Motif ID: ADNP_IRX_SIX_ZHX.p2

Z-value: 0.914


Transcription factors associated with ADNP_IRX_SIX_ZHX.p2:

Gene SymbolEntrez IDGene Name
ADNP 23394 activity-dependent neuroprotector homeobox
IRX4 50805 iroquois homeobox 4
IRX5 10265 iroquois homeobox 5
SIX2 10736 SIX homeobox 2
SIX5 147912 SIX homeobox 5
ZHX1 11244 zinc fingers and homeoboxes 1
ZHX2 22882 zinc fingers and homeoboxes 2
ZHX3 23051 zinc fingers and homeoboxes 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SIX2chr2_-_450900250.648.0e-03Click!
ADNPchr20_-_489808580.611.2e-02Click!
IRX5chr16_+_535226110.476.8e-02Click!
ZHX2chr8_+_123863075-0.273.1e-01Click!
ZHX3chr20_-_393795330.273.2e-01Click!
ZHX1chr8_-_1243556700.224.2e-01Click!
IRX4chr5_-_19357640.077.9e-01Click!
SIX5chr19_-_509643360.068.2e-01Click!


Activity profile for motif ADNP_IRX_SIX_ZHX.p2.

activity profile for motif ADNP_IRX_SIX_ZHX.p2


Sorted Z-values histogram for motif ADNP_IRX_SIX_ZHX.p2

Sorted Z-values for motif ADNP_IRX_SIX_ZHX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ADNP_IRX_SIX_ZHX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_52697160 1.296 HOXC5
HOXC6
homeobox C5
homeobox C6
chr7_-_27171673 1.291 NM_152739
HOXA9
homeobox A9
chr8_+_77756061 1.166 NM_024721
ZFHX4
zinc finger homeobox 4
chr3_-_168674502 1.153 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr7_-_27171648 1.096 HOXA9
homeobox A9
chr8_+_77756077 1.093 ZFHX4
zinc finger homeobox 4
chr16_+_7322751 1.057 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr3_-_55489973 1.055 WNT5A
wingless-type MMTV integration site family, member 5A
chr7_-_27171600 0.990 HOXA9
homeobox A9
chr5_+_125786975 0.984 GRAMD3
GRAM domain containing 3
chr12_+_52696908 0.976 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr9_+_102380156 0.817 NM_001018116
MURC
muscle-related coiled-coil protein
chr7_-_76667045 0.750 NM_006682
FGL2
fibrinogen-like 2
chr15_+_40427592 0.713 NM_212465
CAPN3
calpain 3, (p94)
chr8_-_72431274 0.704 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr13_+_100902942 0.693 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr2_-_45090025 0.665 NM_016932
SIX2
SIX homeobox 2
chr9_-_205892 0.665 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr17_-_10265991 0.659 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr4_-_72868598 0.648 NM_000583
GC
group-specific component (vitamin D binding protein)
chr9_-_14076901 0.606 NFIB
nuclear factor I/B
chr12_+_52680143 0.599 NM_006897
HOXC9
homeobox C9
chr15_-_53996597 0.584 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr5_+_155686333 0.576 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr6_+_21701942 0.570 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr8_-_72436519 0.556 EYA1
eyes absent homolog 1 (Drosophila)
chr4_+_41309668 0.533 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr16_+_85169615 0.520 NM_005250
FOXL1
forkhead box L1
chr4_-_87989291 0.517 NM_197965
SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter family), member 6
chr6_-_101018271 0.498 NM_005068
SIM1
single-minded homolog 1 (Drosophila)
chr11_-_5946299 0.497 NM_001146033
OR56A5
olfactory receptor, family 56, subfamily A, member 5
chr8_-_49996353 0.494 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr12_-_89922888 0.463 NM_004950
EPYC
epiphycan
chrX_+_107174855 0.457 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr8_-_125252884 0.442 C8orf78
chromosome 8 open reading frame 78
chr2_+_200031333 0.436


chr13_-_29322795 0.435 NM_007106
UBL3
ubiquitin-like 3
chr1_+_201286933 0.435 NM_015053
PPFIA4
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
chr14_-_19252330 0.427 NM_001197287
OR11H2
olfactory receptor, family 11, subfamily H, member 2
chr12_-_21379098 0.427 NM_021094
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr3_+_46894239 0.426 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr11_+_10433241 0.424 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr11_+_113280727 0.421 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr3_-_115380539 0.419 NM_000796
NM_033663
DRD3

