Motif ID: ETS1,2.p2

Z-value: 2.111


Transcription factors associated with ETS1,2.p2:

Gene SymbolEntrez IDGene Name
ETS1 2113 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
ETS2 2114 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ETS2chr21_+_391170640.505.0e-02Click!
ETS1chr11_-_127897271-0.253.6e-01Click!


Activity profile for motif ETS1,2.p2.

activity profile for motif ETS1,2.p2


Sorted Z-values histogram for motif ETS1,2.p2

Sorted Z-values for motif ETS1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ETS1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_15955719 2.110 FBLIM1
filamin binding LIM protein 1
chr8_+_22493928 1.883 NM_176871
NM_198042
PDLIM2

PDZ and LIM domain 2 (mystique)

chr21_-_45165302 1.575 NM_000211
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr21_-_45165249 1.510 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr1_+_24755152 1.469 NM_001010980
C1orf130
chromosome 1 open reading frame 130
chr12_-_121780835 1.328 NM_032554
GPR81
G protein-coupled receptor 81
chrX_-_40480005 1.226 MED14
mediator complex subunit 14
chr19_-_61324412 1.201 ZNF787
zinc finger protein 787
chr11_-_46678715 1.192 ARHGAP1
Rho GTPase activating protein 1
chr10_+_71060008 1.184 NM_145306
C10orf35
chromosome 10 open reading frame 35
chr6_+_10663934 1.157 NM_001491
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr9_-_132759045 1.151 NM_198180
QRFP
pyroglutamylated RFamide peptide
chr21_-_45165204 1.144 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr11_-_46678736 1.133 ARHGAP1
Rho GTPase activating protein 1
chr11_-_46678691 1.128 NM_004308
ARHGAP1
Rho GTPase activating protein 1
chr3_-_184756101 1.079 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr18_+_21967813 1.079 NM_001025096
NM_001025097
NM_144662
PSMA8


proteasome (prosome, macropain) subunit, alpha type, 8


chr12_-_109372489 1.064 ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr1_-_6468108 1.059 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr6_-_11490487 1.056 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr8_+_23016271 1.039 NM_003841
TNFRSF10C
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
chr18_+_13208777 1.034 NM_181481
NM_181482
C18orf1

chromosome 18 open reading frame 1

chr11_+_46678892 1.021 NM_024741
ZNF408
zinc finger protein 408
chr10_+_49562866 1.003 WDFY4
WDFY family member 4
chr12_-_109372481 1.003 ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr19_+_17723285 0.986 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chrX_-_40479718 0.983 NM_004229
MED14
mediator complex subunit 14
chr22_+_35586950 0.979 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr1_+_18680010 0.965 NM_152375
KLHDC7A
kelch domain containing 7A
chrX_+_65152004 0.963


chr12_-_109372517 0.923 ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr22_+_17337970 0.912 DGCR5
DiGeorge syndrome critical region gene 5 (non-protein coding)
chr1_-_119333701 0.908 NM_152380
TBX15
T-box 15
chr11_-_407324 0.902 NM_001135053
NM_021805
SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

chr19_+_63386193 0.900 NM_016324
NM_016325
NM_133502
ZNF274


zinc finger protein 274


chrX_-_40479893 0.898 MED14
mediator complex subunit 14
chr8_-_146023228 0.892 LOC100130027
hypothetical LOC100130027
chr17_+_7549138 0.889 NM_001406
EFNB3
ephrin-B3
chr10_+_35934343 0.881 NM_153368
GJD4
gap junction protein, delta 4, 40.1kDa
chr19_-_61324456 0.878 NM_001002836
ZNF787
zinc finger protein 787
chr17_-_60208083 0.875 LOC146880
hypothetical LOC146880
chr17_+_4283967 0.868 NM_182538
SPNS3
spinster homolog 3 (Drosophila)
chr6_+_31661934 0.857 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr12_-_109372543 0.850 ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr11_+_2877486 0.842 NM_183233
SLC22A18
solute carrier family 22, member 18
chr12_-_109372462 0.840 ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chrX_-_40479607 0.836 MED14
mediator complex subunit 14
chr1_-_31003260 0.834 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr12_-_56445653 0.828 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr12_-_6668787 0.818 NM_001039918
NM_133476
ZNF384

