Motif ID: HAND1,2.p2

Z-value: 1.816


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
HAND1 9421 heart and neural crest derivatives expressed 1
HAND2 9464 heart and neural crest derivatives expressed 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HAND2chr4_-_174687931-0.292.8e-01Click!
HAND1chr5_-_153838013-0.204.5e-01Click!


Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_557269 1.823


chr5_+_150008030 1.409 SYNPO
synaptopodin
chr1_+_556968 1.342


chr7_+_142270634 1.310 EPHB6
EPH receptor B6
chr6_-_31196174 1.181 NM_001264
CDSN
corneodesmosin
chr1_+_199519202 1.156 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr1_+_200358594 1.155 NM_004767
GPR37L1
G protein-coupled receptor 37 like 1
chr8_-_19584373 1.131 NM_018371
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr22_+_21053972 1.130


chr11_+_118463906 1.094 NM_001024382
HMBS
hydroxymethylbilane synthase
chr1_-_199348316 1.084 NM_000069
CACNA1S
calcium channel, voltage-dependent, L type, alpha 1S subunit
chr1_-_23393808 1.046 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr20_-_29441946 1.008 NM_153289
NM_153323
NM_173460
DEFB119


defensin, beta 119


chr19_-_59542197 0.989 NM_012276
LILRA4
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
chr11_+_18244383 0.982 NM_000331
NM_001178006
NM_199161
SAA1


serum amyloid A1


chr7_+_104539548 0.980 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr20_-_55718982 0.965 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr11_-_119504726 0.964 TRIM29
tripartite motif containing 29
chr1_+_17404206 0.964 NM_013358
PADI1
peptidyl arginine deiminase, type I
chr12_+_27511009 0.953 NM_001145010
C12orf70
chromosome 12 open reading frame 70
chr15_-_50316996 0.944 MYO5C
myosin VC
chr8_-_18585721 0.933 PSD3
pleckstrin and Sec7 domain containing 3
chr3_-_124893875 0.923 MYLK
myosin light chain kinase
chr22_+_21393107 0.917 IGLJ3
immunoglobulin lambda joining 3
chr20_+_29420081 0.914 NM_054112
DEFB118
defensin, beta 118
chr15_+_66695932 0.912 NM_001190456
CORO2B
coronin, actin binding protein, 2B
chr1_+_151035850 0.909 NM_178352
LCE1D
late cornified envelope 1D
chr6_-_21631992 0.908


chr17_+_71235324 0.897 ITGB4
integrin, beta 4
chr6_+_29732736 0.874 NM_001008228
NM_001008229
NM_001170418
NM_002433
NM_206809
NM_206810
NM_206811
NM_206812
NM_206814
MOG








myelin oligodendrocyte glycoprotein








chr22_+_23329113 0.860 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr20_+_36643251 0.860 NM_001018082
ADIG
adipogenin
chr6_+_167445284 0.860 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr4_+_76700281 0.857 NM_178497
C4orf26
chromosome 4 open reading frame 26
chr11_-_4893468 0.843 NM_001005238
OR51G2
olfactory receptor, family 51, subfamily G, member 2
chr5_-_121842680 0.843


chr14_-_87806913 0.837 NM_138318
KCNK10
potassium channel, subfamily K, member 10
chr8_-_28403652 0.834 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr17_-_36899641 0.822 NM_003771
KRT36
keratin 36
chr4_+_40032146 0.821 NM_017581
CHRNA9
cholinergic receptor, nicotinic, alpha 9
chr3_+_196933422 0.817 NM_152673
MUC20
mucin 20, cell surface associated
chr1_+_28134090 0.813 NM_001009568
NM_014474
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr1_-_166149867 0.809 NM_001167749
NM_018417
ADCY10

adenylate cyclase 10 (soluble)

chr1_+_26358097 0.800 NM_024869
GRRP1
glycine/arginine rich protein 1
chr6_+_31016755 0.793 NM_080870
DPCR1
diffuse panbronchiolitis critical region 1
chr10_-_70846573 0.793 NM_001057
TACR2
tachykinin receptor 2
chr7_+_99654806 0.765 NM_024070
PVRIG
poliovirus receptor related immunoglobulin domain containing
chr8_-_38577891 0.761


chr19_+_50144267 0.733 APOC2
apolipoprotein C-II
chr8_+_134272463 0.732 NM_003882
NM_080838
WISP1

