Motif ID: IKZF2.p2

Z-value: 2.204


Transcription factors associated with IKZF2.p2:

Gene SymbolEntrez IDGene Name
IKZF2 22807 IKAROS family zinc finger 2 (Helios)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IKZF2chr2_-_2137232980.361.7e-01Click!


Activity profile for motif IKZF2.p2.

activity profile for motif IKZF2.p2


Sorted Z-values histogram for motif IKZF2.p2

Sorted Z-values for motif IKZF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_106653429 3.035 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr6_+_50789215 2.386 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr1_-_116184846 2.032 NM_001111061
NHLH2
nescient helix loop helix 2
chr10_-_45131061 1.662 NM_001004297
OR13A1
olfactory receptor, family 13, subfamily A, member 1
chr2_+_202379442 1.628 NM_139158
CDK15
cyclin-dependent kinase 15
chr12_+_54011750 1.619 NM_054104
OR6C3
olfactory receptor, family 6, subfamily C, member 3
chr12_-_8584658 1.579 NM_014358
CLEC4E
C-type lectin domain family 4, member E
chr5_-_88004891 1.572 LOC645323
hypothetical LOC645323
chr4_-_122357104 1.557 NM_001128843
TNIP3
TNFAIP3 interacting protein 3
chr20_+_1132097 1.555 NM_001009612
C20orf202
chromosome 20 open reading frame 202
chr10_+_111755715 1.525 NM_019903
ADD3
adducin 3 (gamma)
chr1_-_150564302 1.452 NM_002016
FLG
filaggrin
chr12_+_99274987 1.452 NM_001145288
NM_139319
SLC17A8

solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8

chr5_-_135259403 1.426 NM_000590
IL9
interleukin 9
chr11_-_40271086 1.414 LRRC4C
leucine rich repeat containing 4C
chr5_+_140690387 1.389 NM_018912
NM_031993
PCDHGA1

protocadherin gamma subfamily A, 1

chr6_+_127940011 1.371 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr3_-_150533948 1.292 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr17_-_36074812 1.277 NM_152349
KRT222
keratin 222
chr2_-_200038055 1.265 NM_001172517
SATB2
SATB homeobox 2
chr1_+_24518398 1.260 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr10_-_51678318 1.251 NM_001143974
NM_019893
ASAH2

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2

chrX_-_15593074 1.210 NM_020665
TMEM27
transmembrane protein 27
chr1_+_169484256 1.207 NM_002021
FMO1
flavin containing monooxygenase 1
chr15_+_60838053 1.197 TLN2
talin 2
chr12_-_9976173 1.193 NM_001130711
CLEC2A
C-type lectin domain family 2, member A
chr21_-_38792173 1.164 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr10_+_90336489 1.145 NM_001010939
LIPJ
lipase, family member J
chr14_+_85066265 1.121 FLRT2
fibronectin leucine rich transmembrane protein 2
chr6_+_132901119 1.116 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr4_+_154083584 1.095 NM_033393
FHDC1
FH2 domain containing 1
chr2_-_134042500 1.091 NM_207363
NM_207481
NCKAP5

NCK-associated protein 5

chr1_-_67039518 1.081 NM_005478
INSL5
insulin-like 5
chr4_+_71283383 1.073 NM_006685
SMR3B
submaxillary gland androgen regulated protein 3B
chr4_+_15080586 1.071 NM_001080522
NM_001164720
NM_020785
CC2D2A


coiled-coil and C2 domain containing 2A


chr17_+_7283412 1.063 NM_004112
FGF11
fibroblast growth factor 11
chr4_-_174774368 1.059 NM_006792
MORF4
mortality factor 4
chr5_-_16561936 1.051 NM_019000
FAM134B
family with sequence similarity 134, member B
chr6_+_129245978 1.030 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr5_+_27508139 1.021 LOC643401
hypothetical protein LOC643401
chr11_+_118259684 1.020 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr3_-_125192888 1.017 NM_017578
ROPN1
rhophilin associated tail protein 1
chr8_-_30826074 1.007 NM_031271
TEX15
testis expressed 15
chr1_-_203657803 1.004 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr8_-_13416554 0.984 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chr3_+_99465777 0.981 NM_001005479
OR5H6
olfactory receptor, family 5, subfamily H, member 6
chr10_-_115413630 0.967 NM_006175
NM_198060
NRAP

nebulin-related anchoring protein

chr15_+_41672543 0.946 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr9_-_72673753 0.936 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr2_+_168383427 0.936 NM_020981
B3GALT1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr7_+_123353144 0.935 NM_001174045
NM_001174046
SPAM1

sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)