zinc finger protein 384

chr1_-_6468600 0.818 NM_001042665
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr1_+_43386180 0.817 NM_001101376
FAM183A
family with sequence similarity 183, member A
chr19_-_5802420 0.807 NM_000149
NM_001097639
NM_001097640
NM_001097641
FUT3



fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)



chr17_+_4784097 0.803 RNF167
ring finger protein 167
chr14_-_93926679 0.800 NM_001002235
NM_001002236
NM_001127700
NM_001127701
NM_001127702
NM_001127703
NM_001127704
NM_001127705
NM_001127706
NM_001127707
SERPINA1









serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1









chr1_+_22200735 0.797 NM_005747
CELA3A
chymotrypsin-like elastase family, member 3A
chr12_-_6668680 0.787 ZNF384
zinc finger protein 384
chrX_-_130792297 0.781 LOC286467
hypothetical LOC286467
chr10_-_72032519 0.780 NM_001083116
NM_005041
PRF1

perforin 1 (pore forming protein)

chr1_+_22176004 0.771 NM_007352
CELA3A
CELA3B
chymotrypsin-like elastase family, member 3A
chymotrypsin-like elastase family, member 3B
chr19_-_10166536 0.768 DNMT1
DNA (cytosine-5-)-methyltransferase 1
chr1_+_38046404 0.768 C1orf122
chromosome 1 open reading frame 122
chr1_+_43539239 0.767 NM_005424
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr14_+_68935172 0.762 SLC39A9
solute carrier family 39 (zinc transporter), member 9
chr5_-_95774444 0.752 NM_001177876
PCSK1
proprotein convertase subtilisin/kexin type 1
chr10_+_129595289 0.746 NM_006504
PTPRE
protein tyrosine phosphatase, receptor type, E
chr15_+_83160914 0.739 NM_020778
ALPK3
alpha-kinase 3
chr1_+_38046055 0.738 NM_001142726
NM_198446
C1orf122

chromosome 1 open reading frame 122

chr5_-_149360314 0.738 NM_030953
LOC728287
TIGD6
hypothetical protein LOC728287
tigger transposable element derived 6
chr7_+_95239753 0.734 NM_001135556
NM_001135557
NM_004411
DYNC1I1


dynein, cytoplasmic 1, intermediate chain 1


chr10_+_75174125 0.732 NM_004922
NM_198597
SEC24C

SEC24 family, member C (S. cerevisiae)

chr10_+_124020810 0.727 NM_144587
BTBD16
BTB (POZ) domain containing 16
chr3_+_47004457 0.722 NBEAL2
neurobeachin-like 2
chr1_-_199635057 0.719 LAD1
ladinin 1
chr5_+_149360361 0.717 NM_014983
HMGXB3
HMG box domain containing 3
chr10_-_72032447 0.716 PRF1
perforin 1 (pore forming protein)
chr15_+_76889873 0.714 MORF4L1
mortality factor 4 like 1
chr1_+_28867801 0.712 NM_006582
NM_024482
GMEB1

glucocorticoid modulatory element binding protein 1

chr1_+_170077234 0.712 NM_001136127
NM_015569
DNM3

dynamin 3

chr15_-_81743198 0.708 BNC1
basonuclin 1
chr1_-_199635339 0.707 LAD1
ladinin 1
chr15_+_55671393 0.705 NM_001018090
NM_001018091
NM_001018100
NM_152451
GCOM1