dopamine receptor D3

chr3_-_57209319 0.413 NM_003865
HESX1
HESX homeobox 1
chr12_-_116890410 0.403 NM_173598
KSR2
kinase suppressor of ras 2
chr7_+_129771865 0.397 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr17_-_44037332 0.388 NM_018952
HOXB6
homeobox B6
chr6_-_133008834 0.387 NM_138327
TAAR1
trace amine associated receptor 1
chr6_+_12825818 0.385 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr5_+_125786717 0.379 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chrX_-_137649180 0.379 NM_033642
FGF13
fibroblast growth factor 13
chr1_-_157950898 0.378 NM_000567
CRP
C-reactive protein, pentraxin-related
chr4_+_41309482 0.375 LIMCH1
LIM and calponin homology domains 1
chr21_+_24722913 0.373 FLJ42200
FLJ42200 protein
chr17_-_10393664 0.371 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr12_-_16321885 0.371 NM_001170798
SLC15A5
solute carrier family 15, member 5
chrX_-_153698930 0.367 HMGN1P37
high-mobility group nucleosome binding domain 1 pseudogene 37
chr12_+_79634820 0.363 NM_005593
MYF5
myogenic factor 5
chr6_-_49820030 0.360 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr4_+_41309690 0.357 LIMCH1
LIM and calponin homology domains 1
chr3_-_25654659 0.356 TOP2B
topoisomerase (DNA) II beta 180kDa
chr3_+_11242666 0.356 NM_001098211
HRH1
histamine receptor H1
chr2_-_190635566 0.351 NM_005259
MSTN
myostatin
chr2_-_87102453 0.351 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr12_+_79362256 0.347 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr11_+_12355600 0.347 NM_018222
PARVA
parvin, alpha
chr4_-_176970407 0.343 GPM6A
glycoprotein M6A
chr5_+_66160359 0.343 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr12_+_20854904 0.343 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr12_-_69434330 0.338 PTPRR
protein tyrosine phosphatase, receptor type, R
chr9_-_99740243 0.337 NM_197978
HEMGN
hemogen
chr8_+_67201684 0.335 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr5_+_140772691 0.330 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr2_+_178893216 0.330 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr3_-_158704056 0.328 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr3_+_190147633 0.328 TPRG1
tumor protein p63 regulated 1
chr14_-_34252695 0.326 NM_021914
CFL2
cofilin 2 (muscle)
chr22_+_44828338 0.326


chr13_+_34948977 0.326 NBEA
neurobeachin
chr11_-_16454493 0.320 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr1_-_201321999 0.319 NM_002479
MYOG
myogenin (myogenic factor 4)
chr5_+_60969392 0.318 NM_173667
FLJ37543
hypothetical protein FLJ37543
chr17_+_7728819 0.314 NM_001005271
CHD3
chromodomain helicase DNA binding protein 3
chr3_-_71625318 0.312 FOXP1
forkhead box P1
chr12_-_89922875 0.310 EPYC
epiphycan
chr8_-_86441115 0.301 NM_001164830
CA1
carbonic anhydrase I
chr6_+_12398514 0.300 NM_001168319
NM_001955
EDN1

endothelin 1

chr9_-_94226380 0.297 NM_005014
OMD
osteomodulin
chr12_+_56802 0.292 NM_015232
IQSEC3
IQ motif and Sec7 domain 3
chr4_-_176970372 0.292 GPM6A
glycoprotein M6A
chr1_-_115039614 0.292 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1

