GPR31	G protein-coupled receptor 31
chr2_+_187266899	1.557	NM_177454	FAM171B	family with sequence similarity 171, member B
chr1_+_208472817	1.429	NM_019605	SERTAD4	SERTA domain containing 4
chr6_-_160599779	1.321	NM_003058	SLC22A2	solute carrier family 22 (organic cation transporter), member 2
chr19_-_55156118	1.278	NM_001135163 NM_052884	SIGLEC11	sialic acid binding Ig-like lectin 11
chr5_-_112658200	1.274		MCC	mutated in colorectal cancers
chr18_-_53621277	1.240	NM_005603	ATP8B1	ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr19_-_56825400	1.214	NM_003830	SIGLEC5	sialic acid binding Ig-like lectin 5
chr7_+_153633127	1.170	NM_001936	DPP6	dipeptidyl-peptidase 6
chr17_-_36346240	1.162		KRT23	keratin 23 (histone deacetylase inducible)
chr5_+_94981735	1.135	NM_199243	GPR150	G protein-coupled receptor 150
chr6_+_21701942	1.132	NM_003107	SOX4	SRY (sex determining region Y)-box 4
chr2_+_132890616	1.122	NM_001508	GPR39	G protein-coupled receptor 39
chr12_-_50871953	1.119	NM_001081492 NM_182507	KRT80	keratin 80
chr9_-_128924706	1.114		ANGPTL2	angiopoietin-like 2
chr9_-_132804243	1.110	NM_001145106	FIBCD1	fibrinogen C domain containing 1
chr6_+_37245860	1.084	NM_002648	PIM1	pim-1 oncogene
chr22_+_17539198	1.082
chr10_-_30388439	1.066	NM_020848	KIAA1462	KIAA1462
chr20_+_31783426	1.058	NM_032819	ZNF341	zinc finger protein 341
chr19_-_59438411	1.049	NM_024318	LILRB3 LILRA6	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chr3_+_32408346	1.034		CMTM7	CKLF-like MARVEL transmembrane domain containing 7
chr1_+_181259317	1.030
chr9_-_128924782	1.017		ANGPTL2	angiopoietin-like 2
chr22_-_19122047	1.016		SCARF2	scavenger receptor class F, member 2
chrX_-_46503415	1.015	NM_032591	SLC9A7	solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr4_-_191143017	1.006	NM_020040	TUBB4Q	tubulin, beta polypeptide 4, member Q
chr16_-_1215254	1.004	NM_012467	TPSG1	tryptase gamma 1
chr17_-_36507900	1.001	NM_031960	KRTAP4-8	keratin associated protein 4-8
chr17_+_46067114	0.999	NM_001144070 NM_003786	ABCC3	ATP-binding cassette, sub-family C (CFTR/MRP), member 3
chr16_-_71650034	0.988	NM_001164766	ZFHX3	zinc finger homeobox 3
chr1_+_143920424	0.988	NM_203458	NOTCH2NL	notch 2 N-terminal like
chr18_-_42804291	0.985	NM_001100817	TCEB3C TCEB3CL	transcription elongation factor B polypeptide 3C (elongin A3) transcription elongation factor B polypeptide 3C-like
chr6_-_154873344	0.963		CNKSR3	CNKSR family member 3
chr6_+_31815703	0.962	NM_002441 NM_025259 NM_172165 NM_172166	MSH5-C6ORF26 MSH5	MSH5-C6orf26 read-through transcript mutS homolog 5 (E. coli)
chr12_-_4425040	0.945	NM_020996	FGF6	fibroblast growth factor 6
chr6_+_36773605	0.939		RAB44	RAB44, member RAS oncogene family
chr22_-_19122107	0.939	NM_153334 NM_182895	SCARF2	scavenger receptor class F, member 2
chr16_+_68765428	0.938	NM_173619	CLEC18C CLEC18A CLEC18B	C-type lectin domain family 18, member C C-type lectin domain family 18, member A C-type lectin domain family 18, member B
chr18_-_42810206	0.936	NM_001100817	TCEB3C TCEB3CL	transcription elongation factor B polypeptide 3C (elongin A3) transcription elongation factor B polypeptide 3C-like