GRINL1A complex locus



chr4_+_2783743 0.701 NM_001145855
SH3BP2
SH3-domain binding protein 2
chr11_+_46679140 0.692 NM_001184751
ZNF408
zinc finger protein 408
chr12_-_6668880 0.691 NM_001039917
NM_001039919
NM_001039920
NM_001135734
ZNF384



zinc finger protein 384



chr1_-_153213483 0.686 NM_001130041
NM_003029
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr7_-_142816019 0.686 NM_005232
EPHA1
EPH receptor A1
chr14_+_68935133 0.685 NM_018375
SLC39A9
solute carrier family 39 (zinc transporter), member 9
chr14_+_60045621 0.682 NM_007374
SIX6
SIX homeobox 6
chr4_-_153920326 0.682 NM_145720
TIGD4
tigger transposable element derived 4
chr3_-_173010921 0.682 NM_001130081
NM_002662
PLD1

phospholipase D1, phosphatidylcholine-specific

chr1_+_38046005 0.681 C1orf122
chromosome 1 open reading frame 122
chr1_+_38046073 0.678 C1orf122
chromosome 1 open reading frame 122
chr22_+_20350272 0.678 NM_014337
NM_148175
NM_148176
PPIL2


peptidylprolyl isomerase (cyclophilin)-like 2


chr17_-_4783943 0.674 NM_001165417
NM_001165418
NM_003562
SLC25A11


solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11


chr10_+_129595349 0.673 PTPRE
protein tyrosine phosphatase, receptor type, E
chr10_+_75174151 0.670 SEC24C
SEC24 family, member C (S. cerevisiae)
chr22_-_35255216 0.661 NM_003753
EIF3D
eukaryotic translation initiation factor 3, subunit D
chr12_-_109372535 0.660 NM_005719
ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr6_+_30212488 0.656 NM_138700
TRIM40
tripartite motif containing 40
chr3_-_124893875 0.651 MYLK
myosin light chain kinase
chr5_-_149304475 0.647 NM_000440
PDE6A
phosphodiesterase 6A, cGMP-specific, rod, alpha
chrX_-_67569894 0.647 NM_002547
OPHN1
oligophrenin 1
chr1_-_181826086 0.647 NCF2
neutrophil cytosolic factor 2
chr1_+_155130146 0.639 NM_001080471
PEAR1
platelet endothelial aggregation receptor 1
chr12_-_108755565 0.639 TRPV4
transient receptor potential cation channel, subfamily V, member 4
chrX_-_73751185 0.636 NM_016120
NM_183353
RLIM

ring finger protein, LIM domain interacting

chr1_-_38046270 0.630 YRDC
yrdC domain containing (E. coli)
chr1_-_199635240 0.628 NM_005558
LAD1
ladinin 1
chrX_+_150316351 0.627 VMA21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr19_-_4253389 0.624 NM_001169126
NM_144615
TMIGD2

transmembrane and immunoglobulin domain containing 2

chr1_+_150428404 0.622


chrX_-_73751152 0.621


chr12_-_49853155 0.620 NM_001173452
NM_001173453
NM_005653
TFCP2


transcription factor CP2


chr2_+_113648020 0.620 NM_012455
PSD4
pleckstrin and Sec7 domain containing 4
chr1_-_240228987 0.618 NM_001004343
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma
chr5_+_149360480 0.614 HMGXB3
HMG box domain containing 3
chrX_-_73751155 0.614 RLIM
ring finger protein, LIM domain interacting
chr20_+_30501108 0.613


chr17_-_36347197 0.612 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr1_+_153213740 0.610 NM_001826
CKS1B
CDC28 protein kinase regulatory subunit 1B
chr3_+_46591048 0.609 NM_001174136
TDGF1
teratocarcinoma-derived growth factor 1
chr22_+_22435207 0.608 NM_182520
C22orf15
chromosome 22 open reading frame 15
chr16_+_65170851 0.607 NM_144673
CMTM2
CKLF-like MARVEL transmembrane domain containing 2
chr1_-_27159462 0.606 NM_152365
C1orf172
chromosome 1 open reading frame 172
chr19_-_10166600 0.606 DNMT1
DNA (cytosine-5-)-methyltransferase 1
chr13_-_27967215 0.604 NM_001159920
NM_001160030
NM_001160031
NM_002019
FLT1



fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)



