Motif ID: AHR_ARNT_ARNT2.p2

Z-value: 1.355


Transcription factors associated with AHR_ARNT_ARNT2.p2:

Gene SymbolEntrez IDGene Name
AHR 196 aryl hydrocarbon receptor
ARNT 405 aryl hydrocarbon receptor nuclear translocator
ARNT2 9915 aryl-hydrocarbon receptor nuclear translocator 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ARNT2chr15_+_784836240.485.7e-02Click!
ARNTchr1_-_1491158350.253.5e-01Click!
AHRchr7_+_173047070.214.3e-01Click!


Activity profile for motif AHR_ARNT_ARNT2.p2.

activity profile for motif AHR_ARNT_ARNT2.p2


Sorted Z-values histogram for motif AHR_ARNT_ARNT2.p2

Sorted Z-values for motif AHR_ARNT_ARNT2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AHR_ARNT_ARNT2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_60663842 1.695 NM_020928
 ZSWIM6
zinc finger, SWIM-type containing 6
chr5_-_172688024 1.296 STC2
stanniocalcin 2
chr5_-_172687798 1.290 STC2
stanniocalcin 2
chr1_+_85819004 1.011 NM_001554
 CYR61
cysteine-rich, angiogenic inducer, 61
chr3_-_65999548 0.997 NM_001033057
NM_004742
NM_015520
 MAGI1


membrane associated guanylate kinase, WW and PDZ domain containing 1


chr18_-_21184824 0.937


chr6_-_163754903 0.911 LOC100526820
hypothetical LOC100526820
chr1_+_219119468 0.833 HLX
H2.0-like homeobox
chr20_-_10602429 0.819 NM_000214
 JAG1
jagged 1
chr21_-_35182842 0.807 NM_001001890
NM_001122607
 RUNX1

runt-related transcription factor 1

chr10_+_94439658 0.796 NM_002729
 HHEX
hematopoietically expressed homeobox
chr7_-_27136876 0.794 NM_002141
 HOXA4
homeobox A4
chr21_-_35182873 0.790 RUNX1
runt-related transcription factor 1
chr19_-_2378581 0.776 TIMM13
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr12_-_74710741 0.773 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr1_+_219119623 0.757 HLX
H2.0-like homeobox
chr2_-_101291483 0.745 NM_173647
 RNF149
ring finger protein 149
chr18_-_24011349 0.741 NM_001792
 CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr2_-_219791638 0.738 ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr19_-_2378530 0.737 TIMM13
translocase of inner mitochondrial membrane 13 homolog (yeast)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 153 entries
enrichment   p-value GO term description
3.66 4.49e-03 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
3.15 2.70e-02 GO:0030509 BMP signaling pathway
2.99 6.67e-04 GO:0014031 mesenchymal cell development
2.92 8.07e-05 GO:0060485 mesenchyme development
2.82 1.96e-02 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
2.78 3.45e-03 GO:0048762 mesenchymal cell differentiation
2.62 3.89e-05 GO:0006469 negative regulation of protein kinase activity
2.52 6.43e-04 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
2.49 1.89e-04 GO:0033673 negative regulation of kinase activity
2.41 2.12e-04 GO:0060537 muscle tissue development
2.37 2.29e-03 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
2.35 1.00e-03 GO:0051348 negative regulation of transferase activity
2.31 4.50e-03 GO:0014706 striated muscle tissue development
1.91 1.58e-02 GO:0048514 blood vessel morphogenesis
1.85 8.10e-04 GO:0001501 skeletal system development
1.85 7.40e-03 GO:0001568 blood vessel development
1.83 1.53e-03 GO:0060284 regulation of cell development
1.83 4.51e-03 GO:0001944 vasculature development
1.83 5.66e-03 GO:0071900 regulation of protein serine/threonine kinase activity
1.80 1.32e-02 GO:0061061 muscle structure development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
4.76 1.14e-03 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
1.85 2.94e-02 GO:0030424 axon
1.55 5.50e-05 GO:0044451 nucleoplasm part
1.49 2.35e-02 GO:0030529 ribonucleoprotein complex
1.41 2.48e-05 GO:0005654 nucleoplasm
1.37 1.39e-06 GO:0031981 nuclear lumen
1.36 2.33e-07 GO:0044428 nuclear part
1.35 1.66e-07 GO:0070013 intracellular organelle lumen
1.34 2.80e-07 GO:0031974 membrane-enclosed lumen
1.34 3.99e-07 GO:0043233 organelle lumen
1.32 2.61e-05 GO:0005829 cytosol
1.28 1.92e-16 GO:0005634 nucleus
1.21 3.34e-04 GO:0032991 macromolecular complex
1.21 1.09e-02 GO:0043228 non-membrane-bounded organelle
1.21 1.09e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.20 1.03e-02 GO:0043234 protein complex
1.18 8.61e-15 GO:0043231 intracellular membrane-bounded organelle
1.18 9.16e-15 GO:0043227 membrane-bounded organelle
1.18 9.64e-13 GO:0005737 cytoplasm
1.17 6.29e-06 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

Showing 1 to 20 of 25 entries
enrichment   p-value GO term description
2.94 1.96e-02 GO:0046332 SMAD binding
1.89 6.53e-03 GO:0000975 regulatory region DNA binding
1.89 6.53e-03 GO:0001067 regulatory region nucleic acid binding
1.89 6.53e-03 GO:0044212 transcription regulatory region DNA binding
1.85 2.28e-02 GO:0010843 promoter binding
1.78 1.83e-03 GO:0008134 transcription factor binding
1.73 2.84e-03 GO:0016563 transcription activator activity
1.71 6.94e-03 GO:0016564 transcription repressor activity
1.57 6.43e-05 GO:0043565 sequence-specific DNA binding
1.54 6.48e-07 GO:0030528 transcription regulator activity
1.48 3.78e-04 GO:0003723 RNA binding
1.42 1.30e-03 GO:0001071 nucleic acid binding transcription factor activity
1.42 1.30e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.40 3.83e-10 GO:0000166 nucleotide binding
1.31 2.56e-04 GO:0035639 purine ribonucleoside triphosphate binding
1.30 6.65e-04 GO:0017076 purine nucleotide binding
1.30 8.07e-04 GO:0032553 ribonucleotide binding
1.30 8.07e-04 GO:0032555 purine ribonucleotide binding
1.30 1.20e-02 GO:0005524 ATP binding
1.28 1.89e-02 GO:0030554 adenyl nucleotide binding