chr11_-_124311512 0.930 NM_152722
HEPACAM
hepatic and glial cell adhesion molecule
chr14_-_20694023 0.917 NM_001004731
OR5AU1
olfactory receptor, family 5, subfamily AU, member 1
chr7_-_83116414 0.916 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr14_+_75907442 0.913 NM_004452
ESRRB
estrogen-related receptor beta
chr9_-_92444886 0.910 NM_017594
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr6_+_132000134 0.910 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr3_-_159306214 0.903


chr6_+_123142559 0.902 FABP7
fatty acid binding protein 7, brain
chr10_+_63092724 0.897 NM_173554
C10orf107
chromosome 10 open reading frame 107
chr4_+_130236731 0.891 NM_001099783
C4orf33
chromosome 4 open reading frame 33
chr1_-_109201228 0.889 NM_152763
AKNAD1
AKNA domain containing 1
chr9_-_14900992 0.887 NM_144966
FREM1
FRAS1 related extracellular matrix 1
chr10_-_100985548 0.884 NM_001166244
NM_001166245
NM_001166246
NM_021828
HPSE2



heparanase 2



chr21_+_38550739 0.884 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr4_-_120462705 0.883 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr1_+_239882202 0.882 NM_144625
WDR64
WD repeat domain 64
chr2_+_66519949 0.878 MEIS1
Meis homeobox 1
chr13_-_33148899 0.867 STARD13
StAR-related lipid transfer (START) domain containing 13
chr1_-_155936904 0.854 NM_052939
FCRL3
Fc receptor-like 3
chr17_-_23244499 0.852 NM_001076680
C17orf108
chromosome 17 open reading frame 108
chr8_+_32698892 0.849 NM_001159996
NRG1
neuregulin 1
chr2_-_179623030 0.846 NM_173648
CCDC141
coiled-coil domain containing 141
chr3_-_27739201 0.842 EOMES
eomesodermin
chr11_+_22316242 0.838 NM_020346
SLC17A6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr17_-_51155073 0.827 NM_018286
TMEM100
transmembrane protein 100
chr18_+_57308754 0.827 NM_031891
CDH20
cadherin 20, type 2
chr1_+_148496792 0.821 NM_012113
CA14
carbonic anhydrase XIV
chr4_+_88187215 0.809 AFF1
AF4/FMR2 family, member 1
chr1_-_146422000 0.809 NM_178230
PPIAL4A
PPIAL4G
peptidylprolyl isomerase A (cyclophilin A)-like 4A
peptidylprolyl isomerase A (cyclophilin A)-like 4G
chr1_+_47261826 0.804 NM_178033
CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr5_+_132176921 0.804 NM_175873
ANKRD43
ankyrin repeat domain 43
chr11_+_101488380 0.792 NM_001195045
YAP1
Yes-associated protein 1
chr13_+_22653059 0.792 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr11_-_5302157 0.791 NM_033180
OR51B2
olfactory receptor, family 51, subfamily B, member 2
chr21_-_26867138 0.791 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr3_-_162572441 0.782 NM_001040100
C3orf57
chromosome 3 open reading frame 57
chr1_-_79244948 0.780 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr10_-_50269912 0.780 NM_001080520
DRGX
dorsal root ganglia homeobox
chr19_-_47623340 0.779 NM_005357
LIPE
lipase, hormone-sensitive
chr6_+_123142344 0.779 NM_001446
FABP7
fatty acid binding protein 7, brain
chr5_+_152850276 0.778 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr8_-_17811750 0.776 FGL1
fibrinogen-like 1
chr4_-_101658094 0.765 NM_001159694
NM_016242
EMCN

endomucin

chr4_+_71492581 0.764 NM_016519
AMBN
ameloblastin (enamel matrix protein)
chr6_-_136829705 0.763 NM_001198615
MAP7
microtubule-associated protein 7
chr20_-_1113116 0.762 NM_018354
C20orf46
chromosome 20 open reading frame 46
chr11_+_89507465 0.761 NM_005467
NAALAD2
N-acetylated alpha-linked acidic dipeptidase 2
chr6_-_89984214 0.754 NM_002042
GABRR1
gamma-aminobutyric acid (GABA) receptor, rho 1
chr3_-_152529999 0.751 NM_176894
P2RY13
purinergic receptor P2Y, G-protein coupled, 13
chr3_+_99592199 0.744 NM_001005516
OR5K3
olfactory receptor, family 5, subfamily K, member 3
chr6_-_11887265 0.741 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr6_-_69401639 0.737


chr1_-_155281785 0.736 NM_014784
NM_198236
ARHGEF11

Rho guanine nucleotide exchange factor (GEF) 11

chr21_-_41479035 0.735 NM_182832
PLAC4
placenta-specific 4
chr14_-_21074875 0.732 NM_005407
SALL2
sal-like 2 (Drosophila)
chr11_-_5247948 0.731 NM_005330
HBE1
hemoglobin, epsilon 1
chr6_-_47117951 0.729 NM_025048
NM_153840
GPR110