chr5_+_152850276 0.292 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr1_-_103269356 0.291 COL11A1
collagen, type XI, alpha 1
chr1_+_84646621 0.291 NM_058248
DNASE2B
deoxyribonuclease II beta
chr7_-_72574528 0.291 NM_032408
BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr21_-_46529663 0.289 NM_003906
MCM3AP
minichromosome maintenance complex component 3 associated protein
chr3_+_123256902 0.288 NM_175862
CD86
CD86 molecule
chr5_+_38481392 0.288 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr7_-_72574474 0.287 BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr2_-_1905508 0.287 MYT1L
myelin transcription factor 1-like
chr11_+_124539768 0.287 NM_022062
PKNOX2
PBX/knotted 1 homeobox 2
chr15_-_48434677 0.284 GABPB1
GA binding protein transcription factor, beta subunit 1
chr15_-_70385709 0.284 NM_001172685
CELF6
CUGBP, Elav-like family member 6
chr12_-_14024187 0.283 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr11_-_83071084 0.282 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr10_-_85975263 0.281 NM_001017924
LRIT2
leucine-rich repeat, immunoglobulin-like and transmembrane domains 2
chr10_+_44726635 0.278 NM_001123376
TMEM72
transmembrane protein 72
chr6_+_157141565 0.278 ARID1B
AT rich interactive domain 1B (SWI1-like)
chr3_+_190831909 0.275 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr6_-_52060327 0.274 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr6_+_158653679 0.270 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr21_-_35343456 0.268 NM_001754
RUNX1
runt-related transcription factor 1
chr21_-_35343428 0.267 RUNX1
runt-related transcription factor 1
chr2_+_73911477 0.266 STAMBP
STAM binding protein
chr12_-_6356783 0.265 NM_001159575
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr4_+_169250281 0.264 NM_007193
ANXA10
annexin A10
chr21_-_35343448 0.263 RUNX1
runt-related transcription factor 1
chr1_-_53972464 0.261 NM_147193
GLIS1
GLIS family zinc finger 1
chrX_+_85404626 0.260 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chr15_-_48434567 0.259 GABPB1
GA binding protein transcription factor, beta subunit 1
chr11_+_133444029 0.256 NM_032801
JAM3
junctional adhesion molecule 3
chrX_-_18600108 0.255 NM_000330
RS1
retinoschisin 1
chr21_+_29439768 0.255 C21orf7
chromosome 21 open reading frame 7
chr1_+_86707113 0.251 NM_001285
CLCA1
chloride channel accessory 1
chr10_+_75343352 0.250 PLAU
plasminogen activator, urokinase
chr12_-_10497195 0.249 NM_002259
NM_007328
KLRC1

killer cell lectin-like receptor subfamily C, member 1

chr2_-_207291364 0.248 NM_001093730
DYTN
dystrotelin
chr2_+_171316462 0.248 EIF2S2
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
chr2_+_102401580 0.247 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chrX_+_144716619 0.246 NM_004709
CXorf1
chromosome X open reading frame 1
chr12_-_4358968 0.246 NM_020638
FGF23
fibroblast growth factor 23
chr12_+_40117751 0.243 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr15_-_48434641 0.243 GABPB1
GA binding protein transcription factor, beta subunit 1
chr12_-_69434650 0.242 PTPRR
protein tyrosine phosphatase, receptor type, R
chr7_-_112514990 0.242 GPR85
G protein-coupled receptor 85
chr12_-_101398503 0.241 NM_000618
NM_001111283
NM_001111285
IGF1


insulin-like growth factor 1 (somatomedin C)


chr7_-_72574383 0.240 BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr10_-_17211795 0.240 NM_001081
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr2_-_200030944 0.237 NM_001172509
SATB2
SATB homeobox 2
chr17_-_10313600 0.236 NM_017533
MYH4
myosin, heavy chain 4, skeletal muscle
chrX_+_146941222 0.235 FTH1P8
ferritin, heavy polypeptide 1 pseudogene 8
chr8_-_37847095 0.233 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chr7_-_135083906 0.233 NM_205855
FAM180A
family with sequence similarity 180, member A
chr15_+_46285789 0.232 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr15_-_48434896 0.232 NM_002041
NM_005254
NM_016654
NM_016655
NM_181427
GABPB1




GA binding protein transcription factor, beta subunit 1




chr1_+_67923331 0.230 NM_001924
GADD45A
growth arrest and DNA-damage-inducible, alpha
chr6_-_127882192 0.230 NM_001012279
C6orf174
chromosome 6 open reading frame 174
chr11_+_34599227 0.230 EHF
ets homologous factor
chr5_+_140698537 0.229 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr4_-_75066533 0.229 NM_002619
PF4
platelet factor 4
chr21_-_35343331 0.229 RUNX1
runt-related transcription factor 1
chr13_-_102517196 0.229 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr10_+_68355797 0.227 NM_178011
LRRTM3
leucine rich repeat transmembrane neuronal 3
chr6_+_130381408 0.226 NM_001007102
NM_032438
L3MBTL3

l(3)mbt-like 3 (Drosophila)