chr5_-_139402909	0.935		NRG2	neuregulin 2
chr16_+_79829794	0.931	NM_017429	BCMO1	beta-carotene 15,15'-monooxygenase 1
chr16_-_15742883	0.930		MYH11	myosin, heavy chain 11, smooth muscle
chr22_-_17303654	0.929		PRODH	proline dehydrogenase (oxidase) 1
chr18_-_42798364	0.922	NM_001100817	TCEB3C TCEB3CL	transcription elongation factor B polypeptide 3C (elongin A3) transcription elongation factor B polypeptide 3C-like
chr21_-_42247007	0.915	NM_015500	C2CD2	C2 calcium-dependent domain containing 2
chr17_+_36515166	0.905	NM_001146041	KRTAP4-9	keratin associated protein 4-9
chr3_-_12983959	0.905	NM_014869	IQSEC1	IQ motif and Sec7 domain 1
chr9_-_128924819	0.904	NM_012098	ANGPTL2	angiopoietin-like 2
chr6_-_168222645	0.903	NM_024919	FRMD1	FERM domain containing 1
chr19_+_21056792	0.900	NM_182515	ZNF714	zinc finger protein 714
chr7_+_100515439	0.890	NM_030961	TRIM56	tripartite motif containing 56
chr1_-_226202210	0.886	NM_003395	WNT9A	wingless-type MMTV integration site family, member 9A
chr12_+_62523648	0.883
chr22_+_21559959	0.880	NM_001178126	IGLL5 IGLC1	immunoglobulin lambda-like polypeptide 5 immunoglobulin lambda constant 1 (Mcg marker)
chr9_-_103397023	0.880	NM_147180	PPP3R2	protein phosphatase 3, regulatory subunit B, beta
chr14_+_92049396	0.879	NM_024832	RIN3	Ras and Rab interactor 3
chr1_-_8008979	0.877	NM_018948	ERRFI1	ERBB receptor feedback inhibitor 1
chr6_-_35804337	0.877	NM_001145775	FKBP5	FK506 binding protein 5
chr1_-_8008934	0.875		ERRFI1	ERBB receptor feedback inhibitor 1
chr17_-_36444626	0.865	NM_030966	KRTAP1-3	keratin associated protein 1-3
chr9_+_128128913	0.862	NM_001011703 NM_033446	FAM125B	family with sequence similarity 125, member B
chr1_+_203503214	0.860		TMCC2	transmembrane and coiled-coil domain family 2
chr6_+_138524717	0.860	NM_020340	KIAA1244	KIAA1244
chr1_+_199975563	0.856	NM_001167738	NAV1	neuron navigator 1
chr1_+_17817397	0.852		ARHGEF10L	Rho guanine nucleotide exchange factor (GEF) 10-like
chr14_-_22354457	0.852		SLC7A7	solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr14_+_23937766	0.850	NM_025081	NYNRIN	NYN domain and retroviral integrase containing
chr1_+_181258952	0.846	NM_002293	LAMC1	laminin, gamma 1 (formerly LAMB2)
chrX_-_19815586	0.843	NM_031892	SH3KBP1	SH3-domain kinase binding protein 1
chr1_-_6585268	0.841		KLHL21	kelch-like 21 (Drosophila)
chr6_+_36754433	0.836	NM_000389	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr19_-_8118367	0.831	NM_032447	FBN3	fibrillin 3
chr1_-_199704773	0.831	NM_012396	PHLDA3	pleckstrin homology-like domain, family A, member 3
chr6_+_31799099	0.829	NM_025260 NM_138272 NM_138273 NM_138274 NM_138275 NM_138277	C6orf25	chromosome 6 open reading frame 25
chr1_-_6474346	0.825	NM_020631	PLEKHG5	pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr2_-_216944911	0.822	NM_020814	MARCH4	membrane-associated ring finger (C3HC4) 4
chr14_-_22354389	0.817		SLC7A7	solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr5_+_61637701	0.816	NM_001098511 NM_004520	KIF2A	kinesin heavy chain member 2A
