Motif ID: SMAD1..7,9.p2

Z-value: 2.502


Transcription factors associated with SMAD1..7,9.p2:

Gene SymbolEntrez IDGene Name
SMAD1 4086 SMAD family member 1
SMAD2 4087 SMAD family member 2
SMAD3 4088 SMAD family member 3
SMAD4 4089 SMAD family member 4
SMAD5 4090 SMAD family member 5
SMAD6 4091 SMAD family member 6
SMAD7 4092 SMAD family member 7
SMAD9 4093 SMAD family member 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SMAD2chr18_-_43710917-0.821.1e-04Click!
SMAD3chr15_+_652174120.639.3e-03Click!
SMAD1chr4_+_146623405-0.439.6e-02Click!
SMAD9chr13_-_363923700.421.0e-01Click!
SMAD6chr15_+_647817230.381.5e-01Click!
SMAD7chr18_-_44723116-0.332.1e-01Click!
SMAD4chr18_+_468104810.204.5e-01Click!
SMAD5chr5_+_135496421-0.194.7e-01Click!


Activity profile for motif SMAD1..7,9.p2.

activity profile for motif SMAD1..7,9.p2


Sorted Z-values histogram for motif SMAD1..7,9.p2

Sorted Z-values for motif SMAD1..7,9.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD1..7,9.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_60475558 3.230 NM_016582
SLC15A3
solute carrier family 15, member 3
chr22_+_23221114 2.523 NM_016327
UPB1
ureidopropionase, beta
chr17_+_19377732 2.389 NM_018242
SLC47A1
solute carrier family 47, member 1
chr10_+_135333667 2.027 NM_033178
NM_012147
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr4_+_191229360 2.001 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr4_+_191242540 1.978 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr11_+_60626505 1.948 NM_014207
CD5
CD5 molecule
chr10_+_135330357 1.923 NM_033178
NM_012147
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr1_+_20751518 1.860 NM_207334
FAM43B
family with sequence similarity 43, member B
chr9_-_139183675 1.842


chr10_+_135343649 1.758 NM_012147
DUX2
double homeobox 2
chr3_+_44601457 1.755 NM_173658
ZNF660
zinc finger protein 660
chrX_+_102749489 1.718 NM_001006933
NM_032926
TCEAL3

transcription elongation factor A (SII)-like 3

chr22_-_22970850 1.714 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr17_-_33753218 1.709 NM_001004334
GPR179
G protein-coupled receptor 179
chr4_+_191232653 1.694 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr5_+_113725914 1.667 NM_021614
KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr11_-_18769703 1.649 NM_001039970
NM_006906
NM_032781
PTPN5


protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)


chr3_-_129689394 1.628 NM_001145662
GATA2
GATA binding protein 2
chr16_+_56219802 1.620 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr9_-_96441654 1.593 NM_000507
FBP1
fructose-1,6-bisphosphatase 1
chr8_+_143542378 1.581 NM_001702
BAI1
brain-specific angiogenesis inhibitor 1
chr21_+_44844924 1.580 NM_198689
KRTAP10-7
keratin associated protein 10-7
chr21_+_44818033 1.575 NM_198687
KRTAP10-4
keratin associated protein 10-4
chr4_+_191226073 1.574 NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
chr11_+_113436438 1.560 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr13_-_32822759 1.552 STARD13
StAR-related lipid transfer (START) domain containing 13
chr8_+_22465368 1.502 SORBS3
sorbin and SH3 domain containing 3
chr22_+_21318779 1.496 NM_199127
GGTLC2
gamma-glutamyltransferase light chain 2
chr1_-_45444812 1.456 NM_020883
ZSWIM5
zinc finger, SWIM-type containing 5
chr1_+_15964045 1.450 NM_001024216
FBLIM1
filamin binding LIM protein 1
chr2_+_176761552 1.439 NM_024501
HOXD1
homeobox D1
chrX_-_102870207 1.420 NM_001024452
NM_001172285
GLRA4

