Motif ID: ADNP_IRX_SIX_ZHX.p2

Z-value: 0.914


Transcription factors associated with ADNP_IRX_SIX_ZHX.p2:

Gene SymbolEntrez IDGene Name
ADNP 23394 activity-dependent neuroprotector homeobox
IRX4 50805 iroquois homeobox 4
IRX5 10265 iroquois homeobox 5
SIX2 10736 SIX homeobox 2
SIX5 147912 SIX homeobox 5
ZHX1 11244 zinc fingers and homeoboxes 1
ZHX2 22882 zinc fingers and homeoboxes 2
ZHX3 23051 zinc fingers and homeoboxes 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SIX2chr2_-_450900250.648.0e-03Click!
ADNPchr20_-_489808580.611.2e-02Click!
IRX5chr16_+_535226110.476.8e-02Click!
ZHX2chr8_+_123863075-0.273.1e-01Click!
ZHX3chr20_-_393795330.273.2e-01Click!
ZHX1chr8_-_1243556700.224.2e-01Click!
IRX4chr5_-_19357640.077.9e-01Click!
SIX5chr19_-_509643360.068.2e-01Click!


Activity profile for motif ADNP_IRX_SIX_ZHX.p2.

activity profile for motif ADNP_IRX_SIX_ZHX.p2


Sorted Z-values histogram for motif ADNP_IRX_SIX_ZHX.p2

Sorted Z-values for motif ADNP_IRX_SIX_ZHX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ADNP_IRX_SIX_ZHX.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_52697160 1.296 HOXC5
HOXC6
homeobox C5
homeobox C6
chr7_-_27171673 1.291 NM_152739
HOXA9
homeobox A9
chr8_+_77756061 1.166 NM_024721
ZFHX4
zinc finger homeobox 4
chr3_-_168674502 1.153 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr7_-_27171648 1.096 HOXA9
homeobox A9
chr8_+_77756077 1.093 ZFHX4
zinc finger homeobox 4
chr16_+_7322751 1.057 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr3_-_55489973 1.055 WNT5A
wingless-type MMTV integration site family, member 5A
chr7_-_27171600 0.990 HOXA9
homeobox A9
chr5_+_125786975 0.984 GRAMD3
GRAM domain containing 3
chr12_+_52696908 0.976 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr9_+_102380156 0.817 NM_001018116
MURC
muscle-related coiled-coil protein
chr7_-_76667045 0.750 NM_006682
FGL2
fibrinogen-like 2
chr15_+_40427592 0.713 NM_212465
CAPN3
calpain 3, (p94)
chr8_-_72431274 0.704 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr13_+_100902942 0.693 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr2_-_45090025 0.665 NM_016932
SIX2
SIX homeobox 2
chr9_-_205892 0.665 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr17_-_10265991 0.659 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr4_-_72868598 0.648 NM_000583
GC
group-specific component (vitamin D binding protein)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
3.57 8.14e-39 GO:0007608 sensory perception of smell
3.48 5.49e-41 GO:0007606 sensory perception of chemical stimulus
2.64 2.76e-35 GO:0007600 sensory perception
2.37 1.70e-02 GO:0007156 homophilic cell adhesion
2.06 8.92e-27 GO:0050877 neurological system process
1.93 5.41e-27 GO:0003008 system process
1.36 3.39e-17 GO:0032501 multicellular organismal process
1.24 1.10e-09 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
1.47 1.72e-09 GO:0005576 extracellular region
1.44 2.28e-20 GO:0005886 plasma membrane
1.44 2.80e-02 GO:0005615 extracellular space
1.43 7.65e-20 GO:0071944 cell periphery
1.42 6.16e-03 GO:0044421 extracellular region part
1.30 1.03e-03 GO:0044459 plasma membrane part
1.27 2.02e-11 GO:0031224 intrinsic to membrane
1.27 9.88e-11 GO:0016021 integral to membrane
1.23 2.48e-10 GO:0044425 membrane part
1.15 5.85e-06 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
4.06 2.01e-02 GO:0015020 glucuronosyltransferase activity
3.66 7.10e-40 GO:0004984 olfactory receptor activity
2.56 4.58e-34 GO:0004930 G-protein coupled receptor activity
2.20 7.14e-33 GO:0004888 transmembrane receptor activity
2.11 4.11e-02 GO:0008509 anion transmembrane transporter activity
2.00 1.03e-32 GO:0004872 receptor activity
1.80 3.93e-27 GO:0004871 signal transducer activity
1.80 3.93e-27 GO:0060089 molecular transducer activity