chr15_+_48434397 0.225 LOC100129387
hypothetical LOC100129387
chr17_-_15495534 0.225 TRIM16
tripartite motif containing 16
chr3_-_57653634 0.225 NM_152678
FAM116A
family with sequence similarity 116, member A
chr11_-_14337167 0.224 NM_012250
RRAS2
related RAS viral (r-ras) oncogene homolog 2
chr5_-_58918031 0.223 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_-_10362583 0.223 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr18_-_29273979 0.223 NM_001105528
C18orf34
chromosome 18 open reading frame 34
chr14_-_75517844 0.222 NM_003239
TGFB3
transforming growth factor, beta 3
chr2_+_28892366 0.222 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr11_+_34599163 0.222 NM_012153
EHF
ets homologous factor
chr10_+_70172257 0.221 CCAR1
cell division cycle and apoptosis regulator 1
chr8_-_30789865 0.221 NM_001009552
PPP2CB
protein phosphatase 2, catalytic subunit, beta isozyme
chr6_+_12825022 0.219 PHACTR1
phosphatase and actin regulator 1
chr3_+_110338250 0.219 FLJ22763
hypothetical LOC401081
chr18_+_28023984 0.218 NM_005925
MEP1B
meprin A, beta
chr12_-_101398470 0.218 IGF1
insulin-like growth factor 1 (somatomedin C)
chr1_-_191422346 0.218 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr3_-_113841200 0.217 CCDC80
coiled-coil domain containing 80
chr10_-_69736600 0.217 PBLD
phenazine biosynthesis-like protein domain containing
chr1_+_81544432 0.217 LPHN2
latrophilin 2
chr12_-_101398429 0.216 IGF1
insulin-like growth factor 1 (somatomedin C)
chr1_-_16217871 0.215 NM_014424
HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr5_+_140509803 0.215 NM_018939
PCDHB6
protocadherin beta 6
chr4_-_69116839 0.215 NM_001077
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B17
chr6_+_12824873 0.215 PHACTR1
phosphatase and actin regulator 1
chrX_-_77801480 0.214 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr8_+_98856984 0.213 NM_018407
LAPTM4B
lysosomal protein transmembrane 4 beta
chr13_-_29322671 0.212 UBL3
ubiquitin-like 3
chr6_-_76838944 0.212 NM_001563
IMPG1
interphotoreceptor matrix proteoglycan 1
chr4_+_169789327 0.212 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr5_+_161206774 0.211 NM_000806
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr21_+_38550739 0.211 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr3_+_162697289 0.210 NM_001080440
OTOL1
otolin 1 homolog (zebrafish)
chr4_-_176970895 0.209 GPM6A
glycoprotein M6A
chrX_-_15243647 0.208 NM_080873
ASB11
ankyrin repeat and SOCS box containing 11
chr6_-_28429950 0.208 NM_145909
ZNF323
zinc finger protein 323
chr19_-_3936343 0.208 EEF2
eukaryotic translation elongation factor 2
chr2_-_200030412 0.207 SATB2
SATB homeobox 2
chr3_-_143230124 0.207 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr4_+_41395493 0.206 LIMCH1
LIM and calponin homology domains 1
chr6_-_155818728 0.206 NM_015718
NOX3
NADPH oxidase 3
chr6_+_46869052 0.205 NM_005588
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr9_-_27287106 0.205 NM_001161585
NM_020641
C9orf11

chromosome 9 open reading frame 11

chr5_-_160044844 0.204 ATP10B
ATPase, class V, type 10B
chrX_+_1670485 0.204 NM_005088
AKAP17A
A kinase (PRKA) anchor protein 17A

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.48 5.49e-41 GO:0007606 sensory perception of chemical stimulus
3.57 8.14e-39 GO:0007608 sensory perception of smell
2.64 2.76e-35 GO:0007600 sensory perception
1.93 5.41e-27 GO:0003008 system process
2.06 8.92e-27 GO:0050877 neurological system process
1.36 3.39e-17 GO:0032501 multicellular organismal process
1.24 1.10e-09 GO:0050896 response to stimulus
2.37 1.70e-02 GO:0007156 homophilic cell adhesion

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.44 2.28e-20 GO:0005886 plasma membrane
1.43 7.65e-20 GO:0071944 cell periphery
1.27 2.02e-11 GO:0031224 intrinsic to membrane
1.27 9.88e-11 GO:0016021 integral to membrane
1.23 2.48e-10 GO:0044425 membrane part
1.47 1.72e-09 GO:0005576 extracellular region
1.15 5.85e-06 GO:0016020 membrane
1.30 1.03e-03 GO:0044459 plasma membrane part
1.42 6.16e-03 GO:0044421 extracellular region part
1.44 2.80e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.66 7.10e-40 GO:0004984 olfactory receptor activity
2.56 4.58e-34 GO:0004930 G-protein coupled receptor activity
2.20 7.14e-33 GO:0004888 transmembrane receptor activity
2.00 1.03e-32 GO:0004872 receptor activity
1.80 3.93e-27 GO:0004871 signal transducer activity
1.80 3.93e-27 GO:0060089 molecular transducer activity
4.06 2.01e-02 GO:0015020 glucuronosyltransferase activity
2.11 4.11e-02 GO:0008509 anion transmembrane transporter activity