glycine receptor, alpha 4

chrX_+_53095230 1.420 NM_018969
GPR173
G protein-coupled receptor 173
chr15_-_50869379 1.400 NM_004498
ONECUT1
one cut homeobox 1
chrX_+_44588192 1.388 NM_022076
DUSP21
dual specificity phosphatase 21
chr1_-_6368324 1.383 NM_181864
ACOT7
acyl-CoA thioesterase 7
chr4_+_191239247 1.374 NM_033178
NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr21_+_44881700 1.333 NM_181688
KRTAP10-10
keratin associated protein 10-10
chr15_-_70385709 1.332 NM_001172685
CELF6
CUGBP, Elav-like family member 6
chr1_-_202595666 1.318 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr9_-_96441567 1.316 FBP1
fructose-1,6-bisphosphatase 1
chr3_+_148610516 1.316 ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr7_-_150283794 1.306 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr1_+_8928508 1.302 NM_001215
CA6
carbonic anhydrase VI
chr1_+_3558958 1.294 NM_005427
TP73
tumor protein p73
chrX_+_101862297 1.287 NM_001142524
NM_001142525
NM_001142526
NM_001142527
NM_001142528
NM_030639
BHLHB9





basic helix-loop-helix domain containing, class B, 9





chr14_+_51850754 1.282 NM_000956
PTGER2
prostaglandin E receptor 2 (subtype EP2), 53kDa
chr4_+_191235959 1.277 NM_001177376
DUX4L4
double homeobox 4 like 4
chr17_-_70099964 1.260 NM_001115152
CD300LD
CD300 molecule-like family member d
chr15_-_88143721 1.253 ANPEP
alanyl (membrane) aminopeptidase
chr15_+_64782468 1.234 SMAD6
SMAD family member 6
chr1_+_63561632 1.218 FOXD3
forkhead box D3
chrX_+_152682772 1.209 NM_001163257
NM_005393
PLXNB3

plexin B3

chr3_-_51968995 1.188 PCBP4
poly(rC) binding protein 4
chr3_+_16901455 1.183 NM_001144382
PLCL2
phospholipase C-like 2
chr8_+_22493928 1.173 NM_176871
NM_198042
PDLIM2

PDZ and LIM domain 2 (mystique)

chr22_+_23153529 1.157 NM_000675
ADORA2A
adenosine A2a receptor
chr5_+_113726203 1.154 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr12_+_48641545 1.150 NM_001651
AQP5
aquaporin 5
chr11_-_70350292 1.125 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr10_+_125415860 1.110 NM_153442
GPR26
G protein-coupled receptor 26
chr10_-_70846573 1.107 NM_001057
TACR2
tachykinin receptor 2
chr3_+_11009419 1.105 NM_003042
SLC6A1
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
chr9_-_96442351 1.092 NM_001127628
FBP1
fructose-1,6-bisphosphatase 1
chr22_-_29290875 1.092 NM_004861
GAL3ST1
galactose-3-O-sulfotransferase 1
chr1_+_210864411 1.084 NM_153606
FAM71A
family with sequence similarity 71, member A
chr21_-_44784499 1.050 NM_198691
KRTAP10-1
keratin associated protein 10-1
chr1_+_157408000 1.042 NM_021189
NM_001127173
CADM3