G protein-coupled receptor 110

chr14_+_61532293 0.729 NM_031914
SYT16
synaptotagmin XVI
chr1_+_169326641 0.728 NM_001002294
NM_006894
FMO3

flavin containing monooxygenase 3

chr5_+_76284435 0.724 NM_001882
CRHBP
corticotropin releasing hormone binding protein
chr14_-_68424653 0.720 ACTN1
actinin, alpha 1
chr4_-_123761615 0.718 NM_021803
IL21
interleukin 21
chr1_+_171871283 0.717 NM_001195190
LOC730159
hypothetical protein LOC730159
chrX_+_135558001 0.715 NM_000074
CD40LG
CD40 ligand
chr17_-_64462976 0.709 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr21_-_42060334 0.705 RIPK4
receptor-interacting serine-threonine kinase 4
chr1_+_147819626 0.704 NM_178230
NM_001135789
PPIAL4A
PPIAL4G
PPIAL4C
peptidylprolyl isomerase A (cyclophilin A)-like 4A
peptidylprolyl isomerase A (cyclophilin A)-like 4G
peptidylprolyl isomerase A (cyclophilin A)-like 4C
chr1_+_156991133 0.704 NM_001005184
OR6K6
olfactory receptor, family 6, subfamily K, member 6
chr2_-_172675873 0.703 DLX2
distal-less homeobox 2
chr14_-_98807307 0.700 BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)
chr11_+_129484540 0.700 APLP2
amyloid beta (A4) precursor-like protein 2
chr15_+_22652790 0.698 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr12_+_52696908 0.696 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr8_+_100025806 0.694 NM_001142462
NM_053001
OSR2

odd-skipped related 2 (Drosophila)

chr1_+_24518501 0.691 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr18_-_51219880 0.687 TCF4
transcription factor 4
chr5_-_59100194 0.687 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr7_-_100645032 0.685 PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr17_-_36403910 0.684 NM_033185
KRTAP3-3
keratin associated protein 3-3
chr15_+_41772375 0.684 NM_001015001
CKMT1A
creatine kinase, mitochondrial 1A
chrX_+_128700605 0.680 NM_003399
XPNPEP2
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
chr8_+_120289735 0.677 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr14_+_98247702 0.676 NM_182560
C14orf177
chromosome 14 open reading frame 177
chr6_+_116956868 0.671 NM_153036
FAM26D
family with sequence similarity 26, member D
chr12_-_45506001 0.670 NM_001143824
NM_018018
SLC38A4

solute carrier family 38, member 4

chr3_-_18455207 0.670 NM_001131010
SATB1
SATB homeobox 1
chr1_-_142559339 0.670 NM_001123068
PPIAL4G
peptidylprolyl isomerase A (cyclophilin A)-like 4G
chr11_+_5597749 0.666 NM_001003827
TRIM34
tripartite motif containing 34
chr2_-_162808123 0.653 NM_004460
FAP
fibroblast activation protein, alpha
chr8_-_17797127 0.651 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chrX_-_31194867 0.648 NM_004015
NM_004016
NM_004017
NM_004018
NM_004019
DMD