WNT1 inducible signaling pathway protein 1

chr3_-_33675484 0.725 CLASP2
cytoplasmic linker associated protein 2
chr22_-_16127520 0.717 CECR3
cat eye syndrome chromosome region, candidate 3
chr6_-_39180390 0.717 C6orf64
chromosome 6 open reading frame 64
chr5_-_149304475 0.708 NM_000440
PDE6A
phosphodiesterase 6A, cGMP-specific, rod, alpha
chr9_-_135074364 0.706 NM_014581
OBP2B
OBP2A
odorant binding protein 2B
odorant binding protein 2A
chr14_+_70209807 0.699 TTC9
tetratricopeptide repeat domain 9
chr1_+_228949752 0.697 NM_006615
NM_016452
CAPN9

calpain 9

chr10_+_82287637 0.685 NM_207372
SH2D4B
SH2 domain containing 4B
chr21_+_34112456 0.683 ITSN1
intersectin 1 (SH3 domain protein)
chr2_+_231569082 0.673 NM_139073
SPATA3
spermatogenesis associated 3
chr3_+_46894239 0.670 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr19_+_52113772 0.669 NM_004491
GRLF1
glucocorticoid receptor DNA binding factor 1
chr2_-_128155829 0.662 NM_001161404
LIMS2
LIM and senescent cell antigen-like domains 2
chr6_-_53121540 0.658 NM_003643
GCM1
glial cells missing homolog 1 (Drosophila)
chr1_-_41722883 0.655 NM_001956
EDN2
endothelin 2
chr1_+_46418786 0.649 TSPAN1
tetraspanin 1
chr12_-_108755588 0.647 NM_021625
TRPV4
transient receptor potential cation channel, subfamily V, member 4
chr11_-_63087430 0.645 NM_017878
HRASLS2
HRAS-like suppressor 2
chr11_+_118332217 0.634 NM_006760
UPK2
uroplakin 2
chr3_-_15357878 0.628 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr10_-_76529253 0.626 NM_016364
DUSP13
dual specificity phosphatase 13
chr2_-_73781974 0.624 NM_016347
NAT8B
N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene)
chr7_-_142293382 0.618 NM_018646
TRPV6
transient receptor potential cation channel, subfamily V, member 6
chr1_+_148511806 0.615 NM_024579
C1orf54
chromosome 1 open reading frame 54
chr19_+_60850765 0.614 NM_013301
CCDC106
coiled-coil domain containing 106
chr2_+_128119908 0.614 NM_001161415
NM_001161416
NM_001161417
NM_005291
GPR17



G protein-coupled receptor 17



chr22_-_21814208 0.610 NM_014433
RTDR1
rhabdoid tumor deletion region gene 1
chr12_+_26096757 0.608 NM_001164746
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr3_-_15515382 0.592 NM_080538
COLQ
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr10_-_73149505 0.588 NM_001164375
C10orf105
chromosome 10 open reading frame 105
chr2_-_219404755 0.586 NM_017431
PRKAG3
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
chr19_-_10074332 0.585 NM_031917
ANGPTL6
angiopoietin-like 6
chr10_-_121286034 0.584 NM_002925
RGS10
regulator of G-protein signaling 10
chr7_+_102078007 0.582 NM_001166339
NM_001031618
SPDYE2L
SPDYE2
WBSCR19-like protein 3
speedy homolog E2 (Xenopus laevis)
chr21_+_29439768 0.579 C21orf7
chromosome 21 open reading frame 7
chr12_-_108755565 0.578 TRPV4
transient receptor potential cation channel, subfamily V, member 4
chr15_+_37330176 0.575 NM_207445
C15orf54
chromosome 15 open reading frame 54
chr15_+_42815851 0.572 NM_080745
NM_182985
TRIM69

tripartite motif containing 69

chr14_-_64508547 0.571 NM_198686
RAB15
RAB15, member RAS onocogene family
chr21_-_45165204 0.570 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr1_-_53972464 0.570 NM_147193
GLIS1
GLIS family zinc finger 1
chr5_+_73145098 0.568 RGNEF
190 kDa guanine nucleotide exchange factor
chr16_+_55612125 0.566 NLRC5
NLR family, CARD domain containing 5
chr19_+_41085221 0.565 NM_001007469
NM_014266
HCST

hematopoietic cell signal transducer

chr11_-_2517390 0.561


chr16_-_3089253 0.557 ZSCAN10
zinc finger and SCAN domain containing 10
chr6_+_88026338 0.548 ZNF292
zinc finger protein 292
chr2_-_27571532 0.545 FNDC4
fibronectin type III domain containing 4
chrX_+_2680092 0.542 NM_001141919
NM_001141920
NM_175569
XGPY2
XG