cell adhesion molecule 3

chr13_+_95541093 1.041 NM_153456
HS6ST3
heparan sulfate 6-O-sulfotransferase 3
chr11_-_70350509 1.039 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr10_-_82106479 1.032 NM_138812
DYDC1
DPY30 domain containing 1
chr9_-_96442377 1.031 FBP1
fructose-1,6-bisphosphatase 1
chr9_+_125813849 1.028 LHX2
LIM homeobox 2
chr11_+_74548472 1.024 NM_001145211
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr19_+_3659358 1.010 TJP3
tight junction protein 3 (zona occludens 3)
chr12_-_121780835 1.009 NM_032554
GPR81
G protein-coupled receptor 81
chr1_-_202432165 1.008 NM_002256
KISS1
KiSS-1 metastasis-suppressor
chr8_+_21971317 1.007 NM_001114135
EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr7_+_142459538 1.001 NM_001001667
OR6V1
olfactory receptor, family 6, subfamily V, member 1
chr19_-_40684638 0.997 NM_001035516
DMKN
dermokine
chr6_+_110406890 0.995 NM_005284
GPR6
G protein-coupled receptor 6
chr12_-_56496107 0.986 NM_006576
AVIL
advillin
chr8_-_131483395 0.983 NM_018482
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr20_-_23915431 0.982 NM_178312
GGTLC1
gamma-glutamyltransferase light chain 1
chr9_-_115101140 0.975 NM_145051
RNF183
ring finger protein 183
chr11_-_116199145 0.971 NM_000482
APOA4
apolipoprotein A-IV
chr19_+_40534284 0.964 NM_005303
FFAR1
free fatty acid receptor 1
chrX_+_101853912 0.950 NM_001004051
NM_001184874
NM_001184875
NM_001184876
NM_138437
GPRASP2




G protein-coupled receptor associated sorting protein 2




chr12_+_50104936 0.945 SLC4A8
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr9_-_96441409 0.939 FBP1
fructose-1,6-bisphosphatase 1
chr19_-_56221681 0.936 NM_001136032
KLK11
kallikrein-related peptidase 11
chr3_-_50324815 0.926 NM_153281
HYAL1
hyaluronoglucosaminidase 1
chr22_+_42137955 0.922 NM_001044370
MPPED1
metallophosphoesterase domain containing 1
chr2_-_31659472 0.917 NM_000348
SRD5A2
steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
chr1_-_1840564 0.909 NM_178545
TMEM52
transmembrane protein 52
chr12_+_55896844 0.907 NM_007224
NXPH4
neurexophilin 4
chrX_-_135941498 0.905 NM_054021
GPR101
G protein-coupled receptor 101
chr19_+_4180494 0.901 NM_005755
EBI3
Epstein-Barr virus induced 3
chr1_-_31618405 0.900 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr11_-_17522430 0.894 NM_005709
NM_153676
USH1C

Usher syndrome 1C (autosomal recessive, severe)

chr19_-_46626474 0.893 NM_198540
B3GNT8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr19_+_9064854 0.889 NM_001004456
OR1M1
olfactory receptor, family 1, subfamily M, member 1
chr14_+_99273751 0.886 EML1
echinoderm microtubule associated protein like 1
chr17_-_42411587 0.886 NM_203400
RPRML
reprimo-like
chr9_+_128764324 0.886 NM_001190728
RALGPS1
Ral GEF with PH domain and SH3 binding motif 1
chrX_+_71318250 0.877 NM_001170747
NM_006223
PIN4

protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)

chrX_-_114703273 0.875


chr4_+_55218663 0.870 NM_000222
NM_001093772
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr1_-_164402575 0.864 NM_001017961
FAM78B
family with sequence similarity 78, member B
chr1_+_63561317 0.859 NM_012183
FOXD3
forkhead box D3
chr19_-_41034734 0.858 NM_004646
NPHS1
nephrosis 1, congenital, Finnish type (nephrin)
chr7_-_44195405 0.857 NM_000162
GCK
glucokinase (hexokinase 4)
chr1_-_154913712 0.857 NM_006617
NES
nestin
chr10_+_82106537 0.853 NM_032372
DYDC2
DPY30 domain containing 2
chr22_+_42138034 0.853 MPPED1
metallophosphoesterase domain containing 1
chr19_+_40465249 0.852 NM_021175
HAMP
hepcidin antimicrobial peptide
chr11_+_47564805 0.843 NM_001164379
FAM180B
family with sequence similarity 180, member B
chr8_-_143820825 0.842 NM_020427
SLURP1
secreted LY6/PLAUR domain containing 1
chr7_+_154493478 0.833 NM_024012
HTR5A
5-hydroxytryptamine (serotonin) receptor 5A
chr6_-_25834733 0.830 NM_170745
HIST1H2AA
histone cluster 1, H2aa
chr21_-_44803049 0.828 NM_198696
KRTAP10-3
keratin associated protein 10-3
chr11_+_122901543 0.822 GRAMD1B
GRAM domain containing 1B
chr12_+_50104859 0.821 NM_001039960
NM_004858
SLC4A8

