Motif ID: SMAD1..7,9.p2

Z-value: 2.502


Transcription factors associated with SMAD1..7,9.p2:

Gene SymbolEntrez IDGene Name
SMAD1 4086 SMAD family member 1
SMAD2 4087 SMAD family member 2
SMAD3 4088 SMAD family member 3
SMAD4 4089 SMAD family member 4
SMAD5 4090 SMAD family member 5
SMAD6 4091 SMAD family member 6
SMAD7 4092 SMAD family member 7
SMAD9 4093 SMAD family member 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SMAD2chr18_-_43710917-0.821.1e-04Click!
SMAD3chr15_+_652174120.639.3e-03Click!
SMAD1chr4_+_146623405-0.439.6e-02Click!
SMAD9chr13_-_363923700.421.0e-01Click!
SMAD6chr15_+_647817230.381.5e-01Click!
SMAD7chr18_-_44723116-0.332.1e-01Click!
SMAD4chr18_+_468104810.204.5e-01Click!
SMAD5chr5_+_135496421-0.194.7e-01Click!


Activity profile for motif SMAD1..7,9.p2.

activity profile for motif SMAD1..7,9.p2


Sorted Z-values histogram for motif SMAD1..7,9.p2

Sorted Z-values for motif SMAD1..7,9.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD1..7,9.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_60475558 3.230 NM_016582
 SLC15A3
solute carrier family 15, member 3
chr22_+_23221114 2.523 NM_016327
 UPB1
ureidopropionase, beta
chr17_+_19377732 2.389 NM_018242
 SLC47A1
solute carrier family 47, member 1
chr10_+_135333667 2.027 NM_033178
NM_012147
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
 DUX4
DUX2
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr4_+_191229360 2.001 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
 DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr4_+_191242540 1.978 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
 DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr11_+_60626505 1.948 NM_014207
 CD5
CD5 molecule
chr10_+_135330357 1.923 NM_033178
NM_012147
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
 DUX4
DUX2
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr1_+_20751518 1.860 NM_207334
 FAM43B
family with sequence similarity 43, member B
chr9_-_139183675 1.842


chr10_+_135343649 1.758 NM_012147
 DUX2
double homeobox 2
chr3_+_44601457 1.755 NM_173658
 ZNF660
zinc finger protein 660
chrX_+_102749489 1.718 NM_001006933
NM_032926
 TCEAL3

transcription elongation factor A (SII)-like 3

chr22_-_22970850 1.714 NM_001099781
NM_001099782
NM_004121
 GGT5


gamma-glutamyltransferase 5


chr17_-_33753218 1.709 NM_001004334
 GPR179
G protein-coupled receptor 179
chr4_+_191232653 1.694 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
 DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr5_+_113725914 1.667 NM_021614
 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr11_-_18769703 1.649 NM_001039970
NM_006906
NM_032781
 PTPN5


protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)


chr3_-_129689394 1.628 NM_001145662
 GATA2
GATA binding protein 2
chr16_+_56219802 1.620 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
 GPR56




G protein-coupled receptor 56





Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 49 entries
enrichment   p-value GO term description
6.09 3.35e-02 GO:0042135 neurotransmitter catabolic process
5.10 1.60e-03 GO:0048484 enteric nervous system development
3.86 2.71e-03 GO:0048483 autonomic nervous system development
3.48 1.72e-03 GO:0021675 nerve development
2.39 2.79e-03 GO:0045761 regulation of adenylate cyclase activity
2.34 4.75e-03 GO:0031279 regulation of cyclase activity
2.30 7.92e-03 GO:0051339 regulation of lyase activity
2.26 4.44e-03 GO:0030817 regulation of cAMP biosynthetic process
2.24 5.65e-03 GO:0030814 regulation of cAMP metabolic process
2.20 4.43e-03 GO:0030802 regulation of cyclic nucleotide biosynthetic process
2.20 4.43e-03 GO:0030808 regulation of nucleotide biosynthetic process
2.15 8.71e-03 GO:0030799 regulation of cyclic nucleotide metabolic process
1.88 1.30e-05 GO:0044057 regulation of system process
1.86 4.56e-03 GO:0030168 platelet activation
1.67 3.41e-02 GO:0006140 regulation of nucleotide metabolic process
1.64 1.24e-02 GO:0090066 regulation of anatomical structure size
1.63 6.12e-04 GO:0019226 transmission of nerve impulse
1.63 6.12e-04 GO:0035637 multicellular organismal signaling
1.63 3.93e-03 GO:0007268 synaptic transmission
1.61 1.22e-03 GO:0007599 hemostasis

Gene overrepresentation in compartment category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
2.52 5.01e-04 GO:0045095 keratin filament
1.70 1.86e-02 GO:0016323 basolateral plasma membrane
1.58 3.29e-03 GO:0045202 synapse
1.49 1.45e-03 GO:0030054 cell junction
1.41 1.88e-03 GO:0005626 insoluble fraction
1.39 6.26e-03 GO:0005624 membrane fraction
1.32 7.73e-03 GO:0000267 cell fraction
1.29 1.97e-02 GO:0005887 integral to plasma membrane
1.27 1.02e-04 GO:0044459 plasma membrane part
1.27 4.58e-02 GO:0031226 intrinsic to plasma membrane
1.21 9.53e-07 GO:0005886 plasma membrane
1.20 2.82e-06 GO:0071944 cell periphery
1.13 3.00e-06 GO:0016020 membrane
1.13 3.07e-04 GO:0044425 membrane part
1.11 4.00e-02 GO:0031224 intrinsic to membrane

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
1.68 2.93e-02 GO:0005096 GTPase activator activity
1.55 4.04e-03 GO:0030695 GTPase regulator activity
1.53 7.67e-03 GO:0060589 nucleoside-triphosphatase regulator activity