chr17_+_29606408 0.601 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr3_+_187840842 0.600 NM_014375
FETUB
fetuin B
chr17_-_72151314 0.600 NM_018414
ST6GALNAC1
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
chr7_+_6622051 0.600 NM_017560
ZNF853
zinc finger protein 853
chrX_-_73751135 0.598 RLIM
ring finger protein, LIM domain interacting
chr1_-_159306210 0.593 ARHGAP30
Rho GTPase activating protein 30
chr7_-_99365178 0.593 NM_181538
GJC3
gap junction protein, gamma 3, 30.2kDa
chr5_+_149360494 0.593 HMGXB3
HMG box domain containing 3
chr1_-_38046410 0.590 YRDC
yrdC domain containing (E. coli)
chr22_+_19543248 0.586 NM_004782
SNAP29
synaptosomal-associated protein, 29kDa
chr11_+_36354110 0.586 NM_001160168
NM_024841
PRR5L

proline rich 5 like

chr11_+_112763722 0.584 NM_178510
ANKK1
ankyrin repeat and kinase domain containing 1
chr14_+_105024576 0.583 CRIP1
cysteine-rich protein 1 (intestinal)
chr11_-_73856241 0.581 NM_005472
KCNE3
potassium voltage-gated channel, Isk-related family, member 3
chr15_+_72861470 0.580 NM_001127190
NM_004383
CSK

c-src tyrosine kinase

chr17_-_4636248 0.578 NM_001144939
NM_001144940
NM_001144941
NM_182566
VMO1



vitelline membrane outer layer 1 homolog (chicken)



chr5_-_138842408 0.577 TMEM173
transmembrane protein 173
chr13_+_23723831 0.575 SPATA13
spermatogenesis associated 13
chr6_-_42270671 0.574 NM_002098
GUCA1B
guanylate cyclase activator 1B (retina)
chr9_-_137992967 0.573 NM_016172
UBAC1
UBA domain containing 1
chr17_+_9489578 0.573 NM_153210
USP43
ubiquitin specific peptidase 43
chr5_+_149360503 0.572 HMGXB3
HMG box domain containing 3
chr17_+_75366524 0.571 NM_005189
NM_032647
CBX2

chromobox homolog 2

chr8_-_133841988 0.570 NM_001145153
NM_144649
TMEM71

transmembrane protein 71

chr19_+_54530546 0.569 CD37
CD37 molecule
chr10_+_26767698 0.567 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr3_-_127303080 0.562 NM_001164475
SLC41A3
solute carrier family 41, member 3
chr8_+_38153223 0.561 NM_004874
BAG4
BCL2-associated athanogene 4
chr5_+_176449156 0.561 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr22_+_43476755 0.559 NM_181334
PRR5-ARHGAP8
PRR5
PRR5-ARHGAP8 readthrough
proline rich 5 (renal)
chr17_-_7106497 0.558 CLDN7
claudin 7
chr1_-_54392030 0.558 NM_201546
CDCP2
CUB domain containing protein 2
chr5_-_945613 0.558 NM_001009877
BRD9
bromodomain containing 9
chr3_+_66527586 0.558


chr4_+_153920382 0.557 NM_001025593
NM_001025595
NM_014447
ARFIP1


ADP-ribosylation factor interacting protein 1


chr21_-_36774257 0.556 NM_001146079
NM_144492
CLDN14

claudin 14

chr22_-_19543069 0.554 NM_058004
PI4KA
phosphatidylinositol 4-kinase, catalytic, alpha
chr1_-_38046433 0.552 YRDC
yrdC domain containing (E. coli)
chr17_-_36719030 0.551 NM_001146182
KRTAP16-1
keratin associated protein 16-1
chr13_-_32658215 0.551 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr1_-_31003181 0.551 LAPTM5
lysosomal protein transmembrane 5
chrX_-_7855764 0.550 NM_001142389
NM_001172672
PNPLA4