Xg pseudogene, Y-linked 2
Xg blood group


chr1_-_181540631 0.542 NM_170706
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chr2_-_138762909 0.540


chr3_-_126215069 0.538 HEG1
HEG homolog 1 (zebrafish)
chr6_-_31215089 0.534 NM_014069
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr5_+_36644187 0.533 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr20_+_34937928 0.533 NM_080628
C20orf118
chromosome 20 open reading frame 118
chr6_+_6533932 0.531 NM_004271
LY86
lymphocyte antigen 86
chr3_+_153499883 0.529 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr1_+_15858950 0.527 NM_006511
RSC1A1
regulatory solute carrier protein, family 1, member 1
chrX_-_69396241 0.518 NM_002565
P2RY4
pyrimidinergic receptor P2Y, G-protein coupled, 4
chr11_-_5494391 0.516 NM_145053
UBQLNL
ubiquilin-like
chr6_-_3665308 0.509


chr21_-_45165249 0.508 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr6_+_37081387 0.503 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr9_-_131555111 0.503 NM_004878
PTGES
prostaglandin E synthase
chr17_+_71232370 0.502 NM_001005619
ITGB4
integrin, beta 4
chr5_-_41906459 0.491 NM_000436
OXCT1
3-oxoacid CoA transferase 1
chr5_-_39400319 0.490 NM_001737
C9
complement component 9
chr1_+_116744992 0.490 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr14_-_30927931 0.490 NM_015473
HEATR5A
HEAT repeat containing 5A
chr2_+_95621492 0.489 NM_138800
TRIM43
tripartite motif containing 43
chr17_-_24426752 0.488 NM_004740
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr7_+_136849104 0.487 RPL41P5
ribosomal protein L41 pseudogene 5
chr12_+_107797985 0.486 NM_001917
DAO
D-amino-acid oxidase
chr1_+_245646080 0.484 NM_001079821
NM_001127461
NLRP3

NLR family, pyrin domain containing 3

chr1_-_151804929 0.480 NM_005978
S100A2
S100 calcium binding protein A2
chr1_+_205038837 0.479 NM_153758
IL19
interleukin 19
chr6_-_167491305 0.479 NM_005299
GPR31
G protein-coupled receptor 31
chr5_+_179065282 0.479 CANX
calnexin
chr15_+_72687765 0.477 NM_003992
CLK3
CDC-like kinase 3
chr5_-_171814026 0.475 NM_001017995
SH3PXD2B
SH3 and PX domains 2B
chr3_+_196933481 0.471 MUC20
mucin 20, cell surface associated
chr9_+_71848316 0.470 NM_153267
MAMDC2
MAM domain containing 2
chr10_+_18669619 0.465 NM_201590
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr7_+_101978777 0.462 NM_001166339
NM_001031618
SPDYE2L
SPDYE2
WBSCR19-like protein 3
speedy homolog E2 (Xenopus laevis)
chr4_+_14985272 0.458 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr3_+_38322430 0.457 NM_004803
SLC22A14
solute carrier family 22, member 14
chr1_-_120413542 0.454 NOTCH2
notch 2
chr15_+_40484249 0.454 NM_173089
NM_173090
CAPN3

calpain 3, (p94)

chr8_-_125649926 0.453 MTSS1
metastasis suppressor 1
chr1_+_45251007 0.450 UROD
uroporphyrinogen decarboxylase
chr21_+_43024936 0.450 PDE9A
phosphodiesterase 9A
chr20_-_41788975 0.449 NM_001008901
NM_176791
GTSF1L

gametocyte specific factor 1-like

chr1_+_184636326 0.445 NM_022375
OCLM
oculomedin
chr3_+_150675117 0.445 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr11_+_66927976 0.443 NM_198517
TBC1D10C
TBC1 domain family, member 10C
chr12_+_119617060 0.442


chr17_+_65582981 0.440 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr1_+_11171967 0.439 NM_021146
ANGPTL7
angiopoietin-like 7
chr3_+_113534604 0.436 NM_001004196
NM_005944
CD200