chr10_-_76831430	0.814	NM_032772	ZNF503	zinc finger protein 503
chr11_-_118693021	0.813	NM_006500	MCAM	melanoma cell adhesion molecule
chr6_-_154873480	0.809		CNKSR3	CNKSR family member 3
chr2_+_152900076	0.808		FMNL2	formin-like 2
chr17_-_74432671	0.807		TIMP2	TIMP metallopeptidase inhibitor 2
chr17_-_36587965	0.807	NM_033062	KRTAP4-2	keratin associated protein 4-2
chrX_-_19815370	0.804		SH3KBP1	SH3-domain kinase binding protein 1
chr1_+_26310854	0.803	NM_152835	PDIK1L	PDLIM1 interacting kinase 1 like
chr1_+_113734997	0.793	NM_001142782 NM_152900	MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3
chr19_+_18543613	0.782	NM_001033930 NM_003333	UBA52	ubiquitin A-52 residue ribosomal protein fusion product 1
chr6_-_132764257	0.781	NM_015529	MOXD1	monooxygenase, DBH-like 1
chr10_+_129735796	0.777	NM_130435	PTPRE	protein tyrosine phosphatase, receptor type, E
chr16_-_83703496	0.776	NM_198491	FAM92B	family with sequence similarity 92, member B
chrX_-_19815526	0.773		SH3KBP1	SH3-domain kinase binding protein 1
chr6_-_143307976	0.772	NM_006734	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2
chr1_+_225124864	0.768	NM_000447 NM_012486	PSEN2	presenilin 2 (Alzheimer disease 4)
chr16_-_87405817	0.768	NM_000485 NM_001030018	APRT	adenine phosphoribosyltransferase
chr6_+_43151922	0.762	NM_002821 NM_152880 NM_152881 NM_152882	PTK7	PTK7 protein tyrosine kinase 7
chr9_+_123544884	0.760	NM_138709	DAB2IP	DAB2 interacting protein
chr5_+_61637822	0.757		KIF2A	kinesin heavy chain member 2A
chr4_-_24523605	0.756	NM_001130726	CCDC149	coiled-coil domain containing 149
chr1_-_20122638	0.755	NM_014589	PLA2G2E	phospholipase A2, group IIE
chr2_-_219404755	0.755	NM_017431	PRKAG3	protein kinase, AMP-activated, gamma 3 non-catalytic subunit
chr5_-_73972055	0.754		ENC1	ectodermal-neural cortex 1 (with BTB-like domain)
chr17_+_36636404	0.754	NM_031961	KRTAP9-2	keratin associated protein 9-2
chr6_+_36754467	0.751		CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr16_+_15435825	0.745	NM_033201	C16orf45	chromosome 16 open reading frame 45
chr17_+_36665161	0.739	NM_030975	KRTAP9-9	keratin associated protein 9-9
chr7_-_16427471	0.735	NM_001101417 NM_001101426	ISPD	isoprenoid synthase domain containing
chr16_+_87021379	0.729	NM_001127464	ZNF469	zinc finger protein 469
chr11_-_6397207	0.727	NM_145689	APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
chr1_+_1104939	0.720	NM_153254	TTLL10	tubulin tyrosine ligase-like family, member 10
chr1_-_16843764	0.714		CROCCP2	ciliary rootlet coiled-coil, rootletin pseudogene 2
chr6_+_11646472	0.713	NM_001100829	TMEM170B	transmembrane protein 170B
chr6_+_32230172	0.708		PPT2	palmitoyl-protein thioesterase 2
chr19_-_50355247	0.704	NM_198478	NKPD1	NTPase, KAP family P-loop domain containing 1
chr14_+_99273751	0.701		EML1	echinoderm microtubule associated protein like 1
chr15_-_68933481	0.695	NM_018357 NM_197958	LARP6	La ribonucleoprotein domain family, member 6
chr2_+_43919606	0.695	NM_022437	ABCG8	ATP-binding cassette, sub-family G (WHITE), member 8
chr1_-_120413542	0.691		NOTCH2	notch 2