solute carrier family 4, sodium bicarbonate cotransporter, member 8

chr19_-_16145285 0.820 NM_054113
CIB3
calcium and integrin binding family member 3
chr5_+_156628929 0.819 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr1_+_24713396 0.817 RCAN3
RCAN family member 3
chr1_-_218168548 0.816 NM_018713
SLC30A10
solute carrier family 30, member 10
chr17_-_24357014 0.815 NM_001098635
NM_178860
SEZ6

seizure related 6 homolog (mouse)

chr16_-_3783475 0.811 CREBBP
CREB binding protein
chr19_+_2200112 0.809 NM_000479
AMH
anti-Mullerian hormone
chr6_-_26038817 0.806 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chrX_-_125127760 0.802 NM_001013628
DCAF12L2
DDB1 and CUL4 associated factor 12-like 2
chr4_+_9392355 0.797 NM_000798
DRD5
dopamine receptor D5
chrX_-_106846684 0.797 TSC22D3
TSC22 domain family, member 3
chr11_-_65860450 0.794 NM_004292
RIN1
Ras and Rab interactor 1
chr3_+_42702014 0.791 NM_152393
KBTBD5
kelch repeat and BTB (POZ) domain containing 5
chr21_+_46370831 0.784 COL6A2
collagen, type VI, alpha 2
chr2_+_70981233 0.778 VAX2
ventral anterior homeobox 2
chrX_-_62487693 0.776 NM_001012968
SPIN4
spindlin family, member 4
chrX_+_102727068 0.771 NM_001006935
NM_001006937
NM_024863
TCEAL4


transcription elongation factor A (SII)-like 4


chr4_+_191245840 0.770 NM_033178
NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr1_-_201321999 0.768 NM_002479
MYOG
myogenin (myogenic factor 4)
chr2_+_97717300 0.764 NM_207519
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chrX_-_108754906 0.764 NM_012282
KCNE1L
KCNE1-like
chr21_+_43462209 0.758 NM_000394
CRYAA
crystallin, alpha A
chr1_+_178466064 0.757 NM_033343
LHX4
LIM homeobox 4
chrX_-_128616594 0.752 NM_017413
APLN
apelin
chr3_+_46717826 0.751 NM_147196
TMIE
transmembrane inner ear
chr22_+_18330049 0.750 NM_007310
COMT
catechol-O-methyltransferase
chr16_-_47872973 0.750 CBLN1
cerebellin 1 precursor
chr19_-_53808505 0.748 NM_017708
FAM83E
family with sequence similarity 83, member E
chr2_+_71016503 0.744 NM_001692
ATP6V1B1
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
chrX_-_50573759 0.744 NM_020717
SHROOM4
shroom family member 4
chr21_-_31175722 0.740 NM_175858
KRTAP11-1
keratin associated protein 11-1
chr3_-_62835601 0.736


chr3_+_52325374 0.735 NM_015512
DNAH1
dynein, axonemal, heavy chain 1
chr17_-_17421050 0.734 PEMT
phosphatidylethanolamine N-methyltransferase
chr15_-_97368546 0.733 NM_001167902
PGPEP1L
pyroglutamyl-peptidase I-like
chr11_+_1420250 0.730 BRSK2
BR serine/threonine kinase 2
chr1_+_226261374 0.729 NM_033131
WNT3A
wingless-type MMTV integration site family, member 3A
chr17_+_43128422 0.726