CD200 molecule

chr6_-_33822659 0.435 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr11_-_111636792 0.433 NM_001145024
C11orf34
chromosome 11 open reading frame 34
chr21_-_35153664 0.432 RUNX1
runt-related transcription factor 1
chr1_+_154178103 0.429 NM_181885
RXFP4
relaxin/insulin-like family peptide receptor 4
chr10_-_75071498 0.428 NM_021245
MYOZ1
myozenin 1
chr10_-_45350804 0.424 NM_001002266
MARCH8
membrane-associated ring finger (C3HC4) 8
chr19_-_40996040 0.423 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr18_-_58946858 0.422 BCL2
B-cell CLL/lymphoma 2
chr11_-_19180092 0.422 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr16_+_76613912 0.421 NM_005752
CLEC3A
C-type lectin domain family 3, member A
chr8_-_27906287 0.412 NM_173833
SCARA5
scavenger receptor class A, member 5 (putative)
chr21_-_42644138 0.410 NM_005423
TFF2
trefoil factor 2
chr8_-_93099040 0.409 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr6_-_25940247 0.409 NM_005074
SLC17A1
solute carrier family 17 (sodium phosphate), member 1
chr20_+_764710 0.408 NM_207121
FAM110A
family with sequence similarity 110, member A
chr1_+_226404037 0.408 NM_020435
GJC2
gap junction protein, gamma 2, 47kDa
chr1_+_44217435 0.406 NM_003780
B4GALT2
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr19_+_54238913 0.403 NM_033043
CGB
CGB5
chorionic gonadotropin, beta polypeptide
chorionic gonadotropin, beta polypeptide 5
chr12_+_111900650 0.402 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chrX_+_1415508 0.397 NM_002183
IL3RA
interleukin 3 receptor, alpha (low affinity)
chr16_+_55553262 0.396 NM_000078
CETP
cholesteryl ester transfer protein, plasma
chr11_+_5558682 0.394 NM_001005162
OR52B6
olfactory receptor, family 52, subfamily B, member 6
chr20_+_19815075 0.394 RIN2
Ras and Rab interactor 2
chr19_-_47586259 0.394 NM_032488
CNFN
cornifelin
chr12_-_55134692 0.393 NM_012064
MIP
major intrinsic protein of lens fiber
chr18_+_41659542 0.391 NM_213602
SIGLEC15
sialic acid binding Ig-like lectin 15
chrX_+_69418746 0.390 NM_001032726
RAB41
RAB41, member RAS oncogene family
chr2_+_113533155 0.389 NM_012275
IL1F5
interleukin 1 family, member 5 (delta)
chr3_-_46761248 0.388 NM_199183
PRSS45
protease, serine, 45
chr6_+_3697328 0.388


chr1_+_33003847 0.385 KIAA1522
KIAA1522
chr17_+_74531873 0.382 C1QTNF1
C1q and tumor necrosis factor related protein 1
chr7_+_75977680 0.382 NM_030570
NM_182684
UPK3B

uroplakin 3B

chr3_+_150675169 0.380 TM4SF4
transmembrane 4 L six family member 4
chr17_+_45617676 0.377


chr1_+_33003814 0.377 NM_001198972
NM_001198973
KIAA1522

KIAA1522

chr14_-_105392671 0.377


chr6_+_37030186 0.377 NM_153370
PI16
peptidase inhibitor 16
chr18_+_19826734 0.375 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr12_-_108736983 0.374 NM_001177431
NM_001177428
NM_001177433
NM_147204
TRPV4



transient receptor potential cation channel, subfamily V, member 4



chr13_-_59485299 0.370 NM_030932
DIAPH3
diaphanous homolog 3 (Drosophila)
chr22_+_40416492 0.367 NM_001142964
C22orf46
chromosome 22 open reading frame 46
chr2_-_27571602 0.367 NM_022823
FNDC4
fibronectin type III domain containing 4
chr1_-_41398126 0.366 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr19_+_60279032 0.365 NM_133180
EPS8L1
EPS8-like 1
chr5_-_179004610 0.362 NM_001142306
C5orf60
chromosome 5 open reading frame 60
chr12_-_56496107 0.359 NM_006576
AVIL
advillin
chr5_-_41906216 0.357 OXCT1
3-oxoacid CoA transferase 1
chr17_-_36587965 0.356 NM_033062
KRTAP4-2
keratin associated protein 4-2
chr10_+_99334411 0.355 HOGA1
4-hydroxy-2-oxoglutarate aldolase 1
chr5_-_41906257 0.350 OXCT1
3-oxoacid CoA transferase 1

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.49 7.25e-06 GO:0005576 extracellular region
1.29 4.91e-05 GO:0071944 cell periphery
1.29 5.22e-05 GO:0005886 plasma membrane
1.49 3.17e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.78 2.09e-03 GO:0003823 antigen binding
1.42 6.37e-03 GO:0004872 receptor activity
1.35 1.87e-02 GO:0004871 signal transducer activity
1.35 1.87e-02 GO:0060089 molecular transducer activity
12.75 3.99e-02 GO:0032052 bile acid binding