dystrophin




chr22_-_35733784 0.648 NM_001163857
NM_178552
C22orf33

chromosome 22 open reading frame 33

chr14_-_23623657 0.646 NM_006177
NRL
neural retina leucine zipper
chr13_+_27392136 0.644 NM_000209
PDX1
pancreatic and duodenal homeobox 1
chr9_+_122890394 0.643 NM_007018
CEP110
centrosomal protein 110kDa
chr4_-_5071996 0.642 NM_018659
CYTL1
cytokine-like 1
chr11_-_123695302 0.641 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr3_+_29297806 0.640 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr12_+_4700012 0.640 NM_017417
GALNT8
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
chr2_-_200028977 0.637 SATB2
SATB homeobox 2
chr1_-_143075560 0.635 NM_178230
NM_001143883
NM_001135789
PPIAL4A
PPIAL4G
PPIAL4B
PPIAL4C
peptidylprolyl isomerase A (cyclophilin A)-like 4A
peptidylprolyl isomerase A (cyclophilin A)-like 4G
peptidylprolyl isomerase A (cyclophilin A)-like 4B
peptidylprolyl isomerase A (cyclophilin A)-like 4C
chr2_-_142605739 0.633 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr8_+_7340777 0.633 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr20_+_5839973 0.633 NM_001819
CHGB
chromogranin B (secretogranin 1)
chr12_-_28016182 0.633 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr10_-_134449467 0.632 NM_177400
NKX6-2
NK6 homeobox 2
chr18_+_54013575 0.631 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr4_-_122304925 0.628 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr13_+_23042722 0.625 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr4_+_74520796 0.625 NM_001134
AFP
alpha-fetoprotein
chr17_+_57811645 0.621 NM_173503
EFCAB3
EF-hand calcium binding domain 3
chr5_-_16791346 0.615 MYO10
myosin X
chr11_+_56187713 0.613 NM_001004730
OR5AR1
olfactory receptor, family 5, subfamily AR, member 1
chr7_-_27133163 0.607 NM_153631
HOXA3
homeobox A3
chr10_-_90601655 0.607 NM_144590
ANKRD22
ankyrin repeat domain 22
chr3_+_148609841 0.607 NM_003412
ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr4_+_159662349 0.605 NM_021634
RXFP1
relaxin/insulin-like family peptide receptor 1
chr12_+_7833292 0.605 NANOG
Nanog homeobox
chr11_+_5367182 0.605 NM_001004756
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr5_+_180269169 0.604 NM_001159710
BTNL8
butyrophilin-like 8
chr5_-_135318420 0.603 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr2_-_213723298 0.601 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr5_+_115415061 0.601 NM_001195581
LOC644100
hypothetical LOC644100
chr4_-_77547481 0.597 NM_001042784
CCDC158
coiled-coil domain containing 158
chr1_+_61642287 0.596 NFIA
nuclear factor I/A
chr1_-_171838802 0.596 NM_178527
SLC9A11
solute carrier family 9, member 11
chr8_-_82606104 0.594 NM_001105281
FABP12
fatty acid binding protein 12
chr3_+_134985566 0.594 NM_021203
SRPRB
signal recognition particle receptor, B subunit
chr6_-_101018271 0.593 NM_005068
SIM1
single-minded homolog 1 (Drosophila)
chr14_+_85066207 0.593 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr11_+_18374388 0.588 NM_001165414
LDHA
lactate dehydrogenase A
chr9_-_21177529 0.584 NM_021068
IFNA4
interferon, alpha 4
chr1_-_151333624 0.584 NM_001024209
SPRR2E
small proline-rich protein 2E
chr11_-_57171554 0.581 YPEL4
yippee-like 4 (Drosophila)
chr5_-_115938305 0.580 NM_020796
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr4_-_100575313 0.580 NM_001166504
NM_000673
ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr1_-_36338436 0.579 NM_005202
COL8A2
collagen, type VIII, alpha 2
chrX_-_74292800 0.579 NM_004299
ABCB7
ATP-binding cassette, sub-family B (MDR/TAP), member 7
chr8_-_82522175 0.577 NM_002677
PMP2
peripheral myelin protein 2
chr11_+_76423082 0.575 NM_138706
B3GNT6
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)
chr12_+_54231249 0.574 NM_001005494
OR6C4
olfactory receptor, family 6, subfamily C, member 4
chr2_-_189752575 0.573 NM_000393
COL5A2
collagen, type V, alpha 2
chr3_+_50119261 0.572 RBM5
RNA binding motif protein 5
chr9_-_15240113 0.569 NM_001168342
TTC39B
tetratricopeptide repeat domain 39B
chr10_+_104580420 0.568


chr8_+_102574012 0.568 GRHL2
grainyhead-like 2 (Drosophila)
chr1_+_146910634 0.565 NM_001144032
PPIAL4E
peptidylprolyl isomerase A (cyclophilin A)-like 4E
chr14_-_31026901 0.562 NM_001197184
GPR33
G protein-coupled receptor 33 (gene/pseudogene)
chr9_-_21358005 0.562 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.21 1.96e-07 GO:0032501 multicellular organismal process
1.85 2.13e-07 GO:0007606 sensory perception of chemical stimulus
1.86 1.49e-06 GO:0007608 sensory perception of smell
1.16 2.33e-05 GO:0050896 response to stimulus
1.48 7.54e-04 GO:0007600 sensory perception
1.30 4.21e-03 GO:0003008 system process
1.33 8.02e-03 GO:0050877 neurological system process
1.43 3.70e-02 GO:0007155 cell adhesion
1.43 3.70e-02 GO:0022610 biological adhesion

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.20 8.79e-06 GO:0005886 plasma membrane
1.19 3.75e-05 GO:0071944 cell periphery
1.36 3.84e-03 GO:0044421 extracellular region part
1.24 5.45e-03 GO:0005576 extracellular region
1.39 1.27e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.89 2.88e-07 GO:0004984 olfactory receptor activity
1.31 1.65e-05 GO:0004871 signal transducer activity
1.31 1.65e-05 GO:0060089 molecular transducer activity
1.51 3.34e-05 GO:0004930 G-protein coupled receptor activity
1.33 1.10e-04 GO:0004872 receptor activity
1.37 3.51e-04 GO:0004888 transmembrane receptor activity