chr22_+_21407066 0.724


chr7_-_27108826 0.723 NM_006735
HOXA2
homeobox A2
chr18_-_45630154 0.715 MYO5B
myosin VB
chr4_-_673107 0.715 MFSD7
major facilitator superfamily domain containing 7
chr19_-_56105805 0.715 NM_004917
KLK4
kallikrein-related peptidase 4
chr7_+_128367961 0.714 NM_001098627
IRF5
interferon regulatory factor 5
chr7_+_75977680 0.714 NM_030570
NM_182684
UPK3B

uroplakin 3B

chr21_-_30614477 0.711 NM_203405
KRTAP26-1
keratin associated protein 26-1
chr22_-_20235372 0.710 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr2_+_70981223 0.709 NM_012476
VAX2
ventral anterior homeobox 2
chr18_-_43821491 0.709 NM_001039360
ZBTB7C
zinc finger and BTB domain containing 7C
chr9_-_115880281 0.707 AMBP
alpha-1-microglobulin/bikunin precursor
chr14_+_105012106 0.702 NM_001312
CRIP2
cysteine-rich protein 2
chr15_+_72253940 0.702 NM_201526
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr7_-_105106844 0.701 NM_138495
ATXN7L1
ataxin 7-like 1
chrX_-_2896285 0.701 ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr1_+_226712430 0.698 NM_175055
HIST3H2BB
histone cluster 3, H2bb
chr16_-_29817841 0.696 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr7_+_73080362 0.695 NM_000501
NM_001081752
NM_001081753
NM_001081754
NM_001081755
ELN




elastin




chrX_-_37916138 0.691 SRPX
sushi-repeat containing protein, X-linked
chr21_+_44890758 0.690 NM_198692
KRTAP10-11
keratin associated protein 10-11
chr3_-_15515382 0.688 NM_080538
COLQ
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chrX_+_70438352 0.685 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr7_-_76667045 0.684 NM_006682
FGL2
fibrinogen-like 2
chr8_+_142501188 0.680 NM_007079
NM_032611
PTP4A3

protein tyrosine phosphatase type IVA, member 3

chr15_+_39918302 0.680 NM_001114633
PLA2G4B
phospholipase A2, group IVB (cytosolic)
chrX_+_49531209 0.678 NM_001145073
USP27X
ubiquitin specific peptidase 27, X-linked
chrX_-_114374860 0.677 NM_020871
LRCH2
leucine-rich repeats and calponin homology (CH) domain containing 2
chrX_-_12972641 0.677 NM_174901
FAM9C
family with sequence similarity 9, member C
chr7_+_70235724 0.676 NM_022479
WBSCR17
Williams-Beuren syndrome chromosome region 17
chr6_-_24466258 0.676 NM_016356
DCDC2
doublecortin domain containing 2
chr22_-_35835548 0.674 TMPRSS6
transmembrane protease, serine 6
chr21_+_44871467 0.672 NM_198690
KRTAP10-9
keratin associated protein 10-9
chr7_+_73080404 0.671 ELN
elastin
chr1_+_199884152 0.671 NAV1
neuron navigator 1
chr9_+_125813672 0.669 NM_004789
LHX2
LIM homeobox 2
chr19_-_11550576 0.669 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chr11_-_60379998 0.668 NM_004778
GPR44
G protein-coupled receptor 44