chr1_+_22224571	0.691		HSPC157	hypothetical LOC29092
chr15_-_53822468	0.688	NM_173814	PRTG	protogenin
chr1_+_68070573	0.688
chr2_+_56265260	0.687
chr1_-_16843744	0.685		CROCCP2	ciliary rootlet coiled-coil, rootletin pseudogene 2
chr1_-_56817568	0.683		PPAP2B	phosphatidic acid phosphatase type 2B
chr11_-_5494391	0.676	NM_145053	UBQLNL	ubiquilin-like
chr8_-_7427584	0.675	NM_001136572	FAM90A7	family with sequence similarity 90, member A7
chr17_-_27210330	0.674	NM_018405	C17orf79	chromosome 17 open reading frame 79
chr5_-_139402989	0.669	NM_001184935 NM_004883 NM_013981 NM_013982 NM_013983	NRG2	neuregulin 2
chr9_-_71476917	0.665	NM_001163	APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1
chr17_+_36493927	0.663	NM_033061	KRTAP4-7	keratin associated protein 4-7
chr6_+_7671267	0.663		BMP6	bone morphogenetic protein 6
chr6_+_31910623	0.662	NM_001040437 NM_001040438	C6orf48	chromosome 6 open reading frame 48
chr1_-_23376860	0.661		LUZP1	leucine zipper protein 1
chr21_-_29286982	0.658	NM_015565	LTN1	listerin E3 ubiquitin protein ligase 1
chr3_-_18441763	0.657	NM_001195470 NM_002971	SATB1	SATB homeobox 1
chr2_-_43919392	0.656	NM_022436	ABCG5	ATP-binding cassette, sub-family G (WHITE), member 5
chr15_+_72253940	0.655	NM_201526	ISLR	immunoglobulin superfamily containing leucine-rich repeat
chr16_-_20323533	0.654	NM_174924	PDILT	protein disulfide isomerase-like, testis expressed
chr10_+_124210980	0.653	NM_002775	HTRA1	HtrA serine peptidase 1
chr13_+_56639331	0.653	NM_198441 NM_001130404 NM_001130405 NM_001130406 NM_001130407	PRR20A PRR20B PRR20C PRR20D PRR20E	proline rich 20A proline rich 20B proline rich 20C proline rich 20D proline rich 20E
chr4_+_169989680	0.649	NM_001166110	PALLD	palladin, cytoskeletal associated protein
chr2_-_20075929	0.648	NM_002381	MATN3	matrilin 3
chr7_-_127833231	0.646	NM_001142573 NM_001142574 NM_001142575	IMPDH1	IMP (inosine 5'-monophosphate) dehydrogenase 1
chr1_-_32176475	0.646		PTP4A2	protein tyrosine phosphatase type IVA, member 2
chr22_+_21359175	0.636		IGLV3-25	immunoglobulin lambda variable 3-25
chr19_+_61379200	0.634	NM_001145546 NM_033106	GALP	galanin-like peptide
chr16_-_73798539	0.634	NM_001025200	CTRB1 CTRB2	chymotrypsinogen B1 chymotrypsinogen B2
chr22_-_18687511	0.633	NM_033257	DGCR6L	DiGeorge syndrome critical region gene 6-like
chr11_+_7965442	0.632	NM_003754	EIF3F	eukaryotic translation initiation factor 3, subunit F
chr19_-_10305186	0.629	NM_133452	RAVER1	ribonucleoprotein, PTB-binding 1
chr16_+_68542310	0.623	NM_182619	CLEC18C CLEC18A CLEC18B	C-type lectin domain family 18, member C C-type lectin domain family 18, member A C-type lectin domain family 18, member B
chr3_-_196787563	0.623		APOD	apolipoprotein D
chr16_-_23515104	0.621	NM_005003	NDUFAB1	NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
chr15_+_39032927	0.620	NM_001142776 NM_024111	CHAC1	ChaC, cation transport regulator homolog 1 (E. coli)
chr9_-_122679387	0.618	NM_001009936 NM_015651	PHF19	PHD finger protein 19
chr3_-_10027770	0.617	NM_001008737	LOC401052	hypothetical LOC401052
chr12_-_51528983	0.615	NM_173352	KRT78	keratin 78