patatin-like phospholipase domain containing 4

chr19_+_62434188 0.548 NM_001015879
NM_003160
NM_001015878
AURKC


aurora kinase C


chr1_+_29435534 0.546 NM_001195001
NM_005704
NM_133177
NM_133178
PTPRU



protein tyrosine phosphatase, receptor type, U



chrX_-_15783015 0.545 NM_003916
AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chrX_+_15435351 0.545 NM_001721
BMX
BMX non-receptor tyrosine kinase
chr1_-_38046439 0.544 NM_024640
YRDC
yrdC domain containing (E. coli)
chr1_-_159306273 0.543 ARHGAP30
Rho GTPase activating protein 30
chr1_+_17404206 0.542 NM_013358
PADI1
peptidyl arginine deiminase, type I
chr2_-_242205556 0.542 NM_001164356
THAP4
THAP domain containing 4
chr9_-_139043035 0.541 NM_212533
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr11_-_8911110 0.539 NM_020643
C11orf16
chromosome 11 open reading frame 16
chr19_-_18891190 0.534 COPE
coatomer protein complex, subunit epsilon
chr11_+_66927955 0.532 TBC1D10C
TBC1 domain family, member 10C
chr22_+_19543350 0.525 SNAP29
synaptosomal-associated protein, 29kDa
chr19_+_52940610 0.525 GLTSCR2
glioma tumor suppressor candidate region gene 2
chr3_-_158700036 0.523 NM_024621
VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr5_+_180583315 0.522 TRIM41
tripartite motif containing 41
chrX_+_133952633 0.519 NM_001163438
LOC644538
hypothetical protein LOC644538
chr12_+_131577229 0.518 NM_001142641
FBRSL1
fibrosin-like 1
chr1_+_6008999 0.518 KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr12_-_6103945 0.517 NM_000552
VWF
von Willebrand factor
chr6_+_43507466 0.516 NM_033450
ABCC10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr19_+_4442610 0.509 HDGFRP2
hepatoma-derived growth factor-related protein 2
chr3_-_162305319 0.509 NM_033169
NM_001038628
NM_003781
NM_033167
NM_033168
B3GALNT1




beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)




chr3_-_156904690 0.507 NM_014996
PLCH1
phospholipase C, eta 1
chr1_+_3531410 0.506 NM_182752
TPRG1L
tumor protein p63 regulated 1-like
chr15_+_41672543 0.506 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr11_-_1007140 0.505 MUC6
mucin 6, oligomeric mucus/gel-forming
chrX_+_67830204 0.505 NM_001142504
STARD8
StAR-related lipid transfer (START) domain containing 8
chr17_+_15788955 0.504 NM_000676
ADORA2B
adenosine A2b receptor
chr19_+_52451642 0.503 CCDC9
coiled-coil domain containing 9
chrX_-_15782842 0.502 AP1S2
adaptor-related protein complex 1, sigma 2 subunit

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.26 8.20e-04 GO:0048583 regulation of response to stimulus
1.30 1.61e-03 GO:0009966 regulation of signal transduction
1.07 1.61e-03 GO:0009987 cellular process
1.25 2.18e-03 GO:0043412 macromolecule modification
1.31 2.37e-03 GO:0002376 immune system process
1.25 4.39e-03 GO:0006464 protein modification process
1.39 7.07e-03 GO:0006955 immune response
1.57 7.92e-03 GO:0051056 regulation of small GTPase mediated signal transduction
1.17 8.90e-03 GO:0007165 signal transduction
1.46 2.68e-02 GO:0001775 cell activation
1.45 3.29e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
3.81 4.64e-02 GO:0032369 negative regulation of lipid transport
1.14 4.79e-02 GO:0051716 cellular response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.08 7.24e-03 GO:0005737 cytoplasm
1.96 1.95e-02 GO:0005925 focal adhesion
1.19 2.33e-02 GO:0005829 cytosol

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 1.65e-06 GO:0005515 protein binding
1.42 3.16e-02 GO:0060589 nucleoside-triphosphatase regulator activity
1.42 3.85e-02 GO:0030695 GTPase regulator activity