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.39 4.24e-09 GO:0065008 regulation of biological quality
1.24 2.49e-06 GO:0023052 signaling
1.88 1.30e-05 GO:0044057 regulation of system process
1.41 4.03e-05 GO:0051239 regulation of multicellular organismal process
1.12 1.17e-04 GO:0065007 biological regulation
1.17 1.36e-04 GO:0032501 multicellular organismal process
1.22 1.81e-04 GO:0007165 signal transduction
1.25 2.35e-04 GO:0048731 system development
1.43 5.24e-04 GO:0007154 cell communication
1.63 6.12e-04 GO:0019226 transmission of nerve impulse
1.63 6.12e-04 GO:0035637 multicellular organismal signaling
1.43 6.31e-04 GO:0009605 response to external stimulus
1.21 1.12e-03 GO:0007275 multicellular organismal development
1.61 1.22e-03 GO:0007599 hemostasis
1.49 1.29e-03 GO:0007267 cell-cell signaling
5.10 1.60e-03 GO:0048484 enteric nervous system development
3.48 1.72e-03 GO:0021675 nerve development
1.56 1.80e-03 GO:0050878 regulation of body fluid levels
1.21 1.83e-03 GO:0048856 anatomical structure development
3.86 2.71e-03 GO:0048483 autonomic nervous system development
2.39 2.79e-03 GO:0045761 regulation of adenylate cyclase activity
1.59 2.96e-03 GO:0007596 blood coagulation
1.59 2.96e-03 GO:0050817 coagulation
1.58 3.49e-03 GO:0006935 chemotaxis
1.58 3.49e-03 GO:0042330 taxis
1.63 3.93e-03 GO:0007268 synaptic transmission
2.20 4.43e-03 GO:0030802 regulation of cyclic nucleotide biosynthetic process
2.20 4.43e-03 GO:0030808 regulation of nucleotide biosynthetic process
2.26 4.44e-03 GO:0030817 regulation of cAMP biosynthetic process
1.86 4.56e-03 GO:0030168 platelet activation
2.34 4.75e-03 GO:0031279 regulation of cyclase activity
2.24 5.65e-03 GO:0030814 regulation of cAMP metabolic process
2.30 7.92e-03 GO:0051339 regulation of lyase activity
1.11 8.10e-03 GO:0050789 regulation of biological process
2.15 8.71e-03 GO:0030799 regulation of cyclic nucleotide metabolic process
1.41 9.22e-03 GO:0009611 response to wounding
1.24 9.73e-03 GO:0048519 negative regulation of biological process
1.18 1.02e-02 GO:0032502 developmental process
1.51 1.18e-02 GO:0042060 wound healing
1.64 1.24e-02 GO:0090066 regulation of anatomical structure size
1.31 1.27e-02 GO:0007399 nervous system development
1.40 1.97e-02 GO:0040011 locomotion
1.16 1.98e-02 GO:0051716 cellular response to stimulus
1.12 2.61e-02 GO:0050896 response to stimulus
6.09 3.35e-02 GO:0042135 neurotransmitter catabolic process
1.67 3.41e-02 GO:0006140 regulation of nucleotide metabolic process
1.24 3.46e-02 GO:0048523 negative regulation of cellular process
1.11 4.23e-02 GO:0050794 regulation of cellular process
1.52 4.23e-02 GO:0031175 neuron projection development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.21 9.53e-07 GO:0005886 plasma membrane
1.20 2.82e-06 GO:0071944 cell periphery
1.13 3.00e-06 GO:0016020 membrane
1.27 1.02e-04 GO:0044459 plasma membrane part
1.13 3.07e-04 GO:0044425 membrane part
2.52 5.01e-04 GO:0045095 keratin filament
1.49 1.45e-03 GO:0030054 cell junction
1.41 1.88e-03 GO:0005626 insoluble fraction
1.58 3.29e-03 GO:0045202 synapse
1.39 6.26e-03 GO:0005624 membrane fraction
1.32 7.73e-03 GO:0000267 cell fraction
1.70 1.86e-02 GO:0016323 basolateral plasma membrane
1.29 1.97e-02 GO:0005887 integral to plasma membrane
1.11 4.00e-02 GO:0031224 intrinsic to membrane
1.27 4.58e-02 GO:0031226 intrinsic to plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.55 4.04e-03 GO:0030695 GTPase regulator activity
1.53 7.67e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.68 2.93e-02 GO:0005096 GTPase activator activity