chr5_+_148186348	0.614	NM_000024	ADRB2	adrenergic, beta-2-, receptor, surface
chr9_-_122679283	0.612		PHF19	PHD finger protein 19
chr1_+_20788027	0.611	NM_001785	CDA	cytidine deaminase
chr3_-_38666122	0.611	NM_000335 NM_001099404 NM_001099405 NM_198056 NM_001160160 NM_001160161	SCN5A	sodium channel, voltage-gated, type V, alpha subunit
chr15_-_62854749	0.609	NM_194272	RBPMS2	RNA binding protein with multiple splicing 2
chr16_+_55199978	0.606	NM_005953	MT2A	metallothionein 2A
chr14_+_30161267	0.605	NM_016106 NM_182835	SCFD1	sec1 family domain containing 1
chr22_+_21393107	0.604		IGLJ3	immunoglobulin lambda joining 3
chr7_+_45894480	0.603	NM_000596	IGFBP1	insulin-like growth factor binding protein 1
chr15_+_84021271	0.600	NM_144767	AKAP13	A kinase (PRKA) anchor protein 13
chr20_-_42373151	0.600	NM_001080472	FITM2	fat storage-inducing transmembrane protein 2
chr1_+_77520315	0.596	NM_174858	AK5	adenylate kinase 5
chr20_+_21231921	0.596	NM_012255	XRN2	5'-3' exoribonuclease 2
chr1_-_16272523	0.595	NM_182623	FAM131C	family with sequence similarity 131, member C
chr1_-_6402467	0.594	NM_019089	HES2	hairy and enhancer of split 2 (Drosophila)
chr16_+_73810383	0.592	NM_001906	CTRB1 CTRB2	chymotrypsinogen B1 chymotrypsinogen B2
chr7_-_95063738	0.592	NM_002612	PDK4	pyruvate dehydrogenase kinase, isozyme 4
chr14_+_30161285	0.589		SCFD1	sec1 family domain containing 1
chr10_-_116382089	0.583		ABLIM1	actin binding LIM protein 1
chr16_-_23559978	0.583	NM_024675	PALB2	partner and localizer of BRCA2
chr12_+_50981915	0.583	NM_002284	KRT86	keratin 86
chr7_+_2525922	0.576	NM_001040167 NM_001040168	LFNG	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr8_+_144711619	0.574	NM_024736	GSDMD	gasdermin D
chr3_-_126257425	0.570	NM_020733	HEG1	HEG homolog 1 (zebrafish)
chr18_+_32131628	0.570	NM_025135	FHOD3	formin homology 2 domain containing 3
chr19_+_56337368	0.565	NM_014385 NM_016543	SIGLEC7	sialic acid binding Ig-like lectin 7
chrX_-_70755023	0.564	NM_001142797 NM_001504	CXCR3	chemokine (C-X-C motif) receptor 3
chr1_+_3531410	0.563	NM_182752	TPRG1L	tumor protein p63 regulated 1-like
chr1_+_32251988	0.561	NM_006559	KHDRBS1	KH domain containing, RNA binding, signal transduction associated 1
chr10_+_88404285	0.561	NM_001030015 NM_033282	OPN4	opsin 4
chr6_-_154873396	0.561	NM_173515	CNKSR3	CNKSR family member 3

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.38	5.86e-03	GO:0016265	death
1.38	6.43e-03	GO:0008219	cell death
1.41	1.61e-02	GO:0006915	apoptosis
1.39	2.51e-02	GO:0012501	programmed cell death

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
3.13	1.64e-10	GO:0045095	keratin filament
1.94	2.95e-05	GO:0045111	intermediate filament cytoskeleton
2.00	5.75e-05	GO:0005882	intermediate filament
1.10	1.82e-04	GO:0005737	cytoplasm
1.52	3.27e-02	GO:0005773	vacuole
1.57	3.52e-02	GO:0000323	lytic vacuole
1.57	3.52e-02	GO:0005764	lysosome
1.10	3.76e-02	GO:0044444	cytoplasmic part

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.10	2.01e-03	GO:0005515	protein binding

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